Solithromycin (BioDeep_00000676950)

   


代谢物信息卡片


(1S,2R,5R,7R,8R,9R,11R,13S,14R)-15-[4-[4-(3-aminophenyl)triazol-1-yl]butyl]-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-5-fluoro-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone

化学式: C43H65FN6O10 (844.4745962000001)
中文名称: 索利霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)(C)F)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=N4)C5=CC(=CC=C5)N)C
InChI: InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

3 个代谢物同义名

(1S,2R,5R,7R,8R,9R,11R,13S,14R)-15-[4-[4-(3-aminophenyl)triazol-1-yl]butyl]-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-5-fluoro-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone; 15-[4-[4-(3-Aminophenyl)triazol-1-yl]butyl]-8-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-5-fluoro-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone; Solithromycin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sara N Salerno, Fernando O Carreño, Andrea N Edginton, Michael Cohen-Wolkowiez, Daniel Gonzalez. Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population. Drug metabolism and disposition: the biological fate of chemicals. 2021 09; 49(9):844-855. doi: 10.1124/dmd.120.000318. [PMID: 34154994]
  • Ryan J Beechinor, Michael Cohen-Wolkowiez, Theresa Jasion, Christoph P Hornik, Jason E Lang, Robert Hernandez, Daniel Gonzalez. A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication. Therapeutic drug monitoring. 2019 12; 41(6):761-765. doi: 10.1097/ftd.0000000000000670. [PMID: 31318840]
  • Olanrewaju O Okusanya, Alan Forrest, Sujata M Bhavnani, Prabhavathi Fernandes, Paul G Ambrose, David R Andes. Pharmacokinetic/Pharmacodynamic Evaluation of Solithromycin against Streptococcus pneumoniae Using Data from a Neutropenic Murine Lung Infection Model. Antimicrobial agents and chemotherapy. 2019 08; 63(8):. doi: 10.1128/aac.02606-18. [PMID: 31182534]
  • Yang Liu, Wendy R Kam, Prabhavathi Fernandes, David A Sullivan. The Effect of Solithromycin, a Cationic Amphiphilic Drug, on the Proliferation and Differentiation of Human Meibomian Gland Epithelial Cells. Current eye research. 2018 06; 43(6):683-688. doi: 10.1080/02713683.2017.1418894. [PMID: 29283676]
  • Christopher MacLauchlin, Stephen E Schneider, Kara Keedy, Prabhavathi Fernandes, Brian D Jamieson. Metabolism, Excretion, and Mass Balance of Solithromycin in Humans. Antimicrobial agents and chemotherapy. 2018 05; 62(5):. doi: 10.1128/aac.01474-17. [PMID: 29507061]
  • Sara N Salerno, Andrea Edginton, Michael Cohen-Wolkowiez, Christoph P Hornik, Kevin M Watt, Brian D Jamieson, Daniel Gonzalez. Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid. CPT: pharmacometrics & systems pharmacology. 2017 12; 6(12):814-822. doi: 10.1002/psp4.12252. [PMID: 29068158]
  • Borje Darpo, Philip T Sager, Prabhavathi Fernandes, Brian D Jamieson, Kara Keedy, Meijian Zhou, David Oldach. Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects. The Journal of antimicrobial chemotherapy. 2017 02; 72(2):515-521. doi: 10.1093/jac/dkw428. [PMID: 27798210]
  • George G Zhanel, Erika Hartel, Heather Adam, Sheryl Zelenitsky, Michael A Zhanel, Alyssa Golden, Frank Schweizer, Bala Gorityala, Philippe R S Lagacé-Wiens, Andrew J Walkty, Alfred S Gin, Daryl J Hoban, Joseph P Lynch, James A Karlowsky. Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia. Drugs. 2016 Dec; 76(18):1737-1757. doi: 10.1007/s40265-016-0667-z. [PMID: 27909995]
  • M Figueira, P Fernandes, S I Pelton. Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae. Antimicrobial agents and chemotherapy. 2016 09; 60(9):5533-8. doi: 10.1128/aac.00863-16. [PMID: 27401563]
  • Mamun-Ur Rashid, Staffan Rosenborg, Georgios Panagiotidis, Johan Holm, Karin Söderberg Löfdal, Andrej Weintraub, Carl Erik Nord. Ecological Effect of Solithromycin on Normal Human Oropharyngeal and Intestinal Microbiota. Antimicrobial agents and chemotherapy. 2016 07; 60(7):4244-51. doi: 10.1128/aac.00461-16. [PMID: 27139483]
  • Daniel Gonzalez, Debra L Palazzi, Leena Bhattacharya-Mithal, Amira Al-Uzri, Laura P James, John Bradley, Natalie Neu, Theresa Jasion, Christoph P Hornik, P Brian Smith, Daniel K Benjamin, Kara Keedy, Prabhavathi Fernandes, Michael Cohen-Wolkowiez. Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents. Antimicrobial agents and chemotherapy. 2016 Apr; 60(4):2572-6. doi: 10.1128/aac.02561-15. [PMID: 26883693]
  • Brian D Jamieson, Sabrina Ciric, Prabhavathi Fernandes. Safety and Pharmacokinetics of Solithromycin in Subjects with Hepatic Impairment. Antimicrobial agents and chemotherapy. 2015 Aug; 59(8):4379-86. doi: 10.1128/aac.04652-14. [PMID: 25870056]
  • Jørgen Skov Jensen, Prabhavathi Fernandes, Magnus Unemo. In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and -susceptible Mycoplasma genitalium strains. Antimicrobial agents and chemotherapy. 2014 Jun; 58(6):3151-6. doi: 10.1128/aac.02411-14. [PMID: 24637681]
  • Jeffrey A Keelan, Matthew W Kemp, Matthew S Payne, David Johnson, Sarah J Stock, Masatoshi Saito, Prabhavathi Fernandes, John P Newnham. Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model. Antimicrobial agents and chemotherapy. 2014; 58(1):447-54. doi: 10.1128/aac.01743-13. [PMID: 24189250]
  • Keith A Rodvold, Mark H Gotfried, J Gordon Still, Kay Clark, Prabhavathi Fernandes. Comparison of plasma, epithelial lining fluid, and alveolar macrophage concentrations of solithromycin (CEM-101) in healthy adult subjects. Antimicrobial agents and chemotherapy. 2012 Oct; 56(10):5076-81. doi: 10.1128/aac.00766-12. [PMID: 22802254]
  • J Gordon Still, Jennifer Schranz, Thorsten P Degenhardt, Drusilla Scott, Prabhavathi Fernandes, Maria J Gutierrez, Kay Clark. Pharmacokinetics of solithromycin (CEM-101) after single or multiple oral doses and effects of food on single-dose bioavailability in healthy adult subjects. Antimicrobial agents and chemotherapy. 2011 May; 55(5):1997-2003. doi: 10.1128/aac.01429-10. [PMID: 21282444]