N-Propargyl-1(S)-aminoindan (BioDeep_00000676755)
代谢物信息卡片
N-Propargyl-1(S)-aminoindan
化学式: C12H13N (171.1047938)
中文名称: (S)-Rasagiline
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CCNC1CCC2=CC=CC=C12
InChI: InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
描述信息
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
D020011 - Protective Agents
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Teng Zhang, Meng-Yan Wang, Guo-Dong Wang, Qiu-Yue Lv, Yu-Qian Huang, Peng Zhang, Wen Wang, Yan Zhang, Ya-Ping Bai, Li-Qun Guo. Metformin improves nonalcoholic fatty liver disease in db/db mice by inhibiting ferroptosis.
European journal of pharmacology.
2024 Mar; 966(?):176341. doi:
10.1016/j.ejphar.2024.176341. [PMID: 38244761] - Huandong Zhao, Ruimin Ding, Jiarui Han. Ginsenoside Rh4 Facilitates the Sensitivity of Renal Cell Carcinoma to Ferroptosis via the NRF2 Pathway.
Archivos espanoles de urologia.
2024 Mar; 77(2):119-128. doi:
10.56434/j.arch.esp.urol.20247702.16. [PMID: 38583003] - B W Mahde, A Abbas Hussein, A S Sahib. Preparation and in vitro Evaluation of Rasagiline Mesylate Hybrid Nanoparticles.
Archives of Razi Institute.
2023 06; 78(3):1023-1028. doi:
10.22092/ari.2022.360193.2563. [PMID: 38028832] - Li Liu, Yi Chen, Rui-Feng Zeng, Yun Liu, Sai-Sai Xie, Jin-Shuai Lan, Yue Ding, Yi-Ting Yang, Jun Yang, Tong Zhang. Design and synthesis of novel 3,4-dihydrocoumarins as potent and selective monoamine oxidase-B inhibitors with the neuroprotection against Parkinson's disease.
Bioorganic chemistry.
2021 04; 109(?):104685. doi:
10.1016/j.bioorg.2021.104685. [PMID: 33640631] - Sai-Sai Xie, Jing Liu, Chunli Tang, Chengyun Pang, Qing Li, Yuelian Qin, Xiaojie Nong, Zhipeng Zhang, Jie Guo, Maojun Cheng, Weizhong Tang, Ningsheng Liang, Neng Jiang. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
European journal of medicinal chemistry.
2020 Sep; 202(?):112475. doi:
10.1016/j.ejmech.2020.112475. [PMID: 32652406] - Meng Wang, Wenjia Zhou, Quanying Zhang, Shunlin Zong, Chengzhe Lv. Pharmacokinetics, Pharmacodynamics, and Safety of a Single Escalating Dose and Repeated Doses of Rasagiline Transdermal Patch in Healthy Chinese Subjects.
Clinical pharmacology in drug development.
2020 07; 9(5):602-609. doi:
10.1002/cpdd.761. [PMID: 31823527] - De-Qi Jiang, Hua-Kun Wang, Yan Wang, Ming-Xing Li, Li-Lin Jiang, Yong Wang. Rasagiline combined with levodopa therapy versus levodopa monotherapy for patients with Parkinson's disease: a systematic review.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2020 Jan; 41(1):101-109. doi:
10.1007/s10072-019-04050-8. [PMID: 31446579] - N Kanwar, R Bhandari, A Kuhad, V R Sinha. Polycaprolactone-based neurotherapeutic delivery of rasagiline targeting behavioral and biochemical deficits in Parkinson's disease.
Drug delivery and translational research.
2019 10; 9(5):891-905. doi:
10.1007/s13346-019-00625-2. [PMID: 30877626] - Anna Elgart, Laura Rabinovich-Guilatt, Eli Eyal, Aviva Gross, Ofer Spiegelstein. Pharmacokinetics and safety of single and multiple doses of rasagiline in healthy Japanese and caucasian subjects.
Basic & clinical pharmacology & toxicology.
2019 Mar; 124(3):273-284. doi:
10.1111/bcpt.13131. [PMID: 30218626] - Sameh Ahmed, Nehad A Abdallah. Dansyl azide as a selective fluorescence tagging probe for click chemistry reactions and its application to monitor rasagiline in pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
2019 Feb; 165(?):357-365. doi:
10.1016/j.jpba.2018.12.026. [PMID: 30580084] - Jeffrey M Statland, Dan Moore, Yunxia Wang, Maureen Walsh, Tahseen Mozaffar, Lauren Elman, Sharon P Nations, Hiroshi Mitsumoto, J Americo Fernandes, David Saperstein, Ghazala Hayat, Laura Herbelin, Chafic Karam, Jonathan Katz, Heather M Wilkins, Abdulbaki Agbas, Russell H Swerdlow, Regina M Santella, Mazen M Dimachkie, Richard J Barohn. Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial.
Muscle & nerve.
2019 02; 59(2):201-207. doi:
10.1002/mus.26335. [PMID: 30192007] - Ying Jiang, Xuemei Zhang, Hongjie Mu, Hongchen Hua, Dongyu Duan, Xiuju Yan, Yiyun Wang, Qingqing Meng, Xiaoyan Lu, Aiping Wang, Wanhui Liu, Youxin Li, Kaoxiang Sun. Preparation and evaluation of injectable Rasagiline mesylate dual-controlled drug delivery system for the treatment of Parkinson's disease.
Drug delivery.
2018 Nov; 25(1):143-152. doi:
10.1080/10717544.2017.1419514. [PMID: 29275639] - Liulin Wang, Kabir H Biswas, Bo Kyeong Yoon, Lisa M Kawakami, Soohyun Park, Jay T Groves, Lin Li, Wei Huang, Nam-Joon Cho. Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers.
Langmuir : the ACS journal of surfaces and colloids.
2018 09; 34(36):10764-10773. doi:
10.1021/acs.langmuir.8b01348. [PMID: 30049212] - Jin-Shuai Lan, Yun Liu, Jian-Wei Hou, Jing Yang, Xin-Yu Zhang, Yuan Zhao, Sai-Sai Xie, Yue Ding, Tong Zhang. Design, synthesis and evaluation of resveratrol-indazole hybrids as novel monoamine oxidases inhibitors with amyloid-β aggregation inhibition.
Bioorganic chemistry.
2018 02; 76(?):130-139. doi:
10.1016/j.bioorg.2017.11.009. [PMID: 29172101] - Wenjia Zhou, Chengzhe Lv, Quanying Zhang, Shunlin Zong, Meng Wang. Pharmacokinetics, Pharmacodynamics, and Safety of Rasagiline Transdermal Patch: A Preliminary Study in Healthy Chinese Subjects.
Clinical drug investigation.
2018 Feb; 38(2):125-133. doi:
10.1007/s40261-017-0588-y. [PMID: 29159774] - Thomas Müller, Peter Riederer, Edna Grünblatt. Determination of Monoamine Oxidase A and B Activity in Long-Term Treated Patients With Parkinson Disease.
Clinical neuropharmacology.
2017 Sep; 40(5):208-211. doi:
10.1097/wnf.0000000000000233. [PMID: 28682929] - Thomas Müller, Peter Riederer, Edna Grünblatt. Simultaneous determination of MAO-A and -B activity following first time intake of an irreversible MAO-B inhibitor in patients with Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996).
2017 06; 124(6):745-748. doi:
10.1007/s00702-017-1705-z. [PMID: 28299453] - M Julia García-Fuster, Jesús A García-Sevilla. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
Psychopharmacology.
2016 Aug; 233(15-16):2955-71. doi:
10.1007/s00213-016-4342-6. [PMID: 27259485] - Ting Wang, Leting Yang, Jing Hua, Huiru Xie, Xuehua Jiang, Ling Wang. Simultaneous bioanalysis of rasagiline and its major metabolites in human plasma by LC-MS/MS: Application to a clinical pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2016 Jun; 125(?):280-5. doi:
10.1016/j.jpba.2016.04.003. [PMID: 27060436] - Xia Chen, Qian Zhao, Ji Jiang, Jian Liu, Pei Hu. Pharmacokinetics of Rasagiline in Healthy Adult Chinese Volunteers with Various Genotypes: A Single-Center, Open-Label, Multiple-Dose Study.
Clinical drug investigation.
2016 May; 36(5):369-76. doi:
10.1007/s40261-016-0380-4. [PMID: 26951202] - Ravindrababu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Siddhartha Nuthakki, Sivaprasad Pendyala, Naveenbabu Kilaru. Pharmacokinetic interaction study between flavanones (hesperetin, naringenin) and rasagiline mesylate in wistar rats.
Drug development and industrial pharmacy.
2016; 42(7):1110-7. doi:
10.3109/03639045.2015.1115868. [PMID: 26530401] - Juthathip Suphanklang, Wichai Santimaleeworagun, Ouppatham Supasyndh. Combination of Escitalopram and Rasagiline Induced Serotonin Syndrome: A Case Report and Review Literature.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2015 Dec; 98(12):1254-7. doi:
NULL. [PMID: 27004312] - Jasmin Bartl, Thomas Müller, Edna Grünblatt, Manfred Gerlach, Peter Riederer. Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity.
Journal of neural transmission (Vienna, Austria : 1996).
2014 Apr; 121(4):379-83. doi:
10.1007/s00702-013-1120-z. [PMID: 24272680] - Boaz Mendzelevski, Craig R Sprenger, Ofer Spiegelstein, Laura Rabinovich-Guilatt. Cardiac safety of rasagiline, a selective monoamine oxidase type B inhibitor for the treatment of Parkinson's disease: a thorough QT/QTc study.
International journal of clinical pharmacology and therapeutics.
2014 Mar; 52(3):192-201. doi:
10.5414/cp201955. [PMID: 24447649] - Niroz Abu-Saleh, Hoda Awad, Mogher Khamaisi, Zaher Armaly, Tony Karram, Samuel N Heyman, Aviva Kaballa, Takaharu Ichimura, James Holman, Zaid Abassi. Nephroprotective effects of TVP1022, a non-MAO inhibitor S-isomer of rasagiline, in an experimental model of diabetic renal ischemic injury.
American journal of physiology. Renal physiology.
2014 Jan; 306(1):F24-33. doi:
10.1152/ajprenal.00379.2013. [PMID: 24197064] - Yu Lin, Yanye Zou, Jialiang Lin, Tao Zhang, Jie Deng. Comparative single-dose pharmacokinetics of rasagiline in minipigs after oral dosing or transdermal administration via a newly developed patch.
Xenobiotica; the fate of foreign compounds in biological systems.
2013 Aug; 43(8):705-10. doi:
10.3109/00498254.2012.758396. [PMID: 23339547] - Thomas Müller, Josef A Hoffmann, Walter Dimpfel, Christian Oehlwein. Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996).
2013 May; 120(5):761-5. doi:
10.1007/s00702-012-0927-3. [PMID: 23196982] - P R Ravi, N Aditya, L Cherian, S Patil. LC method for determination of rasagiline mesylate in different plasma matrices and its application to oral pharmacokinetic study in rabbits.
Journal of chromatographic science.
2013 Jan; 51(1):1-7. doi:
10.1093/chromsci/bms096. [PMID: 22689899] - Susan R Meier-Davis, Kevin Dines, Fatima M Arjmand, Richard Hamlin, Betsy Huang, Jainye Wen, Chad Christianson, Jutaro Shudo, Tetsuto Nagata. Comparison of oral and transdermal administration of rasagiline mesylate on human melanoma tumor growth in vivo.
Cutaneous and ocular toxicology.
2012 Dec; 31(4):312-7. doi:
10.3109/15569527.2012.676119. [PMID: 22515841] - S Nag, L Lehmann, G Kettschau, T Heinrich, A Thiele, A Varrone, B Gulyas, C Halldin. Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).
Bioorganic & medicinal chemistry.
2012 May; 20(9):3065-71. doi:
10.1016/j.bmc.2012.02.056. [PMID: 22436387] - Zaid A Abassi, Yaron D Barac, Sawa Kostin, Ariel Roguin, Elena Ovcharenko, Hoda Awad, Ayelet Blank, Orit Bar-Am, Tamar Amit, Jutta Schaper, Moussa Youdim, Ofer Binah. TVP1022 attenuates cardiac remodeling and kidney dysfunction in experimental volume overload-induced congestive heart failure.
Circulation. Heart failure.
2011 Jul; 4(4):463-73. doi:
10.1161/circheartfailure.111.961037. [PMID: 21558446] - Offir Ertracht, Esti Liani, Noa Bachner-Hinenzon, Orit Bar-Am, Luba Frolov, Elena Ovcharenko, Huda Awad, Shany Blum, Yaron Barac, Tamar Amit, Dan Adam, Moussa Youdim, Ofer Binah. The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion.
British journal of pharmacology.
2011 Jun; 163(4):755-69. doi:
10.1111/j.1476-5381.2011.01274.x. [PMID: 21323905] - Tamar Goren, Liat Adar, Nissim Sasson, Yoni M Weiss. Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline.
Journal of clinical pharmacology.
2010 Dec; 50(12):1420-8. doi:
10.1177/0091270010369674. [PMID: 20445015] - Johanna Hilli, Tuomas Korhonen, Kari Laine. Lack of clinically significant interactions between concomitantly administered rasagiline and escitalopram.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Nov; 33(8):1526-32. doi:
10.1016/j.pnpbp.2009.08.014. [PMID: 19733607] - Min Song, Li Wang, Hua Zhao, Taijun Hang, Aidong Wen, Lin Yang, Lee Jia. Rapid and sensitive liquid chromatography-tandem mass spectrometry: assay development, validation and application to a human pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Nov; 875(2):515-21. doi:
10.1016/j.jchromb.2008.10.005. [PMID: 18952510] - Jinfei Ma, Xiaoyan Chen, Xiaotao Duan, Pan Deng, Hui Wang, Dafang Zhong. Validated LC-MS/MS method for quantitative determination of rasagiline in human plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Oct; 873(2):203-8. doi:
10.1016/j.jchromb.2008.08.024. [PMID: 18799367] - Yana Kleiner, Orit Bar-Am, Tamar Amit, Alexandra Berdichevski, Esti Liani, Gila Maor, Irina Reiter, Moussa B H Youdim, Ofer Binah. TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity.
Journal of cardiovascular pharmacology.
2008 Sep; 52(3):268-77. doi:
10.1097/fjc.0b013e3181862441. [PMID: 18806608] - Claire Henchcliffe, H Christian Schumacher, F Tuna Burgut. Recent advances in Parkinson's disease therapy: use of monoamine oxidase inhibitors.
Expert review of neurotherapeutics.
2005 Nov; 5(6):811-21. doi:
10.1586/14737175.5.6.811. [PMID: 16274338] - Orit Bar-Am, Orly Weinreb, Tamar Amit, Moussa B H Youdim. Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2005 Nov; 19(13):1899-901. doi:
10.1096/fj.05-3794fje. [PMID: 16148027] - Orly Weinreb, Tamar Amit, Orit Bar-Am, Orly Chillag-Talmor, Moussa B H Youdim. Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.
Annals of the New York Academy of Sciences.
2005 Aug; 1053(?):348-55. doi:
10.1196/annals.1344.030. [PMID: 16179541] - Dafna Bonneh-Barkay, Noam Ziv, John P M Finberg. Characterization of the neuroprotective activity of rasagiline in cerebellar granule cells.
Neuropharmacology.
2005 Mar; 48(3):406-16. doi:
10.1016/j.neuropharm.2004.10.016. [PMID: 15721173] - Moussa B H Youdim, Mati Fridkin, Hailin Zheng. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.
Mechanisms of ageing and development.
2005 Feb; 126(2):317-26. doi:
10.1016/j.mad.2004.08.023. [PMID: 15621213] - John J Thébault, Michel Guillaume, Ruth Levy. Tolerability, safety, pharmacodynamics, and pharmacokinetics of rasagiline: a potent, selective, and irreversible monoamine oxidase type B inhibitor.
Pharmacotherapy.
2004 Oct; 24(10):1295-305. doi:
10.1592/phco.24.14.1295.43156. [PMID: 15628826] - Orly Weinreb, Orit Bar-Am, Tamar Amit, Orly Chillag-Talmor, Moussa B H Youdim. Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004 Sep; 18(12):1471-3. doi:
10.1096/fj.04-1916fje. [PMID: 15247150] - Orit Bar Am, Tamar Amit, Moussa B H Youdim. Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline.
Neuroscience letters.
2004 Jan; 355(3):169-72. doi:
10.1016/j.neulet.2003.10.067. [PMID: 14732458] - M B Youdim, A Wadia, W Tatton, M Weinstock. The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo.
Annals of the New York Academy of Sciences.
2001 Jun; 939(?):450-8. doi:
10.1111/j.1749-6632.2001.tb03656.x. [PMID: 11462801] - K Kitani, C Minami, T Yamamoto, W Maruyama, S Kanai, G O Ivy, M C Carrillo. Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy.
Annals of the New York Academy of Sciences.
2001 Apr; 928(?):248-60. doi:
10.1111/j.1749-6632.2001.tb05654.x. [PMID: 11795516] - S Eliash, Z Speiser, S Cohen. Rasagiline and its (S) enantiomer increase survival and prevent stroke in salt-loaded stroke-prone spontaneously hypertensive rats.
Journal of neural transmission (Vienna, Austria : 1996).
2001; 108(8-9):909-23. doi:
10.1007/s007020170012. [PMID: 11716145] - M C Carrillo, C Minami, K Kitani, W Maruyama, K Ohashi, T Yamamoto, M Naoi, S Kanai, M B Youdim. Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat.
Life sciences.
2000 Jun; 67(5):577-85. doi:
10.1016/s0024-3205(00)00643-3. [PMID: 10993123] - J P Finberg, T Takeshima, J M Johnston, J W Commissiong. Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor.
Neuroreport.
1998 Mar; 9(4):703-7. doi:
10.1097/00001756-199803090-00026. [PMID: 9559942]