Demeclocycline hydrochloride (BioDeep_00000676260)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Demeclocycline hydrochloride

化学式: C21H22Cl2N2O8 (500.0753152)
中文名称: 盐酸地美环素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 5.77%

分子结构信息

SMILES: CN(C)C1C2CC3C(C4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)Cl)O.Cl
InChI: /m0./s1

描述信息

C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Demeclocycline hydrochloride is a tetracycline antibiotic; is an antibiotic in the treatment of Lyme disease, acne, and bronchitis.

同义名列表

2 个代谢物同义名

Demeclocycline hydrochloride; Demeclocycline (hydrochloride)



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Shabnam Allahverdiyeva, Yavuz Yardım, Zühre Şentürk. Electrooxidation of tetracycline antibiotic demeclocycline at unmodified boron-doped diamond electrode and its enhancement determination in surfactant-containing media. Talanta. 2021 Feb; 223(Pt 1):121695. doi: 10.1016/j.talanta.2020.121695. [PMID: 33303147]
  • Naxin Wu, He Huang, Taoling Min, Haifeng Hu. [Genome sequencing of Streptomyces aureofaciens DM-1 and analysis of 6-demethylchlortetracycline biosynthesis gene cluster]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2020 Dec; 36(12):2685-2694. doi: 10.13345/j.cjb.200317. [PMID: 33398964]
  • Naxin Wu, He Huang, Taoling Min, Haifeng Hu. TAR cloning and integrated overexpression of 6-demethylchlortetracycline biosynthetic gene cluster in Streptomyces aureofaciens. Acta biochimica et biophysica Sinica. 2017 Dec; 49(12):1129-1134. doi: 10.1093/abbs/gmx110. [PMID: 29087452]
  • Ploutarchos Tzoulis, Helen Carr, Emmanouil Bagkeris, Pierre Marc Bouloux. Improving care and outcomes of inpatients with syndrome of inappropriate antidiuresis (SIAD): a prospective intervention study of intensive endocrine input vs. routine care. Endocrine. 2017 Feb; 55(2):539-546. doi: 10.1007/s12020-016-1161-9. [PMID: 27837439]
  • J Miell, P Dhanjal, C Jamookeeah. Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review. International journal of clinical practice. 2015 Dec; 69(12):1396-417. doi: 10.1111/ijcp.12713. [PMID: 26289137]
  • A Peri, C Giuliani. Management of euvolemic hyponatremia attributed to SIADH in the hospital setting. Minerva endocrinologica. 2014 Mar; 39(1):33-41. doi: NULL. [PMID: 24513602]
  • Marleen L A Kortenoeven, Anne P Sinke, Niels Hadrup, Christiane Trimpert, Jack F M Wetzels, Robert A Fenton, Peter M T Deen. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. American journal of physiology. Renal physiology. 2013 Dec; 305(12):F1705-18. doi: 10.1152/ajprenal.00723.2012. [PMID: 24154696]
  • Chengyu Dong, Shuying Ma, Ying Liu. Studies of the interaction between demeclocycline and human serum albumin by multi-spectroscopic and molecular docking methods. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2013 Feb; 103(?):179-86. doi: 10.1016/j.saa.2012.10.050. [PMID: 23261611]
  • Terry J Aspray. Serum sodium disorders: safe management. Clinical medicine (London, England). 2010 Aug; 10(4):418; author reply 418-9. doi: 10.7861/clinmedicine.10-4-418a. [PMID: 20853539]
  • Joseph G Verbalis. Managing hyponatremia in patients with syndrome of inappropriate antidiuretic hormone secretion. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion. 2010 May; 57 Suppl 2(?):30-40. doi: 10.1016/s1575-0922(10)70020-6. [PMID: 21130960]
  • Ferenc Laczi. [Etiology, diagnostics and therapy of hyponatremias]. Orvosi hetilap. 2008 Jul; 149(29):1347-54. doi: 10.1556/oh.2008.28409. [PMID: 18617466]
  • M C Mahedero, D Bohoyo, F Salinas, T Ardila, D Airado, B Roldán. Improvements in europium sensitized fluorimetric determination of demeclocycline and methacycline. Journal of pharmaceutical and biomedical analysis. 2005 Apr; 37(5):1101-4. doi: 10.1016/j.jpba.2004.10.040. [PMID: 15862691]
  • Kyuzi Kamoi, Satoshi Soda, Hideo Sasaki. Hyponatremia secondary to multiple etiologies: a case report. Journal of medicine. 2004; 35(1-6):125-40. doi: NULL. [PMID: 18084871]
  • Nicola J Curtis, Charles van Heyningen, John J Turner. Irreversible nephrotoxicity from demeclocycline in the treatment of hyponatremia. Age and ageing. 2002 Mar; 31(2):151-2. doi: 10.1093/ageing/31.2.151-a. [PMID: 11937482]
  • W Jiménez. [Aquaretic agents]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia. 2002; 22 Suppl 5(?):52-5. doi: NULL. [PMID: 12107918]
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  • P Igaz, M Tóth, M Mezödy, E Gláz, I Pénzes, K Rácz, Z Tulassay. [Effective demeclocycline therapy in a patient with over-secretion of antidiuretic hormone following head trauma]. Orvosi hetilap. 1999 Dec; 140(51):2873-5. doi: NULL. [PMID: 10647278]
  • K Kamoi, M Toyama, M Takagi, T Koizumi, K Niishiyama, K Takahashi, H Sasaki, T Muto. Osmoregulation of vasopressin secretion in patients with the syndrome of inappropriate antidiuresis associated with central nervous system disorders. Endocrine journal. 1999 Apr; 46(2):269-77. doi: 10.1507/endocrj.46.269. [PMID: 10460011]
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  • W V Vieweg, E C Wilkinson, J J David, W T Rowe, W B Hobbs, W W Spradlin. The use of demeclocycline in the treatment of patients with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome). The Psychiatric quarterly. 1988; 59(1):62-8. doi: 10.1007/bf01064293. [PMID: 3131788]
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  • M B Goldman, D J Luchins. Demeclocycline improves hyponatremia in chronic schizophrenics. Biological psychiatry. 1985 Nov; 20(11):1149-55. doi: 10.1016/0006-3223(85)90172-6. [PMID: 3931706]
  • G L Braden, M A Geheb, A Shook, I Singer, M Cox. Demeclocycline-induced natriuresis and renal insufficiency: in vivo and in vitro studies. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1985 May; 5(5):270-7. doi: 10.1016/s0272-6386(85)80121-9. [PMID: 3923829]
  • A Satta, R Faedda, N A Olmeo, G F Branca, G Soggia, E Bartoli. Effect of demeclocycline on the renal tubule of patients with cirrhosis of the liver. Panminerva medica. 1984 Oct; 26(4):273-8. doi: NULL. [PMID: 6442767]
  • S Ishikawa. [Water diuretics]. Nihon rinsho. Japanese journal of clinical medicine. 1984 Sep; 42(9):2118-23. doi: NULL. [PMID: 6441035]
  • F W Ballardie, J C Mucklow. Partial reversal of carbamazepine-induced water intolerance by demeclocycline. British journal of clinical pharmacology. 1984 Jun; 17(6):763-5. doi: 10.1111/j.1365-2125.1984.tb02415.x. [PMID: 6430315]
  • N H Dubin, T H Parmley, R B Ghodgaonkar, J D Strandberg, N B Rosenshein, T M King. Effect of intrauterine administration of tetracyclines on cynomolgus monkeys. Contraception. 1984 Jun; 29(6):561-71. doi: 10.1016/s0010-7824(84)80018-9. [PMID: 6432434]
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  • R M Pérez-Ayuso, V Arroyo, J Camps, W Jiménez, M Rodamilans, A Rimola, J Gaya, F Rivera, J Rodés. Effect of demeclocycline on renal function and urinary prostaglandin E2 and kallikrein in hyponatremic cirrhotics. Nephron. 1984; 36(1):30-7. doi: 10.1159/000183112. [PMID: 6419136]
  • G Decaux. The syndrome of inappropriate secretion of ADH (SIADH): recent clinical data. Acta clinica Belgica. 1984; 39(1):1-5. doi: 10.1080/22953337.1984.11718973. [PMID: 6426226]
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  • H W Lim, H Novotny, I Gigli. Role of complement and polymorphonuclear cells in demethylchlortetracycline-induced phototoxicity in guinea pigs. Inhibition by decomplementation in vivo. The Journal of clinical investigation. 1983 Oct; 72(4):1326-35. doi: 10.1172/jci111088. [PMID: 6415108]
  • T H Mitchell, T C Stamp, M V Jenkins. Steatorrhoea after tetracycline. British medical journal (Clinical research ed.). 1982 Sep; 285(6344):780. doi: 10.1136/bmj.285.6344.780. [PMID: 6810999]
  • A P Quintanilla. Pathophysiology of renal concentrating defects. Annals of clinical and laboratory science. 1981 Jul; 11(4):300-7. doi: NULL. [PMID: 6791572]
  • D L Trump. Serious hyponatremia in patients with cancer: management with demeclocycline. Cancer. 1981 Jun; 47(12):2908-12. doi: 10.1002/1097-0142(19810615)47:12<2908::aid-cncr2820471228>3.0.co;2-r. [PMID: 6790160]
  • J Clavier, J Cledes, A Lamotte, D Guillerm, G Kergrat. [Organic renal insufficiency during treatment with demethylchlortetracycline]. La Nouvelle presse medicale. 1981 Jan; 10(2):106. doi: NULL. [PMID: 6780975]
  • P G Brock, J A Chaplin, G W Hill, E L Richards, M P Short. Comparison of the in vitro serum microbiological activity of a triple tetracycline tablet, 300 mg B.I.D. with oxytetracyline, 250 mg Q.I.D. The Journal of international medical research. 1981; 9(5):360-4. doi: 10.1177/030006058100900511. [PMID: 6795070]
  • E R Serros, A G Lowe, M A Kirschenbaum. Effect of prostaglandin inhibition on demeclocycline administration in conscious rats. Prostaglandins and medicine. 1980 Sep; 5(3):175-82. doi: 10.1016/s0161-4630(80)80003-6. [PMID: 6774355]
  • P D Miller, S L Linas, R W Schrier. Plasma demeclocycline levels and nephrotoxicity. Correlation in hyponatremic cirrhotic patients. JAMA. 1980 Jun; 243(24):2513-5. doi: NULL. [PMID: 6770106]
  • M Geheb, M Cox. Renal effects of demeclocycline. JAMA. 1980 Jun; 243(24):2519-20. doi: NULL. [PMID: 6770107]
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