diminazene aceturate (BioDeep_00000676211)
代谢物信息卡片
diminazene aceturate
化学式: C22H29N9O6 (515.2240694)
中文名称: 二乙酰胺三氮脒
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NCC(=O)O.CC(=O)NCC(=O)O.C1=CC(=CC=C1C(=N)N)NN=NC2=CC=C(C=C2)C(=N)N
InChI: 2*2H2,1H3,(H,5,6)(H,7,8)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D007364 - Intercalating Agents
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Betelhem Sirak, Gizachew Kassahun Bizuneh, Peter Imming, Kaleab Asres. In vitro and in vivo antitrypanosomal activity of the fresh leaves of Ranunculus Multifidus Forsk and its major compound anemonin against Trypanosoma congolense field isolate.
BMC veterinary research.
2024 Jan; 20(1):32. doi:
10.1186/s12917-023-03856-1. [PMID: 38279149] - Zhaoqing Lu, Di Wu, Zheng Wang, Hanyu Zhang, Yufan Du, Guoxing Wang. Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model.
BMC pharmacology & toxicology.
2022 07; 23(1):44. doi:
10.1186/s40360-022-00584-4. [PMID: 35787308] - Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukla. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease.
ACS chemical neuroscience.
2022 05; 13(10):1491-1504. doi:
10.1021/acschemneuro.1c00797. [PMID: 35533351] - Shengwei Ji, Mingming Liu, Eloiza May Galon, Mohamed Abdo Rizk, Jixu Li, Yongchang Li, Iqra Zafar, Ikuo Igarashi, Xuenan Xuan. In vitro screening of novel anti-Babesia gibsoni drugs from natural products.
Parasitology international.
2021 Dec; 85(?):102437. doi:
10.1016/j.parint.2021.102437. [PMID: 34389492] - Aneta Stachowicz, Anna Wiśniewska, Katarzyna Kuś, Magdalena Białas, Magdalena Łomnicka, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Beata Bujak-Giżycka, Jacek Jawień, Rafał Olszanecki. Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine Biosynthesis.
International journal of molecular sciences.
2021 May; 22(11):. doi:
10.3390/ijms22115861. [PMID: 34070749] - Tatiane Cristine Silva de Almeida, Katharina Lanza, Roberta da Silva Filha, Leda Maria de Castro C Campos, Esdras G Fonseca, Mariana W Chagas, Natalia Pessoa Rocha, Marcos Augusto de Sá, Maria Aparecida Ribeiro Vieira, Marcelo Vidigal Caliari, Lucas M Kangussu, Anderson José Ferreira, Ana Cristina Simões E Silva. ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats.
Clinical science (London, England : 1979).
2020 12; 134(23):3093-3106. doi:
10.1042/cs20201022. [PMID: 33206153] - Nisha Sharma, Anil Bhanudas Gaikwad. Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction.
Environmental toxicology and pharmacology.
2020 Nov; 80(?):103501. doi:
10.1016/j.etap.2020.103501. [PMID: 32979558] - Mariana G de Brito, Ana C Mengarda, George L Oliveira, Maria E Cirino, Tais C Silva, Rosimeire N de Oliveira, Silmara M Allegretti, Josué de Moraes. Therapeutic Effect of Diminazene Aceturate on Parasitic Blood Fluke Schistosoma mansoni Infection.
Antimicrobial agents and chemotherapy.
2020 10; 64(11):. doi:
10.1128/aac.01372-20. [PMID: 32816737] - Tawar Qaradakhi, Laura Gadanec, John Matsoukas, Vasso Apostolopoulos, Anthony Zulli. Could DIZE be the answer to COVID-19?.
Maturitas.
2020 10; 140(?):83-84. doi:
10.1016/j.maturitas.2020.07.002. [PMID: 32636103] - Thaiany G Souza-Silva, Diego F Vilas-Boas, Elda Gonçalves-Santos, Ana Lia Mazzeti, Ivo S Caldas, Reggiani V Gonçalves, Lívia F Diniz, Rômulo D Novaes. Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study.
Life sciences.
2020 Sep; 257(?):118067. doi:
10.1016/j.lfs.2020.118067. [PMID: 32652140] - Nisha Sharma, Anil Bhanudas Gaikwad. Effects of renal ischemia injury on brain in diabetic and non-diabetic rats: Role of angiotensin II type 2 receptor and angiotensin-converting enzyme 2.
European journal of pharmacology.
2020 Sep; 882(?):173241. doi:
10.1016/j.ejphar.2020.173241. [PMID: 32565336] - Hesham Farouk Hasan, Eman M Elgazzar, Dalia M Mostafa. Diminazene aceturate extenuate the renal deleterious consequences of angiotensin-II induced by γ-irradiation through boosting ACE2 signaling cascade.
Life sciences.
2020 Jul; 253(?):117749. doi:
10.1016/j.lfs.2020.117749. [PMID: 32380079] - M W Maichomo, J M Nginyi, A Caruso-Varès, E O Mungube, G Pagny, C Chevtzoff, J C Njanja, P A Lumumba, J F Collin, N Isaka. Efficacy of VERYL® in the treatment of cattle naturally infected with gastro-intestinal nematodes in Kenya.
Tropical animal health and production.
2020 Jul; 52(4):1699-1705. doi:
10.1007/s11250-019-02179-4. [PMID: 31865537] - Gaber El-Saber Batiha, Amany Magdy Beshbishy, Oluyomi Stephen Adeyemi, Eman Nadwa, Eman Rashwan, Naoaki Yokoyama, Ikuo Igarashi. Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.
PloS one.
2020; 15(2):e0228996. doi:
10.1371/journal.pone.0228996. [PMID: 32053698] - I-Chen Chen, Jao-Yu Lin, Yi-Ching Liu, Chee-Yin Chai, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan Wu, Zen-Kong Dai. The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction.
International journal of medical sciences.
2020; 17(16):2594-2602. doi:
10.7150/ijms.48096. [PMID: 33029102] - Amanda S M Bessa, Érika F Jesus, Allancer D C Nunes, Carolina N R Pontes, Ismaley S Lacerda, Jaqueline M Costa, Elisângela J Souza, Ruy S Lino-Júnior, Manoel F Biancardi, Fernanda C A Dos Santos, Gustavo R Pedrino, Diego B Colugnati, Renata Mazaro-Costa, Elizabeth P Mendes, Carlos H Castro. Stimulation of the ACE2/Ang-(1-7)/Mas axis in hypertensive pregnant rats attenuates cardiovascular dysfunction in adult male offspring.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 12; 42(12):1883-1893. doi:
10.1038/s41440-019-0321-8. [PMID: 31506648] - Vajir Malek, Nisha Sharma, Anil Bhanudas Gaikwad. Simultaneous inhibition of neprilysin and activation of ACE2 prevented diabetic cardiomyopathy.
Pharmacological reports : PR.
2019 Oct; 71(5):958-967. doi:
10.1016/j.pharep.2019.05.008. [PMID: 31470292] - Vajir Malek, Nisha Sharma, Himanshu Sankrityayan, Anil Bhanudas Gaikwad. Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy.
Life sciences.
2019 Mar; 221(?):159-167. doi:
10.1016/j.lfs.2019.02.027. [PMID: 30769114] - Shimaa Abd El-Salam El-Sayed, Mohamed Abdo Rizk, Naoaki Yokoyama, Ikuo Igarashi. Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.
Parasites & vectors.
2019 Jan; 12(1):37. doi:
10.1186/s13071-019-3296-z. [PMID: 30651142] - Lucas Miranda Kangussu, Tatiane Cristine S de Almeida, Thiago Ruiz R Prestes, Marilda Luz de Andrade De Maria, Roberta da Silva Filha, Maria Aparecida Ribeiro Vieira, Ana Cristina Simões E Silva, Anderson José Ferreira. Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension.
Protein and peptide letters.
2019; 26(7):523-531. doi:
10.2174/0929866526666190405123422. [PMID: 30950337] - Lei A Wang, Annette D de Kloet, Michael D Smeltzer, Karlena M Cahill, Helmut Hiller, Erin B Bruce, David J Pioquinto, Jacob A Ludin, Michael J Katovich, Mohan K Raizada, Eric G Krause. Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice.
Neuropharmacology.
2018 05; 133(?):85-93. doi:
10.1016/j.neuropharm.2018.01.025. [PMID: 29360543] - Azirwan Guswanto, Arifin Budiman Nugraha, Bumduuren Tuvshintulga, Dickson Stuart Tayebwa, Mohamed Abdo Rizk, Gaber El-Saber Batiha, Sambuu Gantuya, Thillaiampalam Sivakumar, Naoaki Yokoyama, Ikuo Igarashi. 17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice.
International journal for parasitology. Drugs and drug resistance.
2018 04; 8(1):104-111. doi:
10.1016/j.ijpddr.2018.02.005. [PMID: 29499568] - Margot Camoin, Arthur Kocher, Piangjai Chalermwong, Sarawut Yangtarra, Nikorn Thongtip, Sathaporn Jittapalapong, Marc Desquesnes. Adaptation and evaluation of an ELISA for Trypanosoma evansi infection (surra) in elephants and its application to a serological survey in Thailand.
Parasitology.
2018 03; 145(3):371-377. doi:
10.1017/s0031182017001585. [PMID: 28942737] - Pu Ge, Xin Yao, Jing Li, Rong Jiang, Jie Dai, Li Zhang. Diminazene aceturate alleviated lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Feb; 98(?):142-148. doi:
10.1016/j.biopha.2017.12.034. [PMID: 29253761] - Santosh Kumar Goru, Almesh Kadakol, Vajir Malek, Anuradha Pandey, Nisha Sharma, Anil Bhanudas Gaikwad. Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes.
British journal of pharmacology.
2017 Sep; 174(18):3118-3130. doi:
10.1111/bph.13946. [PMID: 28688122] - Maxwell W Waema, Naomi W Maina, Maina Ngotho, Simon M Karanja, Beatrice M Gachie, Dawn N Maranga, John M Kagira. IgM, lgG and IL-6 profiles in the Trypanosoma brucei brucei monkey model of human African trypanosomiasis.
Acta tropica.
2017 Apr; 168(?):45-49. doi:
10.1016/j.actatropica.2017.01.012. [PMID: 28099874] - Andriy Buchynskyy, J Robert Gillespie, Matthew A Hulverson, Joshua McQueen, Sharon A Creason, Ranae M Ranade, Nicole A Duster, Michael H Gelb, Frederick S Buckner. Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Bioorganic & medicinal chemistry.
2017 03; 25(5):1571-1584. doi:
10.1016/j.bmc.2016.11.019. [PMID: 28187957] - Luan Kelves M Souza, Lucas A D Nicolau, Nayara A Sousa, Thiago S L Araújo, Francisca Beatriz M Sousa, Douglas S Costa, Fabiana M Souza, Dvison M Pacífico, Conceição S Martins, Renan O Silva, Marcellus H L P Souza, Gilberto S Cerqueira, Jand Venes R Medeiros. Diminazene aceturate, an angiotensin-converting enzyme II activator, prevents gastric mucosal damage in mice: Role of the angiotensin-(1-7)/Mas receptor axis.
Biochemical pharmacology.
2016 07; 112(?):50-9. doi:
10.1016/j.bcp.2016.05.010. [PMID: 27241079] - Zuzana Husková, Libor Kopkan, Lenka Červenková, Šárka Doleželová, Zdeňka Vaňourková, Petra Škaroupková, Akira Nishiyama, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Herbert J Kramer, Luděk Červenka. Intrarenal alterations of the angiotensin-converting enzyme type 2/angiotensin 1-7 complex of the renin-angiotensin system do not alter the course of malignant hypertension in Cyp1a1-Ren-2 transgenic rats.
Clinical and experimental pharmacology & physiology.
2016 Apr; 43(4):438-49. doi:
10.1111/1440-1681.12553. [PMID: 26833491] - Elena Velkoska, Sheila K Patel, Karen Griggs, Louise M Burrell. Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease.
PloS one.
2016; 11(8):e0161760. doi:
10.1371/journal.pone.0161760. [PMID: 27571511] - Rodrigo A Fraga-Silva, Fabiana P Costa-Fraga, Fabrizio Montecucco, Mikael Sturny, Younoss Faye, François Mach, Graziano Pelli, Vinayak Shenoy, Rafaela F da Silva, Mohan K Raizada, Robson A S Santos, Nikolaos Stergiopulos. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury.
The journal of sexual medicine.
2015 Feb; 12(2):289-302. doi:
10.1111/jsm.12757. [PMID: 25411084] - Guilherme M Do Carmo, Matheus D Baldissera, Rodrigo A Vaucher, Virginia Cielo Rech, Camila B Oliveira, Michele Rorato Sagrillo, Aline A Boligon, Margareth L Athayde, Marta P Alves, Raqueli T França, Sonia T A Lopes, Claiton I Schwertz, Ricardo E Mendes, Silvia G Monteiro, Aleksandro S Da Silva. Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi.
Experimental parasitology.
2015 Feb; 149(?):39-46. doi:
10.1016/j.exppara.2014.12.005. [PMID: 25499512] - Simone Moreira de Macedo, Talita Antunes Guimarares, Joao Marcus Oliveira Andrade, Andre Luiz Sena Guimaraes, Alfredo Mauricio Batista Batista de Paula, Anderson Jose Ferreira, Sergio Henrique Sousa Santos. Angiotensin converting enzyme 2 activator (DIZE) modulates metabolic profiles in mice, decreasing lipogenesis.
Protein and peptide letters.
2015; 22(4):332-40. doi:
10.2174/0929866522666150209125401. [PMID: 25666042] - Elena Velkoska, Sheila K Patel, Karen Griggs, Raelene J Pickering, Chris Tikellis, Louise M Burrell. Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy.
PloS one.
2015; 10(3):e0118758. doi:
10.1371/journal.pone.0118758. [PMID: 25786223] - Uche Samuel Ndidi, Ismaila Alhaji Umar, Aminu Mohammed, Cosmas Samuel, Amos Oladiran Oladeru, Rahinat Nimma Yakubu. Effects of aqueous extracts of Acacia albida stem bark on Wistar albino rats infected with Trypanosoma evansi.
Natural product research.
2015; 29(12):1153-6. doi:
10.1080/14786419.2014.981184. [PMID: 25420715] - A Gęgotek, M Cyuńczyk, W Łuczaj, A Bielawska, K Bielawski, E Skrzydlewska. The redox status of human breast cancer cell lines (MCF-7 and MDA-MB231) treated with novel dinuclear berenil-platinum(II) complexes.
Die Pharmazie.
2014 Dec; 69(12):923-8. doi:
. [PMID: 25951667] - Sean E Thatcher, Xuan Zhang, Deborah A Howatt, Frederique Yiannikouris, Susan B Gurley, Terri Ennis, John A Curci, Alan Daugherty, Lisa A Cassis. Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.
Arteriosclerosis, thrombosis, and vascular biology.
2014 Dec; 34(12):2617-23. doi:
10.1161/atvbaha.114.304613. [PMID: 25301841] - Camila Belmonte Oliveira, Lucas Almeida Rigo, Raqueli T França, Lucas T Gressler, Luciana Dalla Rosa, Aline F Ourique, Dionatan T Oliveira, Rovaina L Doyle, Karen Luise dos Santos Moreira, Marcelo L Veiga, Sonia T A Lopes, Ruy Carlos R Beck, Aleksandro S Da Silva, Silvia G Monteiro. Diminazene aceturate liposomes: morphometric and biochemical liver, kidney, and spleen of rats infected with Trypanosoma evansi.
Pathology, research and practice.
2014 Dec; 210(12):840-6. doi:
10.1016/j.prp.2014.08.010. [PMID: 25270332] - Teka Feyera, Getachew Terefe, Workineh Shibeshi. Evaluation of in vivo antitrypanosomal activity of crude extracts of Artemisia abyssinica against aTrypanosoma congolense isolate.
BMC complementary and alternative medicine.
2014 Apr; 14(?):117. doi:
10.1186/1472-6882-14-117. [PMID: 24684992] - Patricia I Kobo, Joseph O Ayo, Tagang Aluwong, Abdulkadir U Zezi, Victor Maikai, Suleiman F Ambali. Flavonoid mixture ameliorates increase in erythrocyte osmotic fragility and malondialdehyde concentration induced by Trypanosoma brucei brucei-infection in Wistar rats.
Research in veterinary science.
2014 Feb; 96(1):139-42. doi:
10.1016/j.rvsc.2013.10.005. [PMID: 24332272] - Muthusamy Ranjithkumar, Buddhi Chandrasekaran Saravanan, Suresh Chandra Yadav, Rajender Kumar, Rajendra Singh, Sahadeb Dey. Neurological trypanosomiasis in quinapyramine sulfate-treated horses--a breach of the blood-brain barrier?.
Tropical animal health and production.
2014 Feb; 46(2):371-7. doi:
10.1007/s11250-013-0498-9. [PMID: 24197687] - C F Obi, R I Obidike, I O Ezeh, V U Omoja, C N Iheagwam, I K Idika, R C Ezeokonkwo. Effects of Trypanosoma brucei infection and diminazene aceturate therapy on testicular morphology and function of Nigerian local dogs.
Veterinary parasitology.
2013 Sep; 196(3-4):283-8. doi:
10.1016/j.vetpar.2013.03.023. [PMID: 23639198] - Gilson P Paixão, André L Lourenção, Camila R Silva, Eduardo G Mendonça, Paulo L Silva, Joel A Oliveira, José C Zanuncio, Maria Goreti A Oliveira. Biochemical responses of Anticarsia gemmatalis (Lepidoptera: Noctuidae) in soybean cultivars sprayed with the protease inhibitor berenil.
Journal of agricultural and food chemistry.
2013 Aug; 61(34):8034-8. doi:
10.1021/jf4027603. [PMID: 23909602] - Matheus D Baldissera, Aleksandro S Da Silva, Camila B Oliveira, Carine E P Zimmermann, Rodrigo A Vaucher, Roberto C V Santos, Virginia C Rech, Alexandre A Tonin, Janice L Giongo, Cristiane B Mattos, Letícia Koester, Janio M Santurio, Silvia G Monteiro. Trypanocidal activity of the essential oils in their conventional and nanoemulsion forms: in vitro tests.
Experimental parasitology.
2013 Jul; 134(3):356-61. doi:
10.1016/j.exppara.2013.03.035. [PMID: 23562884] - K M Lewis, L A Cohn, H S Marr, A J Birkenheuer. Diminazene diaceturate for treatment of chronic Cytauxzoon felis parasitemia in naturally infected cats.
Journal of veterinary internal medicine.
2012 Nov; 26(6):1490-3. doi:
10.1111/j.1939-1676.2012.01003.x. [PMID: 22998161] - Jeanne Scardini Marinho-Prado, A L Lourenção, R N C Guedes, A Pallini, J A Oliveira, M G A Oliveira. Enzymatic response of the eucalypt defoliator Thyrinteina arnobia (Stoll) (Lepidoptera: Geometridae) to a bis-benzamidine proteinase Inhibitor. i.
Neotropical entomology.
2012 Oct; 41(5):420-5. doi:
10.1007/s13744-012-0063-7. [PMID: 23950094] - Shiby Kuriakose, Helen M Muleme, Chukwunonso Onyilagha, Rani Singh, Ping Jia, Jude E Uzonna. Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection.
PloS one.
2012; 7(11):e48696. doi:
10.1371/journal.pone.0048696. [PMID: 23144931] - Alexandre A Tonin, Aleksandro S Da Silva, Marcio M Costa, Mateus A Otto, Gustavo R Thomé, Kaio S Tavares, Luiz C Miletti, Marta R Leal, Sonia T A Lopes, Cinthia M Mazzanti, Silvia G Monteiro, Mario L de La Rue. Diminazene aceturate associated with sodium selenite and vitamin E in the treatment of Trypanosoma evansi infection in rats.
Experimental parasitology.
2011 Jul; 128(3):243-9. doi:
10.1016/j.exppara.2011.03.003. [PMID: 21420954] - V U Omoja, A O Anaga, I R Obidike, T E Ihedioha, P U Umeakuana, L I Mhomga, I U Asuzu, S M Anika. The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats.
Asian Pacific journal of tropical medicine.
2011 May; 4(5):337-41. doi:
10.1016/s1995-7645(11)60099-0. [PMID: 21771672] - N E Nweze, B M Anene, I U Asuzu. Investigation of the antitrypanosomal activity of Buchholzia coriacea seed extract against a field strain of Trypanosoma congolense.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2011; 8(5 Suppl):175-80. doi:
10.4314/ajtcam.v8i5s.23. [PMID: 22754072] - M Ngotho, J M Kagira, H E Jensen, S M Karanja, I O Farah, J Hau. Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys.
Tropical medicine & international health : TM & IH.
2009 Jul; 14(7):736-47. doi:
10.1111/j.1365-3156.2009.02285.x. [PMID: 19573160] - P O Akpa, R C Ezeokonkwo, C A Eze, B M Anene. Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs.
Veterinary parasitology.
2008 Feb; 151(2-4):139-49. doi:
10.1016/j.vetpar.2007.10.024. [PMID: 18155842] - R M Ngure, P D Eckersall, F W Jennings, J Mburu, J Burke, N Mungatana, M Murray. Acute phase response in mice experimentally infected with Trypanosoma congolense: a molecular gauge of parasite-host interaction.
Veterinary parasitology.
2008 Jan; 151(1):14-20. doi:
10.1016/j.vetpar.2007.10.007. [PMID: 18063482] - Subeki, Hideyuki Matsuura, Kosaku Takahashi, Kensuke Nabeta, Masahiro Yamasaki, Yoshimitsu Maede, Ken Katakura. Screening of Indonesian medicinal plant extracts for antibabesial activity and isolation of new quassinoids from Brucea javanica.
Journal of natural products.
2007 Oct; 70(10):1654-7. doi:
10.1021/np070236h. [PMID: 17896817] - J S Batista, F Riet-Correa, M M G Teixeira, C R Madruga, S D V Simões, T F Maia. Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: Description of an outbreak and lesions in the nervous system.
Veterinary parasitology.
2007 Jan; 143(2):174-81. doi:
10.1016/j.vetpar.2006.08.017. [PMID: 16965857] - Sherri B Turnipseed, Susan B Clark, Wendy C Andersen, Christine M Karbiwnyk, Keith E Miller, Jeffrey A Hurlbut. Confirmation of diminazene diaceturate in bovine plasma using electrospray liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Nov; 844(1):127-33. doi:
10.1016/j.jchromb.2006.07.016. [PMID: 16891161] - S A Staroverov, D V Pristensky, D N Yermilov, K P Gabalov, D A Zhemerichkin, V A Sidorkin, A A Shcherbakov, S Yu Shchyogolev, L A Dykman. The effectivity analysis of accumulation of liposomal, micellar, and water-soluble forms of diminazene in cells and in organs.
Drug delivery.
2006 Sep; 13(5):351-5. doi:
10.1080/10717540500459084. [PMID: 16877310] - D Olila, J J McDermott, M C Eisler, E S Mitema, R J Patzelt, P-H Clausen, C J Poetzsch, K-H Zessin, D Mehlitz, A S Peregrine. Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda.
Acta tropica.
2002 Oct; 84(1):19-30. doi:
10.1016/s0001-706x(02)00137-7. [PMID: 12387907] - Carsten Olbrich, Andrea Gessner, Oliver Kayser, Rainer Helmut Müller. Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate.
Journal of drug targeting.
2002 Aug; 10(5):387-96. doi:
10.1080/1061186021000001832. [PMID: 12442809] - A A Ariyibi, O O Odunuga, O O Olorunsogo. Concentration-dependent inhibition of sheep erythrocyte ghost plasma membrane Ca2+-ATPase activity by Berenil.
Journal of veterinary pharmacology and therapeutics.
2001 Jun; 24(3):233-6. doi:
10.1046/j.1365-2885.2001.00322.x. [PMID: 11442804] - P D Eckersall, J W Gow, C McComb, B Bradley, J Rodgers, M Murray, P G Kennedy. Cytokines and the acute phase response in post-treatment reactive encephalopathy of Trypanosoma brucei brucei infected mice.
Parasitology international.
2001 Mar; 50(1):15-26. doi:
10.1016/s1383-5769(00)00065-9. [PMID: 11267928] - A Sahoo, R C Patra, N N Pathak, S K Dwivedi, P K Dash. Enhanced lipid peroxide levels in the erythrocytes of calves with haemoglobinuria.
Veterinary research communications.
2001 Jan; 25(1):55-9. doi:
10.1023/a:1026710002039. [PMID: 11214672] - B Rabanal, E de Paz, G Merino, A Negro. Determination by capillary zone electrophoresis of berenil, phenamidine, diampron and dibromopropamidine in serum and urine.
Journal of chromatography. B, Biomedical sciences and applications.
2000 Feb; 738(2):293-303. doi:
10.1016/s0378-4347(99)00530-7. [PMID: 10718647] - B Goossens, S Osaer, M Ndao, J Van Winghem, S Geerts. The susceptibility of Djallonké and Djallonké-Sahelian crossbred sheep to Trypanosoma congolense and helminth infection under different diet levels.
Veterinary parasitology.
1999 Aug; 85(1):25-41. doi:
10.1016/s0304-4017(99)00087-4. [PMID: 10447190] - J E Uzonna, R S Kaushik, J R Gordon, H Tabel. Cytokines and antibody responses during Trypanosoma congolense infections in two inbred mouse strains that differ in resistance.
Parasite immunology.
1999 Feb; 21(2):57-71. doi:
10.1046/j.1365-3024.1999.00202.x. [PMID: 10101716] - J E Uzonna, R S Kaushik, J R Gordon, H Tabel. Immunoregulation in experimental murine Trypanosoma congolense infection: anti-IL-10 antibodies reverse trypanosome-mediated suppression of lymphocyte proliferation in vitro and moderately prolong the lifespan of genetically susceptible BALB/c mice.
Parasite immunology.
1998 Jun; 20(6):293-302. doi:
10.1046/j.1365-3024.1998.00156.x. [PMID: 9651931] - R J Milner, F Reyers, J H Taylor, J S van den Berg. The effect of diminazene aceturate on cholinesterase activity in dogs with canine babesiosis.
Journal of the South African Veterinary Association.
1997 Dec; 68(4):111-3. doi:
10.4102/jsava.v68i4.890. [PMID: 9561493] - A G Scott, A Tait, C M Turner. Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites.
Experimental parasitology.
1997 Jul; 86(3):181-90. doi:
10.1006/expr.1997.4167. [PMID: 9225768] - I E Odika, I U Asuzu, S M Anika. The effects of hyperosmolar agents lithium chloride and sucrose on the brain concentration of diminazene aceturate in rats.
Acta tropica.
1995 Oct; 60(2):119-25. doi:
10.1016/0001-706x(95)00098-y. [PMID: 8610539] - S M Mwangi, F McOdimba, L Logan-Henfrey. The effect of Trypanosoma brucei brucei infection on rabbit plasma iron and zinc concentrations.
Acta tropica.
1995 Aug; 59(4):283-91. doi:
10.1016/0001-706x(95)00091-r. [PMID: 8533664] - R E Mdachi, G A Murilla, J N Omukuba, V Cagnolati. Disposition of diminazene aceturate (Berenil) in trypanosome-infected pregnant and lactating cows.
Veterinary parasitology.
1995 Jun; 58(3):215-25. doi:
10.1016/0304-4017(94)00722-o. [PMID: 7571326] - T N Egbe-Nwiyi, R E Antia. Use of monoclonal antibodies for detecting T brucei brucei infection in splenectomised dogs.
The Journal of small animal practice.
1995 May; 36(5):229-32. doi:
10.1111/j.1748-5827.1995.tb02904.x. [PMID: 7650918] - B Gummow, G E Swan, J L Du Preez. A bioequivalence and pharmacokinetic evaluation of two commercial diminazene aceturate formulations administered intramuscularly to cattle.
The Onderstepoort journal of veterinary research.
1994 Dec; 61(4):317-26. doi:
NULL. [PMID: 7501363] - R Kaminsky, F Chuma, R P Wasike. Time-dose response of Trypanosoma congolense bloodstream forms to diminazene and isometamidium.
Veterinary parasitology.
1994 Apr; 52(3-4):235-42. doi:
10.1016/0304-4017(94)90115-5. [PMID: 8073607] - T Ono, Y Ohnishi, K Nagamune, M Kano. Gametocytogenesis induction by Berenil in cultured Plasmodium falciparum.
Experimental parasitology.
1993 Aug; 77(1):74-8. doi:
10.1006/expr.1993.1062. [PMID: 8344408] - R Kaminsky, M Mamman, F Chuma, E Zweygarth. Time-dose-response of Trypanosoma brucei brucei to diminazene aceturate (Berenil) and in vitro simulation of drug-concentration-time profiles in cattle plasma.
Acta tropica.
1993 Jun; 54(1):19-30. doi:
10.1016/0001-706x(93)90065-j. [PMID: 8103625] - J C Cubría, R Balaña Fouce, M L Alvarez-Bujidos, A Negro, A I Ortiz, D Ordóñez. Aromatic diamidines are reversible inhibitors of porcine kidney diamine oxidase.
Biochemical pharmacology.
1993 Mar; 45(6):1355-7. doi:
10.1016/0006-2952(93)90290-d. [PMID: 8466555] - J S Gray, P Gannon. Preliminary development of a live drug-controlled vaccine against bovine babesiosis using the Mongolian gerbil, Meriones unguiculatus.
Veterinary parasitology.
1992 May; 42(3-4):179-88. doi:
10.1016/0304-4017(92)90060-m. [PMID: 1496778] - W Olaho-Mukani, W K Munyua, A R Njogu. An enzyme-linked immunosorbent assay (ELISA) for the detection of trypanosomal antigens in goat serum using a monoclonal antibody.
Journal of immunoassay.
1992; 13(2):217-29. doi:
10.1080/15321819208021228. [PMID: 1430240] - M L van Velthuysen, J A Bruijn, E H van Leer, G J Fleuren. Pathogenesis of trypanosomiasis-induced glomerulonephritis in mice.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1992; 7(6):507-15. doi:
NULL. [PMID: 1320230] - M Akiba, H Saeki, T Ishii, S Yamamoto, K Ueda. Immunological changes in Babesia rodhaini infected BALB/c mice after treated with anti-babesial drug; diminazene diaceturate.
The Journal of veterinary medical science.
1991 Jun; 53(3):371-7. doi:
10.1292/jvms.53.371. [PMID: 1832024] - T J Byers, B G Kim, L E King, E R Hugo. Molecular aspects of the cell cycle and encystment of Acanthamoeba.
Reviews of infectious diseases.
1991 Mar; 13 Suppl 5(?):S373-84. doi:
10.1093/clind/13.supplement_5.s373. [PMID: 2047666] - P A Onyeyili, S M Anika. Diminazene aceturate residues in the tissues of healthy, Trypanosoma congolense and Trypanosoma brucei brucei infected dogs.
The British veterinary journal.
1991 Mar; 147(2):155-62. doi:
10.1016/0007-1935(91)90106-w. [PMID: 1868320] - C A Ross, A M Taylor. Trypanosoma congolense: an in vitro assay to distinguish drug-resistant from drug-sensitive populations.
Parasitology research.
1990; 76(4):326-31. doi:
10.1007/bf00928187. [PMID: 2336447] - R Kaminsky, I D Gumm, E Zweygarth, F Chuma. A drug incubation infectivity test (DIIT) for assessing resistance in trypanosomes.
Veterinary parasitology.
1990 Jan; 34(4):335-43. doi:
10.1016/0304-4017(90)90079-q. [PMID: 2316178] - S M Anika, P A Onyeyili. Effects of trypanosomal infection on the pharmacokinetics of diminazene aceturate in dogs.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ).
1989 Dec; 40(4):419-21. doi:
NULL. [PMID: 2623423] - R Brun, C Kunz. In vitro drug sensitivity test for Trypanosoma brucei subgroup bloodstream trypomastigotes.
Acta tropica.
1989 Oct; 46(5-6):361-8. doi:
10.1016/0001-706x(89)90048-x. [PMID: 2575871] - B T Wellde, J M Preston, R M Kovatch, J Higgs, D A Chumo. Trypanosoma congolense: erythrocyte indices, plasma iron turnover and effects of treatment in infected cattle.
Annals of tropical medicine and parasitology.
1989 Aug; 83 Suppl 1(?):201-6. doi:
10.1080/00034983.1989.11812425. [PMID: 2619395] - L O Wosu, C C Ibe. Use of extracts of Picralima nitida bark in the treatment of experimental trypanosomiasis: a preliminary study.
Journal of ethnopharmacology.
1989 May; 25(3):263-8. doi:
10.1016/0378-8741(89)90032-9. [PMID: 2747261] - M A Akanji, E O Ngaha. Effect of repeated administration of berenil on urinary enzyme excretion with corresponding tissue pattern in rats.
Pharmacology & toxicology.
1989 Mar; 64(3):272-5. doi:
10.1111/j.1600-0773.1989.tb00645.x. [PMID: 2726690] - P A Onyeyili, S M Anika. The influence of Trypanosoma congolense infection on the disposition kinetics of diminazene aceturate in the dog.
Veterinary research communications.
1989; 13(3):231-6. doi:
10.1007/bf00142049. [PMID: 2781721] - J W Harvey, J Taboada, J C Lewis. Babesiosis in a litter of pups.
Journal of the American Veterinary Medical Association.
1988 Jun; 192(12):1751-2. doi:
NULL. [PMID: 3410795] - S M Mahan, L Hendershot, S J Black. Control of trypanodestructive antibody responses and parasitemia in mice infected with Trypanosoma (Duttonella) vivax.
Infection and immunity.
1986 Oct; 54(1):213-21. doi:
10.1128/iai.54.1.213-221.1986. [PMID: 3489676] - S J Black, C N Sendashonga, P Webster, G L Koch, S Z Shapiro. Regulation of parasite-specific antibody responses in resistant (C57BL/6) and susceptible (C3H/HE) mice infected with Trypanosoma (trypanozoon) brucei brucei.
Parasite immunology.
1986 Sep; 8(5):425-42. doi:
10.1111/j.1365-3024.1986.tb00859.x. [PMID: 3774375] - M N Malu, H Tabel. The alternative pathway of complement in sheep during the course of infection with Trypanosoma congolense and after Berenil treatment.
Parasite immunology.
1986 May; 8(3):217-29. doi:
10.1111/j.1365-3024.1986.tb01034.x. [PMID: 3088536] - J E Moulton. Relapse infection after chemotherapy in goats experimentally infected with Trypanosoma brucei: pathological changes in central nervous system.
Veterinary pathology.
1986 Jan; 23(1):21-8. doi:
10.1177/030098588602300104. [PMID: 3946052] - N K Borowy, E Fink, H Hirumi. Trypanosoma brucei: five commonly used trypanocides assayed in vitro with a mammalian feeder layer system for cultivation of bloodstream forms.
Experimental parasitology.
1985 Dec; 60(3):323-30. doi:
10.1016/0014-4894(85)90038-4. [PMID: 4076388] - E S Mitema. Comparative studies of the effects of quinuronium sulfate and diminazene diaceturate in sheep.
Veterinary and human toxicology.
1985 Dec; 27(6):539-42. doi:
NULL. [PMID: 4082473] - H M Kellner, H G Eckert, M H Volz. Studies in cattle on the disposition of the anti-trypanosomal drug diminazene diaceturate (Berenil).
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ).
1985 Dec; 36(4):199-204. doi:
NULL. [PMID: 4089474]