BAY 61-3606 (BioDeep_00000675625)
代谢物信息卡片
化学式: C20H18N6O3 (390.1440318)
中文名称: Syk抑制剂IV,BAY 61-3606 HCl
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC
InChI: InChI=1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91426
- PubChem: 10200390
- ChEMBL: CHEMBL1242100
- ChEMBL: CHEMBL1190711
- CAS: 732983-37-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xuejun He, Yimin Huang, Yanchao Liu, Xincheng Zhang, Pengjie Yue, Xiaopeng Ma, Zhuangzhuang Miao, Xiaobing Long, Yiping Yang, Xueyan Wan, Jin Lei, Kai Shu, Ting Lei, Chao Gan, Huaqiu Zhang. BAY61‑3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury.
International journal of molecular medicine.
2022 01; 49(1):. doi:
10.3892/ijmm.2021.5060. [PMID: 34751408] - Demet Unsal, Meltem Kacan, Meryem Temiz-Resitoglu, Demet S Guden, Belma Korkmaz, Ayse N Sari, Cuneyt K Buharalioglu, Hatice Yildirim-Yaroglu, Lulufer Tamer-Gumus, Bahar Tunctan, Kafait U Malik, Seyhan Sahan-Firat. The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock.
Clinical and experimental pharmacology & physiology.
2018 02; 45(2):155-165. doi:
10.1111/1440-1681.12864. [PMID: 28949404] - Won Seok Yang, Jai Won Chang, Nam Jeong Han, Sang Koo Lee, Su-Kil Park. Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-β1 up-regulation in proximal tubular epithelial cells.
Experimental cell research.
2012 Sep; 318(15):1867-76. doi:
10.1016/j.yexcr.2012.05.016. [PMID: 22659134] - J F Arthur, J Qiao, Y Shen, A K Davis, E Dunne, M C Berndt, E E Gardiner, R K Andrews. ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways.
Journal of thrombosis and haemostasis : JTH.
2012 Jun; 10(6):1133-41. doi:
10.1111/j.1538-7836.2012.04734.x. [PMID: 22489915] - Noriyuki Yamamoto, Keisuke Takeshita, Michitaka Shichijo, Toshio Kokubo, Masako Sato, Kosuke Nakashima, Mina Ishimori, Hiroichi Nagai, Ying-Fu Li, Takeshi Yura, Kevin B Bacon. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents.
The Journal of pharmacology and experimental therapeutics.
2003 Sep; 306(3):1174-81. doi:
10.1124/jpet.103.052316. [PMID: 12766258]