enviroxime (BioDeep_00000674544)
代谢物信息卡片
化学式: C17H18N4O3S (358.11)
中文名称: 恩韦肟
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)S(=O)(=O)N1C2=C(C=CC(=C2)C(=NO)C3=CC=CC=C3)N=C1N
InChI: InChI=1S/C17H18N4O3S/c1-11(2)25(23,24)21-15-10-13(8-9-14(15)19-17(21)18)16(20-22)12-6-4-3-5-7-12/h3-11,22H,1-2H3,(H2,18,19)/b20-16+
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Dilip K Tosh, Kiran S Toti, Brett L Hurst, Justin G Julander, Kenneth A Jacobson. Structure activity relationship of novel antiviral nucleosides against Enterovirus A71.
Bioorganic & medicinal chemistry letters.
2020 12; 30(23):127599. doi:
10.1016/j.bmcl.2020.127599. [PMID: 33031923] - A B Sioofy-Khojine, A Honkimaa, H Hyöty. A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses.
Diabetic medicine : a journal of the British Diabetic Association.
2020 11; 37(11):1849-1853. doi:
10.1111/dme.14175. [PMID: 31705692] - Leen Delang, Christian Harak, Mohammed Benkheil, Hayat Khan, Pieter Leyssen, Martin Andrews, Volker Lohmann, Johan Neyts. PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases.
The Journal of antimicrobial chemotherapy.
2018 12; 73(12):3375-3384. doi:
10.1093/jac/dky327. [PMID: 30219827] - Ana-Maria Osiceanu, Lyre Espada Murao, Denny Kollanur, Jan Swinnen, Annebel R De Vleeschauwer, David J Lefebvre, Kris De Clercq, Johan Neyts, Nesya Goris. In vitro surrogate models to aid in the development of antivirals for the containment of foot-and-mouth disease outbreaks.
Antiviral research.
2014 May; 105(?):59-63. doi:
10.1016/j.antiviral.2014.02.009. [PMID: 24583031] - Catherine Spickler, Julie Lippens, Marie-Kristine Laberge, Sophie Desmeules, Édith Bellavance, Michel Garneau, Tim Guo, Oliver Hucke, Pieter Leyssen, Johan Neyts, Fréderic H Vaillancourt, Anne Décor, Jeff O'Meara, Michael Franti, Annick Gauthier. Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.
Antimicrobial agents and chemotherapy.
2013 Jul; 57(7):3358-68. doi:
10.1128/aac.00303-13. [PMID: 23650168] - Hilde M van der Schaar, Lonneke van der Linden, Kjerstin H W Lanke, Jeroen R P M Strating, Gerhard Pürstinger, Erik de Vries, Cornelis A M de Haan, Johan Neyts, Frank J M van Kuppeveld. Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.
Cell research.
2012 Nov; 22(11):1576-92. doi:
10.1038/cr.2012.129. [PMID: 22945356] - Nirmalendu Saha, Lucy M Jyrwa, Manas Das, Kuheli Biswas. Influence of increased environmental water salinity on gluconeogenesis in the air-breathing walking catfish, Clarias batrachus.
Fish physiology and biochemistry.
2011 Sep; 37(3):681-92. doi:
10.1007/s10695-011-9468-1. [PMID: 21327497] - M J Tebbe, W A Spitzer, F Victor, S C Miller, C C Lee, T R Sattelberg, E McKinney, J C Tang. Antirhino/enteroviral vinylacetylene benzimidazoles: a study of their activity and oral plasma levels in mice.
Journal of medicinal chemistry.
1997 Nov; 40(24):3937-46. doi:
10.1021/jm970423k. [PMID: 9397174] - D A Hilding. Literature review: the common cold.
Ear, nose, & throat journal.
1994 Sep; 73(9):639-43, 46. doi:
. [PMID: 7988393] - J Tang, J M Colacino, S H Larsen, W Spitzer. Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses.
Antiviral research.
1990 Jun; 13(6):313-25. doi:
10.1016/0166-3542(90)90015-y. [PMID: 1699494] - N M Garcon, H R Six, J Frazer, C Hazlewood, B E Gilbert, V Knight. Liposomes of enviroxime and phosphatidylcholine: definition of the drug-phospholipid interactions.
Antiviral research.
1989 Mar; 11(2):89-98. doi:
10.1016/0166-3542(89)90011-9. [PMID: 2729956] - B E Gilbert, H R Six, S Z Wilson, P R Wyde, V Knight. Small particle aerosols of enviroxime-containing liposomes.
Antiviral research.
1988 Sep; 9(6):355-65. doi:
10.1016/0166-3542(88)90037-x. [PMID: 3228281] - M Ogata, H Matsumoto, S Shimizu, S Kida, T Wada, M Shiro, K Sato. Synthesis and antiviral activity of sulfonamidobenzophenone oximes and sulfonamidobenzamides.
Journal of medicinal chemistry.
1986 Mar; 29(3):417-23. doi:
10.1021/jm00153a018. [PMID: 3005577] - V Knight, B E Gilbert. Chemotherapy of respiratory viruses.
Advances in internal medicine.
1986; 31(?):95-118. doi:
. [PMID: 2418643] - R J Bopp, D J Miner. Determination of enviroxime in a variety of biological matrixes by liquid chromatography with electrochemical detection.
Journal of pharmaceutical sciences.
1982 Dec; 71(12):1402-6. doi:
10.1002/jps.2600711223. [PMID: 7153892]
