LOXITANE C (BioDeep_00000674383)
代谢物信息卡片
Loxapine hydrochloride
化学式: C18H19Cl2N3O (363.0905104)
中文名称: 洛沙平盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl.Cl
InChI: 1H
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tyler Ruch, Sharon Nuss, Rajashekar Reddy Yeruva, Yonglin Gao, Gulay Tegin, Christina Terrell, Rif S El-Mallakh. Inhaled loxapine for acute agitation in a psychiatric emergency service.
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.
2021 08; 33(3):162-167. doi:
10.12788/acp.0032. [PMID: 34398731] - Sally Selim, Robert Riesenberg, James Cassella, Jeevan Kunta, Edward Hellriegel, Mark A Smith, Alexander A Vinks, Laura Rabinovich-Guilatt. Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents.
Journal of clinical pharmacology.
2017 10; 57(10):1244-1257. doi:
10.1002/jcph.932. [PMID: 28510296] - Min Meng, Nan Zhao, Carrie C Pederson, Edward Harrison, Charisse Green, Steven H Gorman, Scott Reuschel. Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Mar; 1046(?):87-97. doi:
10.1016/j.jchromb.2017.01.007. [PMID: 28152454] - Charles V Pollack. Inhaled loxapine for the urgent treatment of acute agitation associated with schizophrenia or bipolar disorder.
Current medical research and opinion.
2016 07; 32(7):1253-60. doi:
10.1185/03007995.2016.1170004. [PMID: 27121764] - James V Cassella, Daniel A Spyker, Paul P Yeung. A randomized, placebo-controlled repeat-dose thorough QT study of inhaled loxapine in healthy volunteers.
International journal of clinical pharmacology and therapeutics.
2015 Nov; 53(11):963-71. doi:
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Pharmacopsychiatry.
2015 Nov; 48(7):265-7. doi:
10.1055/s-0035-1564088. [PMID: 26398280] - Daniel A Spyker, Robert A Riesenberg, James V Cassella. Multiple dose pharmacokinetics of inhaled loxapine in subjects on chronic, stable antipsychotic regimens.
Journal of clinical pharmacology.
2015 Sep; 55(9):985-94. doi:
10.1002/jcph.502. [PMID: 25808074] - A Fernandez, E Dor, M-L Menard, F Askenazy, S Thümmler. [Carbamazepine and psychotropic treatment interaction: Two case studies of carbamazepine overdosage].
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Pharmaceutical research.
2014 Aug; 31(8):2107-23. doi:
10.1007/s11095-014-1312-8. [PMID: 24554118] - Daniel A Spyker, Polina Voloshko, Eugene R Heyman, James V Cassella. Loxapine delivered as a thermally generated aerosol does not prolong QTc in a thorough QT/QTc study in healthy subjects.
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2014 Jun; 54(6):665-74. doi:
10.1002/jcph.257. [PMID: 24375070] - Yin Cheong Wong, Zhong Zuo. Brain disposition and catalepsy after intranasal delivery of loxapine: role of metabolism in PK/PD of intranasal CNS drugs.
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2013 Sep; 30(9):2368-84. doi:
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2012 Sep; 38(4):351-5. doi:
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Drug metabolism letters.
2012 Mar; 6(1):26-32. doi:
10.2174/187231212800229255. [PMID: 22300294] - Yin Cheong Wong, Siu Kwan Wo, Zhong Zuo. Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2012 Jan; 58(?):83-93. doi:
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2011 Mar; 65(3):330-40. doi:
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Bioanalysis.
2010 Dec; 2(12):1989-2000. doi:
10.4155/bio.10.156. [PMID: 21110742] - Daniel A Spyker, Patrik Munzar, James V Cassella. Pharmacokinetics of loxapine following inhalation of a thermally generated aerosol in healthy volunteers.
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2010 Feb; 50(2):169-79. doi:
10.1177/0091270009347866. [PMID: 19915181] - L V Rao, M L Snyder, G M Vallaro. Rapid liquid chromatography/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (norclozapine) in human serum.
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Journal of pharmaceutical sciences.
1999 Sep; 88(9):928-32. doi:
10.1021/js980382v. [PMID: 10479356] - S Ulrich, S Kruggel, H Weigmann, C Hiemke. Fishing for a drug: solid-phase microextraction for the assay of clozapine in human plasma.
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1999 Aug; 731(2):231-40. doi:
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Therapeutic drug monitoring.
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Biochemical and biophysical research communications.
1997 Sep; 238(1):252-5. doi:
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1995 Mar; 25(3):291-301. doi:
10.3109/00498259509061853. [PMID: 7618355] - R J Roberge, T G Martin. Mixed fluoxetine/loxapine overdose and atrial flutter.
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1994 Mar; 23(3):586-90. doi:
10.1016/s0196-0644(94)70083-4. [PMID: 8135440] - D M Collins, B E Gidal, M E Pitterle. Potential interaction between carbamazepine and loxapine: case report and retrospective review.
The Annals of pharmacotherapy.
1993 Oct; 27(10):1180-7. doi:
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International journal of clinical pharmacology, therapy, and toxicology.
1993 Apr; 31(4):177-83. doi:
NULL. [PMID: 8500919] - S W Cheung, S W Tang, G Remington. Simultaneous quantitation of loxapine, amoxapine and their 7- and 8-hydroxy metabolites in plasma by high-performance liquid chromatography.
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1984 Sep; 13(1):51-8. doi:
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