Finafloxacin (BioDeep_00000672648)
代谢物信息卡片
化学式: C20H19FN4O4 (398.1390266)
中文名称: 非那沙星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)C#N)N4CC5C(C4)OCCN5)F)C(=O)O
InChI: InChI=1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1
描述信息
A quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, 7 and 8 by cyclopropyl, fluoro, hexahydropyrrolo[3,4-b][1,4]oxazin-6-yl and cyano groups respectively; an antibiotic used for treatment of acute otitis externa (swimmers ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:85176
- KEGGdrug: D10575
- PubChem: 11567473
- DrugBank: DB09047
- ChEMBL: CHEMBL1908370
- CAS: 209342-40-5
- MetaboLights: MTBLC85176
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kay B Barnes, Mark I Richards, Thomas R Laws, Alejandro Núñez, Joanne E Thwaite, Christine Bentley, Sarah V Harding. Finafloxacin Is an Effective Treatment for Inhalational Tularemia and Plague in Mouse Models of Infection.
Antimicrobial agents and chemotherapy.
2021 05; 65(6):. doi:
10.1128/aac.02294-20. [PMID: 33753342] - Max Taubert, Mark Lückermann, Andreas Vente, Axel Dalhoff, Uwe Fuhr. Population Pharmacokinetics of Finafloxacin in Healthy Volunteers and Patients with Complicated Urinary Tract Infections.
Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
10.1128/aac.02328-17. [PMID: 29339394] - F Wagenlehner, M Nowicki, C Bentley, M Lückermann, S Wohlert, C Fischer, A Vente, K Naber, A Dalhoff. Explorative Randomized Phase II Clinical Study of the Efficacy and Safety of Finafloxacin versus Ciprofloxacin for Treatment of Complicated Urinary Tract Infections.
Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
10.1128/aac.02317-17. [PMID: 29339395] - Andreas Vente, Christine Bentley, Mark Lückermann, Paul Tambyah, Axel Dalhoff. Early Clinical Assessment of the Antimicrobial Activity of Finafloxacin Compared to Ciprofloxacin in Subsets of Microbiologically Characterized Isolates.
Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
10.1128/aac.02325-17. [PMID: 29339393] - Max Taubert, Joseph Chiesa, Mark Lückermann, Carsten Fischer, Axel Dalhoff, Uwe Fuhr. Pharmacokinetics of Intravenous Finafloxacin in Healthy Volunteers.
Antimicrobial agents and chemotherapy.
2017 10; 61(10):. doi:
10.1128/aac.01122-17. [PMID: 28784673] - A Dalhoff, S Schubert, A Vente. Pharmacodynamics of Finafloxacin, Ciprofloxacin, and Levofloxacin in Serum and Urine against TEM- and SHV-Type Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae Isolates from Patients with Urinary Tract Infections.
Antimicrobial agents and chemotherapy.
2017 05; 61(5):. doi:
10.1128/aac.02446-16. [PMID: 28193648] - Heena Patel, Arne Andresen, Andreas Vente, Hans-Dietrich Heilmann, Will Stubbings, Michael Seiberling, Luis Lopez-Lazaro, Rolf Pokorny, Harald Labischinski. Human pharmacokinetics and safety profile of finafloxacin, a new fluoroquinolone antibiotic, in healthy volunteers.
Antimicrobial agents and chemotherapy.
2011 Sep; 55(9):4386-93. doi:
10.1128/aac.00832-10. [PMID: 21709093] - Florian M E Wagenlehner, Christine M Wagenlehner, Birgit Blenk, Holger Blenk, Sabine Schubert, Axel Dalhoff, Kurt G Naber. Urinary pharmacokinetics and bactericidal activity of finafloxacin (200 and 800 mg) in healthy volunteers receiving a single oral dose.
Chemotherapy.
2011; 57(2):97-107. doi:
10.1159/000321028. [PMID: 21358200]