Tedizolid (BioDeep_00000672397)
Chemicals and Drugs
代谢物信息卡片
Tedizolid
化学式: C17H15FN6O3 (370.119)
中文名称: 特地唑胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)CO)F
InChI: InChI=1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1
描述信息
A member of the class of pyridines that is pyridine which is substituted by a 2-methyl-2H-tetrazol-5-yl group at position 2 and by a 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl group at position 5. It is used as its phosphate pro-drug used for the treatment of acute bacterial skin and skin structure infections caused by certain susceptible bacteria, including Staphylococcus aureus (including methicillin-resistant strains (MRSA) and methicillin-susceptible strains), various Streptococcus species, and Enterococcus faecalis.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D023303 - Oxazolidinones
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:82717
- KEGGdrug: D09685
- PubChem: 11234049
- DrugBank: DB14569
- ChEMBL: CHEMBL1257051
- CAS: 856866-72-3
- MetaboLights: MTBLC82717
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Masahiro Toyokawa, Noboru Ohana, Daiki Tanno, Minako Imai, Yukiko Takano, Kazutaka Ohashi, Tomonari Yamashita, Kyoichi Saito, Hiroki Takahashi, Hiroki Shimura. In vitro activity of tedizolid against 43 species of Nocardia species.
Scientific reports.
2024 03; 14(1):5342. doi:
10.1038/s41598-024-55916-7. [PMID: 38438563] - Anselm Jorda, Beatrix Wulkersdorfer, Christian Schörgenhofer, Peter Matzneller, Valentin Al Jalali, Martin Bauer, Michael Wölf-Duchek, Edith Lackner, Christoph Dorn, Bernd Jilma, Markus Zeitlinger. Influence of tedizolid on the cytokine response to the endotoxin challenge in healthy volunteers: a cross-over trial.
The Journal of antimicrobial chemotherapy.
2022 04; 77(5):1424-1431. doi:
10.1093/jac/dkac039. [PMID: 35165727] - Yuki Sato, Yoh Takekuma, Takayuki Daisho, Hitoshi Kashiwagi, Shungo Imai, Mitsuru Sugawara. Development of a Method of Liquid Chromatography Coupled with Tandem Mass Spectrometry for Simultaneous Determination of Linezolid and Tedizolid in Human Plasma.
Biological & pharmaceutical bulletin.
2022; 45(4):421-428. doi:
10.1248/bpb.b21-00798. [PMID: 35370266] - Yasuhiro Tsuji, Miki Numajiri, Chika Ogami, Fumihiro Kurosaki, Aoi Miyamoto, Takahiko Aoyama, Hitoshi Kawasuji, Kentaro Nagaoka, Yoshiaki Matsumoto, Hideto To, Yoshihiro Yamamoto. Development of a simple method for measuring tedizolid concentration in human serum using HPLC with a fluorescent detector.
Medicine.
2021 Dec; 100(49):e28127. doi:
10.1097/md.0000000000028127. [PMID: 34889275] - Ying-Chun Chien, Yu-Lin Lee, Po-Yu Liu, Min-Chi Lu, Pei-Lan Shao, Po-Liang Lu, Shu-Hsing Cheng, Chi-Ying Lin, Ting-Shu Wu, Muh-Yong Yen, Lih-Shinn Wang, Chang-Pan Liu, Wen-Sen Lee, Zhi-Yuan Shi, Yao-Shen Chen, Fu-Der Wang, Shu-Hui Tseng, Yu-Hui Chen, Wang-Huei Sheng, Chun-Ming Lee, Yen-Hsu Chen, Wen-Chien Ko, Po-Ren Hsueh. National surveillance of antimicrobial susceptibilities to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics and serotype distribution of invasive Streptococcus pneumoniae isolates in adults: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) programme in 2017-2020.
Journal of global antimicrobial resistance.
2021 09; 26(?):308-316. doi:
10.1016/j.jgar.2021.07.005. [PMID: 34289409] - Makoto Kai, Ryota Tanaka, Yosuke Suzuki, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh. Simultaneous quantification of plasma levels of 12 antimicrobial agents including carbapenem, anti-methicillin-resistant Staphylococcus aureus agent, quinolone and azole used in intensive care unit using UHPLC-MS/MS method.
Clinical biochemistry.
2021 Apr; 90(?):40-49. doi:
10.1016/j.clinbiochem.2021.01.012. [PMID: 33539809] - Ryota Tanaka, Makoto Kai, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh. High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2021 Feb; 194(?):113764. doi:
10.1016/j.jpba.2020.113764. [PMID: 33298382] - Christoph Dorn, Selina Schießer, Beatrix Wulkersdorfer, Florian Hitzenbichler, Martin G Kees, Markus Zeitlinger. Determination of free clindamycin, flucloxacillin or tedizolid in plasma: Pay attention to physiological conditions when using ultrafiltration.
Biomedical chromatography : BMC.
2020 Jun; 34(6):e4820. doi:
10.1002/bmc.4820. [PMID: 32115736] - Liqiang Gu, Munong Ma, Yuan Zhang, Lijiang Zhang, Sheng Zhang, Mincong Huang, Majuan Zhang, Yanfei Xin, Gaoli Zheng, Suhong Chen. Comparative pharmacokinetics of tedizolid in rat plasma and cerebrospinal fluid.
Regulatory toxicology and pharmacology : RTP.
2019 Oct; 107(?):104420. doi:
10.1016/j.yrtph.2019.104420. [PMID: 31295511] - Shan Wang, Yun Li, Feng Xue, Jian Liu, Weiwei Yang, Jia Zhang, Martin Glenschek-Sieberth, Yuan Lyu. Comparative in vitro potency and kill curve activity of tedizolid and linezolid against Gram-positive bacteria isolated from Chinese hospitalized patients in 2013-2016.
Journal of chemotherapy (Florence, Italy).
2019 Oct; 31(6):313-319. doi:
10.1080/1120009x.2019.1623968. [PMID: 31215343] - Matthieu Grégoire, Julia Brochard Libois, Denis Waast, Benjamin Gaborit, Marc Dauty, Guillaume Deslandes, Eric Dailly, Sophie Touchais, David Boutoille, Nicolas Grégoire, William Couet. Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery.
Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
10.1128/aac.02432-17. [PMID: 29378714] - Mekki Bensaci, Shawn Flanagan, Taylor Sandison. Determination of Tedizolid susceptibility interpretive criteria for gram-positive pathogens according to clinical and laboratory standards institute guidelines.
Diagnostic microbiology and infectious disease.
2018 Mar; 90(3):214-220. doi:
10.1016/j.diagmicrobio.2017.10.023. [PMID: 29277464] - Sean M Stainton, Marguerite L Monogue, Arlinda Baummer-Carr, Ashley K Shepard, James F Nugent, Joseph L Kuti, David P Nicolau. Comparative Assessment of Tedizolid Pharmacokinetics and Tissue Penetration between Diabetic Patients with Wound Infections and Healthy Volunteers via In Vivo Microdialysis.
Antimicrobial agents and chemotherapy.
2018 01; 62(1):. doi:
10.1128/aac.01880-17. [PMID: 29109162] - Manjunath P Pai. Pharmacokinetics of Tedizolid in Morbidly Obese and Covariate-Matched Nonobese Adults.
Antimicrobial agents and chemotherapy.
2016 08; 60(8):4585-9. doi:
10.1128/aac.00682-16. [PMID: 27185808] - Shawn Flanagan, Philippe Prokocimer. Reduction in Tedizolid Plasma Exposure among End-Stage Renal Disease Patients Undergoing Dialysis Is Explained by Variations in Ideal Body Weight.
Antimicrobial agents and chemotherapy.
2016 05; 60(5):3246-7. doi:
10.1128/aac.03127-15. [PMID: 26926636] - Hua-chen Yu, Chen-wei Pan, Qi-peng Xie, Yi Zheng, Yue-zheng Hu, Yi-mu Lin. Simultaneous determination of tedizolid and linezolid in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Feb; 1011(?):94-8. doi:
10.1016/j.jchromb.2015.12.056. [PMID: 26773886] - Shawn Flanagan, Edward E McKee, Debaditya Das, Paul M Tulkens, Hiromi Hosako, Jill Fiedler-Kelly, Julie Passarell, Ann Radovsky, Philippe Prokocimer. Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function.
Antimicrobial agents and chemotherapy.
2015 Jan; 59(1):178-85. doi:
10.1128/aac.03684-14. [PMID: 25331703] - S Flanagan, S L Minassian, D Morris, R Ponnuraj, T C Marbury, H W Alcorn, E Fang, P Prokocimer. Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment.
Antimicrobial agents and chemotherapy.
2014 Nov; 58(11):6471-6. doi:
10.1128/aac.03431-14. [PMID: 25136024] - Martina Sahre, Sreedharan Sabarinath, Maria Grant, Christoph Seubert, Carisa Deanda, Philippe Prokocimer, Hartmut Derendorf. Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.
International journal of antimicrobial agents.
2012 Jul; 40(1):51-4. doi:
10.1016/j.ijantimicag.2012.03.006. [PMID: 22584101] - Seth T Housman, J Samuel Pope, John Russomanno, Edward Salerno, Eric Shore, Joseph L Kuti, David P Nicolau. Pulmonary disposition of tedizolid following administration of once-daily oral 200-milligram tedizolid phosphate in healthy adult volunteers.
Antimicrobial agents and chemotherapy.
2012 May; 56(5):2627-34. doi:
10.1128/aac.05354-11. [PMID: 22330925] - Arnold Louie, Weiguo Liu, Robert Kulawy, G L Drusano. In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model.
Antimicrobial agents and chemotherapy.
2011 Jul; 55(7):3453-60. doi:
10.1128/aac.01565-10. [PMID: 21502615]
