TDZD-8 (BioDeep_00000671705)
代谢物信息卡片
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
化学式: C10H10N2O2S (222.046296)
中文名称: 4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=O)N(C(=O)S1)CC2=CC=CC=C2
InChI: InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuan Li, Jialu Huang, Jie Wang, Simin Xia, Hong Ran, Lenyu Gao, Chengjian Feng, Li Gui, Zhenhua Zhou, Jichao Yuan. Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis.
Journal of neuroinflammation.
2023 Feb; 20(1):49. doi:
10.1186/s12974-023-02738-5. [PMID: 36829224] - He-Yu Yang, Xu Sun, Shu-Qing Zhen, Liang-Zhu Yu, Jie-Qiong Ding, Ling Liu, Min Xie, Hai-Li Zhu. GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation.
PloS one.
2023; 18(4):e0284332. doi:
10.1371/journal.pone.0284332. [PMID: 37058473] - Amal F Dawood, Sheren Younes, Norah M Alzamil, Faten A Alradini, Maha Fahad Saja. Inhibition of glycogen synthase kinase-3β protects against collagen type II-induced arthritis associated with the inhibition of miR155/24 and inflammation and upregulation of apoptosis in rats.
Archives of physiology and biochemistry.
2022 Jun; 128(3):679-687. doi:
10.1080/13813455.2020.1716021. [PMID: 31994915] - Qiaojuan Liu, Yonglun Kong, Xiangdong Guo, Baien Liang, Haixia Xie, Shan Hu, Mengke Han, Xiaoduo Zhao, Pinning Feng, Qianqian Lyu, Wei Dong, Xinling Liang, Weidong Wang, Chunling Li. GSK-3β inhibitor TDZD-8 prevents reduction of aquaporin-1 expression via activating autophagy under renal ischemia reperfusion injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 08; 35(8):e21809. doi:
10.1096/fj.202100549r. [PMID: 34314052] - Jin Deng, Xin Wang, Qin Zhou, Yue Xia, Chongxiang Xiong, Xiaofei Shao, Hequn Zou. Inhibition of Glycogen Synthase Kinase 3β Alleviates Chronic Renal Allograft Dysfunction in Rats.
Transplantation.
2021 04; 105(4):757-767. doi:
10.1097/tp.0000000000003446. [PMID: 32890133] - Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E Campillo, Ana Martinez. COVID-19: Drug Targets and Potential Treatments.
Journal of medicinal chemistry.
2020 11; 63(21):12359-12386. doi:
10.1021/acs.jmedchem.0c00606. [PMID: 32511912] - Jia Guo, Min Lei, Fei Cheng, Yong Liu, Mengwen Zhou, Wen Zheng, Yali Zhou, Rujun Gong, Zhangsuo Liu. RNA-binding proteins tristetraprolin and human antigen R are novel modulators of podocyte injury in diabetic kidney disease.
Cell death & disease.
2020 06; 11(6):413. doi:
10.1038/s41419-020-2630-x. [PMID: 32487989] - Shuai Su, Peng Zhang, Qilin Zhang, Zhikang Yin. GSK-3β Inhibitor Induces Expression of the TLR4/MyD88/NF-κB Signaling Pathway to Protect Against Renal Ischemia-Reperfusion Injury During Rat Kidney Transplantation.
Inflammation.
2019 Dec; 42(6):2105-2118. doi:
10.1007/s10753-019-01074-2. [PMID: 31440938] - Bo Hu, Jie Tang, Yi Zhang, Zhenyi Ma, Yungang Shan, Jie Liu, Xiaohua Shen, Ping Qian. Glycogen Synthase Kinase-3β Inhibitor Attenuates Renal Damage Through Regulating Antioxidant and Anti-inflammation in Rat Kidney Transplant With Cold Ischemia Reperfusion.
Transplantation proceedings.
2019 Jul; 51(6):2066-2070. doi:
10.1016/j.transproceed.2019.05.010. [PMID: 31399185] - Tsuneo Takenaka, Tsutomu Inoue, Takashi Miyazaki, Hiroyuki Kobori, Akira Nishiyama, Naohito Ishii, Matsuhiko Hayashi, Hiromichi Suzuki. Klotho suppresses the renin-angiotensin system in adriamycin nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2017 May; 32(5):791-800. doi:
10.1093/ndt/gfw340. [PMID: 27798196] - Dong Wang, Xinjie Zhang, Defang Li, Wenjin Hao, Fanqing Meng, Bo Wang, Jichun Han, Qiusheng Zheng. Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway.
Mediators of inflammation.
2017; 2017(?):5278218. doi:
10.1155/2017/5278218. [PMID: 28928604] - Xiaohua Shen, Bo Hu, Guangtao Xu, Fengjuan Chen, Ruifen Ma, Nenghua Zhang, Jie Liu, Xiaoqin Ma, Jia Zhu, Yuhong Wu, Ruilin Shen. Activation of Nrf2/HO-1 Pathway by Glycogen Synthase Kinase-3β Inhibition Attenuates Renal Ischemia/Reperfusion Injury in Diabetic Rats.
Kidney & blood pressure research.
2017; 42(2):369-378. doi:
10.1159/000477947. [PMID: 28624830] - Haiyan Zhou, Jun Liu, Jiashun Zeng, Bailong Hu, Xiuyi Fang, Long Li. Inhibition of GSK-3β Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats.
Medical science monitor : international medical journal of experimental and clinical research.
2016 Mar; 22(?):1047-52. doi:
10.12659/msm.897739. [PMID: 27029564] - Bo Hu, Yuhong Wu, Jie Liu, Xiaohua Shen, Fei Tong, Guangtao Xu, Ruilin Shen. GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats.
Kidney & blood pressure research.
2016; 41(6):937-946. doi:
10.1159/000452598. [PMID: 27924803] - Guido Furlotti, Maria Alessandra Alisi, Nicola Cazzolla, Patrizia Dragone, Lucia Durando, Gabriele Magarò, Francesca Mancini, Giorgina Mangano, Rosella Ombrato, Marco Vitiello, Andrea Armirotti, Valeria Capurro, Massimiliano Lanfranco, Giuliana Ottonello, Maria Summa, Angelo Reggiani. Hit Optimization of 5-Substituted-N-(piperidin-4-ylmethyl)-1H-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders.
Journal of medicinal chemistry.
2015 Nov; 58(22):8920-37. doi:
10.1021/acs.jmedchem.5b01208. [PMID: 26486317] - Hua Liu, Shanshan Ou, Xiaoyu Xiao, Yingxian Zhu, Shaopeng Zhou. Diabetes Worsens Ischemia-Reperfusion Brain Injury in Rats Through GSK-3β.
The American journal of the medical sciences.
2015 Sep; 350(3):204-11. doi:
10.1097/maj.0000000000000540. [PMID: 26226547] - Shailendra P Singh, Shixin Tao, Timothy A Fields, Sydney Webb, Raymond C Harris, Reena Rao. Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice.
Disease models & mechanisms.
2015 Aug; 8(8):931-40. doi:
10.1242/dmm.020511. [PMID: 26092126] - Shixin Tao, Vijayakumar R Kakade, James R Woodgett, Pankaj Pandey, Erin D Suderman, Madhumitha Rajagopal, Reena Rao. Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease.
Kidney international.
2015 Jun; 87(6):1164-75. doi:
10.1038/ki.2014.427. [PMID: 25629553] - Hui Bao, Yan Ge, Ai Peng, Rujun Gong. Fine-tuning of NFκB by glycogen synthase kinase 3β directs the fate of glomerular podocytes upon injury.
Kidney international.
2015 Jun; 87(6):1176-90. doi:
10.1038/ki.2014.428. [PMID: 25629551] - Jijun Zhao, Hongyue Wang, Yuefang Huang, Hui Zhang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu. Lupus nephritis: glycogen synthase kinase 3β promotion of renal damage through activation of the NLRP3 inflammasome in lupus-prone mice.
Arthritis & rheumatology (Hoboken, N.J.).
2015 Apr; 67(4):1036-44. doi:
10.1002/art.38993. [PMID: 25512114] - Joao Rocha, Maria-Eduardo Figueira, Andreia Barateiro, Adelaide Fernandes, Dora Brites, Rui Pinto, Marisa Freitas, Eduarda Fernandes, Helder Mota-Filipe, Bruno Sepodes. Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat.
Shock (Augusta, Ga.).
2015 Apr; 43(4):369-78. doi:
10.1097/shk.0000000000000298. [PMID: 25394244] - Zhen Wang, Hui Bao, Yan Ge, Shougang Zhuang, Ai Peng, Rujun Gong. Pharmacological targeting of GSK3β confers protection against podocytopathy and proteinuria by desensitizing mitochondrial permeability transition.
British journal of pharmacology.
2015 Feb; 172(3):895-909. doi:
10.1111/bph.12952. [PMID: 25262943] - Julie A Vrana, Holly N Currie, Alice A Han, Jonathan Boyd. Forecasting cell death dose-response from early signal transduction responses in vitro.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Aug; 140(2):338-51. doi:
10.1093/toxsci/kfu089. [PMID: 24824809] - Lena Jellestad, Tobias Fink, Sascha Pradarutti, Darius Kubulus, Beate Wolf, Inge Bauer, Chris Thiemermann, Hauke Rensing. Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock.
European journal of pharmacology.
2014 Feb; 724(?):175-84. doi:
10.1016/j.ejphar.2013.12.029. [PMID: 24389157] - Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Hye Young Kim, Won Suk Lee, Byung Yong Rhim, Ki Whan Hong, Chi Dae Kim. Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol.
Journal of neuroscience research.
2014 Feb; 92(2):206-17. doi:
10.1002/jnr.23310. [PMID: 24254769] - Christiana Howard, Shixin Tao, Hai-Chun Yang, Agnes B Fogo, James R Woodgett, Raymond C Harris, Reena Rao. Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice.
Kidney international.
2012 Nov; 82(9):1000-9. doi:
10.1038/ki.2012.239. [PMID: 22785175] - Hao Bao, Yan Ge, Shougang Zhuang, Lance D Dworkin, Zhihong Liu, Rujun Gong. Inhibition of glycogen synthase kinase-3β prevents NSAID-induced acute kidney injury.
Kidney international.
2012 Apr; 81(7):662-73. doi:
10.1038/ki.2011.443. [PMID: 22258319] - Sung-E Choi, Hyun-Ju Jang, Yup Kang, Jong Gab Jung, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee. Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice.
Vascular pharmacology.
2010 Nov; 53(5-6):264-72. doi:
10.1016/j.vph.2010.09.004. [PMID: 20888430] - Peter J Nelson, Lloyd Cantley. GSK3beta plays dirty in acute kidney injury.
Journal of the American Society of Nephrology : JASN.
2010 Feb; 21(2):199-200. doi:
10.1681/asn.2009121214. [PMID: 20056749] - Zhiyong Wang, Andrea Havasi, Jonathan Gall, Ramon Bonegio, Zhijian Li, Haiping Mao, John H Schwartz, Steven C Borkan. GSK3beta promotes apoptosis after renal ischemic injury.
Journal of the American Society of Nephrology : JASN.
2010 Feb; 21(2):284-94. doi:
10.1681/asn.2009080828. [PMID: 20093356] - Thomas Waldow, Wolfgang Witt, Klaus Matschke. Inhibition of glycogen synthase kinase-3β prevents activation of focal adhesion kinase after ischemia/reperfusion of the rat lung.
Clinical hemorheology and microcirculation.
2010; 46(2-3):169-81. doi:
10.3233/ch-2010-1343. [PMID: 21135492] - Y Wang, W C Huang, C Y Wang, C C Tsai, C L Chen, Y T Chang, J I Kai, C F Lin. Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis.
British journal of pharmacology.
2009 Jul; 157(6):1004-13. doi:
10.1111/j.1476-5381.2009.00284.x. [PMID: 19508392] - Massimo Collino, Manuela Aragno, Sara Castiglia, Chiara Tomasinelli, Christoph Thiemermann, Giuseppe Boccuzzi, Roberto Fantozzi. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta.
Diabetes.
2009 Jan; 58(1):235-42. doi:
10.2337/db08-0691. [PMID: 18840784] - Massimo Collino, Christoph Thiemermann, Raffaella Mastrocola, Margherita Gallicchio, Elisa Benetti, Gianluca Miglio, Sara Castiglia, Oliviero Danni, Oliver Murch, Chiara Dianzani, Manuela Aragno, Roberto Fantozzi. Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus.
Shock (Augusta, Ga.).
2008 Sep; 30(3):299-307. doi:
10.1097/shk.0b013e318164e762. [PMID: 18323734] - Salvatore Cuzzocrea, Giuseppe Malleo, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Carmelo Muià, Maha Abdelrahman, Rosanna Di Paola, Cristoph Thiemermann. Effects of glycogen synthase kinase-3beta inhibition on the development of cerulein-induced acute pancreatitis in mice.
Critical care medicine.
2007 Dec; 35(12):2811-21. doi:
10.1097/01.ccm.0000295303.62996.9f. [PMID: 18074481] - Zhang Bao, Shuhui Lim, Wupeng Liao, Yuzhi Lin, Christoph Thiemermann, Bernard P Leung, W S Fred Wong. Glycogen synthase kinase-3beta inhibition attenuates asthma in mice.
American journal of respiratory and critical care medicine.
2007 Sep; 176(5):431-8. doi:
10.1164/rccm.200609-1292oc. [PMID: 17556716] - Laura Dugo, Marika Collin, David A Allen, Nimesh S A Patel, Inge Bauer, Eero Mervaala, Marjut Louhelainen, Simon J Foster, Muhammad M Yaqoob, Christoph Thiemermann. Inhibiting glycogen synthase kinase 3beta in sepsis.
Novartis Foundation symposium.
2007; 280(?):128-42; discussion 142. doi:
NULL. [PMID: 17380792] - S Cuzzocrea, C Crisafulli, E Mazzon, E Esposito, C Muià, M Abdelrahman, R Di Paola, C Thiemermann. Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice.
British journal of pharmacology.
2006 Nov; 149(6):687-702. doi:
10.1038/sj.bjp.0706902. [PMID: 17016509] - Salvatore Cuzzocrea, Emanuela Mazzon, Rosanna Di Paola, Carmelo Muià, Concetta Crisafulli, Laura Dugo, Marika Collin, Domenico Britti, Achille P Caputi, Christoph Thiemermann. Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse.
Clinical immunology (Orlando, Fla.).
2006 Jul; 120(1):57-67. doi:
10.1016/j.clim.2006.03.005. [PMID: 16631408] - Laura Dugo, Maha Abdelrahman, Oliver Murch, Emanuela Mazzon, Salvatore Cuzzocrea, Christoph Thiemermann. Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation.
Shock (Augusta, Ga.).
2006 May; 25(5):485-91. doi:
10.1097/01.shk.0000209545.29671.31. [PMID: 16680013] - Laura Dugo, Marika Collin, David A Allen, Oliver Murch, Simon J Foster, Muhammad M Yaqoob, Christoph Thiemermann. Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: role of glycogen synthase kinase-3beta inhibition.
Critical care medicine.
2006 May; 34(5):1489-96. doi:
10.1097/01.ccm.0000215457.83953.e3. [PMID: 16557150] - Laura Dugo, Marika Collin, David A Allen, Nimesh S A Patel, Inge Bauer, Eero M A Mervaala, Marjut Louhelainen, Simon J Foster, Muhammad M Yaqoob, Christoph Thiemermann. GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.
Critical care medicine.
2005 Sep; 33(9):1903-12. doi:
10.1097/01.ccm.0000178350.21839.44. [PMID: 16148458] - A Tourian. Control of phenylalanine hydroxylase synthesis in tissue culture by serum and insulin.
Journal of cellular physiology.
1976 Jan; 87(1):15-24. doi:
10.1002/jcp.1040870104. [PMID: 1401]