Atipamezole (BioDeep_00000671633)
代谢物信息卡片
Atipamezole
化学式: C14H16N2 (212.1313)
中文名称: 阿替美唑, 沸石
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(C2=CN=CN2)CC3=C(C=CC=C3)C1
InChI: InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
Atipamezole (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM[1].
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- KEGGdrug: D03002
- PubChem: 71310
- DrugBank: DB11481
- ChEMBL: CHEMBL353972
- CAS: 308081-08-5
- CAS: 104054-27-5
- medchemexpress: HY-12380A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mizuho Tashiro, Atsushi Tohei. Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice.
The Journal of veterinary medical science.
2022 Mar; 84(3):445-453. doi:
10.1292/jvms.21-0479. [PMID: 35135936] - Etienne Côté, Lesley A Zwicker, Erin L Anderson, Henrik Stryhn, Jenny Yu, Erin Andersen. Effects of dexmedetomidine and its reversal with atipamezole on echocardiographic measurements and circulating cardiac biomarker concentrations in normal cats.
Journal of the American Veterinary Medical Association.
2022 02; 260(8):1-9. doi:
10.2460/javma.21.06.0299. [PMID: 35175929] - Michael S McEntire, Edward C Ramsay, Josh Price, Andrew C Cushing. THE EFFECTS OF PROCEDURE DURATION AND ATIPAMEZOLE ADMINISTRATION ON HYPERKALEMIA IN TIGERS (PANTHERA TIGRIS) AND LIONS (PANTHERA LEO) ANESTHETIZED WITH α-2 AGONISTS.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2020 Nov; 51(3):490-496. doi:
10.1638/2019-0128. [PMID: 33480524] - Lisa L Wolfe, Travis Mays, Mark C Fisher, Michael W Miller. Tissue Residue Levels of the Tranquilizer Combination of Butorphanol, Azaperone, and Medetomidine, and the Antagonists, Naltrexone, Atipamezole, and Tolazoline, in Black Bears (Ursus americanus) Postimmobilization.
Journal of wildlife diseases.
2020 10; 56(4):933-936. doi:
10.7589/jwd-d-19-00012. [PMID: 32348204] - Jianbo Ma, Qian Chen, Juanjuan Li, Hailin Zhao, Emma Mi, Yan Chen, Bin Yi, Jiaolin Ning, Daqing Ma, Kaizhi Lu, Jianteng Gu. Dexmedetomidine-Mediated Prevention of Renal Ischemia-Reperfusion Injury Depends in Part on Cholinergic Anti-Inflammatory Mechanisms.
Anesthesia and analgesia.
2020 04; 130(4):1054-1062. doi:
10.1213/ane.0000000000003820. [PMID: 30346356] - Heta Turunen, Marja R Raekallio, Juhana M Honkavaara, Flavia Restitutti, Ira J Kallio-Kujala, Magdy Adam, Katri Nevanperä, Mika Scheinin, Sofia K Männikkö, Heidi J Hautajärvi, Paula Larenza Menzies, Outi M Vainio. Cardiovascular and sedation reversal effects of intramuscular administration of atipamezole in dogs treated with medetomidine hydrochloride with or without the peripheral α2-adrenoceptor antagonist vatinoxan hydrochloride.
American journal of veterinary research.
2019 Oct; 80(10):912-922. doi:
10.2460/ajvr.80.10.912. [PMID: 31556714] - Paola Devoto, Giovanna Flore, Pierluigi Saba, Simona Scheggi, Giovanna Mulas, Carla Gambarana, Saturnino Spiga, Gian Luigi Gessa. Noradrenergic terminals are the primary source of α2-adrenoceptor mediated dopamine release in the medial prefrontal cortex.
Progress in neuro-psychopharmacology & biological psychiatry.
2019 03; 90(?):97-103. doi:
10.1016/j.pnpbp.2018.11.015. [PMID: 30472147] - Magdy Adam, Marja R Raekallio, Outi M Vainio. Sedative effect of intramuscular medetomidine with and without vatinoxan (MK-467), and its reversal with atipamezole in sheep.
Veterinary anaesthesia and analgesia.
2018 Nov; 45(6):788-793. doi:
10.1016/j.vaa.2018.06.009. [PMID: 30301665] - Magdy Adam, Marja R Raekallio, Kati M Salla, Juhana M Honkavaara, Sofia Männikkö, Mika Scheinin, Marena Kajula, Sari H Mölsä, Outi M Vainio. Effects of the peripherally acting α2-adrenoceptor antagonist MK-467 on cardiopulmonary function in sheep sedated by intramuscular administration of medetomidine and ketamine and reversed by intramuscular administration of atipamezole.
American journal of veterinary research.
2018 Sep; 79(9):921-932. doi:
10.2460/ajvr.79.9.921. [PMID: 30153057] - Rongzong Qiu, Weifeng Yao, Haocong Ji, Dongdong Yuan, Xiaofeng Gao, Weiping Sha, Fei Wang, Pinjie Huang, Ziqing Hei. Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model.
Life sciences.
2018 Jul; 204(?):1-8. doi:
10.1016/j.lfs.2018.05.001. [PMID: 29733849] - M Adam, M R Raekallio, T Keskitalo, J M Honkavaara, M Scheinin, M Kajula, S Mölsä, O M Vainio. The impact of MK-467 on plasma drug concentrations, sedation and cardiopulmonary changes in sheep treated with intramuscular medetomidine and atipamezole for reversal.
Journal of veterinary pharmacology and therapeutics.
2018 Jun; 41(3):447-456. doi:
10.1111/jvp.12486. [PMID: 29352473] - Lisa L Wolfe, Pauline Nol, Matthew P McCollum, Travis Mays, Morgan E Wehtje, William R Lance, Mark C Fisher, Michael W Miller. Tissue Residue Levels after Immobilization of Rocky Mountain Elk ( Cervus elaphus nelsoni) using a Combination of Nalbuphine, Medetomidine, and Azaperone Antagonized with Naltrexone, Atipamezole, and Tolazoline.
Journal of wildlife diseases.
2018 04; 54(2):362-365. doi:
10.7589/2017-06-132. [PMID: 29148888] - Teppei Nakamura, Naoya Karakida, Ai Dantsuka, Osamu Ichii, Yaser Hosny Ali Elewa, Yasuhiro Kon, Ken-Ichi Nagasaki, Hideki Hattori, Tomoji Yoshiyasu. Effects of a mixture of medetomidine, midazolam and butorphanol on anesthesia and blood biochemistry and the antagonizing action of atipamezole in hamsters.
The Journal of veterinary medical science.
2017 Jul; 79(7):1230-1235. doi:
10.1292/jvms.17-0210. [PMID: 28603217] - Bing-Qian Xiang, Hui Gao, Zi-Yin Luo, Zhou-Xi Fang, Wan-Tie Wang. [Effect of dexmedetomidine on renal injury induced by lung ischemia/reperfusion in mice].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2017 Apr; 33(4):380-384. doi:
10.12047/j.cjap.5500.2017.092. [PMID: 29926648] - Qian Chen, Bin Yi, Jianbo Ma, Jiaoling Ning, Lingzhi Wu, Daqing Ma, Kaizhi Lu, Jianteng Gu. α2-adrenoreceptor modulated FAK pathway induced by dexmedetomidine attenuates pulmonary microvascular hyper-permeability following kidney injury.
Oncotarget.
2016 Aug; 7(35):55990-56001. doi:
10.18632/oncotarget.10809. [PMID: 27463003] - P N McCormick, P J Fletcher, V S Wilson, G J Remington. The adrenergic α2 antagonist atipamezole alters the behavioural effects of pramipexole and increases pramipexole concentration in blood plasma.
Life sciences.
2016 Apr; 151(?):300-304. doi:
10.1016/j.lfs.2016.03.017. [PMID: 26976325] - Naotami Ueoka, Yoshiaki Hikasa. Effects in cats of atipamezole, flumazenil and 4-aminopyridine on stress-related neurohormonal and metabolic responses induced by medetomidine, midazolam and ketamine.
Journal of feline medicine and surgery.
2015 Aug; 17(8):711-8. doi:
10.1177/1098612x14556557. [PMID: 25366173] - Yusuke Murahata, Yuya Miki, Yoshiaki Hikasa. Antagonistic effects of atipamezole, yohimbine, and prazosin on xylazine-induced diuresis in clinically normal cats.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2014 Oct; 78(4):304-15. doi:
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The Journal of veterinary medical science.
2014 Mar; 76(2):173-82. doi:
10.1292/jvms.13-0398. [PMID: 24107430] - Heather K Knych, Scott D Stanley. Effects of three antagonists on selected pharmacodynamic effects of sublingually administered detomidine in the horse.
Veterinary anaesthesia and analgesia.
2014 Jan; 41(1):36-47. doi:
10.1111/vaa.12081. [PMID: 24134603] - Kimberly L Rainwater, Marc T Valitutto, Penny Kalk, Robert P Moore, John M Sykes. Comparison of two injectable immobilization combinations in Himalayan tahr (Hemitragus jemlahicus): medetomidine, ketamine, and atipamezole versus carfentanil, xylazine, naltrexone, and atipamezole.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2013 Sep; 44(3):596-604. doi:
10.1638/2012-0140r1.1. [PMID: 24063087] - David Wellington, Igor Mikaelian, Laura Singer. Comparison of ketamine-xylazine and ketamine-dexmedetomidine anesthesia and intraperitoneal tolerance in rats.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2013 Jul; 52(4):481-7. doi:
NULL. [PMID: 23849447] - J Gu, J Chen, P Xia, G Tao, H Zhao, D Ma. Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice.
Acta anaesthesiologica Scandinavica.
2011 Nov; 55(10):1272-8. doi:
10.1111/j.1399-6576.2011.02526.x. [PMID: 22092133] - Md Hasanuzzaman Talukder, Yoshiaki Hikasa, Hajime Takahashi, Kanako Sato, Aya Matsuu. Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2009 Oct; 73(4):260-70. doi:
. [PMID: 20046627] - Hasanuzzaman Talukder, Yoshiaki Hikasa, Aya Matsuu, Hiroe Kawamura. Antagonistic effects of atipamezole and yohimbine on xylazine-induced diuresis in healthy dogs.
The Journal of veterinary medical science.
2009 May; 71(5):539-48. doi:
10.1292/jvms.71.539. [PMID: 19498277] - Bernát János Béres, Emese Tóth-Zsámboki, Katarína Vargová, Adám László, Tamás Masszi, Gábor Kerecsen, István Préda, Róbert Gábor Kiss. Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy.
Thrombosis and haemostasis.
2008 Nov; 100(5):829-38. doi:
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The Veterinary record.
2007 Jul; 161(1):15-21. doi:
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European journal of pharmacology.
2004 Nov; 505(1-3):243-52. doi:
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Autonomic & autacoid pharmacology.
2004 Jul; 24(3):69-75. doi:
10.1111/j.1474-8673.2004.00318.x. [PMID: 15541014] - Maria Konstandi, Elizabeth O Johnson, Marios Marselos, Dimitris Kostakis, Andreas Fotopoulos, Matti A Lang. Stress-mediated modulation of B(alpha)P-induced hepatic CYP1A1: role of catecholamines.
Chemico-biological interactions.
2004 Jan; 147(1):65-77. doi:
10.1016/j.cbi.2003.10.007. [PMID: 14726153] - Eric A Stone, Gary L Grunewald, Yan Lin, Rashedul Ahsan, Helen Rosengarten, H Kenneth Kramer, David Quartermain. Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice.
Synapse (New York, N.Y.).
2003 Jul; 49(1):67-76. doi:
10.1002/syn.10212. [PMID: 12710017] - T D Ambrisko, Y Hikasa. The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2003 Jan; 67(1):64-7. doi:
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Journal of veterinary pharmacology and therapeutics.
2000 Dec; 23(6):379-87. doi:
10.1046/j.1365-2885.2000.00291.x. [PMID: 11168916] - P O Talke, D L Traber, C A Richardson, D D Harper, L D Traber. The effect of alpha(2) agonist-induced sedation and its reversal with an alpha(2) antagonist on organ blood flow in sheep.
Anesthesia and analgesia.
2000 May; 90(5):1060-6. doi:
10.1097/00000539-200005000-00011. [PMID: 10781453] - B Ranheim, J M Arnemo, K A Ryeng, N E Søli, T E Horsberg. A pharmacokinetic study including some relevant clinical effect of medetomidine and atipamezole in lactating dairy cows.
Journal of veterinary pharmacology and therapeutics.
1999 Dec; 22(6):368-73. doi:
10.1046/j.1365-2885.1999.00231.x. [PMID: 10651465] - B Sjöholm, J Lähdesmäki, K Pyykkö, M Hillilä, M Scheinin. Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors.
British journal of pharmacology.
1999 Nov; 128(6):1215-22. doi:
10.1038/sj.bjp.0702917. [PMID: 10578134] - Y Hikasa, M Abe, T Satoh, Y Hisashi, S Ogasawara, H Matsuda. Effects of imidazoline and non-imidazoline alpha-adrenergic agents on canine platelet aggregation.
Pharmacology.
1999 Apr; 58(4):171-82. doi:
10.1159/000028279. [PMID: 10077736] - T Soveri, S Sankari, J S Salonen, M Nieminen. Effects of immobilization with medetomidine and reversal with atipamezole on blood chemistry of semi-domesticated reindeer (Rangifer tarandus tarandus L.) in autumn and late winter.
Acta veterinaria Scandinavica.
1999; 40(4):335-49. doi:
10.1186/bf03547013. [PMID: 10918903] - B Ranheim, N E Søli, K A Ryeng, J M Arnemo, T E Horsberg. Pharmacokinetics of medetomidine and atipamezole in dairy calves: an agonist-antagonist interaction.
Journal of veterinary pharmacology and therapeutics.
1998 Dec; 21(6):428-32. doi:
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Berliner und Munchener tierarztliche Wochenschrift.
1998 Nov; 111(11-12):438-51. doi:
NULL. [PMID: 9880940] - H Scheinin, R Aantaa, M Anttila, P Hakola, A Helminen, S Karhuvaara. Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2-adrenoceptor antagonist atipamezole: a pharmacodynamic and kinetic study in healthy volunteers.
Anesthesiology.
1998 Sep; 89(3):574-84. doi:
10.1097/00000542-199809000-00005. [PMID: 9743392] - B Ranheim, T E Horsberg, U Nymoen, N E Søli, N J Tyler, J M Arnemo. Reversal of medetomidine-induced sedation in reindeer (Rangifer tarandus tarandus) with atipamezole increases the medetomidine concentration in plasma.
Journal of veterinary pharmacology and therapeutics.
1997 Oct; 20(5):350-4. doi:
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The Journal of urology.
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Endocrine journal.
1996 Oct; 43(5):551-6. doi:
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European journal of pharmacology.
1996 Feb; 297(1-2):19-26. doi:
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British journal of pharmacology.
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Clinical pharmacology and therapeutics.
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European journal of pharmacology.
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Biomedical chromatography : BMC.
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European journal of pharmacology.
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