(R)-Bicalutamide (BioDeep_00000671604)
代谢物信息卡片
(R)-Bicalutamide
化学式: C18H14F4N2O4S (430.06103720000004)
中文名称: (R)-比卡鲁胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
InChI: InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:39589
- ChEBI: CHEBI:3090
- PubChem: 56069
- DrugBank: DB02932
- ChEMBL: CHEMBL63560
- CAS: 122544-02-9
- CAS: 113299-40-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kuldeep Sharma, Gopal V Pawar, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of bicalutamide in mouse plasma: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Dec; 26(12):1589-95. doi:
10.1002/bmc.2736. [PMID: 22495777] - Ramesh R Kaini, Laurel O Sillerud, Siqin Zhaorigetu, Chien-An A Hu. Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells.
The Prostate.
2012 Sep; 72(13):1412-22. doi:
10.1002/pros.22489. [PMID: 22294520] - Vincenzo Serretta, Vincenzo Altieri, Giuseppe Morgia, Federico Nicolosi, Gaetano De Grande, Rosaria Mazza, Darwin Melloni, Rosalinda Allegro, Francesco Ferraù, Vittorio Gebbia. A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia.
Clinical genitourinary cancer.
2012 Sep; 10(3):174-9. doi:
10.1016/j.clgc.2012.03.002. [PMID: 22502790] - Rachel M Squillace, David Miller, Scott D Wardwell, Frank Wang, Tim Clackson, Victor M Rivera. Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models.
International journal of oncology.
2012 Aug; 41(2):425-32. doi:
10.3892/ijo.2012.1487. [PMID: 22614157] - Chien-Chang Kao, Yen-Hwa Chang, Tony Wu, Guang-Huan Sun, Dah-Shyong Yu, Sun-Yran Chang, Tai-Lung Cha. Open, multi-center, phase IV study to assess the efficacy and tolerability of triptorelin in Taiwanese patients with advanced prostate cancer.
Journal of the Chinese Medical Association : JCMA.
2012 Jun; 75(6):255-61. doi:
10.1016/j.jcma.2012.04.010. [PMID: 22721619] - Christian Thomas, Latif A Wafa, Francois Lamoureux, Helen Cheng, Ladan Fazli, Martin E Gleave, Paul S Rennie. Carbidopa enhances antitumoral activity of bicalutamide on the androgen receptor-axis in castration-resistant prostate tumors.
The Prostate.
2012 Jun; 72(8):875-85. doi:
10.1002/pros.21490. [PMID: 22072572] - Juliet Richards, Ai Chiin Lim, Colin W Hay, Angela E Taylor, Anna Wingate, Karolina Nowakowska, Carmel Pezaro, Suzanne Carreira, Jane Goodall, Wiebke Arlt, Iain J McEwan, Johann S de Bono, Gerhardt Attard. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100.
Cancer research.
2012 May; 72(9):2176-82. doi:
10.1158/0008-5472.can-11-3980. [PMID: 22411952] - C Salvador, J Planas, C Raventós, J Ropero, J Placer, M A López, J Morote. [Impact of androgen deprivation on the lipid profile and atherogenic risk in prostate cancer patients].
Actas urologicas espanolas.
2012 Apr; 36(4):205-9. doi:
10.1016/j.acuro.2011.09.006. [PMID: 22178349] - Nicola J Clegg, John Wongvipat, James D Joseph, Chris Tran, Samedy Ouk, Anna Dilhas, Yu Chen, Kate Grillot, Eric D Bischoff, Ling Cai, Anna Aparicio, Steven Dorow, Vivek Arora, Gang Shao, Jing Qian, Hong Zhao, Guangbin Yang, Chunyan Cao, John Sensintaffar, Teresa Wasielewska, Mark R Herbert, Celine Bonnefous, Beatrice Darimont, Howard I Scher, Peter Smith-Jones, Mark Klang, Nicholas D Smith, Elisa De Stanchina, Nian Wu, Ouathek Ouerfelli, Peter J Rix, Richard A Heyman, Michael E Jung, Charles L Sawyers, Jeffrey H Hager. ARN-509: a novel antiandrogen for prostate cancer treatment.
Cancer research.
2012 Mar; 72(6):1494-503. doi:
10.1158/0008-5472.can-11-3948. [PMID: 22266222] - Jun Yan, Bingxian Xie, Jillian L Capodice, Aaron E Katz. Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutimide to inhibit prostate cancer cell growth.
The Prostate.
2012 Feb; 72(3):244-52. doi:
10.1002/pros.21426. [PMID: 21656835] - Tammy P S Pang, Michele V Clarke, Ali Ghasem-Zadeh, Nicole K L Lee, Rachel A Davey, Helen E MacLean. A physiological role for androgen actions in the absence of androgen receptor DNA binding activity.
Molecular and cellular endocrinology.
2012 Jan; 348(1):189-97. doi:
10.1016/j.mce.2011.08.017. [PMID: 21872641] - Fumio Ito, Nobuyuki Goya, Hayakazu Nakazawa, Toshiaki Suzuki, Keiko Suzuki, Kazuo Kubo, Takeshi Kihara. A study of plasma bicalutamide concentrations in hemodialysis patients.
Urologia internationalis.
2012; 89(2):162-5. doi:
10.1159/000339919. [PMID: 22868217] - H-M Lu, M Ye. The relative bioavailability study and fasting and fed states pharmacokinetics of bicalutamide 50-mg tablets in healthy Chinese volunteers.
Arzneimittel-Forschung.
2012 Jan; 62(1):18-21. doi:
10.1055/s-0031-1295429. [PMID: 22331758] - Antonio Aversa, Davide Francomano, Andrea Lenzi. Cardiometabolic complications after androgen deprivation therapy in a man with prostate cancer: effects of 3 years intermittent testosterone supplementation.
Frontiers in endocrinology.
2012; 3(?):17. doi:
10.3389/fendo.2012.00017. [PMID: 22645517] - Shawn E Lupold, Tamara Johnson, Wasim H Chowdhury, Ronald Rodriguez. A real time Metridia luciferase based non-invasive reporter assay of mammalian cell viability and cytotoxicity via the β-actin promoter and enhancer.
PloS one.
2012; 7(5):e36535. doi:
10.1371/journal.pone.0036535. [PMID: 22590558] - Ahmed Elattar, Katharine G Warburton, Asima Mukhopadhyay, Rebecca M Freer, Fadhel Shaheen, Paul Cross, E Ruth Plummer, Craig N Robson, Richard J Edmondson. Androgen receptor expression is a biological marker for androgen sensitivity in high grade serous epithelial ovarian cancer.
Gynecologic oncology.
2012 Jan; 124(1):142-7. doi:
10.1016/j.ygyno.2011.09.004. [PMID: 22001143] - Shinichi Yamashita, Kuo-Pao Lai, Kun-Lung Chuang, Defeng Xu, Hiroshi Miyamoto, Tatsuo Tochigi, See-Tong Pang, Lei Li, Yoichi Arai, Hsing-Jien Kung, Shuyuan Yeh, Chawnshang Chang. ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.
Neoplasia (New York, N.Y.).
2012 Jan; 14(1):74-83. doi:
10.1593/neo.111436. [PMID: 22355276] - Gabriele Multhoff, Jürgen Radons. Radiation, inflammation, and immune responses in cancer.
Frontiers in oncology.
2012; 2(?):58. doi:
10.3389/fonc.2012.00058. [PMID: 22675673] - Ryoko Sakata, Akira Iwasaki, Masataka Kobayashi, Kimito Osaka, Atsushi Fujikawa, Futoshi Tsuchiya, Eiichi Ishizuka. [Renal metastasis from prostatic adenocarcinoma : a case report].
Hinyokika kiyo. Acta urologica Japonica.
2011 Dec; 57(12):683-7. doi:
NULL. [PMID: 22240301] - Chiara Fuccio, Riccardo Schiavina, Paolo Castellucci, Domenico Rubello, Giuseppe Martorana, Monica Celli, Claudio Malizia, Marta Barios Profitos, Maria Cristina Marzola, Vincenzina Pettinato, Stefano Fanti. Androgen deprivation therapy influences the uptake of 11C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study.
European journal of nuclear medicine and molecular imaging.
2011 Nov; 38(11):1985-9. doi:
10.1007/s00259-011-1867-0. [PMID: 21732105] - Nae Yu Kim, Soo Jung Gong, Jimyung Kim, Seon Min Youn, Jung-Ae Lee. Multiple myeloma with biclonal gammopathy accompanied by prostate cancer.
The Korean journal of laboratory medicine.
2011 Oct; 31(4):285-9. doi:
10.3343/kjlm.2011.31.4.285. [PMID: 22016684] - Jing Chen, Chang-Yi Quan, Ji-Wu Chang, Yu-Ming Yang, Bo Li, Wen-Liang Chang, Jiang Wang, Yuan-Jie Niu. [Prostate cancer with five different histological features: a case report and review of the literature].
Zhonghua nan ke xue = National journal of andrology.
2011 Sep; 17(9):825-8. doi:
. [PMID: 21961246] - Hiromitsu Kawata, Shinichi Arai, Toshito Nakagawa, Nobuyuki Ishikura, Ayako Nishimoto, Hitoshi Yoshino, Takuya Shiraishi, Kazutaka Tachibana, Ryo Nakamura, Haruhiko Sato. Biological properties of androgen receptor pure antagonist for treatment of castration-resistant prostate cancer: optimization from lead compound to CH5137291.
The Prostate.
2011 Sep; 71(12):1344-56. doi:
10.1002/pros.21351. [PMID: 21308717] - Glenn Tisman, April Garcia. Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.
Journal of medical case reports.
2011 Aug; 5(?):413. doi:
10.1186/1752-1947-5-413. [PMID: 21867542] - Yoshiki Hiyama, Hiroshi Kitamura, Satoshi Takahashi, Naoya Masumori, Tetsuya Shindo, Mitsuhiro Tsujiwaki, Tomoko Mitsuhashi, Tadashi Hasegawa, Taiji Tsukamoto. Peritoneal dissemination of prostate cancer due to laparoscopic radical prostatectomy: a case report.
Journal of medical case reports.
2011 Aug; 5(?):355. doi:
10.1186/1752-1947-5-355. [PMID: 21819588] - Joon Il Choi, Yun Beom Kim, Seung Ok Yang, Jeong Kee Lee, Tae Young Jung. Efficacy of alternative antiandrogen therapy for prostate cancer that relapsed after initial maximum androgen blockade.
Korean journal of urology.
2011 Jul; 52(7):461-5. doi:
10.4111/kju.2011.52.7.461. [PMID: 21860766] - Norio Nonomura, Hitoshi Takayama, Masashi Nakayama, Yasutomo Nakai, Atsunari Kawashima, Masatoshi Mukai, Akira Nagahara, Katsuyuki Aozasa, Akira Tsujimura. Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer.
BJU international.
2011 Jun; 107(12):1918-22. doi:
10.1111/j.1464-410x.2010.09804.x. [PMID: 21044246] - Wei-Lin W Wang, Namita Chatterjee, Sridar V Chittur, JoEllen Welsh, Martin P Tenniswood. Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells.
Molecular cancer.
2011 May; 10(?):58. doi:
10.1186/1476-4598-10-58. [PMID: 21592394] - Christian Tovar, Brian Higgins, Kenneth Kolinsky, Mingxuan Xia, Kathryn Packman, David C Heimbrook, Lyubomir T Vassilev. MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer.
Molecular cancer.
2011 May; 10(?):49. doi:
10.1186/1476-4598-10-49. [PMID: 21539745] - Arne Solberg, Olav A Haugen, Trond Viset, Anders Bergh, Ilker Tasdemir, Göran Ahlgren, Anders Widmark, Anders Angelsen. Residual prostate cancer in patients treated with endocrine therapy with or without radical radiotherapy: a side study of the SPCG-7 randomized trial.
International journal of radiation oncology, biology, physics.
2011 May; 80(1):55-61. doi:
10.1016/j.ijrobp.2010.01.072. [PMID: 20598453] - Nigel P Murray, Leonardo V Badinez, Ricardo R Dueñas, Nelson Orellana, Pablo Tapia. Positive HER-2 protein expression in circulating prostate cells and micro-metastasis, resistant to androgen blockage but not diethylstilbestrol.
Indian journal of urology : IJU : journal of the Urological Society of India.
2011 Apr; 27(2):200-7. doi:
10.4103/0970-1591.82838. [PMID: 21814310] - Hein Van Poppel, Bertrand Tombal. Cardiovascular risk during hormonal treatment in patients with prostate cancer.
Cancer management and research.
2011 Mar; 3(?):49-55. doi:
10.2147/cmr.s16893. [PMID: 21448299] - Hanna Paatela, Veera Vihma, Matti Jauhiainen, Eero Mervaala, Matti J Tikkanen. Dehydroepiandrosterone fatty acyl esters in high density lipoprotein: interaction with human vascular endothelial cells and vascular responses ex vivo.
Steroids.
2011 Mar; 76(4):376-80. doi:
10.1016/j.steroids.2010.12.007. [PMID: 21168430] - Kohei Hashimoto, Naoya Masumori, Jiro Hashimoto, Akio Takayanagi, Fumimasa Fukuta, Taiji Tsukamoto. Serum testosterone level to predict the efficacy of sequential use of antiandrogens as second-line treatment following androgen deprivation monotherapy in patients with castration-resistant prostate cancer.
Japanese journal of clinical oncology.
2011 Mar; 41(3):405-10. doi:
10.1093/jjco/hyq193. [PMID: 20947624] - M Rumsby, J Schmitt, M Sharrard, G Rodrigues, M Stower, N Maitland. Human prostate cell lines from normal and tumourigenic epithelia differ in the pattern and control of choline lipid headgroups released into the medium on stimulation of protein kinase C.
British journal of cancer.
2011 Feb; 104(4):673-84. doi:
10.1038/sj.bjc.6606077. [PMID: 21266973] - Bulent Yildiz, Evren Fidan, Kadriye Yildiz, Fazil Aydin. Penile metastasis from adenocarcinoma of the prostate in a patient with colorectal carcinoma.
Acta dermatovenerologica Croatica : ADC.
2011; 19(1):36-8. doi:
NULL. [PMID: 21489365] - David E Kang, Michael C Lee, Jaydip Das Gupta, Eric A Klein, Robert H Silverman. XMRV Discovery and Prostate Cancer-Related Research.
Advances in virology.
2011; 2011(?):432837. doi:
10.1155/2011/432837. [PMID: 22312343] - N Janus, V Launay-Vacher, E Byloos, J-P Machiels, L Duck, J Kerger, W Wynendaele, J-L Canon, W Lybaert, J Nortier, G Deray, H Wildiers. Cancer and renal insufficiency results of the BIRMA study.
British journal of cancer.
2010 Dec; 103(12):1815-21. doi:
10.1038/sj.bjc.6605979. [PMID: 21063408] - Seunghwan Lee, Seo Hyun Yoon, Joo-Youn Cho, Sang-Goo Shin, In-Jin Jang, Kyung-Sang Yu. Relative bioavailability and tolerability of two formulations of bicalutamide 50-mg tablets: a randomized-sequence, open-label, two-period crossover study in healthy Korean male subjects.
Clinical therapeutics.
2010 Dec; 32(14):2496-501. doi:
10.1016/j.clinthera.2011.01.017. [PMID: 21353117] - Michele Lodde, Louis Lacombe, Yves Fradet. Salvage therapy with bicalutamide 150 mg in nonmetastatic castration-resistant prostate cancer.
Urology.
2010 Nov; 76(5):1189-93. doi:
10.1016/j.urology.2009.12.057. [PMID: 20303155] - Matthew D Schmitz, Gilbert D A Padula, Patrick Y Chun, Alan T Davis. Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer.
Radiation oncology (London, England).
2010 Sep; 5(?):80. doi:
10.1186/1748-717x-5-80. [PMID: 20846422] - H L Bennett, J T Fleming, J O'Prey, K M Ryan, H Y Leung. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells.
Cell death & disease.
2010 Sep; 1(?):e72. doi:
10.1038/cddis.2010.50. [PMID: 21364676] - Shuang Liu, Yanfeng Qi, Yubin Ge, Tamika Duplessis, Brian G Rowan, Clement Ip, Helen Cheng, Paul S Rennie, Izumi Horikawa, Arthur J Lustig, Qun Yu, Haitao Zhang, Yan Dong. Telomerase as an important target of androgen signaling blockade for prostate cancer treatment.
Molecular cancer therapeutics.
2010 Jul; 9(7):2016-25. doi:
10.1158/1535-7163.mct-09-0924. [PMID: 20571066] - Takeshi Yuasa, Shinya Maita, Norihiko Tsuchiya, Zhiyong Ma, Shintaro Narita, Yohei Horikawa, Shinya Yamamoto, Junji Yonese, Iwao Fukui, Shunji Takahashi, Kiyohiko Hatake, Tomonori Habuchi. Relationship between bone mineral density and androgen-deprivation therapy in Japanese prostate cancer patients.
Urology.
2010 May; 75(5):1131-7. doi:
10.1016/j.urology.2009.10.075. [PMID: 20163839] - Renduo Song, Loleta D Harris, Curtis A Pettaway. Downmodulation of Bcl-2 sensitizes metastatic LNCaP-LN3 cells to undergo apoptosis via the intrinsic pathway.
The Prostate.
2010 May; 70(6):571-83. doi:
10.1002/pros.21091. [PMID: 19938012] - Kazutaka Narimoto, Atsushi Mizokami, Kouji Izumi, Shinya Mihara, Kiyoshi Sawada, Toshiaki Sugata, Masayoshi Shimamura, Kimiomi Miyazaki, Akio Nishino, Mikio Namiki. Adrenal androgen levels as predictors of outcome in castration-resistant prostate cancer patients treated with combined androgen blockade using flutamide as a second-line anti-androgen.
International journal of urology : official journal of the Japanese Urological Association.
2010 Apr; 17(4):337-45. doi:
10.1111/j.1442-2042.2010.02473.x. [PMID: 20202011] - Zoran Persec, Jasminka Persec, Tomislav Sović, Zeljko Romic, Maja Bosnar Herak, Zlatko Hrgovic. Metastatic prostate cancer in an asymptomatic patient with an initial prostate-specific antigen (PSA) serum concentration of 21,380 ng/ml.
Onkologie.
2010; 33(3):110-2. doi:
10.1159/000277743. [PMID: 20215802] - Fernand Labrie. Hormonal therapy of prostate cancer.
Progress in brain research.
2010; 182(?):321-41. doi:
10.1016/s0079-6123(10)82014-x. [PMID: 20541672] - SeungHwan Lee, Yong-Ju Chung, Bo-Hyung Kim, Jun-Hwa Shim, Seo-Hyun Yoon, Sang-Goo Shin, In-Jin Jang, Kyung-Sang Yu. Comparative pharmacokinetic evaluation of two formulations of bicalutamide 50-mg tablets: an open-label, randomized-sequence, single-dose, two-period crossover study in healthy Korean male volunteers.
Clinical therapeutics.
2009 Dec; 31(12):3000-8. doi:
10.1016/j.clinthera.2009.12.004. [PMID: 20110037] - Audrey Dayon, Leyre Brizuela, Claire Martin, Catherine Mazerolles, Nelly Pirot, Nicolas Doumerc, Leonor Nogueira, Muriel Golzio, Justin Teissié, Guy Serre, Pascal Rischmann, Bernard Malavaud, Olivier Cuvillier. Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.
PloS one.
2009 Nov; 4(11):e8048. doi:
10.1371/journal.pone.0008048. [PMID: 19956567] - Oliver Sartor, Leonard G Gomella, Paul Gagnier, Karen Melich, Rebekkah Dann. Dutasteride and bicalutamide in patients with hormone-refractory prostate cancer: the Therapy Assessed by Rising PSA (TARP) study rationale and design.
The Canadian journal of urology.
2009 Oct; 16(5):4806-12. doi:
NULL. [PMID: 19796455] - Rohini Kashimshetty, Varsha G Desai, Vijay M Kale, Taewon Lee, Carrie L Moland, William S Branham, Lee S New, Eric C Y Chan, Husam Younis, Urs A Boelsterli. Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.
Toxicology and applied pharmacology.
2009 Jul; 238(2):150-9. doi:
10.1016/j.taap.2009.05.007. [PMID: 19442681] - Ajeet Kumar Singh, Akash Chaurasiya, Gaurav K Jain, Anshumali Awasthi, Dinesh Asati, Gautam Mishra, Roop K Khar, Rama Mukherjee. High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats.
Talanta.
2009 Jun; 78(4-5):1310-4. doi:
10.1016/j.talanta.2009.01.058. [PMID: 19362193] - Zhe Wang, Hyo-Jeong Lee, Lei Wang, Cheng Jiang, Nam-In Baek, Sung-Hoon Kim, Junxuan Lü. Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds.
Pharmaceutical research.
2009 May; 26(5):1140-8. doi:
10.1007/s11095-009-9833-2. [PMID: 19266268] - Nicolas Henry, Phillipe Sebe, Olivier Cussenot. Inappropriate treatment of prostate cancer caused by heterophilic antibody interference.
Nature clinical practice. Urology.
2009 Mar; 6(3):164-7. doi:
10.1038/ncpuro1317. [PMID: 19265858] - Jeffrey Turner, Uzair Chaudhary. Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer.
Anti-cancer drugs.
2009 Mar; 20(3):215-6. doi:
10.1097/cad.0b013e3283163c26. [PMID: 19104437] - Juan Morote, Jacques Planas, Carlos Salvador, Carles X Raventós, Roberto Catalán, Jaume Reventós. Individual variations of serum testosterone in patients with prostate cancer receiving androgen deprivation therapy.
BJU international.
2009 Feb; 103(3):332-5; discussion 335. doi:
10.1111/j.1464-410x.2008.08062.x. [PMID: 19007366] - I M Spitz, B Chertin, A Fridmans, A Farkas, A Belanger, H Hartman, F Labrie. Partial androgen suppression consequent to increased secretion of adrenal androgens in a patient with prostate cancer treated with long-acting GnRH agonists.
Prostate cancer and prostatic diseases.
2009; 12(1):100-3. doi:
10.1038/pcan.2008.15. [PMID: 18574491] - J Miller, T H Tarter. Combination therapy with dutasteride and tamsulosin for the treatment of symptomatic enlarged prostate.
Clinical interventions in aging.
2009; 4(?):251-8. doi:
10.2147/cia.s4102. [PMID: 19554096] - Vandana Gupta, Shalender Bhasin, Wen Guo, Rajan Singh, Rika Miki, Pratibha Chauhan, Karen Choong, Tamara Tchkonia, Nathan K Lebrasseur, John N Flanagan, James A Hamilton, Jason C Viereck, Navjot S Narula, James L Kirkland, Ravi Jasuja. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes.
Molecular and cellular endocrinology.
2008 Dec; 296(1-2):32-40. doi:
10.1016/j.mce.2008.08.019. [PMID: 18801408] - Guo-Lan Wu, Hui-Li Zhou, Jian-Zhong Shentu, Qiao-Jun He, Bo Yang. Determination of lansoprazole in human plasma by rapid resolution liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
Journal of pharmaceutical and biomedical analysis.
2008 Dec; 48(5):1485-9. doi:
10.1016/j.jpba.2008.09.046. [PMID: 19019616] - Yiu-Keung Lau, Manpreet K Chadha, Alan Litwin, Donald L Trump. A dramatic, objective antiandrogen withdrawal response: case report and review of the literature.
Journal of hematology & oncology.
2008 Nov; 1(?):21. doi:
10.1186/1756-8722-1-21. [PMID: 18986533] - Reagan L Ross, Michelle R Serock, Raouf A Khalil. Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease.
Current cardiology reviews.
2008 Nov; 4(4):309-22. doi:
10.2174/157340308786349462. [PMID: 20066139] - V Primavera, G Querques, B Guigui, I Turco, C Iaculli, V Russo, N Delle Noci. [Choroidal metastasis from clinically regressed prostate adenocarcinoma: imaging of a rare case].
Journal francais d'ophtalmologie.
2008 Nov; 31(9):877-82. doi:
10.1016/s0181-5512(08)74728-4. [PMID: 19107059] - Naghma Khan, Mohammad Asim, Farrukh Afaq, Mohammad Abu Zaid, Hasan Mukhtar. A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.
Cancer research.
2008 Oct; 68(20):8555-63. doi:
10.1158/0008-5472.can-08-0240. [PMID: 18922931] - Cindy L O'Bryant, Thomas W Flaig, Kenneth J Utz. Bicalutamide-associated fulminant hepatotoxicity.
Pharmacotherapy.
2008 Aug; 28(8):1071-5. doi:
10.1592/phco.28.8.1071. [PMID: 18657023] - Shuichiro Kobayashi, Tetsuro Tsukamoto, Akira Tohsaka, Tsuguhiro Tohma. [Estramustine phosphate withdrawal syndrome in relapsed prostate cancer: two case reports].
Hinyokika kiyo. Acta urologica Japonica.
2008 Jun; 54(6):423-6. doi:
. [PMID: 18634439] - Y Yamada, S Takahashi, T Fujimura, H Nishimatsu, A Ishikawa, H Kume, K Tomita, T Takeuchi, T Kitamura. The effect of combined androgen blockade on bone turnover and bone mineral density in men with prostate cancer.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2008 Mar; 19(3):321-7. doi:
10.1007/s00198-007-0472-3. [PMID: 17906826] - Kazuhiro Iguchi, Mai Ito, Shigeyuki Usui, Atsushi Mizokami, Mikio Namiki, Kazuyuki Hirano. Downregulation of thymosin beta4 expression by androgen in prostate cancer LNCaP cells.
Journal of andrology.
2008 Mar; 29(2):207-12. doi:
10.2164/jandrol.107.003608. [PMID: 17916567] - Matthew R Smith, Hang Lee, Mary Anne Fallon, David M Nathan. Adipocytokines, obesity, and insulin resistance during combined androgen blockade for prostate cancer.
Urology.
2008 Feb; 71(2):318-22. doi:
10.1016/j.urology.2007.08.035. [PMID: 18308111] - Shahrokh F Shariat, Dolores J Lamb, Radha G Iyengar, Claus G Roehrborn, Kevin M Slawin. Herbal/hormonal dietary supplement possibly associated with prostate cancer progression.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2008 Jan; 14(2):607-11. doi:
10.1158/1078-0432.ccr-07-1576. [PMID: 18223237] - William H Tu, Kristin Jensen, Fuad Freiha, Joseph C Liao. A case of prostatic adenocarcinoma recurrence presenting as ductal carcinoma of the prostate.
Nature clinical practice. Urology.
2008 Jan; 5(1):55-8. doi:
10.1038/ncpuro0994. [PMID: 18185514] - Bekir Cinar, Nishit K Mukhopadhyay, Gaoyuan Meng, Michael R Freeman. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains.
The Journal of biological chemistry.
2007 Oct; 282(40):29584-93. doi:
10.1074/jbc.m703310200. [PMID: 17635910] - Juan Morote, Anna Orsola, Jacques Planas, Enrique Trilla, Carles X Raventós, Lluís Cecchini, Roberto Catalán. Redefining clinically significant castration levels in patients with prostate cancer receiving continuous androgen deprivation therapy.
The Journal of urology.
2007 Oct; 178(4 Pt 1):1290-5. doi:
10.1016/j.juro.2007.05.129. [PMID: 17698136] - Jehonathan H Pinthus, Jian-Ping Lu, Laure A Bidaisee, Helen Lin, Inna Bryskine, Radhey S Gupta, Gurmit Singh. Androgen-dependent regulation of medium and long chain fatty acids uptake in prostate cancer.
The Prostate.
2007 Sep; 67(12):1330-8. doi:
10.1002/pros.20609. [PMID: 17626249] - Hayley C Whitaker, David P B Stanbury, Claire Brinham, Joanne Girling, Sarah Hanrahan, Nick Totty, David E Neal. Labeling and identification of LNCaP cell surface proteins: a pilot study.
The Prostate.
2007 Jun; 67(9):943-54. doi:
10.1002/pros.20580. [PMID: 17440980] - Katsumi Shigemura, Shian-Ying Sung, Hiroyuki Kubo, Rebecca S Arnold, Masato Fujisawa, Akinobu Gotoh, Haiyen E Zhau, Leland W K Chung. Reactive oxygen species mediate androgen receptor- and serum starvation-elicited downstream signaling of ADAM9 expression in human prostate cancer cells.
The Prostate.
2007 May; 67(7):722-31. doi:
10.1002/pros.20565. [PMID: 17342749] - Joe Miller, Thomas H Tarter. Update on the use of dutasteride in the management of benign prostatic hypertrophy.
Clinical interventions in aging.
2007; 2(1):99-104. doi:
10.2147/ciia.2007.2.1.99. [PMID: 18044081] - Takahiro Yoshida, Kensaku Nishimura, Motohide Uemura, Katsuhiro Nakagawa, Yasunori Harada, Nobuhumi Kanno, Susumu Miyoshi, Kiyoshi Kawano. [Prostate small cell carcinoma: report of two cases that differed in treatment responsiveness].
Hinyokika kiyo. Acta urologica Japonica.
2006 Nov; 52(11):891-4. doi:
NULL. [PMID: 17176877] - Dong Jin Hwang, Jun Yang, Huiping Xu, Igor M Rakov, Michael L Mohler, James T Dalton, Duane D Miller. Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.
Bioorganic & medicinal chemistry.
2006 Oct; 14(19):6525-38. doi:
10.1016/j.bmc.2006.06.019. [PMID: 16828557] - Takatsugu Okegawa, Manami Kinjo, Kikuo Nutahara, Eiji Higashihara. Pretreatment serum level of HER2/nue as a prognostic factor in metastatic prostate cancer patients about to undergo endocrine therapy.
International journal of urology : official journal of the Japanese Urological Association.
2006 Sep; 13(9):1197-201. doi:
10.1111/j.1442-2042.2006.01533.x. [PMID: 16984552] - Jennifer Yannucci, Judi Manola, Marc B Garnick, Gajanan Bhat, Glenn J Bubley. The effect of androgen deprivation therapy on fasting serum lipid and glucose parameters.
The Journal of urology.
2006 Aug; 176(2):520-5. doi:
10.1016/j.juro.2006.03.057. [PMID: 16813881] - G Kramer, S Schwarz, M Hägg, A Mandic Havelka, S Linder. Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles.
British journal of cancer.
2006 Jun; 94(11):1592-8. doi:
10.1038/sj.bjc.6603129. [PMID: 16685278] - Yasuhisa Fujii, Satoru Kawakami, Hitoshi Masuda, Tsuyoshi Kobayashi, Nobuhiko Hyochi, Yukio Kageyama, Kazunori Kihara. Deferred combined androgen blockade therapy using bicalutamide in patients with hormone-refractory prostate cancer during androgen deprivation monotherapy.
BJU international.
2006 Jun; 97(6):1184-9. doi:
10.1111/j.1464-410x.2006.06149.x. [PMID: 16686709] - F Boccardo, A Rubagotti, M Battaglia, F Zattoni, A Bertaccini, A Romagnoli, G Conti. Influence of bicalutamide with or without tamoxifen or anastrozole on insulin-like growth factor 1 and binding proteins in prostate cancer patients.
The International journal of biological markers.
2006 Apr; 21(2):123-6. doi:
10.5301/jbm.2008.4771. [PMID: 16847815] - Jun Yang, Casey E Bohl, Vipin A Nair, Suni M Mustafa, Seoung Soo Hong, Duane D Miller, James T Dalton. Preclinical pharmacology of a nonsteroidal ligand for androgen receptor-mediated imaging of prostate cancer.
The Journal of pharmacology and experimental therapeutics.
2006 Apr; 317(1):402-8. doi:
10.1124/jpet.105.094334. [PMID: 16434567] - A Sciarra, A Cardi, C Dattilo, G Mariotti, F Di Monaco, F Di Silverio. New perspective in the management of neuroendocrine differentiation in prostate adenocarcinoma.
International journal of clinical practice.
2006 Apr; 60(4):462-70. doi:
10.1111/j.1742-1241.2006.00750.x. [PMID: 16620361] - Matthew R Smith, Hang Lee, David M Nathan. Insulin sensitivity during combined androgen blockade for prostate cancer.
The Journal of clinical endocrinology and metabolism.
2006 Apr; 91(4):1305-8. doi:
10.1210/jc.2005-2507. [PMID: 16434464] - Hideaki Miyake, Mototsugu Muramaki, Toshifumi Kurahashi, Kazuki Yamanaka, Isao Hara, Masato Fujisawa. Enhanced expression of heat shock protein 27 following neoadjuvant hormonal therapy is associated with poor clinical outcome in patients undergoing radical prostatectomy for prostate cancer.
Anticancer research.
2006 Mar; 26(2B):1583-7. doi:
NULL. [PMID: 16619575] - Mireille Cantarini, Rainard Fuhr, Thomas Morris. Pharmacokinetics of two novel bicalutamide formulations in healthy male volunteers.
Pharmacology.
2006; 77(4):171-8. doi:
10.1159/000094599. [PMID: 16847400] - Juan Morote, Salvador Esquena, José M Abascal, Enrique Trilla, Luis Cecchini, Carles X Raventós, Roberto Catalán, Jaume Reventós. Failure to maintain a suppressed level of serum testosterone during long-acting depot luteinizing hormone-releasing hormone agonist therapy in patients with advanced prostate cancer.
Urologia internationalis.
2006; 77(2):135-8. doi:
10.1159/000093907. [PMID: 16888418] - Hideaki Miyake, Iori Sakai, Taka-Aki Inoue, Isao Hara, Masato Fujisawa. The limited significance of a longer duration of neoadjuvant hormonal therapy prior to radical prostatectomy for high-risk prostate cancer in Japanese men.
Urologia internationalis.
2006; 77(2):122-6. doi:
10.1159/000093904. [PMID: 16888415] - Francesco Boccardo, Alessandra Rubagotti, Giario Conti, Domenico Potenzoni, Antonio Manganelli, Demetrio Del Monaco. Exploratory study of drug plasma levels during bicalutamide 150 mg therapy co-administered with tamoxifen or anastrozole for prophylaxis of gynecomastia and breast pain in men with prostate cancer.
Cancer chemotherapy and pharmacology.
2005 Oct; 56(4):415-20. doi:
10.1007/s00280-005-1016-1. [PMID: 15838655] - Hideaki Miyake, Isao Hara, Hiroshi Eto. Clinical outcome of maximum androgen blockade using flutamide as second-line hormonal therapy for hormone-refractory prostate cancer.
BJU international.
2005 Oct; 96(6):791-5. doi:
10.1111/j.1464-410x.2005.05766.x. [PMID: 16153202] - A Berruti, M Tucci, A Mosca, R Tarabuzzi, G Gorzegno, C Terrone, F Vana, G Lamanna, M Tampellini, F Porpiglia, A Angeli, R M Scarpa, L Dogliotti. Predictive factors for skeletal complications in hormone-refractory prostate cancer patients with metastatic bone disease.
British journal of cancer.
2005 Sep; 93(6):633-8. doi:
10.1038/sj.bjc.6602767. [PMID: 16222309] - Hideaki Miyake, Isao Hara, Hiroshi Yamazaki, Hiroshi Eto. Clinical outcome of oral uracil/tegafur (UFT) therapy for patients with hormone refractory prostate cancer.
Oncology reports.
2005 Sep; 14(3):673-6. doi:
. [PMID: 16077973] - Juan Morote, Salvador Esquena, Anna Orsola, Carlos Salvador, Enrique Trilla, Luis Cecchini, Carles X Raventós, Jacques Planas, Roberto Catalán, Jaume Reventós. Effect of androgen deprivation therapy in the thyroid function test of patients with prostate cancer.
Anti-cancer drugs.
2005 Sep; 16(8):863-6. doi:
10.1097/01.cad.0000173474.82486.74. [PMID: 16096434] - Venkatesh D Handratta, Tadas S Vasaitis, Vincent C O Njar, Lalji K Gediya, Ritesh Kataria, Pankaj Chopra, Donnell Newman, Rena Farquhar, Zhiyong Guo, Yun Qiu, Angela M H Brodie. Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Journal of medicinal chemistry.
2005 Apr; 48(8):2972-84. doi:
10.1021/jm040202w. [PMID: 15828836] - Arif Hussain, Nancy Dawson, Pradip Amin, Christine Engstrom, Brenda Dorsey, Eliot Siegel, Chuanfa Guo. Docetaxel followed by hormone therapy in men experiencing increasing prostate-specific antigen after primary local treatments for prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2005 Apr; 23(12):2789-96. doi:
10.1200/jco.2005.07.152. [PMID: 15837994]