(R,R)-(-)-1,2-Diaminocyclohexane (BioDeep_00000671565)
代谢物信息卡片
(1R,2R)-(-)-1,2-Diaminocyclohexane
化学式: C6H14N2 (114.1157)
中文名称: (1R,2R)-(-)-1,2-环己二胺, 反式-1,2-环己二胺, （1R，2R）-（-）-1,2-二氨基环己烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(C(C1)N)N
InChI: InChI=1S/C6H14N2/c7-5-3-1-2-4-6(5)8/h5-6H,1-4,7-8H2/t5-,6-/m1/s1
描述信息
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代谢反应
0 个相关的代谢反应过程信息。
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Nayan Roy, Surjatapa Nath, Pradip C Paul, T Sanjoy Singh. Fluorescence Behavior of Schiff Base-N, N'-bis(salicylidene) Trans 1, 2-Diaminocyclohexane in Proteinous and Micellar Environments.
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Internal medicine (Tokyo, Japan).
2012; 51(6):619-23. doi:
10.2169/internalmedicine.51.6486. [PMID: 22449671] - Ayako Mizota, Kohei Shitara, Chihiro Kondo, Motoo Nomura, Tomoya Yokota, Daisuke Takahari, Takashi Ura, Kei Muro. A case of heavily pretreated rectal cancer with disseminated intravascular coagulation that improved following reintroduction of FOLFOX plus bevacizumab.
International journal of clinical oncology.
2011 Dec; 16(6):766-9. doi:
10.1007/s10147-011-0242-2. [PMID: 21560034] - Thititip Tippayamontri, Rami Kotb, Benoit Paquette, Léon Sanche. Cellular uptake and cytoplasm / DNA distribution of cisplatin and oxaliplatin and their liposomal formulation in human colorectal cancer cell HCT116.
Investigational new drugs.
2011 Dec; 29(6):1321-7. doi:
10.1007/s10637-010-9494-3. [PMID: 20658169] - Yuji Wang, Guifeng Kang, Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Yifan Yang, Jiawang Liu, Shiqi Peng. A new platinum-complex showing easy preparation, promising anti-tumor activity, and better efficacy and distribution properties than oxaliplatin.
Molecular bioSystems.
2011 Dec; 7(12):3245-52. doi:
10.1039/c1mb05266g. [PMID: 22008999] - Maurice C van Staveren, Barbara Theeuwes-Oonk, Henk Jan Guchelaar, André B P van Kuilenburg, Jan Gerard Maring. Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency.
Cancer chemotherapy and pharmacology.
2011 Dec; 68(6):1611-7. doi:
10.1007/s00280-011-1661-5. [PMID: 21590448] - Dohan Weeraratne, Alin Chen, Jason J Pennucci, Chi-Yuan Wu, Kathy Zhang, Jacqueline Wright, Juan José Pérez-Ruixo, Bing-Bing Yang, Arunan Kaliyaperumal, Shalini Gupta, Steven J Swanson, Narendra Chirmule, Marta Starcevic. Immunogenicity of panitumumab in combination chemotherapy clinical trials.
BMC clinical pharmacology.
2011 Nov; 11(?):17. doi:
10.1186/1472-6904-11-17. [PMID: 22070868] - Brad T Benedetti, Susana Quintal, Nicholas P Farrell. Modulation of drug activation profiles through carboxylate ligand modification in cytotoxic trans-platinum planar amine compounds.
Dalton transactions (Cambridge, England : 2003).
2011 Nov; 40(41):10983-8. doi:
10.1039/c1dt10964b. [PMID: 21918760] - Hiroshi Kuwabara, Hironobu Baba, Mai Wakabayashi, Hiroshi Nakamura, Takahiro Sanada, Hiroyuki Baba, Kazumi Nakajima, Narihide Goseki. [mFOLFOX6 and FOLFIRI/bevacizumab treatment in a patient on hemodialysis with metastatic colon cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2011 Nov; 38(12):2250-2. doi:
NULL. [PMID: 22202345] - E Hinchliffe, R L Allcock, W Mansoor, M A Myers. A patient with a metastatic gastroenteropancreatic endocrine carcinoma causing hyperinsulinaemic hypoglycaemia and the carcinoid syndrome.
Annals of clinical biochemistry.
2011 Nov; 48(Pt 6):579-83. doi:
10.1258/acb.2011.011068. [PMID: 21948491] - Hong Jae Chon, Sun Young Rha, Hyung Soon Park, Sang Joon Shin, Hyo Song Kim, Jae Kyung Roh, Sung Hoon Noh, Hyun Cheol Chung, Hei-Cheul Jeung. Salvage chemotherapy of biweekly irinotecan plus S-1 (biweekly IRIS) in previously treated patients with advanced gastric cancer.
Cancer chemotherapy and pharmacology.
2011 Oct; 68(4):991-9. doi:
10.1007/s00280-011-1560-9. [PMID: 21327684] - Aref Zayed, George D D Jones, Helen J Reid, Tamer Shoeib, Sarah E Taylor, Anne L Thomas, Joanna P Wood, Barry L Sharp. Speciation of oxaliplatin adducts with DNA nucleotides.
Metallomics : integrated biometal science.
2011 Oct; 3(10):991-1000. doi:
10.1039/c1mt00041a. [PMID: 21858382] - T Kampfenkel, I Tischoff, H Bonhag, M Eckardt, W Schmiegel, A Tannapfel, A Reinacher-Schick, R Viebahn. [Chemotherapy-associated steatohepatitis in patients with colorectal cancer and surgery on hepatic metastasis: clinical validation of a histopathological scoring system and preoperative risk assessment].
Zeitschrift fur Gastroenterologie.
2011 Oct; 49(10):1407-11. doi:
10.1055/s-0031-1281749. [PMID: 21964894] - Thomas Mueller, Wieland Voigt. Fermented wheat germ extract--nutritional supplement or anticancer drug?.
Nutrition journal.
2011 Sep; 10(?):89. doi:
10.1186/1475-2891-10-89. [PMID: 21892933] - Annabelle Ballesta, Sandrine Dulong, Chadi Abbara, Boris Cohen, Alper Okyar, Jean Clairambault, Francis Levi. A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery.
PLoS computational biology.
2011 Sep; 7(9):e1002143. doi:
10.1371/journal.pcbi.1002143. [PMID: 21931543] - Marco Agostini, Salvatore Pucciarelli, Maria Vittoria Enzo, Paola Del Bianco, Marta Briarava, Chiara Bedin, Isacco Maretto, Maria Luisa Friso, Sara Lonardi, Claudia Mescoli, Paola Toppan, Emanuele Urso, Donato Nitti. Circulating cell-free DNA: a promising marker of pathologic tumor response in rectal cancer patients receiving preoperative chemoradiotherapy.
Annals of surgical oncology.
2011 Sep; 18(9):2461-8. doi:
10.1245/s10434-011-1638-y. [PMID: 21416156] - Rosalinda Guerrero, Ashish Bhargava, Zeina Nahleh. Rhodococcus equi venous catheter infection: a case report and review of the literature.
Journal of medical case reports.
2011 Aug; 5(?):358. doi:
10.1186/1752-1947-5-358. [PMID: 21827681] - Jürgen Eckes, Oliver Schmah, Jan W Siebers, Ursula Groh, Stefan Zschiedrich, Beate Rautenberg, Annette Hasenburg, Martin Jansen, Martin J Hug, Karl Winkler, Gerhard Pütz. Kinetic targeting of pegylated liposomal doxorubicin: a new approach to reduce toxicity during chemotherapy (CARL-trial).
BMC cancer.
2011 Aug; 11(?):337. doi:
10.1186/1471-2407-11-337. [PMID: 21816044] - Regina M Leger, George Garratty. Antibodies to oxaliplatin, a chemotherapeutic, are found in plasma of healthy blood donors.
Transfusion.
2011 Aug; 51(8):1740-4. doi:
10.1111/j.1537-2995.2010.03040.x. [PMID: 21303372] - Nancy N Jong, Takeo Nakanishi, Johnson J Liu, Ikumi Tamai, Mark J McKeage. Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons.
The Journal of pharmacology and experimental therapeutics.
2011 Aug; 338(2):537-47. doi:
10.1124/jpet.111.181297. [PMID: 21606177] - Bo Cao, Shao-tang Li, Zhi Li, Wen-ling Deng. Yiqi zhuyu decoction combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer.
Chinese journal of integrative medicine.
2011 Aug; 17(8):593-9. doi:
10.1007/s11655-011-0822-z. [PMID: 21826593] - Klaus Mross, Annette Frost, Max E Scheulen, Jürgen Krauss, Dirk Strumberg, Beate Schultheiss, Ulrike Fasol, Martin Büchert, Jörn Krätzschmer, Heinz Delesen, Prabhu Rajagopalan, Olaf Christensen. Phase I study of telatinib (BAY 57-9352): analysis of safety, pharmacokinetics, tumor efficacy, and biomarkers in patients with colorectal cancer.
Vascular cell.
2011 Jul; 3(?):16. doi:
10.1186/2045-824x-3-16. [PMID: 21801343] - Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen, Yitao Wang. Anti-cancer natural products isolated from chinese medicinal herbs.
Chinese medicine.
2011 Jul; 6(1):27. doi:
10.1186/1749-8546-6-27. [PMID: 21777476] - Piroska Virag, Ioana Brie, Eva Fischer-Fodor, Maria Perde-Schrepler, Corina Tatomir, Ovidiu Balacescu, Alexandru Irimie, Ion Dan Postescu. Assessment of cytotoxicity, apoptosis and DNA damages in Colo320 colorectal cancer cells selected for oxaliplatin resistance.
Cell biochemistry and function.
2011 Jul; 29(5):351-5. doi:
10.1002/cbf.1754. [PMID: 21491469] - Takahiro Horimatsu, Shin'ichi Miyamoto, Shuko Morita, Yoko Mashimo, Yasumasa Ezoe, Manabu Muto, Tsutomu Chiba. Pharmacokinetics of oxaliplatin in a hemodialytic patient treated with modified FOLFOX-6 plus bevacizumab therapy.
Cancer chemotherapy and pharmacology.
2011 Jul; 68(1):263-6. doi:
10.1007/s00280-011-1633-9. [PMID: 21499694] - Ken Houben, Ruben P Jolie, Ilse Fraeye, Ann M Van Loey, Marc E Hendrickx. Comparative study of the cell wall composition of broccoli, carrot, and tomato: structural characterization of the extractable pectins and hemicelluloses.
Carbohydrate research.
2011 Jul; 346(9):1105-11. doi:
10.1016/j.carres.2011.04.014. [PMID: 21536260] - Ayako Mizota, Kohei Shitara, Chihiro Kondo, Motoo Nomura, Tomoya Yokota, Daisuke Takahari, Takashi Ura, Kei Muro. FOLFOX plus cetuximab for a patient with metastatic colorectal cancer with icterus due to multiple liver metastases.
Gan to kagaku ryoho. Cancer & chemotherapy.
2011 Jul; 38(7):1205-8. doi:
NULL. [PMID: 21772113] - Clarisse S Muenyi, Vanessa A States, Joshua H Masters, Teresa W Fan, C William Helm, J Christopher States. Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC).
Journal of ovarian research.
2011 Jun; 4(?):9. doi:
10.1186/1757-2215-4-9. [PMID: 21696631] - Takuya Osada, Minyong Chen, Xiao Yi Yang, Ivan Spasojevic, Jeffrey B Vandeusen, David Hsu, Bryan M Clary, Timothy M Clay, Wei Chen, Michael A Morse, H Kim Lyerly. Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.
Cancer research.
2011 Jun; 71(12):4172-82. doi:
10.1158/0008-5472.can-10-3978. [PMID: 21531761] - Hironori Fujii, Hirotoshi Iihara, Koji Yasuda, Katsuhiko Matsuura, Takao Takahashi, Kazuhiro Yoshida, Yoshinori Itoh. Evaluation of efficacy and safety of generic levofolinate in patients who received colorectal cancer chemotherapy.
Medical oncology (Northwood, London, England).
2011 Jun; 28(2):488-93. doi:
10.1007/s12032-010-9487-2. [PMID: 20354823] - Chi-Hui Tang, Christi Parham, Ellyn Shocron, Gerald McMahon, Neela Patel. Picoplatin overcomes resistance to cell toxicity in small-cell lung cancer cells previously treated with cisplatin and carboplatin.
Cancer chemotherapy and pharmacology.
2011 Jun; 67(6):1389-400. doi:
10.1007/s00280-010-1435-5. [PMID: 20809122] - Peter-Michael Krieger, Dietmar Tamandl, Beata Herberger, Peter Faybik, Edith Fleischmann, Judith Maresch, Thomas Gruenberger. Evaluation of chemotherapy-associated liver injury in patients with colorectal cancer liver metastases using indocyanine green clearance testing.
Annals of surgical oncology.
2011 Jun; 18(6):1644-50. doi:
10.1245/s10434-010-1494-1. [PMID: 21207168] - J Randolph Hecht, Tanja Trarbach, John D Hainsworth, Pierre Major, Elke Jäger, Robert A Wolff, Katherine Lloyd-Salvant, György Bodoky, Kelly Pendergrass, William Berg, Bee-Lian Chen, Tarja Jalava, Gerold Meinhardt, Dirk Laurent, David Lebwohl, David Kerr. Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2011 May; 29(15):1997-2003. doi:
10.1200/jco.2010.29.4496. [PMID: 21464406] - U Wallin, B Glimelius, K Jirström, S Darmanis, R Y Nong, F Pontén, C Johansson, L Påhlman, H Birgisson. Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer.
British journal of cancer.
2011 May; 104(10):1619-27. doi:
10.1038/bjc.2011.112. [PMID: 21468045] - Li Tang, Lie-Jun Mei, Xiao-Jun Yang, Chao-Qun Huang, Yun-Feng Zhou, Yutaka Yonemura, Yan Li. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study.
Journal of translational medicine.
2011 May; 9(?):53. doi:
10.1186/1479-5876-9-53. [PMID: 21548973] - Keiichiro Hiramoto, Michio Kuroki, Eriko Nakano, Nana Kanno, Yoshifumi Matsumura, Atsushi Miura, Yoshifumi Kikuchi, Hidetoshi Hirakawa. [Successful management with partial splenic embolization (PSE) of splenomegaly and thrombocytopenia caused by oxaliplatin-based chemotherapy for advanced colorectal cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2011 May; 38(5):835-9. doi:
NULL. [PMID: 21566449] - Qing-chao Zhu, Zhi-ming Jin. [Efficacy and side effects of combination therapy of oxaliplatin and S-1 for colorectal cancer].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2011 May; 33(5):388-90. doi:
NULL. [PMID: 21875473] - B Vincenzi, S Galluzzo, D Santini, L Rocci, F Loupakis, P Correale, R Addeo, A Zoccoli, A Napolitano, F Graziano, A Ruzzo, A Falcone, G Francini, G Dicuonzo, G Tonini. Early magnesium modifications as a surrogate marker of efficacy of cetuximab-based anticancer treatment in KRAS wild-type advanced colorectal cancer patients.
Annals of oncology : official journal of the European Society for Medical Oncology.
2011 May; 22(5):1141-1146. doi:
10.1093/annonc/mdq550. [PMID: 21115601] - Bettina M Kaminski, Andreas Weigert, Bernhard Brüne, Marco Schumacher, Uwe Wenzel, Dieter Steinhilber, Jürgen Stein, Sandra Ulrich. Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death.
Cancer chemotherapy and pharmacology.
2011 May; 67(5):1167-78. doi:
10.1007/s00280-010-1413-y. [PMID: 20689952] - Ulrik Franzen, Tam T T N Nguyen, Charlotte Vermehren, Bente Gammelgaard, Jesper Ostergaard. Characterization of a liposome-based formulation of oxaliplatin using capillary electrophoresis: encapsulation and leakage.
Journal of pharmaceutical and biomedical analysis.
2011 Apr; 55(1):16-22. doi:
10.1016/j.jpba.2010.12.037. [PMID: 21282028]
