Tiplasinin (BioDeep_00000671496)
代谢物信息卡片
Tiplaxtinin
化学式: C24H16F3NO4 (439.10313720000005)
中文名称: Tiplaxtinin
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O
InChI: InChI=1S/C24H16F3NO4/c25-24(26,27)32-18-9-6-16(7-10-18)17-8-11-21-19(12-17)20(22(29)23(30)31)14-28(21)13-15-4-2-1-3-5-15/h1-12,14H,13H2,(H,30,31)
描述信息
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D007210 - Indoleacetic Acids
C78275 - Agent Affecting Blood or Body Fluid > C29750 - Thrombolytic Agent
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yu-Ju Tseng, Chih-Hung Lee, Wei-Yu Chen, Jenq-Lin Yang, Hong-Tai Tzeng. Inhibition of PAI-1 Blocks PD-L1 Endocytosis and Improves the Response of Melanoma Cells to Immune Checkpoint Blockade.
The Journal of investigative dermatology.
2021 11; 141(11):2690-2698.e6. doi:
10.1016/j.jid.2021.03.030. [PMID: 34000287] - Hekmat B Khoukaz, Yan Ji, Drew J Braet, Manisha Vadali, Ahmed A Abdelhamid, Cory D Emal, Daniel A Lawrence, William P Fay. Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.
Arteriosclerosis, thrombosis, and vascular biology.
2020 06; 40(6):1479-1490. doi:
10.1161/atvbaha.119.313775. [PMID: 32268785] - Yong Liu, Lin Wang, Mao Luo, Ni Chen, Xin Deng, Jing He, Liping Zhang, Pei Luo, Jianbo Wu. Inhibition of PAI-1 attenuates perirenal fat inflammation and the associated nephropathy in high-fat diet-induced obese mice.
American journal of physiology. Endocrinology and metabolism.
2019 02; 316(2):E260-E267. doi:
10.1152/ajpendo.00387.2018. [PMID: 30532990] - Anna E Daniel, Ilse Timmerman, Igor Kovacevic, Peter L Hordijk, Luc Adriaanse, Ilkka Paatero, Heinz-Georg Belting, Jaap D van Buul. Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking.
PloS one.
2015; 10(12):e0145684. doi:
10.1371/journal.pone.0145684. [PMID: 26714278] - Matthew P Krause, Jasmin Moradi, Aliyah A Nissar, Michael C Riddell, Thomas J Hawke. Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice.
Diabetes.
2011 Jul; 60(7):1964-72. doi:
10.2337/db11-0007. [PMID: 21593201] - Nancy J Brown. Therapeutic potential of plasminogen activator inhibitor-1 inhibitors.
Therapeutic advances in cardiovascular disease.
2010 Oct; 4(5):315-24. doi:
10.1177/1753944710379126. [PMID: 20660535] - Ewa Skrzypczak-Jankun, Jerzy Jankun. Theaflavin digallate inactivates plasminogen activator inhibitor: could tea help in Alzheimer's disease and obesity?.
International journal of molecular medicine.
2010 Jul; 26(1):45-50. doi:
10.3892/ijmm_00000433. [PMID: 20514421] - Rym Abderrahmani, Agnès François, Valérie Buard, Marc Benderitter, Jean-Christophe Sabourin, David L Crandall, Fabien Milliat. Effects of pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 in radiation-induced intestinal injury.
International journal of radiation oncology, biology, physics.
2009 Jul; 74(3):942-8. doi:
10.1016/j.ijrobp.2009.01.077. [PMID: 19480973] - Sanjiv Baxi, David L Crandall, Thomas R Meier, Shirley Wrobleski, Angela Hawley, Diana Farris, Hassan Elokdah, Robert Sigler, Robert G Schaub, Thomas Wakefield, Daniel Myers. Dose-dependent thrombus resolution due to oral plaminogen activator inhibitor (PAI)-1 inhibition with tiplaxtinin in a rat stenosis model of venous thrombosis.
Thrombosis and haemostasis.
2008 Apr; 99(4):749-58. doi:
10.1160/th07-11-0669. [PMID: 18392333] - Alain Rupin, Roger Gaertner, Philippe Mennecier, Isabelle Richard, Alain Benoist, Guillaume De Nanteuil, Tony J Verbeuren. S35225 is a direct inhibitor of Plasminogen Activator Inhibitor type-1 activity in the blood.
Thrombosis research.
2008; 122(2):265-70. doi:
10.1016/j.thromres.2007.11.006. [PMID: 18177924] - Natalia V Gorlatova, Jacqueline M Cale, Hassan Elokdah, Donghua Li, Kristi Fan, Mark Warnock, David L Crandall, Daniel A Lawrence. Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor.
The Journal of biological chemistry.
2007 Mar; 282(12):9288-96. doi:
10.1074/jbc.m611642200. [PMID: 17276980] - H Roger Lijnen, Marie-Christine Alessi, Liesbeth Frederix, Désiré Collen, Irène Juhan-Vague. Tiplaxtinin impairs nutritionally induced obesity in mice.
Thrombosis and haemostasis.
2006 Dec; 96(6):731-7. doi:
10.1160/th06-08-0422. [PMID: 17139366] - David L Crandall, Elaine M Quinet, Soulaf El Ayachi, Amy L Hreha, Courtney E Leik, Dawn A Savio, Irene Juhan-Vague, Marie-Christine Alessi. Modulation of adipose tissue development by pharmacological inhibition of PAI-1.
Arteriosclerosis, thrombosis, and vascular biology.
2006 Oct; 26(10):2209-15. doi:
10.1161/01.atv.0000235605.51400.9d. [PMID: 16825598] - James K Hennan, Hassan Elokdah, Mauricio Leal, Allena Ji, Gregory S Friedrichs, Gwen A Morgan, Robert E Swillo, Thomas M Antrilli, Amy Hreha, David L Crandall. Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis.
The Journal of pharmacology and experimental therapeutics.
2005 Aug; 314(2):710-6. doi:
10.1124/jpet.105.084129. [PMID: 15860572] - Baihua Hu, James W Jetter, Jay E Wrobel, Thomas M Antrilli, Jean S Bauer, Li Di, Sergiusz Polakowski, Uday Jain, David L Crandall. Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1.
Bioorganic & medicinal chemistry letters.
2005 Aug; 15(15):3514-8. doi:
10.1016/j.bmcl.2005.05.095. [PMID: 15982877] - Alec D Weisberg, Francisco Albornoz, Jane P Griffin, David L Crandall, Hassan Elokdah, Agnes B Fogo, Douglas E Vaughan, Nancy J Brown. Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling.
Arteriosclerosis, thrombosis, and vascular biology.
2005 Feb; 25(2):365-71. doi:
10.1161/01.atv.0000152356.85791.52. [PMID: 15576638]