Eslicarbazepine (BioDeep_00000671429)
代谢物信息卡片
化学式: C15H14N2O2 (254.1055224)
中文名称: S-10-单羟基二氢卡马西平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N)O
InChI: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m0/s1
描述信息
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AF - Carboxamide derivatives
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:174358
- KEGGdrug: D09215
- PubChem: 9881504
- DrugBank: DB14575
- ChEMBL: CHEMBL315985
- CAS: 104746-04-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anne Hagemann, Dennis Klimpel, Christian G Bien, Christian Brandt, Theodor W May. Influence of dose and antiepileptic comedication on brivaracetam serum concentrations in patients with epilepsy.
Epilepsia.
2020 05; 61(5):e43-e48. doi:
10.1111/epi.16500. [PMID: 32304097] - Robert T Wechsler, Rodney A Radtke, Michael Smith, David G Vossler, Laura Strom, Eugen Trinka, Hailong Cheng, Todd Grinnell, David Blum, Mariana Vieira, Joana Moreira, Francisco Rocha. Serum sodium levels and related treatment-emergent adverse events during eslicarbazepine acetate use in adults with epilepsy.
Epilepsia.
2019 07; 60(7):1341-1352. doi:
10.1111/epi.16069. [PMID: 31260089] - Tengfei Li, Bin Huang, Duo Li, Yantong Zhu, Li Ding, Chang Shu. Development and validation of a specific and sensitive LC-MS/MS method for determination of eslicarbazepine in human plasma and its clinical pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Apr; 1112(?):61-66. doi:
10.1016/j.jchromb.2019.02.027. [PMID: 30856604] - Barry E Gidal, Scott Mintzer, Matthias Schwab, Ralph Schutz, Jahnavi Kharidia, David Blum, Todd Grinnell, Soujanya Sunkaraneni. Evidence for a pharmacokinetic interaction between eslicarbazepine and rosuvastatin: Potential effects on xenobiotic transporters.
Epilepsy research.
2017 09; 135(?):64-70. doi:
10.1016/j.eplepsyres.2017.05.005. [PMID: 28624574] - Gaetano Zaccara, Fabio Giovannelli, Massimo Cincotta, Alessia Carelli, Alberto Verrotti. Clinical utility of eslicarbazepine: current evidence.
Drug design, development and therapy.
2015; 9(?):781-9. doi:
10.2147/dddt.s57409. [PMID: 25709402] - Germán Sierra-Paredes, Ana I Loureiro, Lyndon C Wright, Germán Sierra-Marcuño, Patrício Soares-da-Silva. Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
BMC neuroscience.
2014 Dec; 15(?):134. doi:
10.1186/s12868-014-0134-2. [PMID: 25526768] - Ana Fortuna, Gilberto Alves, Anabela Almeida, Bruno Lopes, Amílcar Falcão, Patrício Soares-da-Silva. A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain.
Biomedical chromatography : BMC.
2012 Mar; 26(3):384-92. doi:
10.1002/bmc.1670. [PMID: 21780155] - G Flesch, C Czendlik, D Renard, P Lloyd. Pharmacokinetics of the monohydroxy derivative of oxcarbazepine and its enantiomers after a single intravenous dose given as racemate compared with a single oral dose of oxcarbazepine.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Jun; 39(6):1103-10. doi:
10.1124/dmd.109.030593. [PMID: 21389120]