guanfacine hydrochloride (BioDeep_00000671271)
代谢物信息卡片
N-CARBAMIMIDOYL-2-(2,6-DICHLOROPHENYL)ACETAMIDE HYDROCHLORIDE
化学式: C9H10Cl3N3O (280.988942)
中文名称: 胍法辛盐酸盐, 盐酸胍法辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:5559
- KEGGdrug: D00606
- PubChem: 71401
- ChEMBL: CHEMBL1200494
- MeSH: Guanfacine
- CAS: 29520-14-7
- CAS: 29110-48-3
- medchemexpress: HY-17416
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
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COVID-19 Disease Map(0)
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Zhiyuan Hou, Difu Shi, Jianing Lin, Xiangcheng Zhao, Hailong Zhang, Jinsong Ding. Effect of ion pair strategy on transdermal delivery of guanfacine: Which factor dominates drug permeation?.
International journal of pharmaceutics.
2024 Jan; 652(?):123835. doi:
10.1016/j.ijpharm.2024.123835. [PMID: 38262582] - Yuki Takahashi, Katsunaka Mikami, Keitaro Kimoto, Yuichi Onishi, Kenji Yamamoto, Hideo Matsumoto. A Case of Nocturnal Enuresis Associated with Attention-deficit/hyperactivity Disorder Successfully Treated with Guanfacine Monotherapy.
The Tokai journal of experimental and clinical medicine.
2022 Jul; 47(2):72-74. doi:
. [PMID: 35801551] - Christopher Wohkittel, Oliver Scherf-Clavel, Stefanie Fekete, Marcel Romanos, Petra Högger, Manfred Gerlach. Determination of Guanfacine in Oral Fluid and Serum of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Short Communication.
Therapeutic drug monitoring.
2022 04; 44(2):340-344. doi:
10.1097/ftd.0000000000000917. [PMID: 34334681] - Kouji Fukuyama, Tomosuke Nakano, Takashi Shiroyama, Motohiro Okada. Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22084122. [PMID: 33923533] - John W Downs, Brandon K Wills, Kirk L Cumpston, Carl E Wolf, S Rutherfoord Rose. Pediatric Guanfacine Toxicity with Severely Elevated Plasma Concentration.
Journal of child and adolescent psychopharmacology.
2020 09; 30(7):473-474. doi:
10.1089/cap.2020.0033. [PMID: 32667829] - Yelizaveta Sher, Beatrice Rabkin, José R Maldonado, Paul Mohabir. COVID-19-Associated Hyperactive Intensive Care Unit Delirium With Proposed Pathophysiology and Treatment: A Case Report.
Psychosomatics.
2020 Sep; 61(5):544-550. doi:
10.1016/j.psym.2020.05.007. [PMID: 32591212] - Yoshiyuki Tsuda, Yumiko Matsuo, Sayaka Matsumoto, Toshihiro Wajima. Population pharmacokinetic and exposure-response analyses of guanfacine in Japanese pediatric ADHD patients.
Drug metabolism and pharmacokinetics.
2019 Dec; 34(6):365-371. doi:
10.1016/j.dmpk.2019.07.001. [PMID: 31563330] - Yuji Inoue, Hirotoshi Morita, Kohei Nozawa, Takushi Kanazu. Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets.
Biopharmaceutics & drug disposition.
2019 Sep; 40(8):282-293. doi:
10.1002/bdd.2201. [PMID: 31313320] - Terril L Verplaetse, Walter Roberts, Kelly E Moore, MacKenzie R Peltier, Lindsay M Oberleitner, Sherry A McKee. Pharmacokinetics and Pharmacodynamics of Immediate-Release Versus Extended-Release Guanfacine in Adult Daily Smokers.
Journal of clinical psychopharmacology.
2019 Mar; 39(2):124-128. doi:
10.1097/jcp.0000000000001004. [PMID: 30707118] - Aiqun Li, Karen Yeo, Devin Welty, Haojing Rong. Development of Guanfacine Extended-Release Dosing Strategies in Children and Adolescents with ADHD Using a Physiologically Based Pharmacokinetic Model to Predict Drug-Drug Interactions with Moderate CYP3A4 Inhibitors or Inducers.
Paediatric drugs.
2018 Apr; 20(2):181-194. doi:
10.1007/s40272-017-0270-0. [PMID: 29098603] - Yumiko Matsuo, Masafumi Okita, James Ermer, Toshihiro Wajima. Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of Guanfacine Extended-Release Formulation in Healthy Japanese and Caucasian Male Adults.
Clinical drug investigation.
2017 Aug; 37(8):745-753. doi:
10.1007/s40261-017-0527-y. [PMID: 28421383] - James L Klotz, Glen E Aiken, Jessica R Bussard, Andrew P Foote, David L Harmon, Ben M Goff, F Neal Schrick, James R Strickland. Vasoactivity and Vasoconstriction Changes in Cattle Related to Time off Toxic Endophyte-Infected Tall Fescue.
Toxins.
2016 09; 8(10):. doi:
10.3390/toxins8100271. [PMID: 27669299] - А О Kibitov, Е М Krupitsky, Е А Blokhina, Е V Verbitskaya, V М Brodyansky, N P Alekseeva, N М Bushara, Т S Yaroslavtseva, V Yа Palatkin, D V Masalov, А М Burakov, Т N Romanova, G Yu Sulimov, A Yа Grinenko, Т Kosten, D Nielsen, E E Zvartau. [A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2016 ; 116(11. Vyp. 2):36-48. doi:
10.17116/jnevro201611611236-48. [PMID: 28300812] - Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Maurizio Parola. Pathogenesis of solute-free water retention in experimental ascitic cirrhosis: is vasopressin the only culprit?.
Clinical science (London, England : 1979).
2016 Jan; 130(2):117-24. doi:
10.1042/cs20150479. [PMID: 26519424] - Patrick Martin, Lawrence Satin, Robert S Kahn, Antoine Robinson, Mary Corcoran, Jaideep Purkayastha, Sharon Youcha, James C Ermer. A thorough QT study of guanfacine.
International journal of clinical pharmacology and therapeutics.
2015 Apr; 53(4):301-16. doi:
10.5414/cp202065. [PMID: 25109412] - Megan M Moran-Santa Maria, Nathaniel L Baker, Viswanathan Ramakrishnan, Kathleen T Brady, Aimee McRae-Clark. Impact of acute guanfacine administration on stress and cue reactivity in cocaine-dependent individuals.
The American journal of drug and alcohol abuse.
2015 Mar; 41(2):146-52. doi:
10.3109/00952990.2014.945590. [PMID: 25140866] - Magdalena Dudek, Joanna Knutelska, Marek Bednarski, Leszek Nowiński, Małgorzata Zygmunt, Barbara Mordyl, Monika Głuch-Lutwin, Grzegorz Kazek, Jacek Sapa, Karolina Pytka. A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.
PloS one.
2015; 10(10):e0141327. doi:
10.1371/journal.pone.0141327. [PMID: 26506439] - Xiaonan Li, Xiaolin Sun, Jiayin Chen, Yang Lu, Yongjie Zhang, Chunfeng Wang, Junxiu Li, Qing Zhang, Di Zhao, Xijing Chen. Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist.
Xenobiotica; the fate of foreign compounds in biological systems.
2015 Jan; 45(1):88-94. doi:
10.3109/00498254.2014.949904. [PMID: 25115365] - William Knebel, James Ermer, Jaideep Purkayastha, Patrick Martin, Marc R Gastonguay. Population pharmacokinetic/pharmacodynamic modeling of guanfacine effects on QTc and heart rate in pediatric patients.
The AAPS journal.
2014 Nov; 16(6):1237-46. doi:
10.1208/s12248-014-9645-0. [PMID: 25135837] - Xiaonan Li, Ning Li, Xiaolin Sun, Wei Yang, Yu Dai, Jie Xu, Wei Zhang, Chunfeng Wang, Suilou Wang, Xijing Chen. Development and validation of a simple, sensitive and accurate LC-MS/MS method for the determination of guanfacine, a selective α2A -adrenergicreceptor agonist, in plasma and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2013 Dec; 27(12):1708-13. doi:
10.1002/bmc.2983. [PMID: 23832392] - Benno Roesch, Mary E Corcoran, Jennifer Fetterolf, Mary Haffey, Patrick Martin, Peter Preston, Jaideep Purkayastha, Phillip Wang, James Ermer. Pharmacokinetics of coadministered guanfacine extended release and lisdexamfetamine dimesylate.
Drugs in R&D.
2013 Jun; 13(2):119-28. doi:
10.1007/s40268-013-0014-8. [PMID: 23615868] - Benno Roesch, Mary Corcoran, Mary Haffey, Annette Stevenson, Phillip Wang, Jaideep Purkayastha, Patrick Martin, James Ermer. Pharmacokinetics of coadministration of guanfacine extended release and methylphenidate extended release.
Drugs in R&D.
2013 Mar; 13(1):53-61. doi:
10.1007/s40268-013-0009-5. [PMID: 23519656] - Yuanyuan Li, Jack Henion, Richard Abbott, Phillip Wang. The use of a membrane filtration device to form dried plasma spots for the quantitative determination of guanfacine in whole blood.
Rapid communications in mass spectrometry : RCM.
2012 May; 26(10):1208-12. doi:
10.1002/rcm.6212. [PMID: 22499196] - Carl E Wolf, Sara J Kester-Florin, Alphonse Poklis. A HPLC-MS method to detect and quantify guanfacine in urine.
Clinical chemistry and laboratory medicine.
2011 Nov; 50(3):535-7. doi:
10.1515/cclm.2011.803. [PMID: 22112053] - Yuanyuan Li, Jack Henion, Richard Abbott, Phillip Wang. Dried blood spots as a sampling technique for the quantitative determination of guanfacine in clinical studies.
Bioanalysis.
2011 Nov; 3(22):2501-14. doi:
10.4155/bio.11.262. [PMID: 22122599] - Roujian Lu, Yong Li, Youwen Zhang, Yunjia Chen, Angela D Shields, Danny G Winder, Timothy Angelotti, Kai Jiao, Lee E Limbird, Yi Zhou, Qin Wang. Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization.
The Journal of biological chemistry.
2009 May; 284(19):13233-43. doi:
10.1074/jbc.m807535200. [PMID: 19276088] - Carrie Haglock, Carl Wolf, Alphonse Poklis. A novel method for the determination of guanfacine in urine by gas chromatography-mass spectrometry.
Journal of analytical toxicology.
2008 Oct; 32(8):544-6. doi:
10.1093/jat/32.8.544. [PMID: 19007502] - Samuel W Boellner, Michael Pennick, Kimberly Fiske, Andrew Lyne, Amir Shojaei. Pharmacokinetics of a guanfacine extended-release formulation in children and adolescents with attention-deficit-hyperactivity disorder.
Pharmacotherapy.
2007 Sep; 27(9):1253-62. doi:
10.1592/phco.27.9.1253. [PMID: 17723079] - Dennis Swearingen, Michael Pennick, Amir Shojaei, Andrew Lyne, Kimberly Fiske. A phase I, randomized, open-label, crossover study of the single-dose pharmacokinetic properties of guanfacine extended-release 1-, 2-, and 4-mg tablets in healthy adults.
Clinical therapeutics.
2007 Apr; 29(4):617-25. doi:
10.1016/j.clinthera.2007.04.016. [PMID: 17617285] - Tsugiyoshi Yamazaki, Hidetsugu Asanoi, Hiroshi Ueno, Kunihiro Yamada, Junya Takagawa, Tomoki Kameyama, Tadakazu Hirai, Shinji Ishizaka, Takashi Nozawa, Hiroshi Inoue. Central sympathetic inhibition augments sleep-related ultradian rhythm of parasympathetic tone in patients with chronic heart failure.
Circulation journal : official journal of the Japanese Circulation Society.
2005 Sep; 69(9):1052-6. doi:
10.1253/circj.69.1052. [PMID: 16127185] - Rongcai Yuan, Zhencai Wu, Igor A Kostenyuk, Jacqueline K Burns. G-protein-coupled alpha2A-adrenoreceptor agonists differentially alter citrus leaf and fruit abscission by affecting expression of ACC synthase and ACC oxidase.
Journal of experimental botany.
2005 Jul; 56(417):1867-75. doi:
10.1093/jxb/eri176. [PMID: 15928018] - Kunihiro Yamada, Hidetsugu Asanoi, Hiroshi Ueno, Shuji Joho, Junya Takagawa, Tomoki Kameyama, Tadakazu Hirai, Takashi Nozawa, Hiroshi Inoue. Role of central sympathoexcitation in enhanced hypercapnic chemosensitivity in patients with heart failure.
American heart journal.
2004 Dec; 148(6):964-70. doi:
10.1016/j.ahj.2004.05.030. [PMID: 15632879] - Shuichi Takishita, Masanobu Yamazato. [Centrally-acting antihypertensive drugs].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Mar; 62 Suppl 3(?):591-5. doi:
NULL. [PMID: 15171442] - Jeffrey M Halperin, Jeffrey H Newcorn, Kathleen E McKay, Larry J Siever, Vanshdeep Sharma. Growth hormone response to guanfacine in boys with attention deficit hyperactivity disorder: a preliminary study.
Journal of child and adolescent psychopharmacology.
2003; 13(3):283-94. doi:
10.1089/104454603322572615. [PMID: 14642016] - Mostafa Khalid, Norelyaquine Ilhami, Yves Giudicelli, Jean-Pierre Dausse. Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes.
The Journal of pharmacology and experimental therapeutics.
2002 Jan; 300(1):43-9. doi:
10.1124/jpet.300.1.43. [PMID: 11752095] - S Brian Penner, Donald D Smyth. Role of alpha 2-adrenoceptors and imidazoline receptors in the A5 region in the regulation of renal function in the rat.
Proceedings of the Western Pharmacology Society.
2002; 45(?):11-2. doi:
NULL. [PMID: 12434511] - Deni Pirnat, S Brian Penner, Donald D Smyth. Effects of rilmenidine and guanfacine in acute renal denervated rats.
Proceedings of the Western Pharmacology Society.
2002; 45(?):15-7. doi:
NULL. [PMID: 12434513] - S Brian Penner, Heather A Mueller, Donald D Smyth. Alpha 2-adrenoceptor stimulation in the periventricular nucleus increases urine flow rate with minimal effects on blood pressure.
Proceedings of the Western Pharmacology Society.
2002; 45(?):13-4. doi:
NULL. [PMID: 12434512] - G Scholtysik, F Regli, R M Bruckmaier, J W Blum. The alpha2-adrenoceptor agonists xylazine and guanfacine exert different central nervous system, but comparable peripheral effects in calves.
Journal of veterinary pharmacology and therapeutics.
1998 Dec; 21(6):477-84. doi:
10.1046/j.1365-2885.1998.00166.x. [PMID: 9885970] - P J Ambrosini, R M Sheikh. Increased plasma valproate concentrations when coadministered with guanfacine.
Journal of child and adolescent psychopharmacology.
1998; 8(2):143-7. doi:
10.1089/cap.1998.8.143. [PMID: 9730080] - H D Intengan, D D Smyth. Renal alpha 2a/d-adrenoceptor subtype function: Wistar as compared to spontaneously hypertensive rats.
British journal of pharmacology.
1997 Jul; 121(5):861-6. doi:
10.1038/sj.bjp.0701198. [PMID: 9222541] - H D Intengan, D D Smyth. Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
The Journal of pharmacology and experimental therapeutics.
1997 Apr; 281(1):48-53. doi:
NULL. [PMID: 9103479] - T Durá Travé, M Juste Ruiz, R González Montero, M Gutiérrez Terán, M Mauri Dot, M Moya Benavent. [Sensitivity of the clonidine and guanfacine tests (alpha-2-adrenergic agonists) as pharmacologic stimulants of growth hormone. Effects on plasma cortisol].
Anales espanoles de pediatria.
1996 Dec; 45(6):575-8. doi:
NULL. [PMID: 9133220] - P A van Zwieten. New central mediators as targets of centrally acting antihypertensive drugs.
Clinical and experimental hypertension (New York, N.Y. : 1993).
1996 Apr; 18(3-4):291-303. doi:
10.3109/10641969609088964. [PMID: 8743022] - K Nishina, K Mikawa, N Maekawa, H Obara. The efficacy of guanfacine in reducing perioperative hemodynamic changes and volatile anesthetic requirement.
Journal of clinical anesthesia.
1995 May; 7(3):211-8. doi:
10.1016/0952-8180(95)00005-3. [PMID: 7669311] - Y Xia, S Uhlén, V Chhajlani, E J Lien, J E Wikberg. Further evidence for the existence of two forms of alpha 2B-adrenoceptors in rat.
Pharmacology & toxicology.
1993 Jan; 72(1):40-9. doi:
10.1111/j.1600-0773.1993.tb01337.x. [PMID: 8095097] - D C Shockley, L H Wade, M M Williams-Johnson. Effects of alpha-2-adrenoceptor agonists on induced diuresis in rats.
Life sciences.
1993; 53(3):251-9. doi:
10.1016/0024-3205(93)90676-t. [PMID: 8100606] - J Jaromczyk-Slisz, A Kubasik, H Jasiel-Wojculewicz, T Badzio, B Krupa-Wojciechowska. [Effect of 5-month guanfacine treatment on the renin-angiotensin-aldosterone system and some metabolic factors in patients with diabetes mellitus type II and hypertension].
Polski tygodnik lekarski (Warsaw, Poland : 1960).
1992 Nov; 47(46-48):1045-7. doi:
NULL. [PMID: 1305723] - M Koshiji, H Ito, S Minatoguchi, H Watanabe, Y Imai, M Kakami, S Hirakawa. A comparison of guanfacine, bunazosin, atenolol and nadolol on blood pressure and plasma noradrenaline responses to cold pressor testing.
Clinical and experimental pharmacology & physiology.
1992 Jul; 19(7):481-8. doi:
10.1111/j.1440-1681.1992.tb00493.x. [PMID: 1354084] - P Sopelana, L Bautista, A Diéguez. [Factors affecting the course of hospital detoxication of drug addicts].
Medicina clinica.
1991 Sep; 97(9):326-30. doi:
NULL. [PMID: 1961059] - S Uhlén, J E Wikberg. Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound.
European journal of pharmacology.
1991 Sep; 202(2):235-43. doi:
10.1016/0014-2999(91)90299-6. [PMID: 1666366] - J R Oster, M Epstein. Use of centrally acting sympatholytic agents in the management of hypertension.
Archives of internal medicine.
1991 Aug; 151(8):1638-44. doi:
NULL. [PMID: 1872668] - K Berkman, N Tözün, Y Taga, A Dedeoğlu, F Onat, N Bekiroğlu. The effect of chronic guanfacine administration on high plasma vasopressin levels in essential hypertension.
International journal of clinical pharmacology, therapy, and toxicology.
1990 Feb; 28(2):67-71. doi:
. [PMID: 2407671] - G Kakuk, G Kurta, I Kárpáti, J Mátyus. Use of tensiomin (captopril) in the antihypertensive treatment of haemodialysis patients.
Therapia Hungarica (English edition).
1990; 38(2):71-6. doi:
NULL. [PMID: 2198678] - V Lachaud, M Bidet, I Coupry, R A Podevin, P Poujeol, A Parini. [Interaction of rilmenidine with renal imidazoline-guanidine sites].
Archives des maladies du coeur et des vaisseaux.
1989 Dec; 82 Spec No 5(?):15-8. doi:
NULL. [PMID: 2576516] - M A Weber. Clinical pharmacology of centrally acting antihypertensive agents.
Journal of clinical pharmacology.
1989 Jul; 29(7):598-602. doi:
10.1002/j.1552-4604.1989.tb03387.x. [PMID: 2668350] - V Lachaud, I Coupry, R A Podevin, E Koenig, A Parini. [Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].
Archives des maladies du coeur et des vaisseaux.
1989 Jul; 82(7):1135-7. doi:
. [PMID: 2573323] - K Knypl, B Wocial, J Chodakowska, E Brym, E Czerniewska, J Wacławek-Maczkowska, K Kuczyńska, H Berent, W Januszewicz. [Effect of long-term treatment with guanfacine on selected humoral metabolic indices in patients with primary hypertension].
Polski tygodnik lekarski (Warsaw, Poland : 1960).
1989 Mar; 44(12-13):293-6. doi:
. [PMID: 2530502] - M J Coves, R Gomis, R Casamitjana, V Lienas, E Vilaradell. Antihypertensive therapy with guanfacine induces elevated plasma growth hormone levels in diabetic patients.
Journal of medicine.
1989; 20(3-4):291-6. doi:
. [PMID: 2572660] - S H Carchman, D A Sica, J Davis, J T Crowe, A J Wasserman, J D Proctor, G J Wright. Steady-state plasma levels and pharmacokinetics of guanfacine in patients with renal insufficiency.
Nephron.
1989; 53(1):18-23. doi:
10.1159/000185695. [PMID: 2674741] - P Hahn, L Srubitski. Cholesterol metabolism in infant rats, effect of 6-hydroxydopamine and guanfacine.
Biology of the neonate.
1989; 55(3):180-4. doi:
10.1159/000242914. [PMID: 2568131] - A B Ebeigbe, E Müller-Schweinitzer, A Vogel. Effects of calcium channel blockade in canine saphenous veins after storage at -190 degrees C.
British journal of pharmacology.
1988 Jun; 94(2):381-8. doi:
10.1111/j.1476-5381.1988.tb11540.x. [PMID: 2456116] - T Ikeda, T Gomi, M Yuhara, J Sakurai, D Nakayama. Effects of guanfacine monotherapy on blood pressure, heart rate, plasma renin activity, aldosterone, and catecholamines in hypertensive patients with chronic glomerulonephritis.
Clinical pharmacology and therapeutics.
1988 Mar; 43(3):278-82. doi:
10.1038/clpt.1988.33. [PMID: 3278821] - L A Cornish. Guanfacine hydrochloride: a centrally acting antihypertensive agent.
Clinical pharmacy.
1988 Mar; 7(3):187-97. doi:
NULL. [PMID: 3281788] - M Sznajderman, J Niegowska, M Sznajderman. [Effect of guanfacine on arterial blood pressure and serum lipids and lipoproteins].
Polski tygodnik lekarski (Warsaw, Poland : 1960).
1987 Dec; 42(51-52):1637-41. doi:
NULL. [PMID: 3330797] - S H Carchman, J T Crowe, G J Wright. The bioavailability and pharmacokinetics of guanfacine after oral and intravenous administration to healthy volunteers.
Journal of clinical pharmacology.
1987 Oct; 27(10):762-7. doi:
10.1002/j.1552-4604.1987.tb02993.x. [PMID: 3323255] - A D Baines. Is there a role for renal alpha 2-adrenoceptors in the pathogenesis of hypertension?.
Canadian journal of physiology and pharmacology.
1987 Aug; 65(8):1638-43. doi:
10.1139/y87-257. [PMID: 2891422] - E Hackenthal, K Aktories, K H Jakobs, R E Lang. Neuropeptide Y inhibits renin release by a pertussis toxin-sensitive mechanism.
The American journal of physiology.
1987 Mar; 252(3 Pt 2):F543-50. doi:
10.1152/ajprenal.1987.252.3.f543. [PMID: 3548437] - M Bramnert, B Hökfelt. Naloxone enhances the increase in plasma growth hormone induced by alpha 2-adrenergic stimulation in healthy males.
Acta endocrinologica.
1987 Feb; 114(2):308-13. doi:
10.1530/acta.0.1140308. [PMID: 2881420] - I Balazovjech, D Skultétyová, M Mikulecký, H Kratochvíl'ová. The effect of small doses of guanfacine (Estulic Sandoz) on the lipid levels and catecholamine excretion in patients with essential hypertension.
Cor et vasa.
1987; 29(4 Suppl 1):46-52. doi:
. [PMID: 3315451] - J H Hauger-Klevene, E C Balossi, J C Scornavacchi. Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension.
The American journal of cardiology.
1986 Mar; 57(9):27E-31E. doi:
10.1016/0002-9149(86)90720-4. [PMID: 3513527] - J H Rosenthal. Hemodynamic and endocrine responses to guanfacine in normotensive volunteers and hypertensive patients.
The American journal of cardiology.
1986 Mar; 57(9):22E-26E. doi:
10.1016/0002-9149(86)90719-8. [PMID: 3513526] - J M Fillingim, J L Blackshear, A Strauss, M Strauss. Guanfacine as monotherapy for systemic hypertension.
The American journal of cardiology.
1986 Mar; 57(9):50E-54E. doi:
10.1016/0002-9149(86)90724-1. [PMID: 3513531] - J R Kiechel. Pharmacokinetics of guanfacine in patients with impaired renal function and in some elderly patients.
The American journal of cardiology.
1986 Mar; 57(9):18E-21E. doi:
10.1016/0002-9149(86)90718-6. [PMID: 3513525] - M F Wilson, O Haring, A Lewin, G Bedsole, W Stepansky, J Fillingim, D Hall, M Roginsky, F G McMahon, P Jagger. Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension.
The American journal of cardiology.
1986 Mar; 57(9):43E-49E. doi:
10.1016/0002-9149(86)90723-x. [PMID: 3513530] - I G Kravchenko, M M Liashenko, A G Tarnakin, S N Chirkov. [Use of the hypotensive drug guanfacine in the treatment of patients with hypertension].
Kardiologiia.
1986 Mar; 26(3):41-5. doi:
. [PMID: 3520085] - M J Brown, A D Struthers, J M Burrin, L Di Silvio, D C Brown. The physiological and pharmacological role of presynaptic alpha- and beta-adrenoceptors in man.
British journal of clinical pharmacology.
1985 Dec; 20(6):649-58. doi:
10.1111/j.1365-2125.1985.tb05124.x. [PMID: 2868743] - M Minami, H Togashi, M Yoshioka. [The effect of clonidine and guanfacine on blood pressure].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1985 Oct; 86(4):241-55. doi:
10.1254/fpj.86.241. [PMID: 2867958] - E Hackenthal, K Aktories, K H Jakobs. Pertussis toxin attenuates angiotensin II-induced vasoconstriction and inhibition of renin release.
Molecular and cellular endocrinology.
1985 Sep; 42(2):113-7. doi:
10.1016/0303-7207(85)90098-x. [PMID: 3934013] - A K Jain, A Hiremath, R Michael, J R Ryan, F G McMahon. Clonidine and guanfacine in hypertension.
Clinical pharmacology and therapeutics.
1985 Mar; 37(3):271-6. doi:
10.1038/clpt.1985.39. [PMID: 3882307] - M J Brown, A D Struthers, L Di Silvio, T Yeo, M Ghatei, J M Burrin. Metabolic and haemodynamic effects of alpha 2-adrenoceptor stimulation and antagonism in man.
Clinical science (London, England : 1979).
1985; 68 Suppl 10(?):137s-139s. doi:
10.1042/cs068s137. [PMID: 2857610] - M J Brown, A D Struthers, L di Silvio. Peripheral alpha 2 adrenoceptor stimulation contributes to the sympatholytic effect of guanfacine in humans.
Journal of cardiovascular pharmacology.
1985; 7 Suppl 6(?):S159-61. doi:
10.1097/00005344-198500076-00027. [PMID: 2414580] - F Collart, M Staroukine, A Verniory. Relationships between blood pressure, heart rate and plasma epinephrine, norepinephrine, angiotensin II concentrations, plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension.
Acta cardiologica.
1985; 40(3):269-76. doi:
NULL. [PMID: 3895792] - J H Hauger-Klevene, J C Scornavacchi. Improvement of glucose tolerance in hypertensive diabetic patients treated with guanfacine one year.
European journal of clinical pharmacology.
1985; 29(4):391-3. doi:
10.1007/bf00613450. [PMID: 3912183] - H Togashi, M Minami, I Saito, M Sano. Guanfacine and clonidine: the effects on adrenal medullary function in spontaneously hypertensive rats.
Archives internationales de pharmacodynamie et de therapie.
1984 Nov; 272(1):79-87. doi:
NULL. [PMID: 6393888] - C Farsang, K Varga, L Vajda, S Alföldi, J Kapocsi. Effects of clonidine and guanfacine in essential hypertension.
Clinical pharmacology and therapeutics.
1984 Nov; 36(5):588-94. doi:
10.1038/clpt.1984.226. [PMID: 6386275] - M J Brown, D Harland, M B Murphy, A D Struthers. Effect of centrally acting alpha-adrenergic agonists on sympathetic nervous system function in humans.
Hypertension (Dallas, Tex. : 1979).
1984 Sep; 6(5 Pt 2):II57-62. doi:
10.1161/01.hyp.6.5_pt_2.ii57. [PMID: 6150000] - T Hedner, G Nyberg, T Mellstrand. Guanfacine in essential hypertension: effects during rest and isometric exercise.
Clinical pharmacology and therapeutics.
1984 May; 35(5):604-9. doi:
10.1038/clpt.1984.83. [PMID: 6370553] - M B Murphy, M J Brown, C T Dollery. Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man.
European journal of clinical pharmacology.
1984; 27(1):23-7. doi:
10.1007/bf02395201. [PMID: 6386488] - M Velasco, A Urbina-Quintana, J Morillo, H Vizcarrondo, A Ramirez, E Hernández, O Hernández-Pieretti. Systemic and cardiac haemodynamic interactions between guanfacine and hydrallazine in hypertensive patients.
European journal of clinical pharmacology.
1984; 27(4):393-6. doi:
10.1007/bf00549584. [PMID: 6394347] - N L Lifshits, V M Ermolenko, T M Rozhdestvenskaia, V A Tatsievskiĭ, V V Panasiuk. [Labetalol and guanfacine in the treatment of arterial hypertension in patients with chronic renal failure].
Terapevticheskii arkhiv.
1984; 56(7):66-9. doi:
NULL. [PMID: 6385325] - R Nami, C Bianchini, G Fiorella, S M Chierichetti, C Gennari. Comparison of effects of guanfacine and clonidine on blood pressure, heart rate, urinary catecholamines, and cyclic nucleotides during and after administration to patients with mild to moderate hypertension.
Journal of cardiovascular pharmacology.
1983 Jul; 5(4):546-51. doi:
10.1097/00005344-198307000-00006. [PMID: 6193349] - J R Kiechel, D Lavene, M Guerret, E Comoy, M Godin, J P Fillastre. Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure.
European journal of clinical pharmacology.
1983; 25(4):463-6. doi:
10.1007/bf00542112. [PMID: 6360692] - M Guerret, C Julien-Larose, J R Kiechel, D Lavène. Determination of 3-hydroxy-guanfacine in biological fluids by electron-capture gas-liquid chromatography.
Journal of chromatography.
1982 Dec; 233(?):181-92. doi:
10.1016/s0378-4347(00)81745-4. [PMID: 6761349] - N D Barber, J L Reid. Comparison of the actions of centrally and peripherally administered clonidine and guanfacine in the rabbit: investigation of the differences.
British journal of pharmacology.
1982 Dec; 77(4):641-7. doi:
10.1111/j.1476-5381.1982.tb09342.x. [PMID: 6758908] - W Kirch, H Kohler, T Axthelm. Pharmacokinetics of guanfacine in patients undergoing haemodialysis.
European journal of drug metabolism and pharmacokinetics.
1982 Oct; 7(4):277-80. doi:
10.1007/bf03189630. [PMID: 6762301] - M Minami, H Togashi, M Kurosawa, K Shimamura, Y Koike, H Saito, T Kobayashi, H Yasuda. Effect of guanethidine, clonidine and guanfacine on urinary catecholamine excretion in cold-stressed spontaneously hypertensive rats.
Japanese journal of pharmacology.
1982 Oct; 32(5):941-4. doi:
10.1254/jjp.32.941. [PMID: 6757504] - H Togashi, M Minami, Y Bando, Y Koike, K Shimamura, H Saito. Effects of clonidine and guanfacine on drinking and ambulation in spontaneously hypertensive rats.
Pharmacology, biochemistry, and behavior.
1982 Sep; 17(3):519-22. doi:
10.1016/0091-3057(82)90313-6. [PMID: 6755492] - M E Safar, Y Loria, Y A Weiss, J R Boutier. Antihypertensive effects and plasma levels of guanfacine in man.
Journal of clinical pharmacology.
1982 Aug; 22(8-9):385-90. doi:
10.1002/j.1552-4604.1982.tb02690.x. [PMID: 6752213]