alpha-Methyl-DL-phenylalanine (BioDeep_00000670806)
代谢物信息卡片
2-Amino-2-methyl-3-phenylpropionic acid
化学式: C10H13NO2 (179.0946)
中文名称: α-甲基-DL-苯丙氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=CC=C1)(C(=O)O)N
InChI: InChI=1S/C10H13NO2/c1-10(11,9(12)13)7-8-5-3-2-4-6-8/h2-6H,7,11H2,1H3,(H,12,13)
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:173496
- PubChem: 108055
- ChEMBL: CHEMBL1222268
- CAS: 1132-26-9
- CAS: 4415-69-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Isa Mahendra, Hirofumi Hanaoka, Aiko Yamaguchi, Tumenjargal Amartuvshin, Yoshito Tsushima. Diagnosis of bladder cancer using 18F-labeled α-methyl-phenylalanine tracers in a mouse model.
Annals of nuclear medicine.
2020 May; 34(5):329-336. doi:
10.1007/s12149-020-01452-z. [PMID: 32144655] - Hirofumi Hanaoka, Yasuhiro Ohshima, Yurika Suzuki, Aiko Yamaguchi, Shigeki Watanabe, Tomoya Uehara, Shushi Nagamori, Yoshikatsu Kanai, Noriko S Ishioka, Yoshito Tsushima, Keigo Endo, Yasushi Arano. Development of a Widely Usable Amino Acid Tracer: ⁷⁶Br-α-Methyl-Phenylalanine for Tumor PET Imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2015 May; 56(5):791-7. doi:
10.2967/jnumed.114.152215. [PMID: 25814518] - Griet Van Zeebroeck, Beatriz Monge Bonini, Matthias Versele, Johan M Thevelein. Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Nature chemical biology.
2009 Jan; 5(1):45-52. doi:
10.1038/nchembio.132. [PMID: 19060912] - Elisa Costabeber, Adriana Kessler, Carlos Severo Dutra-Filho, Angela Terezinha de Souza Wyse, Moacir Wajner, Clóvis Milton Duval Wannmacher. Hyperphenylalaninemia reduces creatine kinase activity in the cerebral cortex of rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2003 Apr; 21(2):111-6. doi:
10.1016/s0736-5748(02)00108-9. [PMID: 12615087] - A T Wyse, M E Noriler, L F Borges, P J Floriano, C G Silva, M Wajner, C M Wannmacher. Alanine prevents the decrease of Na+,K+-ATPase activity in experimental phenylketonuria.
Metabolic brain disease.
1999 Jun; 14(2):95-101. doi:
10.1023/a:1020705713548. [PMID: 10488911] - R E Austic, C L Su, B J Strupp, D A Levitsky. Effects of dietary mixtures of amino acids on fetal growth and maternal and fetal amino acid pools in experimental maternal phenylketonuria.
The American journal of clinical nutrition.
1999 Apr; 69(4):687-96. doi:
10.1093/ajcn/69.4.687. [PMID: 10197570] - F Gobeil, S Charland, C Filteau, S I Perron, W Neugebauer, D Regoli. Kinin B1 receptor antagonists containing alpha-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities.
Hypertension (Dallas, Tex. : 1979).
1999 Mar; 33(3):823-9. doi:
10.1161/01.hyp.33.3.823. [PMID: 10082494] - A Diamond, V Ciaramitaro, E Donner, S Djali, M B Robinson. An animal model of early-treated PKU.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1994 May; 14(5 Pt 2):3072-82. doi:
. [PMID: 7514214] - M Castillo, M F Zafra, E Garcia-Peregrin. Effect of experimental hyperphenylalaninemia induced by dietary phenylalanine plus alpha-methylphenylalanine administration on amino acid concentration in neonatal chick brain, plasma, and liver.
Neurochemical research.
1988 Jun; 13(6):547-50. doi:
10.1007/bf00973295. [PMID: 3405379] - M Castillo, M F Zafra, E Garcia-Peregrin. Inhibition of brain and liver 3-hydroxy-3-methylglutaryl-CoA reductase and mevalonate-5-pyrophosphate decarboxylase in experimental hyperphenylalaninemia.
Neurochemical research.
1988 Jun; 13(6):551-5. doi:
10.1007/bf00973296. [PMID: 3405380] - O Greengard, C A Brass. Developmental changes of cerebral phenylalanine uptake from severely elevated blood levels.
Neurochemical research.
1984 Jun; 9(6):837-48. doi:
10.1007/bf00965670. [PMID: 6541764] - P Binek-Singer, T C Johnson. The effects of chronic hyperphenylalaninaemia on mouse brain protein synthesis can be prevented by other amino acids.
The Biochemical journal.
1982 Aug; 206(2):407-14. doi:
10.1042/bj2060407. [PMID: 7150251] - C A Brass, C E Isaacs, R McChesney, O Greengard. The effects of hyperphenylalaninemia on fetal development: a new animal model of maternal phenylketonuria.
Pediatric research.
1982 May; 16(5):388-94. doi:
10.1203/00006450-198205000-00014. [PMID: 7201630] - P A Binek, T C Johnson, C J Kelly. Effect of alpha-methylphenylalanine and phenylalanine on brain polyribosomes and protein synthesis.
Journal of neurochemistry.
1981 Apr; 36(4):1476-84. doi:
10.1111/j.1471-4159.1981.tb00589.x. [PMID: 7264644] - R C Johnson, S N Shah. Effects of alpha-methylphenylalanine plus phenylalanine treatment during development on myelin in rat brain.
Neurochemical research.
1980 Jul; 5(7):709-18. doi:
10.1007/bf00964709. [PMID: 7422057] - J D Lane, B Schöne, U Langenbeck, V Neuhoff. Characterization of experimental phenylketonuria. Augmentation of hyperphenylalaninemia with alpha-methylphenylalanine and p-chlorophenylalanine.
Biochimica et biophysica acta.
1980 Jan; 627(2):144-56. doi:
10.1016/0304-4165(80)90316-5. [PMID: 6444271] - J A Delvalle, G Dienel, O Greengard. Comparison of alpha-methylphenylalanine and p-chlorophenylalanine as inducers of chronic hyperphenylalaninaemia in developing rats.
The Biochemical journal.
1978 Mar; 170(3):449-59. doi:
10.1042/bj1700449b. [PMID: 148273] - O Greengard, M S Yoss, J A Del Valle. Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats.
Science (New York, N.Y.).
1976 Jun; 192(4243):1007-8. doi:
10.1126/science.944951. [PMID: 944951]
