N-Acetyl-S-(2-cyanoethyl)-L-cysteine (BioDeep_00000669010)
代谢物信息卡片
N-Acetyl-S-(2-cyanoethyl)-L-cysteine
化学式: C8H12N2O3S (216.0568602)
中文名称: N-乙酰-S-(2-氰乙基)-L-2-氨基-3-巯基丙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC(CSCCC#N)C(=O)O
InChI: InChI=1S/C8H12N2O3S/c1-6(11)10-7(8(12)13)5-14-4-2-3-9/h7H,2,4-5H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Banrida Wahlang, Tyler C Gripshover, Hong Gao, Tatiana Krivokhizhina, Rachel J Keith, Israel D Sithu, Shesh N Rai, Aruni Bhatnagar, Craig J McClain, Sanjay Srivastava, Mathew C Cave. Associations Between Residential Exposure to Volatile Organic Compounds and Liver Injury Markers.
Toxicological sciences : an official journal of the Society of Toxicology.
2021 12; 185(1):50-63. doi:
10.1093/toxsci/kfab119. [PMID: 34668566] - Shannon Kindilien, Elle Goldberg. Household tobacco smoke exposure and acrylonitrile metabolite levels in a US pediatric sample.
Environmental toxicology and pharmacology.
2021 May; 84(?):103616. doi:
10.1016/j.etap.2021.103616. [PMID: 33609751] - Menglan Chen, Steven G Carmella, Chistopher Sipe, Joni Jensen, Xianghua Luo, Chap T Le, Sharon E Murphy, Neal L Benowitz, F Joseph McClernon, Ryan Vandrey, Sharon S Allen, Rachel Denlinger-Apte, Paul M Cinciripini, Andrew A Strasser, Mustafa al'Absi, Jason D Robinson, Eric C Donny, Dorothy Hatsukami, Stephen S Hecht. Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein.
PloS one.
2019; 14(1):e0210104. doi:
10.1371/journal.pone.0210104. [PMID: 30608961] - Chien-Yu Lin, Hui-Ling Lee, Fung-Chang Sung, Ta-Chen Su. Investigating the association between urinary levels of acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine and the oxidative stress product 8-hydroxydeoxyguanosine in adolescents and young adults.
Environmental pollution (Barking, Essex : 1987).
2018 Aug; 239(?):493-498. doi:
10.1016/j.envpol.2018.04.010. [PMID: 29684876] - Zhang Xiaotao, Hou Hongwei, Xiong Wei, Hu Qingyuan. Simultaneous measurement of N-Acetyl-S-(2-cyanoethyl)-cysteine and N-acetyl-S-(2-hydroxyethyl)-cysteine in human urine by liquid chromatography-tandem mass spectrometry.
Journal of chromatographic science.
2014 Aug; 52(7):719-24. doi:
10.1093/chromsci/bmt106. [PMID: 23902664] - Hongwei Hou, Wei Xiong, Na Gao, Xiaotao Zhang, Gangling Tang, Qingyuan Hu. A column-switching liquid chromatography-tandem mass spectrometry method for quantitation of 2-cyanoethylmercapturic acid and 2-hydroxyethylmercapturic acid in Chinese smokers.
Analytical biochemistry.
2012 Nov; 430(1):75-82. doi:
10.1016/j.ab.2012.07.026. [PMID: 22868354] - T Schettgen, J Bertram, T Kraus. Accurate quantification of the mercapturic acids of acrylonitrile and its genotoxic metabolite cyanoethylene-epoxide in human urine by isotope-dilution LC-ESI/MS/MS.
Talanta.
2012 Aug; 98(?):211-9. doi:
10.1016/j.talanta.2012.06.074. [PMID: 22939149] - Chia-Fang Wu, Shi-Nian Uang, Su-Yin Chiang, Wei-Chung Shih, Yu-Fang Huang, Kuen-Yuh Wu. Simultaneous quantitation of urinary cotinine and acrylonitrile-derived mercapturic acids with ultraperformance liquid chromatography-tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2012 Feb; 402(6):2113-20. doi:
10.1007/s00216-011-5661-4. [PMID: 22231508] - Emmanuel Minet, Francis Cheung, Graham Errington, Katharina Sterz, Gerhard Scherer. Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2011 Feb; 16(1):89-96. doi:
10.3109/1354750x.2010.533287. [PMID: 21108560] - T Schettgen, A Musiol, A Alt, E Ochsmann, T Kraus. A method for the quantification of biomarkers of exposure to acrylonitrile and 1,3-butadiene in human urine by column-switching liquid chromatography-tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2009 Feb; 393(3):969-81. doi:
10.1007/s00216-008-2510-1. [PMID: 19018522] - . Toxicology and carcinogenesis studies of acrylonitrile (CAS No. 107-13-1) in B6C3F1 mice (gavage studies).
National Toxicology Program technical report series.
2001 Oct; ?(506):1-201. doi:
. [PMID: 11803701] - K Norpoth, G Müller. [Determination of mercapturic acid in urine samples for the monitoring of occupational exposure to xenobiotics].
Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete.
1989; 35(8):487-90. doi:
. [PMID: 2815877] - M Jakubowski, I Linhart, G Pielas, J Kopecký. 2-Cyanoethylmercapturic acid (CEMA) in the urine as a possible indicator of exposure to acrylonitrile.
British journal of industrial medicine.
1987 Dec; 44(12):834-40. doi:
10.1136/oem.44.12.834. [PMID: 3689720] - P J van Bladeren, L P Delbressine, J J Hoogeterp, A H Beaumont, D D Breimer, F Seutter-Berlage, A van der Gen. Formation of mercapturic acids from acrylonitrile, crotononitrile, and cinnamonitrile by direct conjugation and via an intermediate oxidation process.
Drug metabolism and disposition: the biological fate of chemicals.
1981 May; 9(3):246-9. doi:
NULL. [PMID: 6113934] - P W Langvardt, C L Putzig, W H Braun, J D Young. Identification of the major urinary metabolites of acrylonitrile in the rat.
Journal of toxicology and environmental health.
1980 Mar; 6(2):273-82. doi:
10.1080/15287398009529851. [PMID: 7392095] - J Kopecký, D Zachardová, I Gut. New findings on acrylonitrile metabolism.
Czechoslovak medicine.
1980; 3(4):295-301. doi:
NULL. [PMID: 7227125] - L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate.
The Journal of urology.
1979 May; 121(5):630-4. doi:
10.1016/s0022-5347(17)56913-x. [PMID: 439260] - T Stuchbury, M Shipton, R Norris, J P Malthouse, K Brocklehurst, J A Herbert, H Suschitzky. A reporter group delivery system with both absolute and selective specificity for thiol groups and an improved fluorescent probe containing the 7-nitrobenzo-2-oxa-1,3-diazole moiety.
The Biochemical journal.
1975 Nov; 151(2):417-32. doi:
10.1042/bj1510417. [PMID: 3168] - A W Mondorf. [Evidence of urinary tubular proteins in inflammatory and toxic kidney damage].
Wiener medizinische Wochenschrift. Supplement.
1975; 27(?):20-3. doi:
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