Rilmazafone (BioDeep_00000668607)

   


代谢物信息卡片


Rilmazafone

化学式: C21H20Cl2N6O3 (474.097387)
中文名称: 利马扎封
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)C(=O)C1=NN(C(=N1)CNC(=O)CN)C2=C(C=C(C=C2)Cl)C(=O)C3=CC=CC=C3Cl
InChI: InChI=1S/C21H20Cl2N6O3/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23/h3-9H,10-11,24H2,1-2H3,(H,25,30)

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic

同义名列表

1 个代谢物同义名

Rilmazafone



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • K Sugaya, S Nishijima, M Miyazato, K Kadekawa, Y Ogawa. Effects of melatonin and rilmazafone on nocturia in the elderly. The Journal of international medical research. 2007 Sep; 35(5):685-91. doi: 10.1177/147323000703500513. [PMID: 17900408]
  • Takashi Matsubara. Safety evaluation and drug development based on biological fate of drugs -efforts made to overcome drug interaction in drug development-. Drug metabolism and pharmacokinetics. 2002; 17(5):379-94. doi: 10.2133/dmpk.17.379. [PMID: 15618690]
  • N Muranushi, S Miyauchi, H Suzuki, Y Sugiyama, M Hanano, H Kinoshita, T Oguma, H Yamada. Comparative hepatic transport of desglycylated and cyclic metabolites of rilmazafone in rats: analysis by multiple indicator dilution method. Biopharmaceutics & drug disposition. 1993 May; 14(4):279-90. doi: 10.1002/bdd.2510140402. [PMID: 8499579]
  • M Koike, R Norikura, K Iwatani, K Sugeno, S Takahashi, Y Nakagawa. Structure determination of metabolites of rilmazafone, a 1H-1,2,4-triazolyl benzophenone derivative in monkey urine. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Mar; 18(3):257-68. doi: 10.3109/00498258809041662. [PMID: 3381539]
  • T Yamaguchi, M Nakanishi, M Yamashita, H Matsumoto, M Nakamura, G Kominami, K Iwatani, Y Nakagawa, M Kono, K Sugeno. [Pharmacology of a new sleep-inducer, a 1H-1,2,4-triazolyl benzophenone derivative, 450191-S (VIII). Examination and determination of metabolites in human plasma and urine]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1987 Oct; 90(4):239-47. doi: 10.1254/fpj.90.239. [PMID: 3428781]
  • T Matsubara, A Touchi, N Yamada. Effect of change of hepatic drug-metabolizing activity on plasma concentrations of major metabolites of the new sleep inducer 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative. Japanese journal of pharmacology. 1987 Aug; 44(4):429-36. doi: 10.1254/jjp.44.429. [PMID: 3682408]
  • G Kominami, H Matsumoto, R Nishimura, T Yamaguchi, R Konaka, K Sugeno, K Hirai, M Kono. Combined high-performance liquid chromatography and enzyme immunoassay for active metabolites of a sleep inducer (rilmazafone), a ring-opened derivative of benzodiazepines, in human plasma. Journal of chromatography. 1987 Jun; 417(1):216-22. doi: 10.1016/0378-4347(87)80111-1. [PMID: 3305535]
  • M Koike, R Norikura, S Futaguchi, T Yamaguchi, K Sugeno, K Iwatani, Y Ikenishi, Y Nakagawa. N-hydroxymethyl metabolites of 450191-S, a 1H-1,2,4,-triazolyl benzophenone derivative, in dog plasma. Drug metabolism and disposition: the biological fate of chemicals. 1987 May; 15(3):426-8. doi: NULL. [PMID: 2886322]
  • G Kominami, H Matsumoto, M Nakamura, M Kono. An enzyme immunoassay for a metabolite of a new sleep inducer (450191-S), a ring-opened derivative of 1,4-benzodiazepine, in human serum. Journal of immunoassay. 1987; 8(2-3):267-81. doi: 10.1080/15321818708057026. [PMID: 3114326]
  • T Yamaguchi, M Yamashita, K Sugeno. [Pharmacology of a new sleep-inducer, 1H-1,2,4-triazolyl benzophenone derivative, 450191-S (VI). Determination of metabolites in monkey plasma by combined high-performance liquid chromatography and enzyme immunoassay]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1986 Nov; 88(5):375-87. doi: 10.1254/fpj.88.375. [PMID: 3546025]
  • M Koike, S Futaguchi, K Sugeno, A Touchi, T Matsubara. Autoinduction of 450191-S, a new sleep inducer of 1H-1,2,4-triazolyl benzophenone derivative, in dogs. Journal of pharmacobio-dynamics. 1986 Nov; 9(11):909-16. doi: 10.1248/bpb1978.9.909. [PMID: 3559881]
  • M Koike, R Norikura, T Yoshimori, S Futaguchi, K Sugeno. Biopharmaceutical characterization of 450191-S, a ring-opened derivative of 1,4-benzodiazepine. I. Active metabolite levels in rat plasma. Journal of pharmacobio-dynamics. 1986 Jul; 9(7):563-9. doi: 10.1248/bpb1978.9.563. [PMID: 3772713]
  • M Kabuto, I Namura, Y Saitoh. Nocturnal enhancement of plasma melatonin could be suppressed by benzodiazepines in humans. Endocrinologia japonica. 1986 Jun; 33(3):405-14. doi: 10.1507/endocrj1954.33.405. [PMID: 3757924]
  • M Koike, R Norikura, K Sugeno. Effect of food on absorption of 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative from rat small intestine. Journal of pharmacobio-dynamics. 1986 May; 9(5):447-52. doi: 10.1248/bpb1978.9.447. [PMID: 3761134]
  • T Matsubara, A Touchi, N Yamada, K Sugeno. Induction of rat liver microsomal drug-metabolizing enzymes by a new sleep inducer 450191-S and plasma levels of 450191-S-metabolites. Journal of pharmacobio-dynamics. 1986 Mar; 9(3):249-56. doi: 10.1248/bpb1978.9.249. [PMID: 3487632]
  • M Koike, R Norikura, K Sugeno. Intestinal activation of a new sleep inducer 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative, in rats. Journal of pharmacobio-dynamics. 1986 Mar; 9(3):315-20. doi: 10.1248/bpb1978.9.315. [PMID: 3454653]
  • H Tanaka, R Norikura, T Yoshimori, K Sugeno. [Transport of a new sleep-inducer, 1H-1,2,4-triazolyl benzophenone derivative (450191-S), and its active metabolites to the brain in rats and mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1985 Aug; 86(2):129-43. doi: 10.1254/fpj.86.129. [PMID: 4054734]
  • K Yamamoto, M Ueda, A Kurosawa, K Hirose, M Doteuchi, M Nakamura, S Ozaki, S Matsumura, S Matsuda, H Satoh. [Pharmacological studies of a new sleep-inducer, 1H-1,2,4-triazolyl benzophenone derivative (450191-S) (V). General pharmacological activities]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1984 Aug; 84(2):175-212. doi: 10.1254/fpj.84.175. [PMID: 6149178]
  • H Szmigielska. The effect of prolonged vasopressin administration on the level and metabolism of catecholamines in the rat brain and kidneys. Acta physiologica Polonica. 1976 May; 27(3):259-64. doi: NULL. [PMID: 7918]