Tetroxoprim (BioDeep_00000668574)
代谢物信息卡片
化学式: C16H22N4O4 (334.1640972)
中文名称: 四氧普林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COCCOC1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC
InChI: InChI=1S/C16H22N4O4/c1-21-4-5-24-14-12(22-2)7-10(8-13(14)23-3)6-11-9-19-16(18)20-15(11)17/h7-9H,4-6H2,1-3H3,(H4,17,18,19,20)
描述信息
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D000890 - Anti-Infective Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:135420
- KEGGdrug: D06097
- PubChem: 65450
- ChEMBL: CHEMBL32039
- CAS: 53808-87-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- G Gabriëls, E Stockem, J Greven. Potassium-sparing renal effects of trimethoprim and structural analogues.
Nephron.
2000 Sep; 86(1):70-8. doi:
10.1159/000045715
. [PMID: 10971156] - H N Alkaysi, M A Salem, A M Gharaibeh, K I Gharaibeh, A A Badwan. Bioequivalency studies on tablet formulation of tetroxoprim and sulphadiazine.
Journal of clinical pharmacy and therapeutics.
1992 Apr; 17(2):97-9. doi:
10.1111/j.1365-2710.1992.tb01274.x
. [PMID: 1583085] - H N Alkaysi, M S Salem, A A Badwan. High performance liquid chromatographic analysis of tetroxoprim and sulphadiazine in serum and urine.
Biomedical chromatography : BMC.
1991 Nov; 5(6):265-8. doi:
10.1002/bmc.1130050608
. [PMID: 1662101] - V Springolo, G Coppi. HPLC determination of tetroxoprim and sulphadiazine in pharmaceutical dosage forms and in biological fluids.
Journal of pharmaceutical and biomedical analysis.
1989; 7(1):57-65. doi:
10.1016/0731-7085(89)80067-6
. [PMID: 2488608] - F Albert, G B Bishop-Freudling, H Vergin. [Diffusion of tetroxoprim and sulfadiazine in the cerebrospinal fluid of neurosurgery patients].
Fortschritte der Medizin.
1984 Nov; 102(41):1064-6. doi:
NULL
. [PMID: 6500470] - P Iversen, H Vergin, P O Madsen. Renal handling and lymph concentration of tetroxoprim and metioprim: an experimental study in dogs.
The Journal of urology.
1984 Aug; 132(2):362-4. doi:
10.1016/s0022-5347(17)49627-3
. [PMID: 6737599] - H Vergin, G B Bishop-Freudling, N Foing, I Szelenyi, H Armengaud, T van Tho. Diffusion of metioprim, tetroxoprim and sulphadiazine in the cerebrospinal fluid of dogs with healthy meninges and dogs with experimental meningitis.
Chemotherapy.
1984; 30(5):297-304. doi:
10.1159/000238284
. [PMID: 6488935] - P Iversen, P O Madsen. Trimethoprim, metioprim, tetroxoprim, and RO 10-5970 in canine bone.
Acta pharmacologica et toxicologica.
1982 Nov; 51(5):446-9. doi:
10.1111/j.1600-0773.1982.tb01051.x
. [PMID: 7164825] - R Schlöbe, H H Thijssen. Quantitative thin-layer chromatography of trimethoprim and tetroxoprim using fluorescence densitometry.
Journal of chromatography.
1982 Jun; 230(1):212-5. doi:
10.1016/s0378-4347(00)81453-x
. [PMID: 7107764] - A Hofstetter, A Friesen, G B Bishop-Freudling, H Vergin. [Co-tetroxazin levels in the prostatic secretion of patients with subacute and chronic prostatitis].
Fortschritte der Medizin.
1982 Jun; 100(21):1017-20. doi:
NULL
. [PMID: 7106664] - H Vergin, G B Bishop-Freudling, K Merk, I Szelenyi. Pancreatic secretion of benzylpyrimidines. Experimental studies in dogs.
Arzneimittel-Forschung.
1982; 32(10):1302-4. doi:
NULL
. [PMID: 6891232] - H Vergin, K Strobel. The pharmacokinetics of tetroxoprim in the dog.
European journal of drug metabolism and pharmacokinetics.
1982; 7(3):197-202. doi:
10.1007/bf03189566
. [PMID: 7173274] - H Vergin, P Luber. Biliary excretion of tetroxoprim in man.
Chemotherapy.
1982; 28(5):313-7. doi:
10.1159/000238097
. [PMID: 7140420] - J H Hengstmann. Pharmacokinetics of trimethoprim and tetroxoprim. A review.
Antibiotics and chemotherapy.
1982; 31(?):211-25. doi:
10.1159/000400134
. [PMID: 7036848] - V Ascalone. Assay of trimethoprim, sulfadiazine and its N4-acetyl metabolite in biological fluids by normal-phase high-performance liquid chromatography.
Journal of chromatography.
1981 Jun; 224(1):59-66. doi:
10.1016/s0378-4347(00)80138-3
. [PMID: 7263821] - H Vergin, G B Bishop. [High-performance liquid chromatographic determination of tetroxoprim and sulfadiazine in biological samples (author's transl)].
Arzneimittel-Forschung.
1980; 30(2):317-9. doi:
NULL
. [PMID: 7378112] - H Vergin, F W Reutter, R Sieber, H Ferber. [Renal elimination kinetics of tetroxoprim and sulfadiazine in patients with renal insufficiency].
Arzneimittel-Forschung.
1980; 30(2):313-7. doi:
NULL
. [PMID: 7378111]