Clometacin (BioDeep_00000668573)

   


代谢物信息卡片


2-[3-(4-chlorobenzoyl)-6-methoxy-2-methylindol-1-yl]acetic acid

化学式: C19H16ClNO4 (357.07678060000006)
中文名称: 氯美辛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C2=C(N1CC(=O)O)C=C(C=C2)OC)C(=O)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C19H16ClNO4/c1-11-18(19(24)12-3-5-13(20)6-4-12)15-8-7-14(25-2)9-16(15)21(11)10-17(22)23/h3-9H,10H2,1-2H3,(H,22,23)

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D007210 - Indoleacetic Acids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

2 个代谢物同义名

2-[3-(4-chlorobenzoyl)-6-methoxy-2-methylindol-1-yl]acetic acid; Clometacin



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • M Andrejak, R Makdassi, P Fievet, B Coevoet, G Lambrey, P Bataille, J L Sebert, A Fournier. [Renal toxicity of nonsteroidal anti-inflammatory agents and clometacin]. Therapie. 1986 Sep; 41(5):331-7. doi: NULL. [PMID: 3810520]
  • P Lang, G Santelli, S Benarbia, S Moritz, B Charpentier, D Fries. [Immunopathological study of acute interstitial nephropathy induced by clometacin]. Presse medicale (Paris, France : 1983). 1986 May; 15(20):915-8. doi: NULL. [PMID: 2940571]
  • G Deray, A Baumelou, A Hornych, H Merdjan, F de Groc. Acute effects of clometacin on renal prostaglandin biosynthesis in healthy subjects. European journal of clinical pharmacology. 1986; 30(4):499-501. doi: 10.1007/bf00607969. [PMID: 3091372]
  • J C Homberg, N Abuaf, S Helmy-Khalil, M Biour, R Poupon, S Islam, F Darnis, V G Levy, P Opolon, M Beaugrand. Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies. Hepatology (Baltimore, Md.). 1985 Sep; 5(5):722-7. doi: 10.1002/hep.1840050504. [PMID: 4029887]
  • J M Métreau, C André, E S Zafrani, M F Saint-Marc Girardin, A Caruana, D Dhumeaux. [Chronic active hepatitis associated with anti-native DNA antibodies: incidence of drug etiology]. Gastroenterologie clinique et biologique. 1984 Nov; 8(11):833-7. doi: NULL. [PMID: 6396151]
  • E Monnin, P Bories, B Canaud, J J Béraud, P Baldet, J Mirouze, H Michel. [Acute renal failure and hepatitis induced by clometacin]. Gastroenterologie clinique et biologique. 1984 Mar; 8(3):264-8. doi: NULL. [PMID: 6714562]
  • A Kopf, F Boue, J F Delfraissy, M Charton, J M Brisset, J M Duclos, P Galanaud. [Eosinophilic cystitis of allergic origin]. Presse medicale (Paris, France : 1983). 1984 Jan; 13(2):83-6. doi: NULL. [PMID: 6229734]
  • S Lavaud, B Mamez, F Lavaud, P Birembaut, O Toupance, J P Brunois, J Chanard. [Acute renal failure caused by clometacin hypersensitivity]. Nephrologie. 1984; 5(3):131-4. doi: NULL. [PMID: 6493431]
  • R Zini, J Barre, P D'Athis, J P Tillement. Binding of clometacin to human serum albumin. Interactions with clofibrate, indomethacin, salicylic acid and warfarin. Biochemical pharmacology. 1983 Oct; 32(19):2909-14. doi: 10.1016/0006-2952(83)90395-7. [PMID: 6626262]
  • D Clerc, J F Delfraissy, D Sallière, C Ramain, M Bisson, P Massias. [Acute renal insufficiency with ketoprofen and clometacin]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1983 May; 59(21):1613-5. doi: NULL. [PMID: 6310774]
  • D Perotin, C Labram. [Reversible renal insufficiency due to clometacin treatment]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1983 May; 59(20):1549-50. doi: NULL. [PMID: 6308779]
  • A Caruana, C Andre, E S Zafrani, M F Girardin, J M Metreau, D Dhumeaux. Serum antibodies against double-stranded DNA in chronic active hepatitis: an index of drug-induced liver disease?. Lancet (London, England). 1983 Apr; 1(8327):776. doi: 10.1016/s0140-6736(83)92073-1. [PMID: 6132127]
  • C Jacquot, A Hornych, C d'Auzac de la Martinie, J Bariéty. [Acute renal insufficiency caused by clometacin. Relapse with diclofenac. Inhibition of the synthesis of prostaglandins]. La Revue de medecine interne. 1982 Dec; 3(4):349-51. doi: 10.1016/s0248-8663(82)80043-x. [PMID: 7163673]
  • I Mary, B Hercelin, R Deraedt. [Clometacin--3. Correlation between plasma levels and analgesic activity in the mouse]. Journal de pharmacie de Belgique. 1982 Nov; 37(6):418-21. doi: NULL. [PMID: 7161701]
  • J Van Cantfort, J De Graeve, B Hercelin, J E Gielen. [Clometacin--1. Metabolism and bioavailability of clometacin and its metabolites in the rat]. Journal de pharmacie de Belgique. 1982 Nov; 37(6):401-9. doi: NULL. [PMID: 7161699]
  • J Van Cantfort, I Mary, J E Gielen. [Clometacin--2. Metabolism and bioavailability in the monkey and in man]. Journal de pharmacie de Belgique. 1982 Nov; 37(6):410-7. doi: NULL. [PMID: 7161700]
  • P Pasquier, G Desfosses, Y Magar, J Aerts. [Reversible acute renal insufficiency caused by clometacin. A case]. La Nouvelle presse medicale. 1982 Oct; 11(41):3064-5. doi: NULL. [PMID: 7145694]
  • D Pessayre, F Degos, G Feldmann, C Degott, J Bernuau, J P Benhamou. Chronic active hepatitis and giant multinucleated hepatocytes in adults treated with clometacin. Digestion. 1981; 22(2):66-72. doi: 10.1159/000198597. [PMID: 7274607]
  • A Ashford. [Effects of adrenergic blockade on adipose tissue lipolysis provoked in cats and humans by intravenous perfusion of isoprenaline]. La Nouvelle presse medicale. 1975 Dec; 4(46 Suppl):3265-7. doi: . [PMID: 3767]
  • P E Phillips. The virus hypothesis in systemic lupus erythematosus. Annals of internal medicine. 1975 Nov; 83(5):709-15. doi: 10.7326/0003-4819-83-5-709. [PMID: 938]