Ifetroban (BioDeep_00000668527)
代谢物信息卡片
Ifetroban
化学式: C25H32N2O5 (440.2311102)
中文名称: 伊非曲班
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCNC(=O)C1=COC(=N1)C2C3CCC(C2CC4=CC=CC=C4CCC(=O)O)O3
InChI: InChI=1S/C25H32N2O5/c1-2-3-6-13-26-24(30)19-15-31-25(27-19)23-18(20-10-11-21(23)32-20)14-17-8-5-4-7-16(17)9-12-22(28)29/h4-5,7-8,15,18,20-21,23H,2-3,6,9-14H2,1H3,(H,26,30)(H,28,29)/t18-,20-,21+,23-/m0/s1
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:188730
- PubChem: 3037233
- DrugBank: DB12321
- ChEMBL: CHEMBL3301673
- CAS: 143443-90-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tanya M Laidlaw, Joshua A Boyce. Platelets in patients with aspirin-exacerbated respiratory disease.
The Journal of allergy and clinical immunology.
2015 Jun; 135(6):1407-14; quiz 1415. doi:
10.1016/j.jaci.2015.02.005. [PMID: 26051947] - Amin A Nanji, Emily C Liong, Jia Xiao, George L Tipoe. Thromboxane inhibitors attenuate inflammatory and fibrotic changes in rat liver despite continued ethanol administrations.
Alcoholism, clinical and experimental research.
2013 Jan; 37(1):31-9. doi:
10.1111/j.1530-0277.2012.01838.x. [PMID: 22676331] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Dan Wang, Tina Chabrashvili, Christopher S Wilcox. Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium.
Circulation research.
2004 Jun; 94(11):1436-42. doi:
10.1161/01.res.0000129578.76799.75. [PMID: 15117817] - Natalia de las Heras, Eva Cediel, M Pilar Oubiña, Paloma Aragoncillo, David Sanz-Rosa, Vicente Lahera, Victoria Cachofeiro. Comparison between the effects of mixed dyslipidaemia and hypercholesterolaemia on endothelial function, atherosclerotic lesions and fibrinolysis in rabbits.
Clinical science (London, England : 1979).
2003 Apr; 104(4):357-65. doi:
10.1042/cs20020199. [PMID: 12653677] - Eva Cediel, Beatriz Vázquez-Cruz, Josefa Navarro-Cid, Natalia de las Heras, David Sanz-Rosa, Victoria Cachofeiro, Vicente Lahera. Role of endothelin-1 and thromboxane A2 in renal vasoconstriction induced by angiotensin II in diabetes and hypertension.
Kidney international. Supplement.
2002 Dec; ?(82):S2-7. doi:
10.1046/j.1523-1755.62.s82.2.x. [PMID: 12410847] - L Rosenfeld, G J Grover, C T Stier. Ifetroban sodium: an effective TxA2/PGH2 receptor antagonist.
Cardiovascular drug reviews.
2001; 19(2):97-115. doi:
10.1111/j.1527-3466.2001.tb00058.x. [PMID: 11484065] - S Vázquez-Pérez, P Aragoncillo, N de Las Heras, J Navarro-Cid, E Cediel, D Sanz-Rosa, L M Ruilope, C Díaz, G Hernández, V Lahera, V Cachofeiro. Atorvastatin prevents glomerulosclerosis and renal endothelial dysfunction in hypercholesterolaemic rabbits.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2001; 16 Suppl 1(?):40-4. doi:
10.1093/ndt/16.suppl_1.40. [PMID: 11369819] - R C Dockens, K S Santone, J G Mitroka, R A Morrison, M Jemal, D S Greene, R H Barbhaiya. Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humans.
Drug metabolism and disposition: the biological fate of chemicals.
2000 Aug; 28(8):973-80. doi:
NULL. [PMID: 10901709] - J V Quinn, G J Slotman. Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock.
Critical care medicine.
1999 Nov; 27(11):2485-94. doi:
10.1097/00003246-199911000-00027. [PMID: 10579269] - H Gao, B Peng, W J Welch, C S Wilcox. Central thromboxane receptors: mRNA expression and mediation of pressor responses.
The American journal of physiology.
1997 May; 272(5 Pt 2):R1493-500. doi:
10.1152/ajpregu.1997.272.5.r1493. [PMID: 9176341] - A A Nanji, S Khwaja, A Rahemtulla, L Miao, S Zhao, S R Tahan. Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat.
Gastroenterology.
1997 Jan; 112(1):200-7. doi:
10.1016/s0016-5085(97)70236-1. [PMID: 8978360] - C S Wilcox, J Cardozo, W J Welch. AT1 and TxA2/PGH2 receptors maintain hypertension throughout 2K,1C Goldblatt hypertension in the rat.
The American journal of physiology.
1996 Oct; 271(4 Pt 2):R891-6. doi:
10.1152/ajpregu.1996.271.4.r891. [PMID: 8897978] - E R Mohler, M T Franklin, L P Adam. Intracellular signaling by 8-epi-prostaglandin F2 alpha is mediated by thromboxane A2/prostaglandin endoperoxide receptors in porcine carotid arteries.
Biochemical and biophysical research communications.
1996 Aug; 225(3):915-23. doi:
10.1006/bbrc.1996.1272. [PMID: 8780711] - M Jemal, A Patel, D S Teitz. Direct injection for high sample throughput capillary gas chromatographic-mass spectrometric bioanalysis.
Journal of chromatography. B, Biomedical applications.
1995 Apr; 666(2):251-7. doi:
10.1016/0378-4347(94)00581-o. [PMID: 7633601] - A W Gomoll, M L Ogletree. Failure of aspirin to interfere with the cardioprotective effects of ifetroban.
European journal of pharmacology.
1994 Dec; 271(2-3):471-9. doi:
10.1016/0014-2999(94)90808-7. [PMID: 7705447] - G Remuzzi, M Noris, A Benigni, O Imberti, M H Sayegh, N Perico. Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides.
The Journal of experimental medicine.
1994 Nov; 180(5):1967-72. doi:
10.1084/jem.180.5.1967. [PMID: 7964472] - W A Schumacher, C L Heran, T E Steinbacher, S Youssef, M L Ogletree. Superior activity of a thromboxane receptor antagonist as compared with aspirin in rat models of arterial and venous thrombosis.
Journal of cardiovascular pharmacology.
1993 Oct; 22(4):526-33. doi:
10.1097/00005344-199310000-00004. [PMID: 7505353] - R N Misra, B R Brown, P M Sher, M M Patel, S E Hall, W C Han, J C Barrish, O Kocy, D N Harris, H J Goldenberg. Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists.
Journal of medicinal chemistry.
1993 May; 36(10):1401-17. doi:
10.1021/jm00062a013. [PMID: 8496908] - M L Ogletree, D N Harris, W A Schumacher, M L Webb, R N Misra. Pharmacological profile of BMS 180,291: a potent, long-acting, orally active thromboxane A2/prostaglandin endoperoxide receptor antagonist.
The Journal of pharmacology and experimental therapeutics.
1993 Feb; 264(2):570-8. doi:
NULL. [PMID: 8437108]