Desoxycorticosterone pivalate (BioDeep_00000668484)

   


代谢物信息卡片


Desoxycorticosterone pivalate

化学式: C26H38O4 (414.277)
中文名称: 脱氧皮质酮新戊酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC3C(C1CCC2C(=O)COC(=O)C(C)(C)C)CCC4=CC(=O)CCC34C
InChI: InChI=1S/C26H38O4/c1-24(2,3)23(29)30-15-22(28)21-9-8-19-18-7-6-16-14-17(27)10-12-25(16,4)20(18)11-13-26(19,21)5/h14,18-21H,6-13,15H2,1-5H3/t18-,19-,20-,21+,25-,26-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

1 个代谢物同义名

Desoxycorticosterone pivalate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Alysha M Vincent, Linda K Okonkowski, Jean M Brudvig, Kent R Refsal, Nora Berghoff, N Bari Olivier, Daniel K Langlois. Low-dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial. Journal of veterinary internal medicine. 2021 Jul; 35(4):1720-1728. doi: 10.1111/jvim.16195. [PMID: 34114259]
  • Nadia S Sieber-Ruckstuhl, Claudia E Reusch, Nathalie Hofer-Inteeworn, Claudia Kuemmerle-Fraune, Claudia Müller, Regina Hofmann-Lehmann, Felicitas S Boretti. Evaluation of a low-dose desoxycorticosterone pivalate treatment protocol for long-term management of dogs with primary hypoadrenocorticism. Journal of veterinary internal medicine. 2019 May; 33(3):1266-1271. doi: 10.1111/jvim.15475. [PMID: 30865322]
  • J A Jaffey, P Nurre, A B Cannon, A E DeClue. Desoxycorticosterone Pivalate Duration of Action and Individualized Dosing Intervals in Dogs with Primary Hypoadrenocorticism. Journal of veterinary internal medicine. 2017 Nov; 31(6):1649-1657. doi: 10.1111/jvim.14828. [PMID: 28892205]
  • J A Bates, S Shott, W D Schall. Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism. Australian veterinary journal. 2013 Mar; 91(3):77-82; discussion 81. doi: 10.1111/avj.12019. [PMID: 23438457]
  • Megan M Greenlee, I Jeanette Lynch, Michelle L Gumz, Brian D Cain, Charles S Wingo. Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases. Journal of the American Society of Nephrology : JASN. 2011 Jan; 22(1):49-58. doi: 10.1681/asn.2010030311. [PMID: 21164026]
  • Miyoko Saito, Natasha J Olby, Leticia Obledo, Jody L Gookin. Muscle cramps in two standard poodles with hypoadrenocorticism. Journal of the American Animal Hospital Association. 2002 Sep; 38(5):437-43. doi: 10.5326/0380437. [PMID: 12220028]
  • M D McCabe, E C Feldman, R C Lynn, P H Kass. Subcutaneous administration of desoxycorticosterone pivalate for the treatment of canine hypoadrenocorticism. Journal of the American Animal Hospital Association. 1995 Mar; 31(2):151-5. doi: 10.5326/15473317-31-2-151. [PMID: 7773761]
  • A J Kaplan, M E Peterson. Effects of desoxycorticosterone pivalate administration on blood pressure in dogs with primary hypoadrenocorticism. Journal of the American Veterinary Medical Association. 1995 Feb; 206(3):327-31. doi: NULL. [PMID: 7751240]
  • H Mäkynen, P Arvola, H Vapaatalo, I Pörsti. High calcium diet effectively opposes the development of deoxycorticosterone-salt hypertension in rats. American journal of hypertension. 1994 Jun; 7(6):520-8. doi: 10.1093/ajh/7.6.520. [PMID: 7917150]
  • E Chow, W R Campbell, J C Turnier, R C Lynn, K L Pavkov. Toxicity of desoxycorticosterone pivalate given at high dosages to clinically normal beagles for six months. American journal of veterinary research. 1993 Nov; 54(11):1954-61. doi: NULL. [PMID: 8291779]
  • R C Lynn, E C Feldman, R W Nelson. Efficacy of microcrystalline desoxycorticosterone pivalate for treatment of hypoadrenocorticism in dogs. DOCP Clinical Study Group. Journal of the American Veterinary Medical Association. 1993 Feb; 202(3):392-6. doi: NULL. [PMID: 8440628]
  • R C Lynn, E C Feldman. Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate. The British veterinary journal. 1991 Sep; 147(5):478-83. doi: 10.1016/0007-1935(91)90091-z. [PMID: 1959020]
  • S M Wall, J M Sands, M F Flessner, H Nonoguchi, K R Spring, M A Knepper. Net acid transport by isolated perfused inner medullary collecting ducts. The American journal of physiology. 1990 Jan; 258(1 Pt 2):F75-84. doi: 10.1152/ajprenal.1990.258.1.f75. [PMID: 2301597]
  • K Tomita, K Ujiie, Y Maeda, Y Iino, N Yoshiyama, T Shiigai. Effects of mineralocorticoid on kininase activity along the distal nephron segments of the rat. Advances in experimental medicine and biology. 1989; 247A(?):181-4. doi: 10.1007/978-1-4615-9543-4_25. [PMID: 2557738]
  • M J Osborne-Pellegrin, M Coutard. Effect of contralateral nephrectomy alone or in association with hypertension on rat renal artery lesions. Atherosclerosis. 1985 Nov; 57(2-3):267-80. doi: 10.1016/0021-9150(85)90039-5. [PMID: 4084358]
  • J F Burris, B Waeber, J Nussberger, H R Brunner. Enhanced acute antihypertensive effect of propranolol in the absence of circulating epinephrine in the rat. Journal of cardiovascular pharmacology. 1984 Jul; 6(4):697-700. doi: 10.1097/00005344-198407000-00023. [PMID: 6206328]
  • V BUSACCHI. [Clinical study of desoxycorticosterone trimethylacetate]. Gazzetta medica italiana. 1954 Sep; 113(9):285-9. doi: NULL. [PMID: 13232218]