hydromorphone hydrochloride (BioDeep_00000667004)
代谢物信息卡片
hydromorphone hydrochloride
化学式: C17H20ClNO3 (321.1131640000001)
中文名称: 盐酸氢吗啡酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(=O)CC4.Cl
InChI: /m0./s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:5791
- KEGGdrug: D00839
- PubChem: 5462347
- ChEMBL: CHEMBL1237055
- MeSH: Hydromorphone
- CAS: 71-68-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Thomas Shi, Jennifer L Shea. A case of fatal overdose involving both hydromorphone and kratom.
Journal of forensic sciences.
2023 Sep; ?(?):. doi:
10.1111/1556-4029.15394. [PMID: 37753815] - Thomas D Brothers, Malcolm Leaman, Matthew Bonn, Dan Lewer, Jacqueline Atkinson, John Fraser, Amy Gillis, Michael Gniewek, Leisha Hawker, Heather Hayman, Peter Jorna, David Martell, Tiffany O'Donnell, Helen Rivers-Bowerman, Leah Genge. Evaluation of an emergency safe supply drugs and managed alcohol program in COVID-19 isolation hotel shelters for people experiencing homelessness.
Drug and alcohol dependence.
2022 06; 235(?):109440. doi:
10.1016/j.drugalcdep.2022.109440. [PMID: 35461084] - Marthe M Vandeputte, Nick Verougstraete, Donna Walther, Grant C Glatfelter, Jeroen Malfliet, Michael H Baumann, Alain G Verstraete, Christophe P Stove. First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass.
Archives of toxicology.
2022 06; 96(6):1865-1880. doi:
10.1007/s00204-022-03294-2. [PMID: 35449307] - Zhong-Biao Nie, Zhi-Hong Li, Bin Lu, Yao-Yao Guo, Ran Zhang. Hydromorphone vs sufentanil in patient-controlled analgesia for postoperative pain management: A meta-analysis.
Medicine.
2022 Jan; 101(3):e28615. doi:
10.1097/md.0000000000028615. [PMID: 35060534] - Yoshito Kumagai. Biotransformation of Morphinone and Its Glutathione Adduct Derived from Morphine by Anaerobic Gut Microbes in Guinea Pigs.
Biological & pharmaceutical bulletin.
2022; 45(7):968-971. doi:
10.1248/bpb.b22-00240. [PMID: 35786605] - Orlando Garner, Jonathan Patterson, Julieta Muñoz Mejia, Vijay Anand, Juan Deleija, Christopher Nemeh, Meghna Vallabh, Kristen A Staggers, Christopher M Howard, Sergio Enrique Treviño, Muhammad Asim Siddique, Christopher K Morgan. Impact of ketamine as an adjunct sedative in acute respiratory distress syndrome due to COVID-19 Pneumonia.
Respiratory medicine.
2021 Nov; 189(?):106667. doi:
10.1016/j.rmed.2021.106667. [PMID: 34757277] - Rongbo Lin, Sunzhi Lin, Shuitu Feng, Qingyi Wu, Jianqian Fu, Fang Wang, Hui Li, Xiaofeng Li, Gaowang Zhang, Yongzhi Yao, Min Xin, Tianyang Lai, Xia Lv, Yigui Chen, Shangwang Yang, Yubiao Lin, Lixia Hong, Zhenyu Cai, Jianfeng Wang, Gen Lin, Shaowei Lin, Shen Zhao, Jinfeng Zhu, Cheng Huang. Comparing Patient-Controlled Analgesia Versus Non-PCA Hydromorphone Titration for Severe Cancer Pain: A Randomized Phase III Trial.
Journal of the National Comprehensive Cancer Network : JNCCN.
2021 08; 19(10):1148-1155. doi:
10.6004/jnccn.2020.7699. [PMID: 34343968] - Terhi J Lohela, Satu Poikola, Mikko Neuvonen, Mikko Niemi, Janne T Backman, Klaus T Olkkola, Tuomas O Lilius. Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers.
Anesthesia and analgesia.
2021 08; 133(2):423-434. doi:
10.1213/ane.0000000000005229. [PMID: 33177323] - Zhi-Hao Yang, Xiao-Qiong Xia, Xiang Gao, Yong-Bo Yu, Ren-Jie Gong, Yuan-Hai Li. [Effects of low-dose dexmedetomidine combined with hydromorphone in postoperative analgesia and on the serum IL-6 and CRP levels of prostate cancer patients].
Zhonghua nan ke xue = National journal of andrology.
2021 Aug; 27(8):713-717. doi:
. [PMID: 34914243] - Min Zhuo, Laura K Triantafylidis, Jiahua Li, Julie M Paik. Opioid Use in the Nondialysis Chronic Kidney Disease Population.
Seminars in nephrology.
2021 01; 41(1):33-41. doi:
10.1016/j.semnephrol.2021.02.004. [PMID: 33896472] - Daniel Brunnhoelzl, Alexander N Hanania, Alfredo Echeverria, Jan Sunde, Connie Tran, Michelle Ludwig. Paracervical blocks facilitate timely brachytherapy amidst COVID-19.
Brachytherapy.
2021 Jan; 20(1):284-289. doi:
10.1016/j.brachy.2020.08.002. [PMID: 32891569] - Andreas Wehrfritz, Harald Ihmsen, Tobias Fuchte, Michael Kim, Sven Kremer, Alexander Weiß, Jürgen Schüttler, Christian Jeleazcov. Postoperative pain therapy with hydromorphone; comparison of patient-controlled analgesia with target-controlled infusion and standard patient-controlled analgesia: A randomised controlled trial.
European journal of anaesthesiology.
2020 12; 37(12):1168-1175. doi:
10.1097/eja.0000000000001360. [PMID: 33009192] - Ke Ma, Yi Jin, Lin Wang, Zhi-Ying Feng, Tao Song, Xiao-Qiu Yang, Fu-Qiang Chen, Bao-Lin Duan, You-Qing Huang, Guang-Lun Xie, Hong-Guang Bao, Kun Wang, Jiang-Tao Xu, Yan Lu, Yan-Qing Liu. Intrathecal delivery of hydromorphone vs morphine for refractory cancer pain: a multicenter, randomized, single-blind, controlled noninferiority trial.
Pain.
2020 11; 161(11):2502-2510. doi:
10.1097/j.pain.0000000000001957. [PMID: 32569090] - Payel J Roy, Melanie Weltman, Laura M Dember, Jane Liebschutz, Manisha Jhamb. Pain management in patients with chronic kidney disease and end-stage kidney disease.
Current opinion in nephrology and hypertension.
2020 11; 29(6):671-680. doi:
10.1097/mnh.0000000000000646. [PMID: 32941189] - David Sanchez-Migallon Guzman, Heather Knych, Jamie Douglas, Joanne R Paul-Murphy. Pharmacokinetics of hydromorphone hydrochloride after intramuscular and intravenous administration of a single dose to orange-winged Amazon parrots (Amazona amazonica).
American journal of veterinary research.
2020 Nov; 81(11):894-898. doi:
10.2460/ajvr.81.11.894. [PMID: 33107746] - Minze Zhu, Andrew K Whittaker, Xingyu Jiang, Rupei Tang, Xuanyu Li, Weizhi Xu, Changkui Fu, Maree T Smith, Felicity Y Han. Use of Microfluidics to Fabricate Bioerodable Lipid Hybrid Nanoparticles Containing Hydromorphone or Ketamine for the Relief of Intractable Pain.
Pharmaceutical research.
2020 Oct; 37(10):211. doi:
10.1007/s11095-020-02939-0. [PMID: 33009588] - Rajiv Balyan, Min Dong, Valentina Pilipenko, Kristie Geisler, Alexander A Vinks, Vidya Chidambaran. Hydromorphone population pharmacokinetics in pediatric surgical patients.
Paediatric anaesthesia.
2020 10; 30(10):1091-1101. doi:
10.1111/pan.13975. [PMID: 32702184] - Yelizaveta Sher, Beatrice Rabkin, José R Maldonado, Paul Mohabir. COVID-19-Associated Hyperactive Intensive Care Unit Delirium With Proposed Pathophysiology and Treatment: A Case Report.
Psychosomatics.
2020 Sep; 61(5):544-550. doi:
10.1016/j.psym.2020.05.007. [PMID: 32591212] - Robert Root-Bernstein, Beth Churchill, Miah Turke. Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21176230. [PMID: 32872204] - Felipe C Martins, Stephanie Cj Keating, Stuart C Clark-Price, David J Schaeffer, Kara M Lascola, Heather DiMaio Knych. Pharmacokinetics and pharmacodynamics of hydromorphone hydrochloride in healthy horses.
Veterinary anaesthesia and analgesia.
2020 Jul; 47(4):509-517. doi:
10.1016/j.vaa.2020.03.005. [PMID: 32409257] - Terhi Puhto, Merja Kokki, Henriikka Hakomäki, Michael Spalding, Teemu Gunnar, Seppo Alahuhta, Merja Vakkala. Single dose epidural hydromorphone in labour pain: maternal pharmacokinetics and neonatal exposure.
European journal of clinical pharmacology.
2020 Jul; 76(7):969-977. doi:
10.1007/s00228-020-02880-6. [PMID: 32363420] - Shane E Brogan, Jill E Sindt, Carina M Jackman, Julia White, Victoria Wilding, Akiko Okifuji. Prospective Association of Serum Opioid Levels and Clinical Outcomes in Patients With Cancer Pain Treated With Intrathecal Opioid Therapy.
Anesthesia and analgesia.
2020 04; 130(4):1035-1044. doi:
10.1213/ane.0000000000004276. [PMID: 31206429] - Barbara Ambros, Heather K Knych, Miranda J Sadar. Pharmacokinetics of hydromorphone hydrochloride after intravenous and intramuscular administration in guinea pigs (Cavia porcellus).
American journal of veterinary research.
2020 Apr; 81(4):361-366. doi:
10.2460/ajvr.81.4.361. [PMID: 32228262] - Rachel A Reed, Heather K Knych, Michele Barletta, Daniel M Sakai, Melanie M Ruch, Carly A Smyth, Clare A Ryan. Pharmacokinetics and pharmacodynamics of hydromorphone after intravenous and intramuscular administration in horses.
Veterinary anaesthesia and analgesia.
2020 Mar; 47(2):210-218. doi:
10.1016/j.vaa.2019.08.049. [PMID: 31959534] - Joseph A Rakowski, Robert W Holloway, Sarfraz Ahmad, Corinne N Jeppson, Jeffrey A James, Giselle B Ghurani, Glenn E Bigsby, James E Kendrick. A prospective randomized trial of intravenous ketorolac vs. acetaminophen administered with opioid patient-controlled analgesia in gynecologic surgery.
Gynecologic oncology.
2019 12; 155(3):468-472. doi:
10.1016/j.ygyno.2019.09.019. [PMID: 31601494] - Marcela L Machado, Joao Hn Soares, Bruno H Pypendop, Natalia Henao-Guerrero, Noah D Pavlisko, Juliet Ross. Effect of heart rate on the pharmacokinetics of fentanyl in dogs anesthetized with isoflurane and hydromorphone.
Veterinary anaesthesia and analgesia.
2019 Nov; 46(6):736-744. doi:
10.1016/j.vaa.2019.06.005. [PMID: 31353195] - Keivan Hosseinnejad, Tyler Yin, Jeremy T Gaskins, M Elaine Stauble, Yanhong Wu, Paul Jannetto, Loralie L Langman, Saeed A Jortani. Lack of Influence by CYP3A4 and CYP3A5 Genotypes on Pain Relief by Hydrocodone in Postoperative Cesarean Section Pain Management.
The journal of applied laboratory medicine.
2019 05; 3(6):954-964. doi:
10.1373/jalm.2018.026070. [PMID: 31639687] - Rachel Reed, Michele Barletta, Krista Mitchell, Amanda Hanafi, Annie Bullington, Heather Knych, Jane Quandt, Clare Ryan, Steeve Giguère. The pharmacokinetics and pharmacodynamics of intravenous hydromorphone in horses.
Veterinary anaesthesia and analgesia.
2019 May; 46(3):395-404. doi:
10.1016/j.vaa.2018.11.001. [PMID: 30930095] - Shawna J Hawkins, Sherry Cox, Taylor J Yaw, Kurt Sladky. Pharmacokinetics of subcutaneously administered hydromorphone in bearded dragons (Pogona vitticeps) and red-eared slider turtles (Trachemys scripta elegans).
Veterinary anaesthesia and analgesia.
2019 May; 46(3):352-359. doi:
10.1016/j.vaa.2018.12.002. [PMID: 30827804] - Naoki Kiyosawa, Kenji Watanabe, Kaoru Toyama, Hitoshi Ishizuka. Circulating miRNA Signature as a Potential Biomarker for the Prediction of Analgesic Efficacy of Hydromorphone.
International journal of molecular sciences.
2019 Apr; 20(7):. doi:
10.3390/ijms20071665. [PMID: 30987164] - Megan L Schultz, Mark Kostic, Sigmund Kharasch. A Case of Toxic Breast-feeding?.
Pediatric emergency care.
2019 Jan; 35(1):e9-e10. doi:
10.1097/pec.0000000000001009. [PMID: 28067687] - Abdisamad M Ibrahim, Zainab Obaidi, Gordon Ruan, Dorcas Adaramola, Sharon Onguti. Nalbuphine for Opioid-Induced Urine Retention.
Annals of internal medicine.
2018 12; 169(12):894-895. doi:
10.7326/l18-0387. [PMID: 30178006] - Robert West, Charles Mikel, Doriane Hofilena, Maria Guevara. Positivity rates of drugs in patients treated for opioid dependence with buprenorphine: A comparison of oral fluid and urine using paired collections and LC-MS/MS.
Drug and alcohol dependence.
2018 12; 193(?):183-191. doi:
10.1016/j.drugalcdep.2018.07.023. [PMID: 30391868] - Sherry Cox, Joan Bergman, Shawna Hawkins, Kurt Sladky. Development of a method for the determination of hydromorphone in plasma by LC-MS.
Biomedical chromatography : BMC.
2018 Dec; 32(12):e4357. doi:
10.1002/bmc.4357. [PMID: 30074252] - Y Liu, L Yang, S-J Tao. Effects of hydromorphone and morphine intravenous analgesia on plasma motilin and postoperative nausea and vomiting in patients undergoing total hysterectomy.
European review for medical and pharmacological sciences.
2018 09; 22(17):5697-5703. doi:
10.26355/eurrev_201809_15837. [PMID: 30229847] - Emma L Houck, David Sanchez-Migallon Guzman, Hugues Beaufrère, Heather K Knych, Joanne R Paul-Murphy. Evaluation of the thermal antinociceptive effects and pharmacokinetics of hydromorphone hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus).
American journal of veterinary research.
2018 Aug; 79(8):820-827. doi:
10.2460/ajvr.79.8.820. [PMID: 30058846] - Geeta Nagpal, Heather Heiman, Shannon Haymond. Interpretation of Urine Drug Screens: Metabolites and Impurities.
JAMA.
2017 Nov; 318(17):1704-1705. doi:
10.1001/jama.2017.10910. [PMID: 29114811] - Kevin Krock, Amadeo Pesce, Dennis Ritz, Richard Thomas, Agnes Cua, Ryan Rogers, Phil Lipnick, Kristen Kilbourn. Lower Cutoffs for LC-MS/MS Urine Drug Testing Indicates Better Patient Compliance.
Pain physician.
2017 11; 20(7):E1107-E1113. doi:
10.36076/ppj/2017.7.e1107. [PMID: 29149155] - Kaoru Toyama, Naoki Kiyosawa, Kenji Watanabe, Hitoshi Ishizuka. Identification of Circulating miRNAs Differentially Regulated by Opioid Treatment.
International journal of molecular sciences.
2017 Sep; 18(9):. doi:
10.3390/ijms18091991. [PMID: 28926935] - Sharon L Walsh, Sandra D Comer, Michelle R Lofwall, Bradley Vince, Naama Levy-Cooperman, Debra Kelsh, Marion A Coe, Jermaine D Jones, Paul A Nuzzo, Fredrik Tiberg, Behshad Sheldon, Sonnie Kim. Effect of Buprenorphine Weekly Depot (CAM2038) and Hydromorphone Blockade in Individuals With Opioid Use Disorder: A Randomized Clinical Trial.
JAMA psychiatry.
2017 09; 74(9):894-902. doi:
10.1001/jamapsychiatry.2017.1874. [PMID: 28655025] - Heather Palis, Kirsten Marchand, Daphne Guh, Suzanne Brissette, Kurt Lock, Scott MacDonald, Scott Harrison, Aslam H Anis, Michael Krausz, David C Marsh, Martin T Schechter, Eugenia Oviedo-Joekes. Men's and women's response to treatment and perceptions of outcomes in a randomized controlled trial of injectable opioid assisted treatment for severe opioid use disorder.
Substance abuse treatment, prevention, and policy.
2017 05; 12(1):25. doi:
10.1186/s13011-017-0110-9. [PMID: 28526048] - Harald Ihmsen, Doris Rohde, Jürgen Schüttler, Christian Jeleazcov. External Validation of a Recently Developed Population Pharmacokinetic Model for Hydromorphone During Postoperative Pain Therapy.
European journal of drug metabolism and pharmacokinetics.
2017 Feb; 42(1):17-28. doi:
10.1007/s13318-015-0318-x. [PMID: 26797808] - Robert B Dixon, Amitava Dasgupta. Suitability of the DRI Hydrocodone/Hydromorphone Immunoassay in the Clinical Environment at a Lower Cutoff: Validation With LC-MS/MS Analysis.
Therapeutic drug monitoring.
2016 12; 38(6):787-790. doi:
10.1097/ftd.0000000000000339. [PMID: 27764026] - Kathleen A Lee, Niharika Ganta, Jay R Horton, Emily Chai. Evidence for Neurotoxicity Due to Morphine or Hydromorphone Use in Renal Impairment: A Systematic Review.
Journal of palliative medicine.
2016 11; 19(11):1179-1187. doi:
10.1089/jpm.2016.0101. [PMID: 27399959] - Anne Z DePriest, Rebecca Heltsley, David L Black, John M Mitchell, Charles LoDico, Ronald Flegel, Edward J Cone. Prescription Opioids. VI. Metabolism and Excretion of Hydromorphone in Urine Following Controlled Single-Dose Administration.
Journal of analytical toxicology.
2016 Oct; 40(8):575-582. doi:
10.1093/jat/bkw066. [PMID: 27405368] - Pongkwan Sitasuwan, Cathleen Melendez, Margarita Marinova, Kaylee R Mastrianni, Alicia Darragh, Emily Ryan, L Andrew Lee. Degradation of Opioids and Opiates During Acid Hydrolysis Leads to Reduced Recovery Compared to Enzymatic Hydrolysis.
Journal of analytical toxicology.
2016 Oct; 40(8):601-607. doi:
10.1093/jat/bkw085. [PMID: 27702939] - Renata Nascimento, Alphonse Poklis, Carl E Wolf. Evaluation of a Newly Formulated Enzyme Immunoassay for the Detection of Hydrocodone and Hydromorphone in Pain Management Compliance Testing.
Journal of analytical toxicology.
2016 Oct; 40(8):583-587. doi:
10.1093/jat/bkw080. [PMID: 27562969] - Waseem Gul, Brandon Stamper, Murrell Godfrey, Shahbaz W Gul, Mahmoud A ElSohly. LC-MS-MS Method for Analysis of Opiates in Wastewater During Football Games II.
Journal of analytical toxicology.
2016 Jun; 40(5):330-7. doi:
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American journal of surgery.
2016 Mar; 211(3):565-70. doi:
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Anesthesiology.
2016 Jan; 124(1):56-68. doi:
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The western journal of emergency medicine.
2015 Dec; 16(7):1079-83. doi:
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Clinical biochemistry.
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American journal of veterinary research.
2015 Sep; 76(9):763-70. doi:
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Journal of clinical pharmacology.
2015 Sep; 55(9):975-84. doi:
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Journal of analytical toxicology.
2015 Jan; 39(1):24-8. doi:
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Journal of analytical toxicology.
2014 Nov; 38(9):653-9. doi:
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Journal of clinical pharmacology.
2014 Oct; 54(10):1170-9. doi:
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British journal of anaesthesia.
2014 Oct; 113(4):677-87. doi:
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Nature chemical biology.
2014 Oct; 10(10):837-44. doi:
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Pain medicine (Malden, Mass.).
2014 Sep; 15(9):1488-95. doi:
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American journal of veterinary research.
2014 Jun; 75(6):527-31. doi:
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Journal of opioid management.
2014 May; 10(3):177-86. doi:
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Journal of analytical toxicology.
2014 Mar; 38(2):86-91. doi:
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2014 Mar; 52(3):217-26. doi:
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