Dexfenfluramine hydrochloride (BioDeep_00000665674)
代谢物信息卡片
(S)-fenfluramine hydrochloride
化学式: C12H17ClF3N (267.1002)
中文名称: 右盐酸芬氟拉明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCNC(C)CC1=CC(=CC=C1)C(F)(F)F.Cl
InChI: 1H/t9-
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:59730
- KEGGdrug: D03713
- PubChem: 66264
- ChEMBL: CHEMBL1887891
- MeSH: Dexfenfluramine
- CAS: 3239-45-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Boris B Quednow, Valerie Treyer, Felix Hasler, Nadja Dörig, Matthias T Wyss, Cyrill Burger, Katharina M Rentsch, Gerrit Westera, Pius August Schubiger, Alfred Buck, Franz X Vollenweider. Assessment of serotonin release capacity in the human brain using dexfenfluramine challenge and [18F]altanserin positron emission tomography.
NeuroImage.
2012 Feb; 59(4):3922-32. doi:
10.1016/j.neuroimage.2011.09.045. [PMID: 21996132] - Sophie M Banas, Stéphane Doly, Katia Boutourlinsky, Silvina L Diaz, Arnauld Belmer, Jacques Callebert, Corinne Collet, Jean-Marie Launay, Luc Maroteaux. Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2011 Jan; 36(2):423-33. doi:
10.1038/npp.2010.173. [PMID: 20927048] - Margaret R Maclean, Yvonne Dempsie. The serotonin hypothesis of pulmonary hypertension revisited.
Advances in experimental medicine and biology.
2010; 661(?):309-22. doi:
10.1007/978-1-60761-500-2_20. [PMID: 20204739] - Sanjeev Bhattacharyya, Anthony H Schapira, Dimitri P Mikhailidis, Joseph Davar. Drug-induced fibrotic valvular heart disease.
Lancet (London, England).
2009 Aug; 374(9689):577-85. doi:
10.1016/s0140-6736(09)60252-x. [PMID: 19683643] - Yvonne Dempsie, Ian Morecroft, David J Welsh, Neil A MacRitchie, Nigel Herold, Lynn Loughlin, Margaret Nilsen, Andrew J Peacock, Anthony Harmar, Michael Bader, Margaret R MacLean. Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice.
Circulation.
2008 Jun; 117(22):2928-37. doi:
10.1161/circulationaha.108.767558. [PMID: 18506000] - M R MacLean. Pulmonary hypertension and the serotonin hypothesis: where are we now?.
International journal of clinical practice. Supplement.
2007 Sep; ?(156):27-31. doi:
10.1111/j.1742-1241.2007.01497.x. [PMID: 17663674] - Una D McCann, Zsolt Szabo, Melin Vranesic, Esen Seckin, Gary Wand, Anna Duval, Robert F Dannals, George A Ricaurte. Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine.
Molecular imaging and biology.
2007 May; 9(3):151-7. doi:
10.1007/s11307-007-0082-7. [PMID: 17473958] - S Coşkun, B Gönül, C Ozer, D Erdoğan, C Elmas. The effects of dexfenfluramine administration on brain serotonin immunoreactivity and lipid peroxidation in mice.
Cell biology and toxicology.
2007 Mar; 23(2):75-82. doi:
10.1007/s10565-006-0107-z. [PMID: 17009098] - Juan M Esteve, Jean-Marie Launay, Odile Kellermann, Luc Maroteaux. Functions of serotonin in hypoxic pulmonary vascular remodeling.
Cell biochemistry and biophysics.
2007; 47(1):33-44. doi:
10.1385/cbb:47:1:33. [PMID: 17406058] - Ciüdem Ozer, Bilge Gönül, Ciüdem Elmas, Deniz Erdoüan, Z Sevim Ercan. Effects of dexfenfluramine on serotonin levels of mice ileum, contractility, glutathione and malondialdehyde level.
Molecular and cellular biochemistry.
2005 Dec; 280(1-2):151-7. doi:
10.1007/s11010-005-8842-7. [PMID: 16311917] - Shahrzad Rezaie-Majd, Jozef Murar, Daniel P Nelson, Rosemary F Kelly, Zhigang Hong, Irene M Lang, Anthony Varghese, E Kenneth Weir. Increased release of serotonin from rat ileum due to dexfenfluramine.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Nov; 287(5):R1209-13. doi:
10.1152/ajpregu.00191.2004. [PMID: 15242826] - G T C Ko, H C K Chan, C C Chow. Dexfenfluramine and heart-valve regurgitation in Chinese patients with type 2 diabetes.
Hong Kong medical journal = Xianggang yi xue za zhi.
2003 Aug; 9(4):243-6. doi:
NULL. [PMID: 12904610] - Frédéric Debelle, Joëlle Nortier, Volker M Arlt, Eric De Prez, Anne Vienne, Isabelle Salmon, David H Phillips, Monique Deschodt-Lanckman, Jean-Louis Vanherweghem. Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy.
Archives of toxicology.
2003 Apr; 77(4):218-26. doi:
10.1007/s00204-003-0438-y. [PMID: 12698237] - Didier Jourdan, Isabelle Piec, Jean-Michel Gaulier, Eric Lacassie, Josette Alliot. Effect of fenfluramine on caloric intake and macronutrient selection in Lou/c rats during aging.
Neurobiology of aging.
2003 Jan; 24(1):67-76. doi:
10.1016/s0197-4580(02)00049-0. [PMID: 12493552] - Paul L Strickland, J F William Deakin, Carol Percival, Joanne Dixon, Richard A Gater, David P Goldberg. Bio-social origins of depression in the community. Interactions between social adversity, cortisol and serotonin neurotransmission.
The British journal of psychiatry : the journal of mental science.
2002 Feb; 180(?):168-73. doi:
10.1192/bjp.180.2.168. [PMID: 11823330] - S L Lee, W W Wang, B L Fanburg. Dexfenfluramine as a mitogen signal via the formation of superoxide anion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2001 May; 15(7):1324-5. doi:
10.1096/fj.00-0431fje. [PMID: 11344128] - S Eddahibi, S Adnot, E Frisdal, M Levame, M Hamon, B Raffestin. Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats.
The Journal of pharmacology and experimental therapeutics.
2001 Apr; 297(1):148-54. doi:
NULL. [PMID: 11259539] - B R Russell, R Laverty. The effect of (R)-HA966 or ACEA 1021 on dexfenfluramine or (S)-MDMA-induced changes in temperature, activity, and neurotoxicity.
Pharmacology, biochemistry, and behavior.
2001 Mar; 68(3):565-74. doi:
10.1016/s0091-3057(01)00454-3. [PMID: 11325413] - N Lima, H Cavaliere, M Knobel, A Halpern, G Medeiros-Neto. Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.
2000 Nov; 24(11):1433-7. doi:
10.1038/sj.ijo.0801406. [PMID: 11126339] - J Hirsch, R M Mackintosh, L J Aronne. The effects of drugs used to treat obesity on the autonomic nervous system.
Obesity research.
2000 May; 8(3):227-33. doi:
10.1038/oby.2000.26. [PMID: 10832765] - G F Watts, S Herrmann, F M Riches. Effects of diet and serotonergic agonist on hepatic apolipoprotein B-100 secretion and endothelial function in obese men.
QJM : monthly journal of the Association of Physicians.
2000 Mar; 93(3):153-61. doi:
10.1093/qjmed/93.3.153. [PMID: 10751234] - J Bíbová, V Hampl. [Anorectics and pulmonary hypertension].
Casopis lekaru ceskych.
2000 Feb; 139(3):67-70. doi:
NULL. [PMID: 10838744] - J D Christensen, D A Yurgelun-Todd, S M Babb, S A Gruber, B M Cohen, P F Renshaw. Measurement of human brain dexfenfluramine concentration by 19F magnetic resonance spectroscopy.
Brain research.
1999 Jul; 834(1-2):1-5. doi:
10.1016/s0006-8993(99)01441-9. [PMID: 10407087] - V S Haritos, M S Ching, H Ghabrial, A S Gross, P Taavitsainen, O Pelkonen, S E Battaglia, R A Smallwood, J T Ahokas. Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2.
Pharmacogenetics.
1998 Oct; 8(5):423-32. doi:
10.1097/00008571-199810000-00007. [PMID: 9825834] - S L Archer, K Djaballah, M Humbert, K E Weir, M Fartoukh, J Dall'ava-Santucci, J C Mercier, G Simonneau, A T Dinh-Xuan. Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension.
American journal of respiratory and critical care medicine.
1998 Oct; 158(4):1061-7. doi:
10.1164/ajrccm.158.4.9802113. [PMID: 9769261] - S J Marks, S Chin, B J Strauss. The metabolic effects of preferential reduction of visceral adipose tissue in abdominally obese men.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.
1998 Sep; 22(9):893-8. doi:
10.1038/sj.ijo.0800678. [PMID: 9756248] - L F Van Gaal, M A Wauters, I H De Leeuw. Anti-obesity drugs: what does sibutramine offer? An analysis of its potential contribution to obesity treatment.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
1998; 106 Suppl 2(?):35-40. doi:
10.1055/s-0029-1212035. [PMID: 9792480]
