Tetrahydroaldosterone (BioDeep_00000665274)
代谢物信息卡片
Tetrahydro Aldosterone
化学式: C21H32O5 (364.2249622)
中文名称: 3α,5β-四氢醛固酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(CC1CCC3C2C4CC5(C3CCC5C(=O)CO)C(O4)O)O
InChI: InChI=1S/C21H32O5/c1-20-7-6-12(23)8-11(20)2-3-13-14-4-5-15(16(24)10-22)21(14)9-17(18(13)20)26-19(21)25/h11-15,17-19,22-23,25H,2-10H2,1H3/t11-,12-,13+,14+,15-,17+,18-,19?,20+,21-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
2 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Matthias B Moor, Nasser A Dhayat, Simeon Schietzel, Michael Grössl, Bruno Vogt, Daniel G Fuster. Urinary tetrahydroaldosterone is associated with circulating FGF23 in kidney stone formers.
Urolithiasis.
2022 Jun; 50(3):333-340. doi:
10.1007/s00240-022-01317-2. [PMID: 35201364] - Murielle Bochud, Judith Jenny-Burri, Menno Pruijm, Belen Ponte, Idris Guessous, Georg Ehret, Dusan Petrovic, Vincent Dudler, Max Haldimann, Geneviève Escher, Bernhard Dick, Markus Mohaupt, Fred Paccaud, Michel Burnier, Antoinette Péchère-Bertschi, Pierre-Yves Martin, Bruno Vogt, Daniel Ackermann. Urinary Cadmium Excretion Is Associated With Increased Synthesis of Cortico- and Sex Steroids in a Population Study.
The Journal of clinical endocrinology and metabolism.
2018 02; 103(2):748-758. doi:
10.1210/jc.2017-01540. [PMID: 29077874] - Carine Gennari-Moser, Geneviève Escher, Simea Kramer, Bernhard Dick, Nicole Eisele, Marc Baumann, Luigi Raio, Felix J Frey, Daniel Surbek, Markus G Mohaupt. Normotensive blood pressure in pregnancy: the role of salt and aldosterone.
Hypertension (Dallas, Tex. : 1979).
2014 Feb; 63(2):362-8. doi:
10.1161/hypertensionaha.113.02320. [PMID: 24296282] - Emily P McQuarrie, Ellen Marie Freel, Patrick B Mark, Robert Fraser, John M C Connell, Alan G Jardine. Urinary sodium excretion is the main determinant of mineralocorticoid excretion rates in patients with chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Jun; 28(6):1526-32. doi:
10.1093/ndt/gft007. [PMID: 23413088] - Emily P McQuarrie, E Marie Freel, Patrick B Mark, Robert Fraser, Rajan K Patel, Henry G Dargie, John M C Connell, Alan G Jardine. Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease.
Clinical science (London, England : 1979).
2012 Sep; 123(5):285-94. doi:
10.1042/cs20120015. [PMID: 22397469] - Geneviève Escher, Martino Cristiano, Maja Causevic, Marc Baumann, Felix J Frey, Daniel Surbek, Markus G Mohaupt. High aldosterone-to-renin variants of CYP11B2 and pregnancy outcome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Jun; 24(6):1870-5. doi:
10.1093/ndt/gfn763. [PMID: 19151144] - Helen Imrie, Marie Freel, Bongani M Mayosi, Eleanor Davies, Robert Fraser, Mary Ingram, Heather J Cordell, Martin Farrall, Peter J Avery, Hugh Watkins, Bernard Keavney, John M C Connell. Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.
The Journal of clinical endocrinology and metabolism.
2006 Dec; 91(12):5051-6. doi:
10.1210/jc.2006-1481. [PMID: 16984984] - Saleh Abdelhamid, Roland Blomer, Gerhard Hommel, Doris Haack, Sabina Lewicka, Peter Fiegel, Bernd Krumme. Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: a comparative study.
American journal of hypertension.
2003 Jul; 16(7):522-30. doi:
10.1016/s0895-7061(03)00858-6. [PMID: 12850384] - A Odermatt, B Dick, P Arnold, T Zaehner, V Plueschke, M N Deregibus, H Repetto, B M Frey, F J Frey, P Ferrari. A mutation in the cofactor-binding domain of 11beta-hydroxysteroid dehydrogenase type 2 associated with mineralocorticoid hypertension.
The Journal of clinical endocrinology and metabolism.
2001 Mar; 86(3):1247-52. doi:
10.1210/jcem.86.3.7334. [PMID: 11238516] - D Armanini, S Lewicka, C Pratesi, M Scali, M C Zennaro, S Zovato, C Gottardo, M Simoncini, A Spigariol, V Zampollo. Further studies on the mechanism of the mineralocorticoid action of licorice in humans.
Journal of endocrinological investigation.
1996 Oct; 19(9):624-9. doi:
10.1007/bf03349029. [PMID: 8957748] - B G Wolthers, G P Kraan, J C van der Molen, G T Nagel, C W Rouwe, F Lenting, E R Boersma. Urinary steroid profile of a newborn suffering from pseudohypoaldosteronism.
Clinica chimica acta; international journal of clinical chemistry.
1995 Apr; 236(1):33-43. doi:
10.1016/0009-8981(95)06034-7. [PMID: 7664464] - J Wacker, P Piel, S Lewicka, D Haack, P Vecsei, G Bastert. Increased aldosterone-18-glucuronide/tetrahydroaldosterone ratios in pregnancy.
Endocrine research.
1995 Feb; 21(1-2):197-202. doi:
10.3109/07435809509030435. [PMID: 7588381] - M Egfjord, H Daugaard, K Olgaard. Effect of uremia on aldosterone metabolism in the isolated perfused rat liver.
Metabolism: clinical and experimental.
1993 Apr; 42(4):470-6. doi:
10.1016/0026-0495(93)90105-w. [PMID: 8487670] - S Ulick, J D Blumenfeld, S A Atlas, J Z Wang, E D Vaughan. The unique steroidogenesis of the aldosteronoma in the differential diagnosis of primary aldosteronism.
The Journal of clinical endocrinology and metabolism.
1993 Apr; 76(4):873-8. doi:
10.1210/jcem.76.4.8473399. [PMID: 8473399] - J Ishida, S Sonezaki, M Yamaguchi, T Yoshitake. High-performance liquid chromatographic determination of 3 alpha,5 beta-tetrahydroaldosterone in human urine with chemiluminescence detection.
The Analyst.
1992 Nov; 117(11):1719-24. doi:
10.1039/an9921701719. [PMID: 1481996] - T Yoshitake, J Ishida, S Sonezaki, M Yamaguchi. High performance liquid chromatographic determination of 3 alpha, 5 beta-tetrahydroaldosterone and cortisol in human urine with fluorescence detection.
Biomedical chromatography : BMC.
1992 Sep; 6(5):217-21. doi:
10.1002/bmc.1130060502. [PMID: 1463931] - M Egfjord, H Daugaard, K Olgaard. Aldosterone metabolism in combined isolated perfused rat liver and kidney.
The American journal of physiology.
1991 Apr; 260(4 Pt 2):F536-48. doi:
10.1152/ajprenal.1991.260.4.f536. [PMID: 2012206] - G T Griffing, T E Wilson, J C Melby. Alterations in aldosterone secretion and metabolism in low renin hypertension.
The Journal of clinical endocrinology and metabolism.
1990 Dec; 71(6):1454-60. doi:
10.1210/jcem-71-6-1454. [PMID: 2229301] - L M Demers, J C Melby, T E Wilson, A Lipton, H A Harvey, R J Santen. The effects of CGS 16949A, an aromatase inhibitor on adrenal mineralocorticoid biosynthesis.
The Journal of clinical endocrinology and metabolism.
1990 Apr; 70(4):1162-6. doi:
. [PMID: 2156889] - G T Griffing, J C Melby. Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by trilostane, an inhibitor of adrenal steroidogenesis.
Metabolism: clinical and experimental.
1989 Apr; 38(4):353-6. doi:
10.1016/0026-0495(89)90124-8. [PMID: 2725277] - T Miyazaki, K Matsuzaki. The metabolism in vivo of 3 alpha, 5 beta-tetrahydroaldosterone in the guinea pig.
Endocrinologia japonica.
1989 Feb; 36(1):95-100. doi:
10.1507/endocrj1954.36.95. [PMID: 2731488] - T Miyazaki, M Fujizaki, T Hirai. Analysis of urinary aldosterone metabolites in the guinea-pig.
Endocrinologia japonica.
1987 Apr; 34(2):161-9. doi:
10.1507/endocrj1954.34.161. [PMID: 3622385] - O B Holland, M Risk, H Brown, K Komes, P Dube, C Swann. High-performance liquid chromatography in the radioimmunoassay of urinary tetrahydroaldosterone.
Journal of chromatography.
1987 Jan; 385(?):393-6. doi:
10.1016/s0021-9673(01)94655-2. [PMID: 3558594] - D Rolland, M C Patricot, B Mathian, A Revol. [Urinary elimination of urinary tetrahydroaldosterone measured by gas-phase chromatography. Normal values in adults].
Annales de biologie clinique.
1987; 45(1):70-3. doi:
NULL. [PMID: 3578938] - T S Fisher, P Vecsei, G A Hoyer, K Lichtwald, D N Kirk. HPLC isolation and GC-MS characterization of a compound strongly cross reacting with tetrahydroaldosterone antiserum.
Journal of steroid biochemistry.
1986 Jul; 25(1):71-82. doi:
10.1016/0022-4731(86)90283-9. [PMID: 3747516] - B J Koopman, I J Lokerse, H Verweij, G T Nagel, J C van der Molen, N M Drayer, B G Wolthers. Improved gas chromatographic-mass fragmentographic assay for tetrahydroaldosterone and aldosterone in urine.
Journal of chromatography.
1986 Jun; 378(2):283-92. doi:
10.1016/s0378-4347(00)80725-2. [PMID: 3733988] - T Miyazaki, H Mizukoshi, M Fujizaki, T Kamidate. Analysis of urinary aldosterone metabolites in the rabbit by gas chromatography-mass spectrometry.
Endocrinologia japonica.
1985 Aug; 32(4):505-9. doi:
10.1507/endocrj1954.32.505. [PMID: 4085412] - G T Griffing, T E Wilson, J C Melby. Converting-enzyme inhibitor administration lowers urinary free 19-nor-deoxycorticosterone levels.
Hypertension (Dallas, Tex. : 1979).
1985 Mar; 7(2):178-81. doi:
10.1161/01.hyp.7.2.178. [PMID: 2984116] - T Miyazaki, H Mizukoshi. The metabolism of aldosterone and 3 alpha, 5 beta-tetrahydroaldosterone in the rabbit.
Endocrinologia japonica.
1985 Feb; 32(1):53-9. doi:
10.1507/endocrj1954.32.53. [PMID: 4017975] - S Lewicka, P Vecsei. Clinical significance of unconjugated 3 alpha,5 beta-tetrahydroaldosterone and 5 beta-dihydroaldosterone measured by radioimmunoassay.
Clinical endocrinology.
1985 Feb; 22(2):123-33. doi:
10.1111/j.1365-2265.1985.tb01074.x. [PMID: 3987065] - C E Gomez-Sanchez, O B Holland, R Upcavage. Urinary free 19-nor-deoxycorticosterone and deoxycorticosterone in human hypertension.
The Journal of clinical endocrinology and metabolism.
1985 Feb; 60(2):234-8. doi:
10.1210/jcem-60-2-234. [PMID: 3880766] - B Hesse, S Rasmussen, J O Lund, P Christensen, M Damkjaer Nielsen. Urinary excretion of kallikrein before and after operation for aldosterone-producing adenoma.
Acta medica Scandinavica.
1985; 217(5):501-5. doi:
10.1111/j.0954-6820.1985.tb03253.x. [PMID: 3895826] - S Abdelhamid, S Lewicka, P Vecsei, J Winter. 21-Deoxytetrahydroaldosterone excretion in primary hyperaldosteronism.
Cardiology.
1985; 72 Suppl 1(?):102-6. doi:
10.1159/000173954. [PMID: 4053120] - C E Gomez-Sanchez, J S Smith, M W Ferris, E P Gomez-Sanchez. Renal receptor-binding activity of reduced metabolites of aldosterone: evidence for a mineralocorticoid effect outside of the classic aldosterone receptor system.
Endocrinology.
1984 Aug; 115(2):712-5. doi:
10.1210/endo-115-2-712. [PMID: 6086276] - M McDermott, S Latif, D J Morris. The metabolism of aldosterone in kidney.
Journal of steroid biochemistry.
1983 Aug; 19(2):1205-11. doi:
10.1016/0022-4731(83)90418-1. [PMID: 6887929] - R C Gaillard, A M Riondel, C A Favrod-Coune, M B Vallotton, A F Muller. Aldosterone escape to chronic ACTH administration in man.
Acta endocrinologica.
1983 May; 103(1):116-24. doi:
10.1530/acta.0.1030116. [PMID: 6305073] - D J Morris, C J Kenyon, S A Latif, M McDermott, T L Goodfriend. The possible biological role of aldosterone metabolites.
Hypertension (Dallas, Tex. : 1979).
1983 Mar; 5(2 Pt 2):I35-40. doi:
10.1161/01.hyp.5.2_pt_2.i35. [PMID: 6826227] - J D Veldhuis, H E Kulin, T E Wilson, J C Melby. Detection of isolated aldosterone deficiency in the neonate.
The Journal of pediatrics.
1983 Jan; 102(1):83-5. doi:
10.1016/s0022-3476(83)80295-9. [PMID: 6848733] - G T Griffing, T E Wilson, J C Melby. Altered fractional tetrahydroaldosterone excretion during pharmacological blockade and activation of the renin-aldosterone system.
The Journal of clinical endocrinology and metabolism.
1982 Dec; 55(6):1217-21. doi:
10.1210/jcem-55-6-1217. [PMID: 6290525] - H Bauknecht, P Vecsei, H Endres, A Hettenbach. Urinary free 18-hydroxycorticosterone, plasma aldosterone, and urinary aldosterone metabolites in normal pregnancy.
American journal of obstetrics and gynecology.
1982 Sep; 144(1):28-34. doi:
10.1016/0002-9378(82)90389-1. [PMID: 7114109] - J W Honour, E G Biglieri, K Lichtwald, D Haack, P Vecsei. Characterisation of aldosterone metabolites cross reacting with aldosterone and tetrahydroaldosterone antibodies.
Journal of steroid biochemistry.
1982 Aug; 17(2):175-9. doi:
10.1016/0022-4731(82)90118-2. [PMID: 7109604] - J W Honour, M J Dillon, C H Shackleton. Analysis of steroids in urine for differentiation of pseudohypoaldosteronism and aldosterone biosynthetic defect.
The Journal of clinical endocrinology and metabolism.
1982 Feb; 54(2):325-31. doi:
10.1210/jcem-54-2-325. [PMID: 7033278] - S Abdelhamid, P Vecsei, D Haack, K H Gless, D Walb, P Fiegel, K Lichtwald. Elevated 'free' 18-hydroxy-corticosterone excretion as a possible indicator for early diagnosis of primary aldosteronism.
Journal of steroid biochemistry.
1981 Sep; 14(9):913-20. doi:
10.1016/0022-4731(81)90240-5. [PMID: 7029142] - C E Gomez-Sanchez, O B Holland. Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients.
The Journal of clinical endocrinology and metabolism.
1981 Feb; 52(2):214-9. doi:
10.1210/jcem-52-2-214. [PMID: 7462387] - S Hata. [Determination of urinary 3 alpha, 5 beta-tetrahydroaldosterone as a parameter of aldosterone secretion in hypersensitive patients (author's transl)].
Nihon Naibunpi Gakkai zasshi.
1981 Jan; 57(1):89-96. doi:
10.1507/endocrine1927.57.1_89. [PMID: 7238957] - S Ulick, W R Eberlein, A R Bliffeld, M D Chu, A M Bongiovanni. Evidence for an aldosterone biosynthetic defect in congenital adrenal hyperplasia.
The Journal of clinical endocrinology and metabolism.
1980 Dec; 51(6):1346-53. doi:
10.1210/jcem-51-6-1346. [PMID: 7440699] - S Abdelhamid, P Vecsei, D Haack, K H Gless, D Walb, K Lichtwald, P Fiegel. Dissociation in the excretion of different aldosterone metabolites and unmetabolized ('free') aldosterone in hypertension.
Clinical science (London, England : 1979).
1979 Nov; 57(5):409-14. doi:
10.1042/cs0570409. [PMID: 519948] - A Delassalle, F Cesselin, A Carayon, S Legrand, J Antreassian, A Lagoguey, J C Legrand, P Desgrez. Radioimmunological determination of urinary tetrahydroaldosterone.
Steroids.
1977 Jun; 29(6):725-38. doi:
10.1016/0039-128x(77)90117-9. [PMID: 910248] - J H Pratt, M M Holbrook, S L Dale, J C Melby. The measurement of urinary tetrahydroaldosterone by radioimmunoassay.
Journal of steroid biochemistry.
1977 Jun; 8(6):677-81. doi:
10.1016/0022-4731(77)90296-5. [PMID: 592793] - J W Honour, C H Shackleton. Mass spectrometric analysis for tetrahydroaldosterone.
Journal of steroid biochemistry.
1977 Apr; 8(4):299-305. doi:
10.1016/0022-4731(77)90023-1. [PMID: 886860] - M S Scandrett, M Wilson, E J Ross. An isolation system for aldosterone and tetrahydroaldosterone prior to estimation by gas liquid chromatography or radioimmunoassay.
Clinica chimica acta; international journal of clinical chemistry.
1976 Oct; 72(1):97-107. doi:
10.1016/0009-8981(76)90040-1. [PMID: 975573]