WAY-100635 (BioDeep_00000665051)

   


代谢物信息卡片


Cyclohexanecarboxamide, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-

化学式: C25H34N4O2 (422.2681624)
中文名称: WAY-100635
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4
InChI: InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist[1][2][3].

同义名列表

2 个代谢物同义名

Cyclohexanecarboxamide, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-; WAY-100635



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Jéssica Iara Gall, Amália Gonçalves Alves, Luiz Roberto Carraro Júnior, Taís da Silva Teixeira Rech, José Sebastião Dos Santos Neto, Diego Alves, Mayara Sandrielly Pereira Soares, Luiza Spohr, Rosélia Maria Spanevello, César Augusto Brüning, Cristiani Folharini Bortolatto. Insights into serotonergic and antioxidant mechanisms involved in antidepressant-like action of 2-phenyl-3-(phenylselanyl)benzofuran in mice. Progress in neuro-psychopharmacology & biological psychiatry. 2020 08; 102(?):109956. doi: 10.1016/j.pnpbp.2020.109956. [PMID: 32371105]
  • Laura Rombolà, Damiana Scuteri, Chizuko Watanabe, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone. Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent. International journal of molecular sciences. 2020 Apr; 21(7):. doi: 10.3390/ijms21072597. [PMID: 32283606]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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  • G Aditya Kumar, Parijat Sarkar, Md Jafurulla, Shishu Pal Singh, Gunda Srinivas, Gopal Pande, Amitabha Chattopadhyay. Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin1A Receptor. Biochemistry. 2019 06; 58(22):2628-2641. doi: 10.1021/acs.biochem.9b00033. [PMID: 30896156]
  • Rosa Estrada-Reyes, Ana María Dorantes-Barrón, Daniel Arrieta-Báez, Mayra Beatriz Gómez-Patiño, Andrea Bernal-Trujillo, Mario Castro-García, Miguel Carro-Juárez, Lucía Martínez-Mota. Piper auritum Kunth (Piperaceae) improves the sexual performance of sluggish male rats through enhancing ejaculation. Journal of ethnopharmacology. 2019 Mar; 231(?):453-463. doi: 10.1016/j.jep.2018.10.030. [PMID: 30545804]
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  • Pia Baldinger, Anna S Höflich, Markus Mitterhauser, Andreas Hahn, Christina Rami-Mark, Marie Spies, Wolfgang Wadsak, Rupert Lanzenberger, Siegfried Kasper. Effects of Silexan on the serotonin-1A receptor and microstructure of the human brain: a randomized, placebo-controlled, double-blind, cross-over study with molecular and structural neuroimaging. The international journal of neuropsychopharmacology. 2014 Oct; 18(4):. doi: 10.1093/ijnp/pyu063. [PMID: 25522403]
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  • Xiaosu Gu, Yong Zhou, Xiaomei Wu, Fen Wang, Cai-Yi Zhang, Chenchen Du, Lihua Shen, Xiang Chen, Jiansheng Shi, Chunfeng Liu, Kaifu Ke. Antidepressant-like effects of auraptenol in mice. Scientific reports. 2014 Mar; 4(?):4433. doi: 10.1038/srep04433. [PMID: 24658501]
  • M V Fogaça, F M C V Reis, A C Campos, F S Guimarães. Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2014 Mar; 24(3):410-9. doi: 10.1016/j.euroneuro.2013.10.012. [PMID: 24321837]
  • Christoph Kraus, Pia Baldinger, Christina Rami-Mark, Gregor Gryglewski, Gregor Gryglewsky, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberger. Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding. PloS one. 2014; 9(9):e106810. doi: 10.1371/journal.pone.0106810. [PMID: 25188405]
  • Dmitry V Zaretsky, Maria V Zaretskaia, Joseph A Dimicco, Pamela J Durant, Christian T Ross, Daniel E Rusyniak. Independent of 5-HT1A receptors, neurons in the paraventricular hypothalamus mediate ACTH responses from MDMA. Neuroscience letters. 2013 Oct; 555(?):42-6. doi: 10.1016/j.neulet.2013.07.053. [PMID: 23933156]
  • Per Stenkrona, Christer Halldin, Johan Lundberg. 5-HTT and 5-HT(1A) receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2013 Oct; 23(10):1190-8. doi: 10.1016/j.euroneuro.2013.01.002. [PMID: 23428337]
  • Carmen Frías-Domínguez, Julieta Garduño, Salvador Hernández, René Drucker-Colin, Stefan Mihailescu. Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. Brain research bulletin. 2013 Sep; 98(?):10-22. doi: 10.1016/j.brainresbull.2013.07.006. [PMID: 23872451]
  • Lea R Chioca, Marcelo M Ferro, Irinéia P Baretta, Sara M Oliveira, Cássia R Silva, Juliano Ferreira, Estela M Losso, Roberto Andreatini. Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission. Journal of ethnopharmacology. 2013 May; 147(2):412-8. doi: 10.1016/j.jep.2013.03.028. [PMID: 23524167]
  • Gregory M Sullivan, R Todd Ogden, Yung-Yu Huang, Maria A Oquendo, J John Mann, Ramin V Parsey. Higher in vivo serotonin-1a binding in posttraumatic stress disorder: a PET study with [11C]WAY-100635. Depression and anxiety. 2013 Mar; 30(3):197-206. doi: 10.1002/da.22019. [PMID: 23408467]
  • Seungheon Lee, Dong Hyun Kim, Ji Hye Lee, Eun Seong Ko, Won Bo Oh, Yong Taek Seo, Young Pyo Jang, Jong Hoon Ryu, Ji Wook Jung. Involvement of histaminergic system in the anxiolytic-like activities of Morus alba leaves in mice. Biological & pharmaceutical bulletin. 2013; 36(11):1692-9. doi: 10.1248/bpb.b13-00126. [PMID: 23965748]
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