Quinupristin (BioDeep_00000006647)

 

Secondary id: BioDeep_00000855497

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-[(3S,6S,12R,15S,16R,19S)-25-{[(3S)-1-azabicyclo[2.2.2]octan-3-ylsulfanyl]methyl}-3-{[4-(dimethylamino)phenyl]methyl}-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaazatricyclo[20.4.0.0⁶,¹⁰]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide

化学式: C53H67N9O10S (1021.4731362)
中文名称: 奎奴普丁
谱图信息: 最多检出来源 Homo sapiens(blood) 97.73%

分子结构信息

SMILES: CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CC(C(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CSC6CN7CCC6CC7)CC8=CC=C(C=C8)N(C)C)C
InChI: InChI=1S/C53H67N9O10S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65)/t31-,35?,37-,38+,39?,40+,43-,44+,45+/m1/s1

描述信息

Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. The combination of the two components acts synergistically and is more effective in vitro than each component alone.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D025361 - Streptogramins
Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits[1] [2].

同义名列表

4 个代谢物同义名

N-[(3S,6S,12R,15S,16R,19S)-25-{[(3S)-1-azabicyclo[2.2.2]octan-3-ylsulfanyl]methyl}-3-{[4-(dimethylamino)phenyl]methyl}-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaazatricyclo[20.4.0.0⁶,¹⁰]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide; N-[(3S,6S,12R,15S,16R,19S)-25-[[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]sulfanylmethyl]-3-[[4-(dimethylamino)phenyl]methyl]-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide; 5DElta-(3-quinuclidinyl)thiomethylpristinamycin ia; Quinupristin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rudramani Pokhrel, Prem Chapagain, Jessica Siltberg-Liberles. Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2. Journal of medical microbiology. 2020 Jun; 69(6):864-873. doi: 10.1099/jmm.0.001203. [PMID: 32469301]
  • L Drago, L Nicola, E De Vecchi. A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2008 Jun; 14(6):608-11. doi: 10.1111/j.1469-0691.2008.01993.x. [PMID: 18397336]
  • A Chaudhury, A G Kumar. In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus. Indian journal of medical microbiology. 2007 Jan; 25(1):50-2. doi: 10.4103/0255-0857.31062. [PMID: 17377353]
  • Thomas G Fraser, Christine Hansen, Jennifer K Long. Newer antibiotics for serious gram-positive infections. Cleveland Clinic journal of medicine. 2006 Sep; 73(9):847-53. doi: 10.3949/ccjm.73.9.847. [PMID: 16970136]
  • Robert L Thompson, Bruce Lavin, George H Talbot. Endocarditis due to vancomycin-resistant Enterococcus faecium in an immunocompromised patient: cure by administering combination therapy with quinupristin/dalfopristin and high-dose ampicillin. Southern medical journal. 2003 Aug; 96(8):818-20. doi: 10.1097/01.smj.0000047962.61701.57. [PMID: 14515928]
  • V Schwenger, E Mündlein, E E Dagrosa, A M Fahr, M Zeier, G Mikus, K Andrassy. Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report. Infection. 2002 Oct; 30(5):257-61. doi: 10.1007/s15010-002-2076-3. [PMID: 12382082]
  • P D Walzer, A Ashbaugh, M Collins, M T Cushion. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii. Antimicrobial agents and chemotherapy. 2001 Nov; 45(11):3234-7. doi: 10.1128/aac.45.11.3234-3237.2001. [PMID: 11600389]
  • L C McDonald, S Rossiter, C Mackinson, Y Y Wang, S Johnson, M Sullivan, R Sokolow, E DeBess, L Gilbert, J A Benson, B Hill, F J Angulo. Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens. The New England journal of medicine. 2001 Oct; 345(16):1155-60. doi: 10.1056/nejmoa010805. [PMID: 11642231]
  • P Chevalier, J Rey, O Pasquier, V Leclerc, J C Baguet, A Meyrier, N Harding, G Montay. Pharmacokinetics of quinupristin/ dalfopristin in patients with severe chronic renal insufficiency. Clinical pharmacokinetics. 2000 Jul; 39(1):77-84. doi: 10.2165/00003088-200039010-00005. [PMID: 10926351]
  • G Werner, I Klare, H Heier, K H Hinz, G Böhme, M Wendt, W Witte. Quinupristin/dalfopristin-resistant enterococci of the satA (vatD) and satG (vatE) genotypes from different ecological origins in Germany. Microbial drug resistance (Larchmont, N.Y.). 2000; 6(1):37-47. doi: 10.1089/mdr.2000.6.37. [PMID: 10868806]
  • B M Lomaestro, L L Briceland. Streptogramins and their potential role in geriatric medicine. Drugs & aging. 1998 Dec; 13(6):443-65. doi: 10.2165/00002512-199813060-00004. [PMID: 9883400]
  • A Le Liboux, O Pasquier, G Montay. Simultaneous high-performance liquid chromatographic determination of quinupristin, dalfopristin and their main metabolites in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1998 Apr; 708(1-2):161-8. doi: 10.1016/s0378-4347(98)00005-x. [PMID: 9653958]