Nicomorphine (BioDeep_00000663886)

   


代谢物信息卡片


[(4R,4aR,7S,7aR,12bS)-3-methyl-9-(pyridine-3-carbonyloxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] pyridine-3-carboxylate

化学式: C29H25N3O5 (495.179412)
中文名称: 尼可吗啡
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OC(=O)C6=CN=CC=C6)OC3C(C=C4)OC(=O)C7=CN=CC=C7
InChI: InChI=1S/C29H25N3O5/c1-32-13-10-29-20-7-9-23(36-28(34)19-5-3-12-31-16-19)26(29)37-25-22(8-6-17(24(25)29)14-21(20)32)35-27(33)18-4-2-11-30-15-18/h2-9,11-12,15-16,20-21,23,26H,10,13-14H2,1H3/t20-,21+,23-,26-,29-/m0/s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AA - Natural opium alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

2 个代谢物同义名

[(4R,4aR,7S,7aR,12bS)-3-methyl-9-(pyridine-3-carbonyloxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] pyridine-3-carboxylate; Nicomorphine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • P M Koopman-Kimenai, T B Vree, L H Booij, R Dirksen. The bioavailability of intramuscularly administered nicomorphine (Vilan) with its metabolites and their glucuronide conjugates in surgical patients. International journal of clinical pharmacology and therapeutics. 1995 Aug; 33(8):442-8. doi: NULL. [PMID: 8556223]
  • P M Koopman-Kimenai, T B Vree, L H Booij, R Dirksen. Rectal administration of nicomorphine in patients improves biological availability of morphine and its glucuronide conjugates. Pharmacy world & science : PWS. 1994 Dec; 16(6):248-53. doi: 10.1007/bf02178565. [PMID: 7889023]
  • P M Koopman-Kimenai, T B Vree, M A Hasenbos, E W Weber, C P Verweij-Van Wissen, L H Booij. Pharmacokinetics of nicomorphine and its metabolites in man after epidural administration. Pharmaceutisch weekblad. Scientific edition. 1991 Jun; 13(3):142-7. doi: 10.1007/bf01981532. [PMID: 1923705]
  • P M Koopman-Kimenai, T B Vree, L H Booij, R Dirksen, G M Nijhuis. Pharmacokinetics of intramuscular nicomorphine and its metabolites in man. European journal of clinical pharmacology. 1991; 41(4):375-8. doi: 10.1007/bf00314971. [PMID: 1804655]
  • M A Hasenbos, M N Eckhaus, R Slappendel, M J Gielen. Continuous high thoracic epidural administration of bupivacaine with sufentanil or nicomorphine for postoperative pain relief after thoracic surgery. Regional anesthesia. 1989 Sep; 14(5):212-8. doi: NULL. [PMID: 2577251]
  • S J Zwarts, M A Hasenbos, M J Gielen, H G Kho. The effect of continuous epidural analgesia with sufentanil and bupivacaine during and after thoracic surgery on the plasma cortisol concentration and pain relief. Regional anesthesia. 1989 Jul; 14(4):183-8. doi: NULL. [PMID: 2535086]
  • H MOSER. [Contribution to the use of Vilan in urology]. Wiener medizinische Wochenschrift (1946). 1963 Apr; 113(?):296-7. doi: NULL. [PMID: 13936131]