1-naphthyl isothiocyanate (BioDeep_00000663728)
代谢物信息卡片
1-naphthyl isothiocyanate
化学式: C11H7NS (185.0299182)
中文名称: 1-萘异硫氰酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=CC=C2N=C=S
InChI: InChI=1S/C11H7NS/c13-8-12-11-7-3-5-9-4-1-2-6-10(9)11/h1-7H
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:35455
- PubChem: 11080
- ChEMBL: CHEMBL1381098
- MeSH: 1-Naphthylisothiocyanate
- CAS: 29962-76-3
- CAS: 551-06-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoliang He, Yingya Zhou, Jingtao Yu, Qinpo Huang, Zhengyuan Chen, Ru Xiao, Changhui Liu, Shuhua Gui, Tianqin Xiong. JiaGaSongTang improves chronic cholestasis via enhancing FXR-mediated bile acid metabolism.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
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10.1016/j.phymed.2024.155347. [PMID: 38493717] - Bin Zou, Shuang Zhang, Fengling Li, Fengyi Weng, Jing Zhao, Jingyi Jin, Dongming Yan, Xiaoqing Xu, Gaofeng Chen, Chenghai Liu, Chengzeng Yao, Yue Li, Furong Qiu. Gancao decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury.
Journal of ethnopharmacology.
2024 May; 326(?):117909. doi:
10.1016/j.jep.2024.117909. [PMID: 38350503] - Yuan Mei, Xinyu Li, Chao He, Yiying Zhang, Weichao Kong, Rufeng Xue, Xin Huang, Yaxiang Shi, Gang Tao, Mengtao Xing, Xinzhi Wang. Detrimental Role of CXCR3 in α-Naphthylisothiocyanate- and Triptolide-Induced Cholestatic Liver Injury.
Chemical research in toxicology.
2024 Jan; 37(1):42-56. doi:
10.1021/acs.chemrestox.3c00250. [PMID: 38091573] - Qianyan Gao, Guodong Li, Yue Zu, Yanjiao Xu, Congyi Wang, Dong Xiang, Wenxi He, Tianze Shang, Xinwei Cheng, Dong Liu, Chengliang Zhang. Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation.
Journal of ethnopharmacology.
2023 Aug; ?(?):117089. doi:
10.1016/j.jep.2023.117089. [PMID: 37634749] - Shasha Qin, Jingzhuo Tian, Yong Zhao, Lianmei Wang, Jinyu Wang, Suyan Liu, Jing Meng, Fang Wang, Chenyue Liu, Jiayin Han, Chen Pan, Yushi Zhang, Yan Yi, Chunying Li, Meiting Liu, Aihua Liang. Gardenia extract protects against intrahepatic cholestasis by regulating bile acid enterohepatic circulation.
Journal of ethnopharmacology.
2023 Aug; ?(?):117083. doi:
10.1016/j.jep.2023.117083. [PMID: 37634748] - Jing Zhao, Guochao Song, Fengyi Weng, Yue Li, Bin Zou, Jingyi Jin, Dongming Yan, Xin Sun, Chenghai Liu, Fu-Rong Qiu. The choleretic role of TUDCA exacerbates ANIT-induced cholestatic liver injury through the FXR/BSEP pathway.
Journal of applied toxicology : JAT.
2023 Feb; ?(?):. doi:
10.1002/jat.4446. [PMID: 36787806] - Juan Zou, Yuanyuan Li, Jingyi Cai, Xiaotian Peng, Lincong Zhang, Tian Tian, Tianming Wang, Rong Shi, Jiasheng Wu, Yueming Ma. Identification of Yinchenwuling fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2023 Jan; 1215(?):123570. doi:
10.1016/j.jchromb.2022.123570. [PMID: 36542898] - Jing Lou, Lei Zhao, Yan-Jie Zhu, Shuai-Qiang Yuan, Fei Wang, Hang-Zhou Zhang, Jiao-Jiao Xu, Xiao-Ke Yu, Liu-Fa Hou. [Study on protective effect of Chaihu Shugan Powder against liver injury in rats with intrahepatic cholestasis by regulating FXR/Nrf2/ARE pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Oct; 47(20):5610-5616. doi:
10.19540/j.cnki.cjcmm.20220519.401. [PMID: 36471979] - Guodong Li, Yanjiao Xu, Qianyan Gao, Sheng Guo, Yue Zu, Ximin Wang, Congyi Wang, Chengliang Zhang, Dong Liu. Ginsenosides Restore Lipid and Redox Homeostasis in Mice with Intrahepatic Cholestasis through SIRT1/AMPK Pathways.
Nutrients.
2022 Sep; 14(19):. doi:
10.3390/nu14193938. [PMID: 36235592] - Mengge Shi, Jie Tang, Tong Zhang, Han Han. Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway.
Journal of ethnopharmacology.
2022 Jun; 291(?):115164. doi:
10.1016/j.jep.2022.115164. [PMID: 35278607] - Soraya Salas-Silva, Jocelyn López-Ramirez, Jonatan Barrera-Chimal, Roberto Lazzarini-Lechuga, Arturo Simoni-Nieves, Verónica Souza, Roxana U Miranda-Labra, Felipe Masso, Marcelo G Roma, María Concepción Gutiérrez-Ruiz, Leticia Bucio-Ortiz, Luis E Gomez-Quiroz. Hepatocyte growth factor reverses cholemic nephropathy associated with α-naphthylisothiocyanate-induced cholestasis in mice.
Life sciences.
2022 Apr; 295(?):120423. doi:
10.1016/j.lfs.2022.120423. [PMID: 35196530] - Jingyi Cai, Jiasheng Wu, Su Fang, Shaoyong Liu, Tianming Wang, Yuanyuan Li, Juan Zou, Rong Shi, Zhengtao Wang, Li Yang, Yueming Ma. Cultured bear bile powder ameliorates acute liver injury in cholestatic mice via inhibition of hepatic inflammation and apoptosis.
Journal of ethnopharmacology.
2022 Feb; 284(?):114829. doi:
10.1016/j.jep.2021.114829. [PMID: 34763041] - Lauren G Poole, Anna-Katherine Fournier, Holly M Cline-Fedewa, Anna K Kopec, James P Luyendyk, Dafna J Groeneveld. Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice.
Toxicology.
2021 11; 463(?):152968. doi:
10.1016/j.tox.2021.152968. [PMID: 34619301] - Kaihui Zhang, Yufeng Yao, Meiqi Wang, Fangle Liu, Qian Wang, Huanhuan Ma, Yuanyuan Xie, Yunxia Ma, Pengyu Dai, Chenchen Zhu, Chaozhan Lin. A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153683. doi:
10.1016/j.phymed.2021.153683. [PMID: 34364160] - Zhengyuan Chen, Yuhuan Wu, Bixia Wang, Jiamin Fang, Changlian Gan, Chuanlan Sang, Zhu Dun, Tajie Luosang, Qing Wang, Dawa Zeren, Tianqin Xiong. Intrahepatic cholestasis induced by α-naphthylisothiocyanate can cause gut-liver axis disorders.
Environmental toxicology and pharmacology.
2021 Aug; 86(?):103672. doi:
10.1016/j.etap.2021.103672. [PMID: 33989784] - FanCheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, GuoWei Wang, ZhiHua Liao, Min Chen. Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 87(?):153588. doi:
10.1016/j.phymed.2021.153588. [PMID: 34091148] - Meiqi Wang, Fangle Liu, Yufeng Yao, Qiuyu Zhang, Zenghui Lu, Runjing Zhang, Changhui Liu, Chaozhan Lin, Chenchen Zhu. Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats.
Journal of ethnopharmacology.
2021 Apr; 270(?):113816. doi:
10.1016/j.jep.2021.113816. [PMID: 33444723] - Jiannan Qiu, Jingyu Yan, Wei Liu, Xinzhu Liu, Jingchao Lin, Zeng Du, Li Qi, Jia Liu, Guoxiang Xie, Ping Liu, Xiaoning Wang. Metabolomics analysis delineates the therapeutic effects of Huangqi decoction and astragalosides on α-naphthylisothiocyanate (ANIT) -induced cholestasis in rats.
Journal of ethnopharmacology.
2021 Mar; 268(?):113658. doi:
10.1016/j.jep.2020.113658. [PMID: 33307056] - Sen Ling Feng, Jing Zhang, Hongliu Jin, Wen Ting Zhu, Zhongwen Yuan. A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Mar; 27(?):e928402. doi:
10.12659/msm.928402. [PMID: 33657087] - Zhuoheng Lu, Shengtao Li, Jia Luo, Yishuang Luo, Manyun Dai, Xiuting Zheng, Jiapeng Qiu, Julin Yang, Aiming Liu. Fenofibrate reverses liver fibrosis in cholestatic mice induced by alpha-naphthylisothiocyanate.
Die Pharmazie.
2021 02; 76(2):103-108. doi:
10.1691/ph.2021.0988. [PMID: 33714287] - Wan Hua, Shiyan Zhang, Qiuxia Lu, Yiran Sun, Shancai Tan, Fang Chen, Lin Tang. Protective effects of n-Butanol extract and iridoid glycosides of Veronica ciliata Fisch. Against ANIT-induced cholestatic liver injury in mice.
Journal of ethnopharmacology.
2021 Feb; 266(?):113432. doi:
10.1016/j.jep.2020.113432. [PMID: 33011367] - Xiaodong Wei, Yingxiong Ma, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Zhihua Liao, Min Chen. Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jan; 80(?):153378. doi:
10.1016/j.phymed.2020.153378. [PMID: 33113499] - Xiuting Zheng, Manyun Dai, Gangming Xu, Liming Chang, Julin Yang, Aiming Liu. Inhibition of inflammation by SP600125 in cholestatic liver injury is dependent on the administration‑based exposure profile.
International journal of molecular medicine.
2020 Dec; 46(6):2271-2279. doi:
10.3892/ijmm.2020.4742. [PMID: 33125089] - Tingting Yang, Xue Wang, Zihang Yuan, Yingying Miao, Ziteng Wu, Yuanyuan Chai, Qiongna Yu, Haiyan Wang, Lixin Sun, Xin Huang, Luyong Zhang, Zhenzhou Jiang. Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.
Toxicology letters.
2020 Oct; 331(?):242-253. doi:
10.1016/j.toxlet.2020.06.018. [PMID: 32579994] - Gangming Xu, Manyun Dai, Xiuting Zheng, Hante Lin, Aiming Liu, Julin Yang. Cholestatic models induced by lithocholic acid and α‑naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling.
Molecular medicine reports.
2020 08; 22(2):1583-1593. doi:
10.3892/mmr.2020.11210. [PMID: 32626965] - Qing Xiao, Shujun Zhang, Huina Ren, Ruoyang Du, Jiajun Li, Jinqiu Zhao, Yue Gao, Yali Zhu, Wenxiang Huang. Ginsenoside Rg1 alleviates ANIT-induced intrahepatic cholestasis in rats via activating farnesoid X receptor and regulating transporters and metabolic enzymes.
Chemico-biological interactions.
2020 Jun; 324(?):109062. doi:
10.1016/j.cbi.2020.109062. [PMID: 32198087] - Guo-Feng Wang, Yuan-Yuan Li, Rong Shi, Tian-Ming Wang, Yi-Fei Li, Wen-Kai Li, Min Zheng, Feng-Bo Fan, Juan Zou, Bin Zan, Jia-Sheng Wu, Yue-Ming Ma. Yinchenzhufu decoction protects against alpha-naphthylisothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses.
Journal of ethnopharmacology.
2020 May; 254(?):112672. doi:
10.1016/j.jep.2020.112672. [PMID: 32084553] - Jin Zhou, Yanlin Tao, Han Zhu, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu. Alpha-naphthylisothiocyanate-induced cholestatic mice display anxiety-like behavior closely related with enhanced serotoninergic signaling transduction in central nervous system.
Neuroreport.
2020 05; 31(7):530-536. doi:
10.1097/wnr.0000000000001437. [PMID: 32282584] - Soraya Salas-Silva, Arturo Simoni-Nieves, María Valeria Razori, Jocelyn López-Ramirez, Jonatan Barrera-Chimal, Roberto Lazzarini, Oscar Bello, Verónica Souza, Roxana U Miranda-Labra, María Concepción Gutiérrez-Ruiz, Luis Enrique Gomez-Quiroz, Marcelo G Roma, Leticia Bucio-Ortiz. HGF induces protective effects in α-naphthylisothiocyanate-induced intrahepatic cholestasis by counteracting oxidative stress.
Biochemical pharmacology.
2020 04; 174(?):113812. doi:
10.1016/j.bcp.2020.113812. [PMID: 31954718] - Shuang Zhang, Miao Yu, Fangling Guo, Xiaoxiao Yang, Yuanli Chen, Chuanrui Ma, Qi Li, Zhuo Wei, Xiaoju Li, Hua Wang, Huaqing Hu, Yujue Zhang, Derun Kong, Qing Robert Miao, Wenquan Hu, David P Hajjar, Yan Zhu, Jihong Han, Yajun Duan. Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ12,14 -PGJ2 and Nogo.
British journal of pharmacology.
2020 03; 177(5):1041-1060. doi:
10.1111/bph.14886. [PMID: 31658492] - Zhiyong Zhang, Yiru Miao, Min Xu, Wenming Cheng, Chuanyan Yang, Xiangjian She, Qianqian Geng, Qunlin Zhang. TianJiu therapy for α-naphthyl isothiocyanate-induced intrahepatic cholestasis in rats treated with fresh Ranunculus sceleratus L.
Journal of ethnopharmacology.
2020 Feb; 248(?):112310. doi:
10.1016/j.jep.2019.112310. [PMID: 31629027] - Runjing Zhang, Tao Huang, Qiuyu Zhang, Yufeng Yao, Changhui Liu, Chaozhan Lin, Chenchen Zhu. Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 179(?):112966. doi:
10.1016/j.jpba.2019.112966. [PMID: 31735473] - Marcelo J A Amar, Lita A Freeman, Takafumi Nishida, Maureen L Sampson, Milton Pryor, Boris L Vaisman, Edward B Neufeld, Sotirios K Karathanasis, Alan T Remaley. LCAT protects against Lipoprotein-X formation in a murine model of drug-induced intrahepatic cholestasis.
Pharmacology research & perspectives.
2020 02; 8(1):e00554. doi:
10.1002/prp2.554. [PMID: 31893124] - Cheng Nong, Mengzhi Zou, Rufeng Xue, Li Bai, Li Liu, Zhenzhou Jiang, Lixin Sun, Xin Huang, Luyong Zhang, Xinzhi Wang. The role of invariant natural killer T cells in experimental xenobiotic-induced cholestatic hepatotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Feb; 122(?):109579. doi:
10.1016/j.biopha.2019.109579. [PMID: 31794947] - Sohair R Fahmy, Dawlat A Sayed, Amel M Soliman, Nesreen Y Almortada, Wafaa E Abd-El Aal. Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
Brazilian journal of biology = Revista brasleira de biologia.
2020 Jan; 80(1):102-111. doi:
10.1590/1519-6984.192697. [PMID: 31017240] - Shengnan Li, Rong Wang, Bin Wu, Yuanyuan Wang, Fuxing Song, Yanqiu Gu, Yongfang Yuan. Salvianolic acid B protects against ANIT-induced cholestatic liver injury through regulating bile acid transporters and enzymes, and NF-κB/IκB and MAPK pathways.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 09; 392(9):1169-1180. doi:
10.1007/s00210-019-01657-8. [PMID: 31098695] - Rick van der Geest, Ronald J van der Sluis, Albert K Groen, Miranda Van Eck, Menno Hoekstra. Cholestasis-associated glucocorticoid overexposure does not increase atherogenesis.
The Journal of endocrinology.
2019 08; 242(2):1-12. doi:
10.1530/joe-19-0079. [PMID: 31035252] - Song Lin, Tian-Yang Wang, Hua-Rong Xu, Xin-Nong Zhang, Qi Wang, Ran Liu, Qing Li, Kai-Shun Bi. A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice.
Journal of pharmaceutical and biomedical analysis.
2019 Jul; 171(?):180-192. doi:
10.1016/j.jpba.2019.04.009. [PMID: 31009873] - Guoxue Zhu, Fang Feng. UPLC-MS-based metabonomic analysis of intervention effects of Da-Huang-Xiao-Shi decoction on ANIT-induced cholestasis.
Journal of ethnopharmacology.
2019 Jun; 238(?):111860. doi:
10.1016/j.jep.2019.111860. [PMID: 30965080] - Fengxia Sun, Xiaoling Li, Chunjun Xu, Pan Li, Jingjing Wu, Jingli Sui. Effect of compound Yindan decoction on alpha-naphthylisothiocyanate-Induced acute intrahepatic cholestasis in rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2019 06; 39(3):315-323. doi:
. [PMID: 32186003] - Shu Yang, Lingling Wei, Ronglin Xia, Lipei Liu, Yuanli Chen, Wenwen Zhang, Qi Li, Ke Feng, Miao Yu, Wei Zhang, Jingtian Qu, Shixin Xu, Jingyuan Mao, Guanwei Fan, Chuanrui Ma. Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα.
Biochemical and biophysical research communications.
2019 05; 512(4):770-778. doi:
10.1016/j.bbrc.2019.03.131. [PMID: 30928103] - Bao-Long Wang, Chang-Wen Zhang, Liang Wang, Kun-Long Tang, Naoki Tanaka, Frank J Gonzalez, Yong Xu, Zhong-Ze Fang. Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 May; 49(5):591-601. doi:
10.1080/00498254.2018.1467065. [PMID: 29737914] - Lei Wang, Fei Cao, Li-Li Zhu, Peng Liu, Yu-Ru Shang, Wen-Hui Liu, Xin Dong, Hai-Dong Bao, Peng Gong, Zhong-Yu Wang. Andrographolide impairs alpha-naphthylisothiocyanate-induced cholestatic liver injury in vivo.
Journal of natural medicines.
2019 Mar; 73(2):388-396. doi:
10.1007/s11418-018-01275-3. [PMID: 30617707] - Qi Zhao, Fang Liu, Yan Cheng, Xue-Rong Xiao, Dan-Dan Hu, Ying-Mei Tang, Wei-Min Bao, Jin-Hui Yang, Tao Jiang, Jia-Peng Hu, Frank J Gonzalez, Fei Li. Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.
Molecular & cellular proteomics : MCP.
2019 03; 18(3):520-533. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2019 03; 168(1):264-278. doi:
10.1093/toxsci/kfy295. [PMID: 30517764] - Guo-Wei Wang, Xiao-Long Zhang, Qing-Hua Wu, Yong-Biao Jin, Chun-Tao Ning, Rui Wang, Jing-Xin Mao, Min Chen. The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 53(?):263-273. doi:
10.1016/j.phymed.2018.09.023. [PMID: 30668406] - Huiying Hua, Manyun Dai, Yishuang Luo, Hante Lin, Gangming Xu, Xiaowei Hu, Liping Xu, Haoyue Zhang, Zhiyuan Tang, Liming Chang, Aiming Liu, Julin Yang. Basal PPARα inhibits bile acid metabolism adaptation in chronic cholestatic model induced by α-naphthylisothiocyanate.
Toxicology letters.
2019 Jan; 300(?):31-39. doi:
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The Journal of pharmacy and pharmacology.
2018 Dec; 70(12):1675-1687. doi:
10.1111/jphp.13008. [PMID: 30277564] - Shou-Yan Wu, Shi-Chao Cui, Le Wang, Yi-Ting Zhang, Xiao-Xia Yan, Heng-Lei Lu, Guo-Zhen Xing, Jin Ren, Li-Kun Gong. 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
Acta pharmacologica Sinica.
2018 Dec; 39(12):1865-1873. doi:
10.1038/s41401-018-0110-y. [PMID: 30061734] - Kimitaka Takitani, Kanta Kishi, Hiroshi Miyazaki, Maki Koh, Hirofumi Tamaki, Akiko Inoue, Hiroshi Tamai. Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model.
International journal of molecular sciences.
2018 Oct; 19(11):. doi:
10.3390/ijms19113337. [PMID: 30373117] - Jianbin Min, Hao Chen, Zipeng Gong, Xian Liu, Tian Wu, Weirong Li, Jiansong Fang, Tianlai Huang, Yingfeng Zhang, Wei Zhao, Chenchen Zhu, Qi Wang, Suiqing Mi, Ningsheng Wang. Pharmacokinetic and Pharmacodynamic Properties of Rosmarinic Acid in Rat Cholestatic Liver Injury.
Molecules (Basel, Switzerland).
2018 Sep; 23(9):. doi:
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Toxicology.
2018 07; 404-405(?):68-75. doi:
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Journal of proteome research.
2018 04; 17(4):1500-1508. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Mar; 42(?):34-42. doi:
10.1016/j.phymed.2018.03.017. [PMID: 29655695] - Linlin Zhang, Huizong Su, Yue Li, Yujuan Fan, Qian Wang, Jian Jiang, Yiyang Hu, Gaofeng Chen, Bo Tan, Furong Qiu. Different effects of ursodeoxycholic acid on intrahepatic cholestasis in acute and recovery stages induced by alpha-naphthylisothiocyanate in mice.
Toxicology and applied pharmacology.
2018 03; 342(?):69-78. doi:
10.1016/j.taap.2018.01.019. [PMID: 29407775] - Ning Tang, Yaping Zhang, Qinghong Liang, Zeyu Liu, Yingping Shi. The role of ursodeoxycholic acid on cholestatic hepatic fibrosis in infant rats.
Molecular medicine reports.
2018 03; 17(3):3837-3844. doi:
10.3892/mmr.2017.8284. [PMID: 29257337] - Han Han, Lili Xu, Kai Xiong, Tong Zhang, Zhengtao Wang. Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 49(4):1304-1319. doi:
10.1159/000493409. [PMID: 30223280] - Lili Ding, Binfeng Zhang, Jinmei Li, Li Yang, Zhengtao Wang. Beneficial effect of resveratrol on α‑naphthyl isothiocyanate‑induced cholestasis via regulation of the FXR pathway.
Molecular medicine reports.
2018 Jan; 17(1):1863-1872. doi:
10.3892/mmr.2017.8051. [PMID: 29138819] - Tingting Yang, Huifang Mei, Dengqiu Xu, Wang Zhou, Xiaoyu Zhu, Lixin Sun, Xin Huang, Xue Wang, Ting Shu, Jia Liu, Jiaxin Ding, H M Hassan, Luyong Zhang, Zhenzhou Jiang. Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Dec; 110(?):1-12. doi:
10.1016/j.fct.2017.09.051. [PMID: 28986171] - Lili Xu, Tingting Sheng, Xiaolong Liu, Tong Zhang, Zhengtao Wang, Han Han. Analyzing the hepatoprotective effect of the Swertia cincta Burkillextract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes.
Journal of ethnopharmacology.
2017 Sep; 209(?):91-99. doi:
10.1016/j.jep.2017.07.031. [PMID: 28734962] - Jingyu Yan, Guoxiang Xie, Chungeng Liang, Yiyang Hu, Aihua Zhao, Fengjie Huang, Ping Hu, Ping Liu, Wei Jia, Xiaoning Wang. Herbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats.
Scientific reports.
2017 06; 7(1):4211. doi:
10.1038/s41598-017-04536-5. [PMID: 28646179] - Zhong-Ze Fang, Naoki Tanaka, Dan Lu, Chang-Tao Jiang, Wei-Hua Zhang, Chunze Zhang, Zuo Du, Zhi-Wei Fu, Peng Gao, Yun-Feng Cao, Hong-Zhi Sun, Zhi-Tu Zhu, Yan Cai, Kristopher W Krausz, Zhi Yao, Frank J Gonzalez. Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
Archives of toxicology.
2017 May; 91(5):2235-2244. doi:
10.1007/s00204-016-1877-6. [PMID: 27853831] - Hou-Qin Zhou, Wei Liu, Jian Wang, Yin-Qiu Huang, Peng-Yan Li, Yun Zhu, Jia-Bo Wang, Xiao Ma, Rui-Sheng Li, Shi-Zhang Wei, Kun Li, Hao-Tian Li, Jian-Yu Li, Xiao-He Xiao, Yan-Ling Zhao. Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 May; 89(?):696-704. doi:
10.1016/j.biopha.2017.02.084. [PMID: 28267673] - Yanling Zhao, Xuan He, Xiao Ma, Jianxia Wen, Pengyan Li, Jiabo Wang, Ruisheng Li, Yun Zhu, Shizhang Wei, Haotian Li, Xuelin Zhou, Kun Li, Honghong Liu, Xiaohe Xiao. Paeoniflorin ameliorates cholestasis via regulating hepatic transporters and suppressing inflammation in ANIT-fed rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 May; 89(?):61-68. doi:
10.1016/j.biopha.2017.02.025. [PMID: 28214689] - Wen-Rui Cao, Jing-Qiu Ge, Xin Xie, Meng-Lin Fan, Xu-Dong Fan, Hong Wang, Zhao-Yue Dong, Zhi-Hua Liao, Xiao-Zhong Lan, Min Chen. Protective effects of petroleum ether extracts of Herpetospermum caudigerum against α-naphthylisothiocyanate-induced acute cholestasis of rats.
Journal of ethnopharmacology.
2017 Feb; 198(?):139-147. doi:
10.1016/j.jep.2017.01.003. [PMID: 28065777] - Nikita Joshi, Anna K Kopec, Holly Cline-Fedewa, James P Luyendyk. Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis.
Toxicology.
2017 02; 377(?):73-80. doi:
10.1016/j.tox.2016.12.009. [PMID: 28049044] - Lingling Wang, Guixin Wu, Feihua Wu, Nan Jiang, Yining Lin. Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats.
Journal of ethnopharmacology.
2017 Jan; 196(?):178-185. doi:
10.1016/j.jep.2016.12.022. [PMID: 27988401] - Zhengyang Wang, Xiaoming Yang, Liang Chen, Xiuling Zhi, Hanyu Lu, Yanxia Ning, Joe Yeong, Sifeng Chen, Lianhua Yin, Xinhong Wang, Xiaobo Li. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury.
Archives of toxicology.
2017 Jan; 91(1):271-287. doi:
10.1007/s00204-016-1693-z. [PMID: 27052460] - Melanie K Bothe, Christoph Meyer, Udo Mueller, Jean-Christophe Queudot, Virginie Roger, Johannes Harleman, Martin Westphal. Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis.
The Journal of toxicological sciences.
2017; 42(6):715-721. doi:
10.2131/jts.42.715. [PMID: 29142170] - Xiaowen Tang, Qiaoling Yang, Fan Yang, Junting Gong, Han Han, Li Yang, Zhengtao Wang. Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice.
Journal of ethnopharmacology.
2016 Dec; 194(?):63-71. doi:
10.1016/j.jep.2016.08.049. [PMID: 27582267] - Yan Ding, Xiao-Li Xiong, Li-Shan Zhou, Su-Qi Yan, Huan Qin, Hua-Rong Li, Ling-Ling Zhang, Peng Chen, Cong Yao, Zhi-Xia Jiang, Lei Zhao. Preliminary study on Emodin alleviating alpha-naphthylisothiocyanate-induced intrahepatic cholestasis by regulation of liver farnesoid X receptor pathway.
International journal of immunopathology and pharmacology.
2016 Dec; 29(4):805-811. doi:
10.1177/0394632016672218. [PMID: 27707957] - Tanaporn Khamphaya, Piyachat Chansela, Pawinee Piyachaturawat, Apichart Suksamrarn, Michael H Nathanson, Jittima Weerachayaphorn. Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.
European journal of pharmacology.
2016 Oct; 789(?):254-264. doi:
10.1016/j.ejphar.2016.07.032. [PMID: 27475677] - Fan Yang, Xiaowen Tang, Lili Ding, Yue Zhou, Qiaoling Yang, Junting Gong, Guangyun Wang, Zhengtao Wang, Li Yang. Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation.
Scientific reports.
2016 09; 6(?):33052. doi:
10.1038/srep33052. [PMID: 27624003] - Qiao-Ling Yang, Fan Yang, Jun-Ting Gong, Xiao-Wen Tang, Guang-Yun Wang, Zheng-Tao Wang, Li Yang. Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses.
Acta pharmacologica Sinica.
2016 Sep; 37(9):1218-28. doi:
10.1038/aps.2016.86. [PMID: 27498779] - Rick van der Geest, Amber B Ouweneel, Ronald J van der Sluis, Albert K Groen, Miranda Van Eck, Menno Hoekstra. Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.
Toxicology and applied pharmacology.
2016 09; 306(?):1-7. doi:
10.1016/j.taap.2016.06.031. [PMID: 27374722] - Zhen Tan, Min Luo, Julin Yang, Yuqing Cheng, Jing Huang, Caide Lu, Danjun Song, Meiling Ye, Manyun Dai, Frank J Gonzalez, Aiming Liu, Bin Guo. Chlorogenic acid inhibits cholestatic liver injury induced by α-naphthylisothiocyanate: involvement of STAT3 and NFκB signalling regulation.
The Journal of pharmacy and pharmacology.
2016 Sep; 68(9):1203-13. doi:
10.1111/jphp.12592. [PMID: 27367057] - Xiaojiaoyang Li, Runping Liu, Linxi Yu, Zihang Yuan, Rong Sun, Hang Yang, Luyong Zhang, Zhenzhou Jiang. Alpha-naphthylisothiocyanate impairs bile acid homeostasis through AMPK-FXR pathways in rat primary hepatocytes.
Toxicology.
2016 Aug; 370(?):106-115. doi:
10.1016/j.tox.2016.09.020. [PMID: 27702592] - Noriko Masubuchi, Takayoshi Nishiya, Masako Imaoka, Kiyoko Mizumaki, Osamu Okazaki. Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.
Chemico-biological interactions.
2016 Aug; 255(?):74-82. doi:
10.1016/j.cbi.2015.09.012. [PMID: 26365562] - Qiao-Qun Ou, Xin-Hua Qian, Ding-You Li, You-Xiang Zhang, Xia-Nan Pei, Jin-Wen Chen, Li Yu. Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions.
Pediatric research.
2016 Apr; 79(4):589-95. doi:
10.1038/pr.2015.252. [PMID: 26646631] - Zhe Chen, Yun Zhu, Yanling Zhao, Xiao Ma, Ming Niu, Jiabo Wang, Haibin Su, Ruilin Wang, Jianyu Li, Liping Liu, Zhenman Wei, Qingguo Zhao, Hongge Chen, Xiaohe Xiao. Serum Metabolomic Profiling in a Rat Model Reveals Protective Function of Paeoniflorin Against ANIT Induced Cholestasis.
Phytotherapy research : PTR.
2016 Apr; 30(4):654-62. doi:
10.1002/ptr.5575. [PMID: 26806614] - Hao Chen, Xiaotao Huang, Jianbin Min, Weirong Li, Rong Zhang, Wei Zhao, Changhui Liu, Lang Yi, Suiqing Mi, Ningsheng Wang, Qi Wang, Chenchen Zhu. Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2.
Journal of ethnopharmacology.
2016 Feb; 179(?):197-207. doi:
10.1016/j.jep.2015.12.033. [PMID: 26723467] - Zhen Tan, Aiming Liu, Min Luo, Xuan Yin, Danjun Song, Manyun Dai, Pengxu Li, Zanbo Chu, Zuquan Zou, Ming Ma, Bin Guo, Bo Chen. Geniposide Inhibits Alpha-Naphthylisothiocyanate-Induced Intrahepatic Cholestasis: The Downregulation of STAT3 and NF[Formula: see text]B Signaling Plays an Important Role.
The American journal of Chinese medicine.
2016; 44(4):721-36. doi:
10.1142/s0192415x16500397. [PMID: 27222070] - Lei-Chi Dong, Ya-Xi Fan, Qiong Yu, Jiang Ma, Xin Dong, Ping Li, Hui-Jun Li. Synergistic effects of rhubarb-gardenia herb pair in cholestatic rats at pharmacodynamic and pharmacokinetic levels.
Journal of ethnopharmacology.
2015 Dec; 175(?):67-74. doi:
10.1016/j.jep.2015.09.012. [PMID: 26376237] - Zhe Chen, Xiao Ma, Yun Zhu, Yanling Zhao, Jiabo Wang, Ruisheng Li, Chang Chen, Shizhang Wei, Wenjuan Jiao, Yaming Zhang, Jianyu Li, Lifu Wang, Ruilin Wang, Honghong Liu, Honghui Shen, Xiaohe Xiao. Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats.
Phytotherapy research : PTR.
2015 Nov; 29(11):1768-75. doi:
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Journal of ethnopharmacology.
2015 Aug; 172(?):402-9. doi:
10.1016/j.jep.2015.06.043. [PMID: 26163196] - Jia-Yin Yan, Guo Ai, Xiao-Jian Zhang, Hai-Jiang Xu, Zheng-Ming Huang. Investigations of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic against α-naphthylisothiocyanate-induced cholestatic liver injury in rats.
Journal of ethnopharmacology.
2015 Aug; 172(?):202-13. doi:
10.1016/j.jep.2015.06.044. [PMID: 26133062] - Yanling Zhao, Xiao Ma, Jiabo Wang, Ruiqing Wen, Lei Jia, Yun Zhu, Ruisheng Li, Ruilin Wang, Jianyu Li, Lifu Wang, Yonggang Li, Xiaohe Xiao. Large dose means significant effect--dose and effect relationship of Chi-Dan-Tui-Huang decoction on alpha-naphthylisothiocyanate-induced cholestatic hepatitis in rats.
BMC complementary and alternative medicine.
2015 Apr; 15(?):104. doi:
10.1186/s12906-015-0637-0. [PMID: 25889085] - Xiao Ma, Yan-ling Zhao, Yun Zhu, Zhe Chen, Jia-bo Wang, Rui-yu Li, Chang Chen, Shi-zhang Wei, Jian-yu Li, Bing Liu, Rui-lin Wang, Yong-gang Li, Li-fu Wang, Xiao-he Xiao. Paeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway.
Drug design, development and therapy.
2015; 9(?):5061-74. doi:
10.2147/dddt.s90030. [PMID: 26366057] - N Joshi, A K Kopec, K M O'Brien, K L Towery, H Cline-Fedewa, K J Williams, B L Copple, M J Flick, J P Luyendyk. Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.
Journal of thrombosis and haemostasis : JTH.
2015 Jan; 13(1):57-71. doi:
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Acta pharmacologica Sinica.
2014 Dec; 35(12):1527-36. doi:
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Toxicology.
2014 Nov; 325(?):85-95. doi:
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BMC complementary and alternative medicine.
2014 Jul; 14(?):249. doi:
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The Journal of pharmacology and experimental therapeutics.
2014 Jun; 349(3):383-92. doi:
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The Journal of pharmacology and experimental therapeutics.
2014 Apr; 349(1):94-8. doi:
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Journal of applied toxicology : JAT.
2013 Oct; 33(10):1120-30. doi:
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Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2013 Sep; 65(6):825-35. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Aug; 58(?):242-8. doi:
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Toxicologic pathology.
2013 Jul; 41(5):795-804. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2013 Jan; 131(1):128-38. doi:
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