Metocurine (BioDeep_00000006631)
代谢物信息卡片
NCGC00181151-01
化学式: C40H48N2O6+2 (652.3512188)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COc1ccc2cc1Oc1cc3c(cc1OC)CC[N+](C)(C)C3Cc1ccc(cc1)Oc1c(OC)c(OC)cc3c1C(C2)[N+](C)(C)CC3
InChI: InChI=1S/C40H48N2O6/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36/h9-14,21-24,31-32H,15-20H2,1-8H3/q+2/t31-,32+/m0/s1
描述信息
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:6900
- KEGG: C07919
- PubChem: 21233
- PubChem: 14955
- DrugBank: DB01336
- ChEMBL: CHEMBL1259
- CAS: 5152-30-7
- PMhub: MS000019702
- PubChem: 10121
- PDB-CCD: CU9
- NIKKAJI: J96.562F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- S O Mashayekhi, M Ghandforoush-Sattari, D C Buss, P A Routledge, R Dw Hain. Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2010; 18(2):107-13. doi:
. [PMID: 22615603] - Man Liu, James P Dilger. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor.
Molecular pharmacology.
2009 Jan; 75(1):166-73. doi:
10.1124/mol.108.051060. [PMID: 18842832] - G A Gronert, D L Fung, S C Haskins, E P Steffey. Deep sedation and mechanical ventilation without paralysis for 3 weeks in normal beagles: exaggerated resistance to metocurine in gastrocnemius muscle.
Anesthesiology.
1999 Jun; 90(6):1741-5. doi:
10.1097/00000542-199906000-00032. [PMID: 10360874] - J F Antognini, R Wood, G A Gronert. Metocurine pharmacokinetics and pharmacodynamics in goats.
Journal of veterinary pharmacology and therapeutics.
1995 Dec; 18(6):464-7. doi:
10.1111/j.1365-2885.1995.tb00627.x. [PMID: 8789701] - J F Antognini, N D Kien. A method for preferential delivery of volatile anesthetics to the in situ goat brain.
Anesthesiology.
1994 May; 80(5):1148-54. doi:
10.1097/00000542-199405000-00024. [PMID: 8017652] - C S Kim, F J Arnold, M S Itani, J A Martyn. Decreased sensitivity to metocurine during long-term phenytoin therapy may be attributable to protein binding and acetylcholine receptor changes.
Anesthesiology.
1992 Sep; 77(3):500-6. doi:
10.1097/00000542-199209000-00015. [PMID: 1519788] - J Futo, J P Kupferberg, J Moss. Inhibition of histamine N-methyltransferase (HNMT) in vitro by neuromuscular relaxants.
Biochemical pharmacology.
1990 Feb; 39(3):415-20. doi:
10.1016/0006-2952(90)90045-m. [PMID: 1968337] - G A Gronert, D A White, S L Shafer, R S Matteo. Exercise produces sensitivity to metocurine.
Anesthesiology.
1989 Jun; 70(6):973-7. doi:
10.1097/00000542-198906000-00015. [PMID: 2729640] - S L Shafer, J R Varvel, G A Gronert. A comparison of parametric with semiparametric analysis of the concentration versus effect relationship of metocurine in dogs and pigs.
Journal of pharmacokinetics and biopharmaceutics.
1989 Jun; 17(3):291-304. doi:
10.1007/bf01061898. [PMID: 2810069] - M J Avram, C A Shanks, T K Henthorn, A K Ronai, J Kinzer, C J Wilkinson. Metocurine kinetics in patients undergoing operations requiring cardiopulmonary bypass.
Clinical pharmacology and therapeutics.
1987 Nov; 42(5):576-81. doi:
10.1038/clpt.1987.199. [PMID: 3315392] - E Ornstein, R S Matteo, W L Young, J Diaz. Resistance to metocurine-induced neuromuscular blockade in patients receiving phenytoin.
Anesthesiology.
1985 Sep; 63(3):294-8. doi:
10.1097/00000542-198509000-00009. [PMID: 3161430] - J R Shayevitz, R S Matteo. Decreased sensitivity to metocurine in patients with upper motoneuron disease.
Anesthesia and analgesia.
1985 Aug; 64(8):767-72. doi:
. [PMID: 3160262] - M J Bennett, J F Hahn. Potentiation of the combination of pancuronium and metocurine by halothane and isoflurane in humans with and without renal failure.
Anesthesiology.
1985 Jun; 62(6):759-64. doi:
10.1097/00000542-198506000-00010. [PMID: 4003796] - R S Matteo, W W Backus, D D McDaniel, W P Brotherton, R Abraham, J Diaz. Pharmacokinetics and pharmacodynamics of d-tubocurarine and metocurine in the elderly.
Anesthesia and analgesia.
1985 Jan; 64(1):23-9. doi:
. [PMID: 3966648] - M J Avram, C A Shanks. Determination of D-tubocurarine chloride or metocurine iodide in human plasma by high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography.
1984 Mar; 306(?):398-404. doi:
10.1016/s0378-4347(00)80906-8. [PMID: 6715480] - J L Rodriguez, C Weissman, M C Damask, J Askanazi, A I Hyman, J M Kinney. Physiologic requirements during rewarming: suppression of the shivering response.
Critical care medicine.
1983 Jul; 11(7):490-7. doi:
. [PMID: 6407803] - V Nigrovic, L S McCullough, A Wajskol, J A Levin, J T Martin. Succinylcholine-induced increases in plasma catecholamine levels in humans.
Anesthesia and analgesia.
1983 Jul; 62(7):627-32. doi:
. [PMID: 6859566] - J A Martyn, N G Goudsouzian, R S Matteo, L M Liu, S K Szyfelbein, R F Kaplan. Metocurine requirements and plasma concentrations in burned paediatric patients.
British journal of anaesthesia.
1983 Apr; 55(4):263-8. doi:
10.1093/bja/55.4.263. [PMID: 6220728] - Y S Tong, C D Qu. [Comparison of Dimethyl-curarine dimethochloride with other nine muscle relaxants through electromyographic quantitative analysis (author's transl)].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
1982 Feb; 4(1):53-6. doi:
". [PMID: 6461433] - N Nussmeier, G W Henry, D C Stevens, R L Schreiner, J L Grosfeld. Dose requirement of d-tubocurarine and metocurine used for chronic respiratory paralysis in neonates.
Journal of pediatric surgery.
1981 Oct; 16(5):700-3. doi:
10.1016/s0022-3468(81)80555-6. [PMID: 7310604] - ". [Laboratory and clinical study on dimethylcurine methochloride---a neuromuscular blocking agent (author's transl)].
Zhonghua yi xue za zhi.
1981 Oct; 61(10):617-9. doi:
". [PMID: 6800604] - W P Brotherton, R S Matteo. Pharmacokinetics and pharmacodynamics of metocurine in humans with and without renal failure.
Anesthesiology.
1981 Sep; 55(3):273-6. doi:
10.1097/00000542-198109000-00015. [PMID: 7023284] - M Wood, A J Wood. Changes in plasma drug binding and alpha 1-acid glycoprotein in mother and newborn infant.
Clinical pharmacology and therapeutics.
1981 Apr; 29(4):522-6. doi:
10.1038/clpt.1981.73. [PMID: 7471620]