Fertirelin (BioDeep_00000663020)

   


代谢物信息卡片


(Des-Gly10,Pro-NHEt9)-LHRH acetate salt

化学式: C55H76N16O12 (1152.5828336)
中文名称: 夫替瑞林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
InChI: InChI=1S/C55H76N16O12/c1-4-59-53(82)44-12-8-20-71(44)54(83)38(11-7-19-60-55(56)57)66-49(78)39(21-30(2)3)65-46(75)27-62-47(76)40(22-31-13-15-34(73)16-14-31)67-52(81)43(28-72)70-50(79)41(23-32-25-61-36-10-6-5-9-35(32)36)68-51(80)42(24-33-26-58-29-63-33)69-48(77)37-17-18-45(74)64-37/h5-6,9-10,13-16,25-26,29-30,37-44,61,72-73H,4,7-8,11-12,17-24,27-28H2,1-3H3,(H,58,63)(H,59,82)(H,62,76)(H,64,74)(H,65,75)(H,66,78)(H,67,81)(H,68,80)(H,69,77)(H,70,79)(H4,56,57,60)/t37-,38-,39-,40-,41-,42-,43-,44-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1910 - Gonadotropin-releasing Hormone Analog
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Fertirelin is a GnRH and LH-RH analogue; it also becomes the treatment choice for reversing cow follicular cysts.

同义名列表

2 个代谢物同义名

(Des-Gly10,Pro-NHEt9)-LHRH acetate salt; Fertirelin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Doungrut Tungmahasuk, Numfa Fungbun, Titaree Laoharatchatathanin, Ryota Terashima, Shiro Kurusu, Mitsumori Kawaminami. Effects of gonadotropin-releasing hormone agonist on human chorionic gonadotropin activity in granulosa cells of immature female rats. The Journal of reproduction and development. 2018 Apr; 64(2):129-134. doi: 10.1262/jrd.2017-142. [PMID: 29249775]
  • M A Hannan, N Kawate, Y Fukami, I N Pathirana, E E Büllesbach, T Inaba, H Tamada. Acute regulation of plasma insulin-like peptide 3 concentrations by luteinizing hormone in male goats. Theriogenology. 2016 Aug; 86(3):749-56. doi: 10.1016/j.theriogenology.2016.02.028. [PMID: 27056416]
  • M A Hannan, Y Fukami, N Kawate, M Sakase, M Fukushima, I N Pathirana, E E Büllesbach, T Inaba, H Tamada. Plasma insulin-like peptide 3 concentrations are acutely regulated by luteinizing hormone in pubertal Japanese Black beef bulls. Theriogenology. 2015 Dec; 84(9):1530-5. doi: 10.1016/j.theriogenology.2015.07.039. [PMID: 26318230]
  • Ryotaro Miura, Shingo Haneda, Motozumi Matsui. Ovulation of the preovulatory follicle originating from the first-wave dominant follicle leads to formation of an active corpus luteum. The Journal of reproduction and development. 2015; 61(4):317-23. doi: 10.1262/jrd.2014-099. [PMID: 26018204]
  • N Isobe, K Yamada, Y Yoshimura. Involvement of plasma progesterone, oestradiol-17beta and cortisol in ovulatory response to gonadotropin-releasing hormone in dairy cows with cystic follicles. Reproduction in domestic animals = Zuchthygiene. 2007 Aug; 42(4):370-5. doi: 10.1111/j.1439-0531.2006.00792.x. [PMID: 17635773]
  • S Tsumagari, T Ishinazaka, G Watanabe, K Taya, M Ishii. Successful pregnancy following gonadotrophin-releasing hormone analogue treatment in a previously infertile bitch. The Journal of small animal practice. 2006 Apr; 47(4):213-5. doi: 10.1111/j.1748-5827.2006.00044.x. [PMID: 16573765]
  • Noritoshi Kawate, Mitsuhiro Sakase, Yasutaka Seo, Moriyuki Fukushima, Masanobu Noda, Kazushi Takeda, Satoru Ueno, Toshio Inaba, Kayoko Kida, Hiromichi Tamada, Tsutomu Sawada. Relations between plasma IGF-I concentrations during treatment with CIDR-based or Ovsynch protocol for timed AI and conception in early postpartum Japanese black beef cows. The Journal of reproduction and development. 2006 Feb; 52(1):81-9. doi: 10.1262/jrd.17043. [PMID: 16293942]
  • M Sakase, Y Seo, M Fukushima, M Noda, K Takeda, S Ueno, T Inaba, H Tamada, T Sawada, N Kawate. Effect of CIDR-based protocols for timed-AI on the conception rate and ovarian functions of Japanese Black beef cows in the early postpartum period. Theriogenology. 2005 Sep; 64(5):1197-211. doi: 10.1016/j.theriogenology.2005.02.008. [PMID: 16125562]
  • N Kawate, T Itami, T Choushi, T Saitoh, T Wada, K Matsuoka, K Uenaka, N Tanaka, A Yamanaka, M Sakase, H Tamada, T Inaba, T Sawada. Improved conception in timed-artificial insemination using a progesterone-releasing intravaginal device and Ovsynch protocol in postpartum suckled Japanese Black beef cows. Theriogenology. 2004 Jan; 61(2-3):399-406. doi: 10.1016/s0093-691x(03)00239-5. [PMID: 14662139]
  • Mehmet Kanter, Cengiz Yildiz, Ismail Meral, Ahmet Koc, Ibrahim Tasal. Effects of a GnRH agonist on oocyte number and maturation in mice superovulated with eCG and hCG. Theriogenology. 2004 Jan; 61(2-3):393-8. doi: 10.1016/s0093-691x(03)00222-x. [PMID: 14662138]
  • Kyoji Yamada, Tosihiko Nakao, Ken Nakada, Gen Matsuda. Influence of GnRH analogue (fertirelin acetate) doses on synchronization of ovulation and fixed-time artificial insemination in lactating dairy cows. Animal reproduction science. 2002 Nov; 74(1-2):27-34. doi: 10.1016/s0378-4320(02)00161-6. [PMID: 12379372]
  • T Osawa, T Nakao, M Moriyoshi, K Nakada. Plasma beta-endorphin around parturition and its relationship to cortisol level and resumption of pituitary and ovarian functions in dairy cows. Animal reproduction science. 1998 Jun; 52(1):27-38. doi: 10.1016/s0378-4320(98)00086-4. [PMID: 9728812]
  • E Kawakami, S Hirayama, T Tsutsui, A Ogasa. Pituitary response of cryptorchid dogs to LH-RH-analogue before and after sexual maturation. The Journal of veterinary medical science. 1993 Feb; 55(1):147-8. doi: 10.1292/jvms.55.147. [PMID: 8096403]
  • I Rettmer, J S Stevenson, L R Corah. Endocrine responses and ovarian changes in inseminated dairy heifers after an injection of a GnRH agonist 11 to 13 days after estrus. Journal of animal science. 1992 Feb; 70(2):508-17. doi: 10.2527/1992.702508x. [PMID: 1548214]
  • E Kawakami, H Tonsho, T Tsutsui, A Ogasa. Effects of LHRH-analogue treatment of spermatogenic dysfunction in the dog. International journal of andrology. 1991 Dec; 14(6):441-52. doi: 10.1111/j.1365-2605.1991.tb01273.x. [PMID: 1761324]
  • A A Rosa-e-Silva, J A Mello-de-Oliveira. Acute administration of human chorionic gonadotropin reverts some of the inhibitory effects of an LH-RH agonist on testicular steroidogenesis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 1991; 24(1):93-7. doi: NULL. [PMID: 1823223]
  • M D Culler, A Negro-Vilar. Pulsatile follicle-stimulating hormone secretion is independent of luteinizing hormone-releasing hormone (LHRH): pulsatile replacement of LHRH bioactivity in LHRH-immunoneutralized rats. Endocrinology. 1987 May; 120(5):2011-21. doi: 10.1210/endo-120-5-2011. [PMID: 2436893]
  • J Okada, S Kondo. Enzyme immunoassay for the determination of des-Gly10-NH2-LH-RH-ethylamide (fertirelin) in bovine plasma. Chemical & pharmaceutical bulletin. 1985 Oct; 33(10):4464-70. doi: 10.1248/cpb.33.4464. [PMID: 3912070]
  • R D'Agata, F Cassorla, A K Munabi, V Mericq, M C Gelato, B D Albertson, D L Loriaux. Direct effect of the luteinizing hormone releasing hormone analog D-Trp6-Pro9-Net-LHRH on rat testicular steroidogenesis. Steroids. 1984 Feb; 43(2):201-7. doi: 10.1016/0039-128x(84)90038-2. [PMID: 6395451]
  • A Caraty, G B Martin, G Montgomery. A new method for studying pituitary responsiveness in vivo using pulses of LH-RH analogue in ewes passively immunized against native LH-RH. Reproduction, nutrition, developpement. 1984; 24(4):439-48. doi: 10.1051/rnd:19840409. [PMID: 6435222]
  • P V Reddy, S Azhar, K M Menon. Multiple inhibitory actions of luteinizing hormone-releasing hormone agonist on luteinizing hormone/human chorionic gonadotropin receptor-mediated ovarian responses. Endocrinology. 1980 Oct; 107(4):930-6. doi: 10.1210/endo-107-4-930. [PMID: 6250799]