2-bromohexadecanoic acid (BioDeep_00000662710)
代谢物信息卡片
2-bromohexadecanoic acid
化学式: C16H31BrO2 (334.1507)
中文名称: 2-溴十六烷酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCC(C(=O)O)Br
InChI: InChI=1S/C16H31BrO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(17)16(18)19/h15H,2-14H2,1H3,(H,18,19)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Dongxiao Liu, Ruth Cruz-Cosme, Yong Wu, Julian Leibowitz, Qiyi Tang. 2-Bromopalmitate depletes lipid droplets to inhibit viral replication.
Journal of virology.
2024 Apr; 98(4):e0017124. doi:
10.1128/jvi.00171-24. [PMID: 38488361] - Rongzhen Deng, Ze Zheng, Shaofan Hu, Meng Wang, Jing Feng, Peter Mattjus, Zhengwen Zhang, Yiguo Zhang. Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of lipids and reactive oxygen species in human hepatoma cells, which is alleviated by 2-bromopalmitate.
Biochimica et biophysica acta. Molecular cell research.
2024 Feb; 1871(2):119644. doi:
10.1016/j.bbamcr.2023.119644. [PMID: 37996059] - Chen Wang, Zhao-Yang Cui, Hai-Yan Chang, Chang-Zhen Wu, Zhao-Yan Yu, Xiao-Ting Wang, Yi-Qing Liu, Chang-Le Li, Xiang-Ge Du, Jian-Feng Li. 2-Bromopalmitate inhibits malignant behaviors of HPSCC cells by hindering the membrane location of Ras protein.
Experimental biology and medicine (Maywood, N.J.).
2023 Dec; 248(23):2393-2407. doi:
10.1177/15353702231220671. [PMID: 38159074] - Saara-Anne Azizi, Clémence Delalande, Tong Lan, Tian Qiu, Bryan C Dickinson. Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20.
ACS medicinal chemistry letters.
2022 Oct; 13(10):1648-1654. doi:
10.1021/acsmedchemlett.2c00336. [PMID: 36262404] - Yun Luo, Chee Wah Tan, Shi-Zhe Xie, Ying Chen, Yu-Lin Yao, Kai Zhao, Yan Zhu, Qi Wang, Mei-Qin Liu, Xing-Lou Yang, Lin-Fa Wang, Zheng-Li Shi. Identification of ZDHHC17 as a Potential Drug Target for Swine Acute Diarrhea Syndrome Coronavirus Infection.
mBio.
2021 10; 12(5):e0234221. doi:
10.1128/mbio.02342-21. [PMID: 34700373] - Alexander L Ticho, Pooja Malhotra, Christopher R Manzella, Pradeep K Dudeja, Seema Saksena, Ravinder K Gill, Waddah A Alrefai. S-acylation modulates the function of the apical sodium-dependent bile acid transporter in human cells.
The Journal of biological chemistry.
2020 04; 295(14):4488-4497. doi:
10.1074/jbc.ra119.011032. [PMID: 32071081] - Mansoor A Siddiqui, Shailja Singh, Pawan Malhotra, Chetan E Chitnis. Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Plasmodium falciparum Merozoites.
ACS infectious diseases.
2020 03; 6(3):379-392. doi:
10.1021/acsinfecdis.9b00321. [PMID: 32003970] - Chansik Hong, Seo Hwa Choi, Misun Kwak, Byeongseok Jeong, Juyeon Ko, Hyung Joon Park, Seok Choi, Jae Yeoul Jun, Insuk So. TRPC5 channel instability induced by depalmitoylation protects striatal neurons against oxidative stress in Huntington's disease.
Biochimica et biophysica acta. Molecular cell research.
2020 02; 1867(2):118620. doi:
10.1016/j.bbamcr.2019.118620. [PMID: 31812495] - Akshay Murthy, Samuel W Workman, Min Jiang, Junping Hu, Ismat Sifa, Tytus Bernas, Wanchun Tang, Isabelle Deschenes, Gea-Ny Tseng. Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes.
Journal of molecular and cellular cardiology.
2019 10; 135(?):1-9. doi:
10.1016/j.yjmcc.2019.07.013. [PMID: 31362018] - Cassiano Martin Batista, Rafael Luis Kessler, Iriane Eger, Maurilio José Soares. Treatment of Trypanosoma cruzi with 2-bromopalmitate alters morphology, endocytosis, differentiation and infectivity.
BMC cell biology.
2018 08; 19(1):19. doi:
10.1186/s12860-018-0170-3. [PMID: 30170543] - Xiao-Long Zhang, Huan-Huan Ding, Ting Xu, Meng Liu, Chao Ma, Shao-Ling Wu, Jia-You Wei, Cui-Cui Liu, Su-Bo Zhang, Wen-Jun Xin. Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Nav1.6 in sensory neurons to promote neuropathic pain.
Science signaling.
2018 03; 11(523):. doi:
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Molecular neurobiology.
2017 05; 54(4):2739-2751. doi:
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Biochimica et biophysica acta.
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Nature communications.
2016 06; 7(?):11932. doi:
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BMC plant biology.
2015 Feb; 15(?):50. doi:
10.1186/s12870-015-0441-5. [PMID: 25849075] - Laura D Hamel, Robert J Deschenes, David A Mitchell. A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening.
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PloS one.
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The Journal of cell biology.
2013 Jul; 202(1):145-61. doi:
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Lipids in health and disease.
2012 Jul; 11(?):66. doi:
10.1186/1476-511x-11-66. [PMID: 22676303] - Agnieszka Łach, Michał Grzybek, Elzbieta Heger, Justyna Korycka, Marcin Wolny, Jakub Kubiak, Adam Kolondra, Dzamila M Bogusławska, Katarzyna Augoff, Michał Majkowski, Joanna Podkalicka, Jakub Kaczor, Adam Stefanko, Kazimierz Kuliczkowski, Aleksander F Sikorski. Palmitoylation of MPP1 (membrane-palmitoylated protein 1)/p55 is crucial for lateral membrane organization in erythroid cells.
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Molecular biology of the cell.
2011 Jun; 22(11):1930-42. doi:
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The Journal of biological chemistry.
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PloS one.
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PloS one.
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2010 Jul; 285(31):23954-62. doi:
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