Netivudine (BioDeep_00000662366)
代谢物信息卡片
化学式: C12H14N2O6 (282.0852)
中文名称: 奈替夫定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C12H14N2O6/c1-2-3-6-4-14(12(19)13-10(6)18)11-9(17)8(16)7(5-15)20-11/h4,7-9,11,15-17H,5H2,1H3,(H,13,18,19)/t7-,8-,9+,11-/m1/s1
描述信息
C471 - Enzyme Inhibitor > C1589 - Reverse Transcriptase Inhibitor > C97452 - Nucleoside Reverse Transcriptase Inhibitor
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- F Le Roy, M Godin, B Legallicler, J P Fillastre, R Bidault, J Posner, R W Peck. Pharmacokinetics of netivudine in haemodialysis patients.
The Journal of antimicrobial chemotherapy.
1996 Nov; 38(5):913-5. doi:
10.1093/jac/38.5.913. [PMID: 8961067] - J P Fillastre, M Godin, B Legallicier, P Chretien, R Bidault, C Gillotin, R Wooton, J Posner, R W Peck. Pharmacokinetics of netivudine, a potent anti-varicella zoster virus drug, in patients with renal impairment.
The Journal of antimicrobial chemotherapy.
1996 May; 37(5):965-74. doi:
10.1093/jac/37.5.965. [PMID: 8737146] - R W Peck, P Crome, M J Wood, M W McKendrick, B Bannister, B K Mandal, R J Crooks. Multiple dose netivudine, a potent anti-varicella zoster virus agent, in healthy elderly volunteers and patients with shingles.
The Journal of antimicrobial chemotherapy.
1996 Mar; 37(3):583-97. doi:
10.1093/jac/37.3.583. [PMID: 9182115] - R Peck, R Wiggs, J Callaghan, R Wootton, P Crome, I Fraser, L Frick, J Posner. Inhibition of dihydropyrimidine dehydrogenase by 5-propynyluracil, a metabolite of the anti-varicella zoster virus agent netivudine.
Clinical pharmacology and therapeutics.
1996 Jan; 59(1):22-31. doi:
10.1016/s0009-9236(96)90020-x. [PMID: 8549030] - R W Peck, R Wootton, D R Lee, S H Jackson, J Posner. The bioavailability and disposition of 1-(beta-D-arabinofuranosyl)-5-(1-propynyl)uracil (882C87), a potent, new anti-varicella zoster virus agent.
British journal of clinical pharmacology.
1995 Feb; 39(2):143-9. doi:
10.1111/j.1365-2125.1995.tb04421.x. [PMID: 7742152] - R W Peck, B C Weatherley, R Wootton, P Crome, T A Holdich, J Posner. Pharmacokinetics and tolerability of single oral doses of 882C87, a potent, new anti-varicella-zoster virus agent, in healthy volunteers.
Antimicrobial agents and chemotherapy.
1995 Jan; 39(1):20-7. doi:
10.1128/aac.39.1.20. [PMID: 7695306] - J D Cooper, C T Sheung, A R Buick. Automated sequential trace enrichment of dialysates combined with high-performance liquid chromatography and automated heart-cutting for the determination of the nucleoside 1-(beta-D-arabinofuranosyl)-5-(1-propynyl)uracil and its metabolite 5-propynyluracil in urine.
Journal of chromatography.
1994 Jan; 652(1):15-21. doi:
10.1016/0378-4347(93)e0398-a. [PMID: 8014223] - G Darby. Acyclovir--and beyond.
The Journal of international medical research.
1994; 22 Suppl 1(?):33A-42A. doi:
NULL. [PMID: 8063023] - A R Buick, C T Sheung. Determination of 1-(beta-D-arabinofuranosyl)-5-(1-propynyl)-uracil and a metabolite, 5-propynyluracil, in plasma using ASTED (automated sequential trace enrichment of dialysates) combined, on-line, with high-performance liquid chromatography.
Journal of chromatography.
1993 Jul; 617(1):65-70. doi:
10.1016/0378-4347(93)80422-z. [PMID: 8376539] - D J Purifoy, L M Beauchamp, P de Miranda, P Ertl, S Lacey, G Roberts, S G Rahim, G Darby, T A Krenitsky, K L Powell. Review of research leading to new anti-herpesvirus agents in clinical development: valaciclovir hydrochloride (256U, the L-valyl ester of acyclovir) and 882C, a specific agent for varicella zoster virus.
Journal of medical virology.
1993; Suppl 1(?):139-45. doi:
10.1002/jmv.1890410527. [PMID: 8245881] - M J Wood, M W McKendrick, B Bannister, B K Mandal, R W Peck, R J Crooks. Preliminary pharmacokinetics and safety of 882C87 in patients with herpes zoster.
Journal of medical virology.
1993; Suppl 1(?):154-7. doi:
10.1002/jmv.1890410530. [PMID: 8245884]
