PDK1 inhibitor AR-12 (BioDeep_00000662332)
代谢物信息卡片
化学式: C26H19F3N4O (460.1511)
中文名称: OSU-03012
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F
InChI: InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34)
描述信息
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jonathan O Rayner, Rosemary A Roberts, Jin Kim, Andrew Poklepovic, Jane L Roberts, Laurence Booth, Paul Dent. AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication.
Biochemical pharmacology.
2020 12; 182(?):114227. doi:
10.1016/j.bcp.2020.114227
. [PMID: 32966814] - Xiaojie Ma, Lan Jin, Xiaoqin Lei, Jingan Tong, Runsheng Wang. MicroRNA‑363‑3p inhibits cell proliferation and induces apoptosis in retinoblastoma cells via the Akt/mTOR signaling pathway by targeting PIK3CA.
Oncology reports.
2020 05; 43(5):1365-1374. doi:
10.3892/or.2020.7544
. [PMID: 32323827] - William T Barker, Ansley M Nemeth, Sara M Brackett, Akash K Basak, Courtney E Chandler, Leigh A Jania, William J Zuercher, Roberta J Melander, Beverly H Koller, Robert K Ernst, Christian Melander. Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria.
ACS infectious diseases.
2019 10; 5(10):1764-1771. doi:
10.1021/acsinfecdis.9b00212
. [PMID: 31434474] - Kristy Koselny, Julianne Green, Louis DiDone, Justin P Halterman, Annette W Fothergill, Nathan P Wiederhold, Thomas F Patterson, Melanie T Cushion, Chad Rappelye, Melanie Wellington, Damian J Krysan. The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Antimicrobial agents and chemotherapy.
2016 12; 60(12):7115-7127. doi:
10.1128/aac.01061-16
. [PMID: 27645246] - Laurence Booth, Jane L Roberts, Mehrad Tavallai, Aida Nourbakhsh, John Chuckalovcak, Jori Carter, Andrew Poklepovic, Paul Dent. OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies.
Journal of cellular physiology.
2015 Aug; 230(8):1982-98. doi:
10.1002/jcp.24977
. [PMID: 25736380]