Nebivolol hydrochloride (BioDeep_00000662142)
代谢物信息卡片
Nebivolol hydrochloride
化学式: C22H26ClF2NO4 (441.1518330000001)
中文名称: 盐酸奈必洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O.Cl
InChI: /m1./s1
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:132912
- ChEBI: CHEBI:132913
- PubChem: 24866733
- MeSH: Nebivolol
- CAS: 152520-56-4
- CAS: 169293-50-9
- medchemexpress: HY-B0203A
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Shahinaze A Fouad, Sara T Khatab, Mahmoud H Teaima, Mohamed A El-Nabarawi, Rehab Abdelmonem. Nanosized ethosomal dispersions for enhanced transdermal delivery of nebivolol using intradermal/transfollicular sustained reservoir: in vitro evaluation, confocal laser scanning microscopy, and in vivo pharmacokinetic studies.
Pharmaceutical development and technology.
2024 Jan; 29(1):40-51. doi:
10.1080/10837450.2023.2294278. [PMID: 38078863] - Inmaculada Xu Lou, Jiayue Chen, Kamran Ali, Qilan Chen. Relationship Between Hypertension, Antihypertensive Drugs and Sexual Dysfunction in Men and Women: A Literature Review.
Vascular health and risk management.
2023; 19(?):691-705. doi:
10.2147/vhrm.s439334. [PMID: 37941540] - Antoinette G Naeem, Reem N El-Naga, Haidy E Michel. Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation.
Inflammopharmacology.
2022 Dec; 30(6):2197-2209. doi:
10.1007/s10787-022-01045-4. [PMID: 35948811] - Massimo Volpe, Valeria Pegoraro, Ilaria Peduto, Franca Heiman, Suada Meto. Extemporaneous combination therapy with nebivolol/zofenopril in hypertensive patients: usage in Italy.
Current medical research and opinion.
2022 10; 38(10):1673-1681. doi:
10.1080/03007995.2022.2096352. [PMID: 35787718] - Thaina Omia Bueno-Pereira, Priscila Rezeck Nunes, Mariana Bertozzi Matheus, Ananda Lini Vieira da Rocha, Valeria Cristina Sandrim. Nebivolol Increases Nitric Oxide Synthase via β3 Adrenergic Receptor in Endothelial Cells Following Exposure to Plasma from Preeclamptic Patients.
Cells.
2022 03; 11(5):. doi:
10.3390/cells11050883. [PMID: 35269505] - E S Said, A H Mohammed, H M Ali, A Y Babiker, R Alnughaymishi, N Z Althaqeel, A S Ahmed. Evaluation of hepatoprotective effect of Nebivolol and sodium copper Chlorophyllin on CCL4-induced hepatotoxicity in mice.
European review for medical and pharmacological sciences.
2022 Mar; 26(5):1717-1728. doi:
10.26355/eurrev_202203_28241. [PMID: 35302221] - Bahia Abbas Moussa, Hanaa M A Hashem, Marianne Alphonse Mahrouse, Sally Tarek Mahmoud. Synchronized determination of sacubitril and valsartan with some co-administered drugs in human plasma via UPLC-MS/MS method using solid-phase extraction.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5203. doi:
10.1002/bmc.5203. [PMID: 34145610] - Abdul Majid, Amir Javed, Mazhar Hussain, Zeeshan Faisal, Asim Elahi, Lubna Akhtar. Effect of nebivolol beneficial on lipid profile and glycemic control in comparison with Atenolol in patients with type 2 DM with concomitant hypertension.
Pakistan journal of pharmaceutical sciences.
2021 Sep; 34(5(Supplementary)):1891-1895. doi:
". [PMID: 34836856] - Jéssica Freitas Araújo Encinas, Carlos Henrique Foncesca Peiró, Matheus Moreira Perez, Joyce Regina Santos Raimundo, Katharyna Cardoso de Gois, Marina Cristina Peres, Patricia Ferrante Draghi, Catherine Giovanna Costas Arcia, Diogo Pimenta Simões, Neif Murad, Beatriz da Costa Aguiar Alves, Fernando Luiz Affonso Fonseca, Glaucia Luciano da Veiga. Does nebivolol have renoprotective action in patients with chronic kidney disease conditions? An integrative review.
European journal of pharmacology.
2021 Aug; 905(?):174180. doi:
10.1016/j.ejphar.2021.174180. [PMID: 34015319] - Hanaa Wanas, Mohamed El-Shabrawy, Amal Mishriki, Hisham Attia, Mohamed Emam, Basma Emad Aboulhoda. Nebivolol protects against cyclophosphamide-induced nephrotoxicity through modulation of oxidative stress, inflammation, and apoptosis.
Clinical and experimental pharmacology & physiology.
2021 05; 48(5):811-819. doi:
10.1111/1440-1681.13481. [PMID: 33590494] - Gabriel T do Vale, Carla B P da Silva, Arthur H Sousa, Natália A Gonzaga, Juliana M Parente, Katiúscia M Araújo, Michele M Castro, Carlos R Tirapelli. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity.
Cardiovascular toxicology.
2021 03; 21(3):224-235. doi:
10.1007/s12012-020-09614-1. [PMID: 33067693] - Yali Yang, Shanshan Yong, Fuhao Li, Liang Dong, Degui Chang. The effect of nebivolol on erectile function in the cases with coronary artery bypass surgery: A protocol for a systematic review and meta-analysis of randomized controlled trials.
Medicine.
2020 Aug; 99(32):e21588. doi:
10.1097/md.0000000000021588. [PMID: 32769911] - Ahmed M Nasr, Samar Rezq, Aya Shaheen, Shimaa M Elshazly. Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2.
Pharmacological reports : PR.
2020 Aug; 72(4):956-968. doi:
10.1007/s43440-020-00059-5. [PMID: 32128711] - Lifang Guo, Shumin Wang, Zirui Wan, Siyang Ni, Benshan Xu, Xiuli Zhao, Lihong Liu. Influence of CYP2D6*5 and *10 polymorphism on the pharmacokinetics of nebivolol in healthy Chinese subjects.
Journal of clinical pharmacy and therapeutics.
2020 Aug; 45(4):632-637. doi:
10.1111/jcpt.13155. [PMID: 32379356] - Carolina Pinto Vieira, Daniel Valente Neves, Glauco Henrique Balthazar Nardotto, Evandro José Cesarino, Adriana Rocha, Ailton Marcelo Castilho Teno Zanardi, Vera Lucia Lanchote. Chronic Chagas disease with low plasma concentrations of IL-6 does not have a major impact on nebivolol glucuronidation.
European journal of clinical pharmacology.
2020 May; 76(5):735-737. doi:
10.1007/s00228-020-02837-9. [PMID: 31982921] - Pradeep Singh Rawat, Punna Rao Ravi, Laxman Kaswan, Rajeev Singh Raghuvanshi. Development and validation of a bio-analytical method for simultaneous quantification of nebivolol and labetalol in aqueous humor and plasma using LC-MS/MS and its application to ocular pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jan; 1136(?):121908. doi:
10.1016/j.jchromb.2019.121908. [PMID: 31862675] - Maurizio Sessa, Annamaria Mascolo, Daniel Bech Rasmussen, Kristian Kragholm, Magnus Thorsten Jensen, Liberata Sportiello, Concetta Rafaniello, Giuseppe Michele Tari, Claudia Pagliaro, Morten Andersen, Francesco Rossi, Annalisa Capuano. Beta-blocker choice and exchangeability in patients with heart failure and chronic obstructive pulmonary disease: an Italian register-based cohort study.
Scientific reports.
2019 08; 9(1):11465. doi:
10.1038/s41598-019-47967-y. [PMID: 31391573] - Azza A K El-Sheikh, Mohamed A Morsy, Rania G Abdel-Latif. Modulation of eNOS/iNOS by nebivolol protects against cyclosporine A-mediated nephrotoxicity through targeting inflammatory and apoptotic pathways.
Environmental toxicology and pharmacology.
2019 Jul; 69(?):26-35. doi:
10.1016/j.etap.2019.03.018. [PMID: 30927701] - Andrzej Wróbel, Barbara Miziak, Małgorzata Bańczerowska-Górska, Aleksandra Szopa, Anna Serefko, Klaudia Stangel-Wójcikiewicz, Piotr Czuczwar, Marzena Laskowska, Edyta Wlaźlak, Jarosław Dudka, Ewa Poleszak. The influence of nebivolol on the activity of BRL 37344 - the β3-adrenergic receptor agonist, in the animal model of detrusor overactivity.
Neurourology and urodynamics.
2019 06; 38(5):1229-1240. doi:
10.1002/nau.23993. [PMID: 30937955] - Dawn Battise, Cassie L Boland, Donald S Nuzum. Nebivolol/Valsartan: A Novel Antihypertensive Fixed-Dose Combination Tablet.
The Annals of pharmacotherapy.
2019 04; 53(4):402-412. doi:
10.1177/1060028018813575. [PMID: 30449127] - Yan Wang, Wenjing An, Fei Zhang, Mengzhen Niu, Yu Liu, Ruizan Shi. Nebivolol ameliorated kidney damage in Zucker diabetic fatty rats by regulation of oxidative stress/NO pathway: Comparison with captopril.
Clinical and experimental pharmacology & physiology.
2018 11; 45(11):1135-1148. doi:
10.1111/1440-1681.13001. [PMID: 29935093] - Arrigo F G Cicero, Masanari Kuwabara, Claudio Borghi. A Critical Review of Nebivolol and its Fixed-Dose Combinations in the Treatment of Hypertension.
Drugs.
2018 Nov; 78(17):1783-1790. doi:
10.1007/s40265-018-0999-y. [PMID: 30426333] - El-Sayed M El-Sayed, Abd El-Aziz H Abd El-Aziz, Mohamed M Amine. Nebivolol enhances the effect of alendronate against methylprednisolone-induced osteoporosis in rats.
Journal of biochemical and molecular toxicology.
2018 Oct; ?(?):e22232. doi:
10.1002/jbt.22232. [PMID: 30291735] - Yan Wang, Mengzhen Niu, Sha Yin, Fei Zhang, Ruizan Shi. Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway.
Pharmacological reports : PR.
2018 Oct; 70(5):917-929. doi:
10.1016/j.pharep.2018.04.004. [PMID: 30099298] - Alexander Vladimirovich Ivanov, Valery Vasil'evich Alexandrin, Alexander Alexandrovich Paltsyn, Edward Danielevich Virus, Ksenya Alexandrovna Nikiforova, Polina Olegovna Bulgakova, Nadezhda Borisovna Sviridkina, Svetlana Alexandrovna Apollonova, Aslan Amirkhanovich Kubatiev. Metoprolol and Nebivolol Prevent the Decline of the Redox Status of Low-Molecular-Weight Aminothiols in Blood Plasma of Rats During Acute Cerebral Ischemia.
Journal of cardiovascular pharmacology.
2018 10; 72(4):195-203. doi:
10.1097/fjc.0000000000000616. [PMID: 30188870] - Yan Wang, Mengzhen Niu, Sha Yin, Fei Zhang, Ruizan Shi. Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway.
Pharmacological reports : PR.
2018 Sep; 70(5):917-929. doi:
NULL. [PMID: 32002962] - Gabriel T do Vale, Janaina A Simplicio, Natália A Gonzaga, Rodrigo Yokota, Amanda A Ribeiro, Dulce E Casarini, Bruno S de Martinis, Carlos R Tirapelli. Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol.
Atherosclerosis.
2018 07; 274(?):67-76. doi:
10.1016/j.atherosclerosis.2018.04.041. [PMID: 29753230] - Marta Walczak-Gałęzewska, Monika Szulińska, Ewa Miller-Kasprzak, Danuta Pupek-Musialik, Paweł Bogdański. The effect of nebivolol and ramipril on selected biochemical parameters, arterial stiffness, and circadian profile of blood pressure in young men with primary hypertension: A 12-week prospective randomized, open-label study trial.
Medicine.
2018 Jul; 97(30):e11717. doi:
10.1097/md.0000000000011717. [PMID: 30045336] - Bhargav M Patel, Arvind G Jangid, B N Suhagia, Nirmal Desai. Novel bio analytical method development, validation and application for simultaneous determination of nebivolol and S-amlodipine in human plasma using ultra performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2018 Mar; 151(?):244-251. doi:
10.1016/j.jpba.2018.01.004. [PMID: 29413973] - Maurizio Sessa, Annamaria Mascolo, Rikke Nørmark Mortensen, Mikkel Porsborg Andersen, Giuseppe Massimo Claudio Rosano, Annalisa Capuano, Francesco Rossi, Gunnar Gislason, Henrik Enghusen-Poulsen, Christian Torp-Pedersen. Relationship between heart failure, concurrent chronic obstructive pulmonary disease and beta-blocker use: a Danish nationwide cohort study.
European journal of heart failure.
2018 03; 20(3):548-556. doi:
10.1002/ejhf.1045. [PMID: 29159953] - Sally A Abuelezz. Nebivolol attenuates oxidative stress and inflammation in a guinea pig model of ovalbumin-induced asthma: a possible mechanism for its favorable respiratory effects.
Canadian journal of physiology and pharmacology.
2018 Mar; 96(3):258-265. doi:
10.1139/cjpp-2017-0230. [PMID: 29319332] - Marwa M M Refaie, Maram El-Hussieny, Nagwa M Zenhom. Protective role of nebivolol in cadmium-induced hepatotoxicity via downregulation of oxidative stress, apoptosis and inflammatory pathways.
Environmental toxicology and pharmacology.
2018 Mar; 58(?):212-219. doi:
10.1016/j.etap.2018.01.011. [PMID: 29408764] - Naini Bhadri, Rema Razdan, Sumanta Kumar Goswami. Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy.
Naunyn-Schmiedeberg's archives of pharmacology.
2018 02; 391(2):207-217. doi:
10.1007/s00210-017-1450-8. [PMID: 29322226] - Ercan Yuvanc, Devrim Tuglu, Tunc Ozan, Ucler Kisa, Mahi Balci, Ertan Batislam, Erdal Yilmaz. Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion.
Acta cirurgica brasileira.
2018 Feb; 33(2):125-133. doi:
10.1590/s0102-865020180020000004. [PMID: 29513811] - M Dursun, S Sahin, H Besiroglu, A Otunctemur, E Ozbek, S S Cakir, M Cekmen, A Somay. Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats.
Bratislavske lekarske listy.
2018 ; 119(11):718-725. doi:
10.4149/bll_2018_128. [PMID: 30686006] - Carolina P Vieira, Daniel V Neves, Eduardo B Coelho, Vera Lucia Lanchote. Effect of CYP2D6 Poor Metabolizer Phenotype on Stereoselective Nebivolol Pharmacokinetics.
Drug metabolism letters.
2018; 12(1):68-70. doi:
10.2174/1872312812666180420104945. [PMID: 29676238] - Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Asif Mahmood, Safirah Maheen, Khurram Afzal, Nabila Iqbal, Mehwish Andleeb, Nazar Abbas. Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology.
Acta pharmaceutica (Zagreb, Croatia).
2017 Dec; 67(4):441-461. doi:
10.1515/acph-2017-0034. [PMID: 29337670] - Daniel A Duprez, Natalia Florea, Sue Duval, Catherine Koukol, Jay N Cohn. Effect of nebivolol or atenolol vs. placebo on cardiovascular health in subjects with borderline blood pressure: the EVIDENCE study.
Journal of human hypertension.
2017 12; 32(1):20-25. doi:
10.1038/s41371-017-0019-9. [PMID: 29184167] - Eva Kociánová, Jan Václavík, Jana Tomková, Peter Ondra, Jiří Jarkovský, Klára Benešová, Tomáš Václavík, Monika Kamasová, Miloš Táborský. Heart rate is a useful marker of adherence to beta-blocker treatment in hypertension.
Blood pressure.
2017 Oct; 26(5):311-318. doi:
10.1080/08037051.2017.1346458. [PMID: 28701047] - Carolina Pinto Vieira, Daniel Valente Neves, Evandro José Cesarino, Adriana Rocha, Séverine Poirier, Vera Lucia Lanchote. An indirect stereoselective analysis of nebivolol glucuronides in plasma by LC-MS/MS: Application to clinical pharmacokinetics.
Journal of pharmaceutical and biomedical analysis.
2017 Sep; 144(?):25-30. doi:
10.1016/j.jpba.2017.01.054. [PMID: 28209351] - Thomas D Giles, John R Cockcroft, Bertram Pitt, Abhijeet Jakate, Harold M Wright. Rationale for nebivolol/valsartan combination for hypertension: review of preclinical and clinical data.
Journal of hypertension.
2017 09; 35(9):1758-1767. doi:
10.1097/hjh.0000000000001412. [PMID: 28509722] - A Coats, S Jain. Protective effects of nebivolol from oxidative stress to prevent hypertension-related target organ damage.
Journal of human hypertension.
2017 06; 31(6):376-381. doi:
10.1038/jhh.2017.8. [PMID: 28252041] - Christian W Mende, Thomas D Giles, David B Bharucha, William G Ferguson, Madhuja Mallick, Mehul D Patel. Efficacy of nebivolol-valsartan single-pill combination in obese and nonobese patients with hypertension.
Journal of clinical hypertension (Greenwich, Conn.).
2017 Jun; 19(6):632-639. doi:
10.1111/jch.12965. [PMID: 28075064] - Celso Francisco Pimentel Vespasiano, Tiago Luders Laurito, Renan Donomae Iwamoto, Ronilson Agnaldo Moreno, Gustavo D Mendes, Gilberto De Nucci. Bioequivalence study between a fixed-dose single-pill formulation of nebivolol plus hydrochlorothiazide and separate formulations in healthy subjects using high-performance liquid chromatography coupled to tandem mass spectrometry.
Biomedical chromatography : BMC.
2017 May; 31(5):. doi:
10.1002/bmc.3884. [PMID: 27809345] - Noha F Abdelkader, Muhammed A Saad, Rania M Abdelsalam. Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats.
Journal of neurochemistry.
2017 05; 141(3):449-460. doi:
10.1111/jnc.13978. [PMID: 28178754] - Gabriel T do Vale, Natália A Gonzaga, Janaina A Simplicio, Carlos R Tirapelli. Nebivolol prevents ethanol-induced reactive oxygen species generation and lipoperoxidation in the rat kidney by regulating NADPH oxidase activation and expression.
European journal of pharmacology.
2017 Mar; 799(?):33-40. doi:
10.1016/j.ejphar.2017.01.036. [PMID: 28132913] - Maria Marketou, Yashaswi Gupta, Shashank Jain, Panos Vardas. Differential Metabolic Effects of Beta-Blockers: an Updated Systematic Review of Nebivolol.
Current hypertension reports.
2017 Mar; 19(3):22. doi:
10.1007/s11906-017-0716-3. [PMID: 28283926] - Ismail Kocyigit, Eray Eroglu, Tevfik Ecder. Nebivolol can be used for combination therapy in patients with autosomal dominant polycystic kidney disease.
Expert opinion on pharmacotherapy.
2017 03; 18(4):455. doi:
10.1080/14656566.2017.1293653. [PMID: 28234564] - Yan Wang, Fei Zhang, Yu Liu, Sha Yin, Xuefen Pang, Zhidong Li, Zehui Wei. Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2017; 39(7):628-639. doi:
10.1080/10641963.2017.1306539. [PMID: 28640644] - Wafaa A Hewedy, Dalia K Mostafa. Nebivolol suppresses asymmetric dimethylarginine and attenuates cyclosporine-induced nephrotoxicity and endothelial dysfunction in rats.
Pharmacological reports : PR.
2016 Dec; 68(6):1319-1325. doi:
10.1016/j.pharep.2016.08.009. [PMID: 27701056] - Karmela Altabas, Velimir Altabas, Tonko Gulin. Nebivolol Induced Hyperkalemia: Case Report.
Acta clinica Croatica.
2016 12; 55(4):663-666. doi:
10.20471/acc.2016.55.04.20. [PMID: 29117660] - Alireza Nazeri, MacArthur A Elayda, Ana Maria Segura, Raymond F Stainback, Joanna Nathan, Vei-Vei Lee, Christina Bove, Luiz Sampaio, Brian Grace, Ali Massumi, Mehdi Razavi. Comparative Efficacy of Nebivolol and Metoprolol to Prevent Tachycardia-Induced Cardiomyopathy in a Porcine Model.
Texas Heart Institute journal.
2016 Dec; 43(6):477-481. doi:
10.14503/thij-15-5495. [PMID: 28100964] - Zhen Tan, Zhichao Xiao, Jinhong Wei, Jingqun Zhang, Qiang Zhou, Chris D Smith, Alma Nani, Guogen Wu, Long-Sheng Song, Thomas G Back, Michael Fill, S R Wayne Chen. Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia.
The Biochemical journal.
2016 Nov; 473(22):4159-4172. doi:
10.1042/bcj20160620. [PMID: 27623776] - Alfonso H Santos, Michael J Casey, Charles M Bucci, Shehzad Rehman, Mark S Segal. Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients.
Journal of clinical hypertension (Greenwich, Conn.).
2016 08; 18(8):741-9. doi:
10.1111/jch.12745. [PMID: 26692375] - Daniel V Neves, Vera L Lanchote, Miguel Moysés Neto, José A Cardeal da Costa, Carolina P Vieira, Eduardo B Coelho. Influence of chronic kidney disease and haemodialysis treatment on pharmacokinetics of nebivolol enantiomers.
British journal of clinical pharmacology.
2016 07; 82(1):83-91. doi:
10.1111/bcp.12917. [PMID: 26914703] - Mohamed A Morsy, Gehan H Heeba. Nebivolol Ameliorates Cisplatin-Induced Nephrotoxicity in Rats.
Basic & clinical pharmacology & toxicology.
2016 Jun; 118(6):449-55. doi:
10.1111/bcpt.12538. [PMID: 26617394] - Fateme Shamekhi Amiri. Recent advances in the treatment of renal diseases with nebivolol: A literature review.
Nephrologie & therapeutique.
2016 Jun; 12(3):140-8. doi:
10.1016/j.nephro.2016.01.011. [PMID: 27117765] - Georgios Liappas, Guadalupe González-Mateo, Anna Rita Aguirre, Hugo Abensur, Patricia Albar-Vizcaino, Emilio González Parra, Pilar Sandoval, Laura García Ramírez, Gloria Del Peso, Juan Manuel Acedo, María A Bajo, Rafael Selgas, José A Sánchez Tomero, Manuel López-Cabrera, Abelardo Aguilera. Nebivolol, a β1-adrenergic blocker, protects from peritoneal membrane damage induced during peritoneal dialysis.
Oncotarget.
2016 May; 7(21):30133-46. doi:
10.18632/oncotarget.8780. [PMID: 27102153] - Neslihan Üstündağ-Okur, Aysu Yurdasiper, Evren Gündoğdu, Evren Homan Gökçe. Modification of solid lipid nanoparticles loaded with nebivolol hydrochloride for improvement of oral bioavailability in treatment of hypertension: polyethylene glycol versus chitosan oligosaccharide lactate.
Journal of microencapsulation.
2016 Feb; 33(1):30-42. doi:
10.3109/02652048.2015.1094532. [PMID: 26444187] - Gary E Sander, Camilo Fernandez, Thomas D Giles. Fixed-dose combination therapy of nebivolol and valsartan for the treatment of hypertension.
Expert review of cardiovascular therapy.
2016; 14(5):563-72. doi:
10.1586/14779072.2016.1167598. [PMID: 26986445] - Ana-Maria Gheldiu, Adina Popa, Maria Neag, Dana Muntean, Corina Bocsan, Anca Buzoianu, Laurian Vlase, Ioan Tomuta, Corina Briciu. Assessment of a Potential Pharmacokinetic Interaction between Nebivolol and Bupropion in Healthy Volunteers.
Pharmacology.
2016; 98(3-4):190-8. doi:
10.1159/000447266. [PMID: 27300331] - Thomas D Giles, George Bakris, Suzanne Oparil, Michael A Weber, Huiling Li, Madhuja Mallick, David B Bharucha, ChunLin Chen, William G Ferguson. Correlations of plasma renin activity and aldosterone concentration with ambulatory blood pressure responses to nebivolol and valsartan, alone and in combination, in hypertension.
Journal of the American Society of Hypertension : JASH.
2015 Nov; 9(11):845-54. doi:
10.1016/j.jash.2015.08.003. [PMID: 26362831] - Frank H Mose, Janni M Jensen, Safa Therwani, Jesper Mortensen, Annebirthe B Hansen, Jesper N Bech, Erling B Pedersen. Effect of nebivolol on renal nitric oxide availability and tubular function in patients with essential hypertension.
British journal of clinical pharmacology.
2015 Sep; 80(3):425-35. doi:
10.1111/bcp.12627. [PMID: 25778445] - Chun Lin Chen, Daksha Desai-Krieger, Stephan Ortiz, Majid Kerolous, Harold M Wright, Parviz Ghahramani. A Single-Center, Open-Label, 3-Way Crossover Trial to Determine the Pharmacokinetic and Pharmacodynamic Interaction Between Nebivolol and Valsartan in Healthy Volunteers at Steady State.
American journal of therapeutics.
2015 Sep; 22(5):e130-40. doi:
10.1097/mjt.0000000000000247. [PMID: 25853236] - Cagdas Akgullu, Mustafa Ahmet Huyut, Murat Boyacioglu, Ozay Guleş, Ufuk Eryilmaz, Tolga Hekim, Emir Dogan, Cemil Zencir, Hasan Güngör. Nebivolol to attenuate the effects of hyper-homocysteinaemia in rats.
Atherosclerosis.
2015 May; 240(1):33-9. doi:
10.1016/j.atherosclerosis.2015.02.054. [PMID: 25746375] - Çağdaş Akgüllü, Tolga Hekim, Ufuk Eryılmaz, Murat Boyacıoğlu, Hasan Güngör, İbrahim Meteoğlu, Aslıhan Karul, Osman Alper Onbaşılı. The usefulness of carvedilol and nebivolol in preventing contrast nephropathy in rats.
Renal failure.
2015 Apr; 37(3):511-7. doi:
10.3109/0886022x.2015.1006087. [PMID: 25608451] - Ştefania Corina Mahu, Monica Hăncianu, Luminiţa Agoroaei, Ioana Cezara Grigoriu, Anca Monica Strugaru, Elena Butnaru. FIXED DOSE COMBINATIONS WITH SELECTIVE BETA-BLOCKERS: QUANTITATIVE DETERMINATION IN BIOLOGICAL FLUIDS.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.
2015 Apr; 119(2):585-91. doi:
NULL. [PMID: 26204671] - Salim S Hayek, Joseph C Poole, Robert Neuman, Alanna A Morris, Mohamed Khayata, Nino Kavtaradze, Matthew L Topel, Jose G Binongo, Qunna Li, Dean P Jones, Edmund K Waller, Arshed A Quyyumi. Differential effects of nebivolol and metoprolol on arterial stiffness, circulating progenitor cells, and oxidative stress.
Journal of the American Society of Hypertension : JASH.
2015 Mar; 9(3):206-13. doi:
10.1016/j.jash.2014.12.013. [PMID: 25681236] - Çağdaş Akgüllü, Ufuk Eryılmaz, Hasan Güngör, Ahmet Huyut, Cemil Zencir, Tolga Hekim. A clinical study about contrast nephropathy: risk factors and the role of beta blockers.
Anatolian journal of cardiology.
2015 Mar; 15(3):232-40. doi:
10.5152/akd.2014.5304. [PMID: 25333980] - Hitesh C Patel, Carl Hayward, Baris Ata Ozdemir, Stuart D Rosen, Henry Krum, Alexander R Lyon, Darrel P Francis, Carlo di Mario. Magnitude of blood pressure reduction in the placebo arms of modern hypertension trials: implications for trials of renal denervation.
Hypertension (Dallas, Tex. : 1979).
2015 Feb; 65(2):401-6. doi:
10.1161/hypertensionaha.114.04640. [PMID: 25403604] - Orcun Altunoren, Mehmet Balli, Necmi Eren, Hakan Tasolar, Abdullah Arpaci, Caglar Emre Caglayan, Yasemin Coskun Yavuz, Ozkan Gungor. Is Nebivolol Really Effective in Preventing Contrast Induced Nephropathy?.
Kidney & blood pressure research.
2015; 40(5):533-41. doi:
10.1159/000368529. [PMID: 26496491] - Burak Veli Ulger, Halil Erbis, Gul Turkcu, Aysun Ekinci, Mehmet Akif Turkoglu, Cenap Ekinci, Vural Taner Yilmaz, Bilsel Bac. Nebivolol Ameliorates Hepatic Ischemia/Reperfusion Injury on Liver But Not on Distant Organs.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2015; 28(5):245-52. doi:
10.3109/08941939.2015.1031923. [PMID: 26305470] - C Briciu, M Neag, D Muntean, L Vlase, C Bocsan, A Buzoianu, A-M Gheldiu, M Achim, A Popa. A pharmacokinetic drug interaction study between nebivolol and paroxetine in healthy volunteers.
Journal of clinical pharmacy and therapeutics.
2014 Oct; 39(5):535-40. doi:
10.1111/jcpt.12180. [PMID: 24845234] - Elen Rizzi, Danielle A Guimaraes, Carla S Ceron, Cibele M Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santos. β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy.
Free radical biology & medicine.
2014 Aug; 73(?):308-17. doi:
10.1016/j.freeradbiomed.2014.05.024. [PMID: 24933619] - Richard A Preston, David Afshartous, Barry J Materson, Rolando Rodco, Alberto B Alonso. Effects of nebivolol versus metoprolol on sodium sensitivity and renal sodium handling in hypertensive Hispanic postmenopausal women.
Hypertension (Dallas, Tex. : 1979).
2014 Aug; 64(2):287-95. doi:
10.1161/hypertensionaha.114.03476. [PMID: 24842917] - Toni L Ripley, Joseph J Saseen. β-blockers: a review of their pharmacological and physiological diversity in hypertension.
The Annals of pharmacotherapy.
2014 Jun; 48(6):723-33. doi:
10.1177/1060028013519591. [PMID: 24687542] - Seyhun Dursun, Serap Çuhadar, Mehmet Köseoğlu, Ayşenur Atay, Safiye Günden Aktaş. The anti-inflammatory and antioxidant effects of pravastatin and nebivolol in rat aorta.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology.
2014 May; 14(3):229-33. doi:
10.5152/akd.2013.4708. [PMID: 24936540] - Stefania Momi, Roberta Caracchini, Emanuela Falcinelli, Stefano Evangelista, Paolo Gresele. Stimulation of platelet nitric oxide production by nebivolol prevents thrombosis.
Arteriosclerosis, thrombosis, and vascular biology.
2014 Apr; 34(4):820-9. doi:
10.1161/atvbaha.114.303290. [PMID: 24558107] - Marica Bordicchia, Antonella Pocognoli, Marco D'Anzeo, Walter Siquini, Daniele Minardi, Giovanni Muzzonigro, Paolo Dessì-Fulgheri, Riccardo Sarzani. Nebivolol induces, via β3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes.
Journal of hypertension.
2014 Feb; 32(2):389-96. doi:
10.1097/hjh.0000000000000024. [PMID: 24256707] - F M Bertera, D M Santa-Cruz, K B Balestrasse, S B Gorzalczany, C Höcht, C A Taira, A H Polizio. Tempol-nebivolol therapy potentiates hypotensive effect increasing NO bioavailability and signaling pathway.
Free radical research.
2014 Feb; 48(2):109-18. doi:
10.3109/10715762.2013.845294. [PMID: 24074298] - O B Kuz'min, V V Belianin, V V Zhezha. [Nephroprotective properties of third-generation beta-adrenoblockers].
Eksperimental'naia i klinicheskaia farmakologiia.
2014; 77(3):40-3. doi:
NULL. [PMID: 24800526] - Soodabeh Saeidnia, Mohammad Abdollahi. Toxicological and pharmacological concerns on oxidative stress and related diseases.
Toxicology and applied pharmacology.
2013 Dec; 273(3):442-55. doi:
10.1016/j.taap.2013.09.031. [PMID: 24121054] - Carla S Ceron, Elen Rizzi, Danielle A Guimarães, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santos. Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension.
Free radical biology & medicine.
2013 Dec; 65(?):47-56. doi:
10.1016/j.freeradbiomed.2013.06.033. [PMID: 23806385] - Daniel Valente Neves, Carolina Pinto Vieira, Eduardo Barbosa Coelho, Maria Paula Marques, Vera Lucia Lanchote. Stereoselective analysis of nebivolol isomers in human plasma by high-performance liquid chromatography-tandem mass spectrometry: application in pharmacokinetics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Dec; 940(?):47-52. doi:
10.1016/j.jchromb.2013.09.031. [PMID: 24141040] - M Usman Khan, Wenyuan Zhao, Tieqiang Zhao, Fahed Al Darazi, Robert A Ahokas, Yao Sun, Syamal K Bhattacharya, Ivan C Gerling, Karl T Weber. Nebivolol: a multifaceted antioxidant and cardioprotectant in hypertensive heart disease.
Journal of cardiovascular pharmacology.
2013 Nov; 62(5):445-51. doi:
10.1097/fjc.0b013e3182a0b5ff. [PMID: 23921314] - Mauro Contini, Anna Apostolo, Gaia Cattadori, Stefania Paolillo, Annamaria Iorio, Erika Bertella, Elisabetta Salvioni, Marina Alimento, Stefania Farina, Pietro Palermo, Monica Loguercio, Valentina Mantegazza, Marlus Karsten, Susanna Sciomer, Damiano Magrì, Cesare Fiorentini, Piergiuseppe Agostoni. Multiparametric comparison of CARvedilol, vs. NEbivolol, vs. BIsoprolol in moderate heart failure: the CARNEBI trial.
International journal of cardiology.
2013 Oct; 168(3):2134-40. doi:
10.1016/j.ijcard.2013.01.277. [PMID: 23506636] - V S Nade, N V Shendye, L A Kawale, N R Patil, M L Khatri. Protective effect of nebivolol on reserpine-induced neurobehavioral and biochemical alterations in rats.
Neurochemistry international.
2013 Oct; 63(4):316-21. doi:
10.1016/j.neuint.2013.07.002. [PMID: 23871717] - Catarina Teixeira, Elisabete Franco, Paula Alexandra Oliveira, Bruno Colaço, Adelina Gama, João Carrola, Carlos André Pires, Aura Colaço, Maria João Pires. Effects of nebivolol on liver fibrosis induced by bile duct ligation in Wistar rats.
In vivo (Athens, Greece).
2013 Sep; 27(5):635-40. doi:
. [PMID: 23988899] - Forugh Sanaee, Daniel Valente Neves, Vera Lucia Lanchote, Fakhreddin Jamali. Pharmacokinetics of nebivolol in the rat: low oral absorption, loss in the gut and systemic stereoselectivity.
Biopharmaceutics & drug disposition.
2013 Sep; 34(6):312-20. doi:
10.1002/bdd.1847. [PMID: 23625744] - Chenglin Huang, Dongrui Chen, Qihai Xie, Ying Yang, Weili Shen. Nebivolol stimulates mitochondrial biogenesis in 3T3-L1 adipocytes.
Biochemical and biophysical research communications.
2013 Aug; 438(1):211-7. doi:
10.1016/j.bbrc.2013.07.055. [PMID: 23886954] - Yan Wang, Ming Sheng Zhang, Yu Liu. Nebivolol treatment improves resistant arterial function and reduces ventricular hypertrophy and angiotensin II in spontaneously hypertension rats.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2013 Jun; 14(2):146-55. doi:
10.1177/1470320312470580. [PMID: 23263161] - Yan Wang, Stefano Evangelista, Yu Liu, Ming-Sheng Zhang. Beneficial effects of nebivolol and hydrochlorothiazide combination in spontaneously hypertensive rats.
The Journal of international medical research.
2013 Jun; 41(3):603-17. doi:
10.1177/0300060513477576. [PMID: 23680668] - Jatin Nandania, S J Rajput, Pritesh Contractor, Pragnesh Vasava, Bhavik Solanki, Mohsin Vohra. Quantitative determination of nebivolol from human plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Apr; 923-924(?):110-9. doi:
10.1016/j.jchromb.2013.01.034. [PMID: 23500355] - Tina Hu, W Scott Beattie, C David Mazer, Howard Leong-Poi, Hiroko Fujii, David F Wilson, Albert K Y Tsui, Elaine Liu, Maimoona Muhammad, Andrew J Baker, Gregory M T Hare. Treatment with a highly selective β₁ antagonist causes dose-dependent impairment of cerebral perfusion after hemodilution in rats.
Anesthesia and analgesia.
2013 Mar; 116(3):649-62. doi:
10.1213/ane.0b013e318280e26d. [PMID: 23400988] - Jason T Davis, Dalal N Pasha, Srikrishna Khandrika, Maple M Fung, Milos Milic, Daniel T O'Connor. Central hemodynamics in prehypertension: effect of the β-adrenergic antagonist nebivolol.
Journal of clinical hypertension (Greenwich, Conn.).
2013 Jan; 15(1):69-74. doi:
10.1111/jch.12031. [PMID: 23282127] - Jun Wang, Harold M Wright, Prashant Vempati, Henry Li, Julie Wangsa, Anastasiya Dzhuan, Karishma Habbu, Lindsay A Knable, Lap Ho, Giulio M Pasinetti. Investigation of nebivolol as a novel therapeutic agent for the treatment of Alzheimer's disease.
Journal of Alzheimer's disease : JAD.
2013; 33(4):1147-56. doi:
10.3233/jad-2012-120904. [PMID: 23128558] - Ramiro J Zepeda, Rodrigo Castillo, Ramón Rodrigo, Juan C Prieto, Ivonne Aramburu, Solange Brugere, Katia Galdames, Viviana Noriega, Hugo F Miranda. Effect of carvedilol and nebivolol on oxidative stress-related parameters and endothelial function in patients with essential hypertension.
Basic & clinical pharmacology & toxicology.
2012 Nov; 111(5):309-16. doi:
10.1111/j.1742-7843.2012.00911.x. [PMID: 22703478] - Ming-Guo Feng, Minolfa C Prieto, L Gabriel Navar. Nebivolol-induced vasodilation of renal afferent arterioles involves β3-adrenergic receptor and nitric oxide synthase activation.
American journal of physiology. Renal physiology.
2012 Sep; 303(5):F775-82. doi:
10.1152/ajprenal.00233.2012. [PMID: 22674024] - Adem Parlak, Atila Iyisoy, Umit Aydogan, Erdinc Cakir, Kenan Saglam. The effect of valsartan and nebivolol treatment on ADMA and pentraxin-3 levels in hypertensive patients.
Medical hypotheses.
2012 Sep; 79(3):294-8. doi:
10.1016/j.mehy.2012.05.011. [PMID: 22698960]