SKF 82958 (BioDeep_00000661239)
代谢物信息卡片
6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
化学式: C19H20ClNO2 (329.11824900000005)
中文名称: 氯-APB氢溴酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=CCN1CCC2=C(C(=C(C=C2C(C1)C3=CC=CC=C3)O)O)Cl
InChI: InChI=1S/C19H20ClNO2/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13/h2-7,11,16,22-23H,1,8-10,12H2
描述信息
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Junliang Hao, James P Beck, John M Schaus, Joseph H Krushinski, Qi Chen, Christopher D Beadle, Paloma Vidal, Matthew R Reinhard, Bruce A Dressman, Steven M Massey, Serge L Boulet, Michael P Cohen, Brian M Watson, David Tupper, Kevin M Gardinier, Jason Myers, Anette M Johansson, Jeffery Richardson, Daniel S Richards, Erik J Hembre, David M Remick, David A Coates, Rajni M Bhardwaj, Benjamin A Diseroad, David Bender, Greg Stephenson, Craig D Wolfangel, Nuria Diaz, Brian G Getman, Xu-Shan Wang, Beverly A Heinz, Jeff W Cramer, Xin Zhou, Deanna L Maren, Julie F Falcone, Rebecca A Wright, Stephen N Mitchell, Guy Carter, Charles R Yang, Robert F Bruns, Kjell A Svensson. Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor.
Journal of medicinal chemistry.
2019 10; 62(19):8711-8732. doi:
10.1021/acs.jmedchem.9b01234. [PMID: 31532644] - Cecile Hryhorczuk, Marc Florea, Demetra Rodaros, Isabelle Poirier, Caroline Daneault, Christine Des Rosiers, Andreas Arvanitogiannis, Thierry Alquier, Stephanie Fulton. Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2016 Feb; 41(3):811-21. doi:
10.1038/npp.2015.207. [PMID: 26171719] - Stefano Espinoza, Valentina Ghisi, Marco Emanuele, Damiana Leo, Ilya Sukhanov, Tatiana D Sotnikova, Evelina Chieregatti, Raul R Gainetdinov. Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1.
Neuropharmacology.
2015 Jun; 93(?):308-13. doi:
10.1016/j.neuropharm.2015.02.010. [PMID: 25721394] - Pedro Barroso-Chinea, Marie-Laure Thiolat, Simone Bido, Audrey Martinez, Evelyne Doudnikoff, Jérôme Baufreton, Mathieu Bourdenx, Bertrand Bloch, Erwan Bezard, Marie-Laure Martin-Negrier. D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly.
Neurobiology of disease.
2015 Jun; 78(?):77-87. doi:
10.1016/j.nbd.2015.02.024. [PMID: 25766677] - Lucy G Chastain, Hongyan Qu, Chase H Bourke, P Michael Iuvone, Paul R Dobner, Charles B Nemeroff, Becky Kinkead. Striatal dopamine receptor plasticity in neurotensin deficient mice.
Behavioural brain research.
2015 Mar; 280(?):160-71. doi:
10.1016/j.bbr.2014.11.014. [PMID: 25449842] - Amandine Berthet, Grégory Porras, Evelyne Doudnikoff, Holger Stark, Martine Cador, Erwan Bezard, Bertrand Bloch. Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Apr; 29(15):4829-35. doi:
10.1523/jneurosci.5884-08.2009. [PMID: 19369551] - Morgane Thomsen, F Scott Hall, George R Uhl, S Barak Caine. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009 Jan; 29(4):1087-92. doi:
10.1523/jneurosci.4037-08.2009. [PMID: 19176817] - Marie-Laure Martin-Negrier, Giselle Charron, Bertrand Bloch. Receptor recycling mediates plasma membrane recovery of dopamine D1 receptors in dendrites and axons after agonist-induced endocytosis in primary cultures of striatal neurons.
Synapse (New York, N.Y.).
2006 Sep; 60(3):194-204. doi:
10.1002/syn.20296. [PMID: 16739117] - Jessica P Ryman-Rasmussen, David E Nichols, Richard B Mailman. Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists.
Molecular pharmacology.
2005 Oct; 68(4):1039-48. doi:
10.1124/mol.105.012153. [PMID: 15985612] - Qing Wang, Wee Lee Ting, Hongyuan Yang, Peter T-H Wong. High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat prefrontal cortex: possible involvement of endothelial nitric oxide synthase.
British journal of pharmacology.
2005 Apr; 144(7):933-9. doi:
10.1038/sj.bjp.0706106. [PMID: 15711596] - Julie Broadbent, Kathryn M Kampmueller, Sharon A Koonse. Role of dopamine in behavioral sensitization to ethanol in DBA/2J mice.
Alcohol (Fayetteville, N.Y.).
2005 Feb; 35(2):137-48. doi:
10.1016/j.alcohol.2005.03.006. [PMID: 15963427] - Christopher Keating, Ian Orchard. The effects of dopamine agonists and antagonists on the secretory responses in the salivary glands of the locust (Locusta migratoria).
Journal of insect physiology.
2004 Jan; 50(1):17-23. doi:
10.1016/j.jinsphys.2003.09.005. [PMID: 15037089] - M Martin-Negrier, G Charron, B Bloch. Agonist stimulation provokes dendritic and axonal dopamine D(1) receptor redistribution in primary cultures of striatal neurons.
Neuroscience.
2000; 99(2):257-66. doi:
10.1016/s0306-4522(00)00187-1. [PMID: 10938431] - M Bek, K G Fischer, S Greiber, C Hupfer, P Mundel, H Pavenstädt. Dopamine depolarizes podocytes via a D1-like receptor.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1999 Mar; 14(3):581-7. doi:
10.1093/ndt/14.3.581. [PMID: 10193803] - B Dumartin, I Caillé, F Gonon, B Bloch. Internalization of D1 dopamine receptor in striatal neurons in vivo as evidence of activation by dopamine agonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998 Mar; 18(5):1650-61. doi:
10.1523/jneurosci.18-05-01650.1998. [PMID: 9464990] - M J Pokora, E K Richfield, D A Cory-Slechta. Preferential vulnerability of nucleus accumbens dopamine binding sites to low-level lead exposure: time course of effects and interactions with chronic dopamine agonist treatments.
Journal of neurochemistry.
1996 Oct; 67(4):1540-50. doi:
10.1046/j.1471-4159.1996.67041540.x. [PMID: 8858938] - M Goulet, R Grondin, P J Blanchet, P J Bédard, T Di Paolo. Dyskinesias and tolerance induced by chronic treatment with a D1 agonist administered in pulsatile or continuous mode do not correlate with changes of putaminal D1 receptors in drug-naive MPTP monkeys.
Brain research.
1996 May; 719(1-2):129-37. doi:
10.1016/0006-8993(96)00157-6. [PMID: 8782872] - A O Wong, J P Chang, R E Peter. In vitro and in vivo evidence that dopamine exerts growth hormone-releasing activity in goldfish.
The American journal of physiology.
1993 Jun; 264(6 Pt 1):E925-32. doi:
10.1152/ajpendo.1993.264.6.e925. [PMID: 8101429] - P Szylman, O S Better, C Chaimowitz, A Rosler. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism.
The New England journal of medicine.
1976 Feb; 294(7):361-5. doi:
10.1056/nejm197602122940703. [PMID: 1674] - R Geigy, L Jenni, M Kauffmann, R J Onyango, N Weiss. Identification of T. brucei-subgroup strains isolated from game.
Acta tropica.
1975; 32(3):190-205. doi:
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