2,5-Dideoxyadenosine (BioDeep_00000661174)

   


代谢物信息卡片


2,5-Dideoxyadenosine

化学式: C10H13N5O2 (235.10691980000004)
中文名称: 2,5-脱氧腺苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(CC(O1)N2C=NC3=C(N=CN=C32)N)O
InChI: InChI=1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1

描述信息

D009676 - Noxae > D000963 - Antimetabolites > D015224 - Dideoxynucleosides
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 μM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 μM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].

同义名列表

2 个代谢物同义名

2,5-Dideoxyadenosine; 2',5'-Dideoxyadenosine



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Abdullah Mayati, Nicolas Levoin, Hervé Paris, Monique N'Diaye, Arnaud Courtois, Philippe Uriac, Dominique Lagadic-Gossmann, Olivier Fardel, Eric Le Ferrec. Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells. The Journal of biological chemistry. 2012 Feb; 287(6):4041-52. doi: 10.1074/jbc.m111.319970. [PMID: 22167199]
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  • Sanja Roje. S-Adenosyl-L-methionine: beyond the universal methyl group donor. Phytochemistry. 2006 Aug; 67(15):1686-98. doi: 10.1016/j.phytochem.2006.04.019. [PMID: 16766004]
  • Akira Ikari, Satomi Matsumoto, Hitoshi Harada, Kuniaki Takagi, Hisayoshi Hayashi, Yuichi Suzuki, Masakuni Degawa, Masao Miwa. Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions. Journal of cell science. 2006 May; 119(Pt 9):1781-9. doi: 10.1242/jcs.02901. [PMID: 16608877]
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  • Voraratt Champattanachai, James R Ketudat Cairns, Vorasuk Shotelersuk, Siriporn Keeratichamroen, Phannee Sawangareetrakul, Chantragan Srisomsap, Verachai Kaewpaluek, Jisnuson Svasti. Novel mutations in a Thai patient with methylmalonic acidemia. Molecular genetics and metabolism. 2003 Aug; 79(4):300-2. doi: 10.1016/s1096-7192(03)00106-9. [PMID: 12948746]
  • R LoBrutto, V Bandarian, O T Magnusson, X Chen, V L Schramm, G H Reed. 5'-Deoxyadenosine contacts the substrate radical intermediate in the active site of ethanolamine ammonia-lyase: 2H and 13C electron nuclear double resonance studies. Biochemistry. 2001 Jan; 40(1):9-14. doi: 10.1021/bi001865s. [PMID: 11141051]
  • S Takasuga, T Katada, M Ui, O Hazeki. Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes. The Journal of biological chemistry. 1999 Jul; 274(28):19545-50. doi: 10.1074/jbc.274.28.19545. [PMID: 10391887]
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