Nortriptyline Hydrochloride (BioDeep_00000661065)
代谢物信息卡片
Nortriptyline Hydrochloride
化学式: C19H22ClN (299.14406820000005)
中文名称: 盐酸去甲替林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:7641
- KEGGdrug: D00816
- PubChem: 441358
- ChEMBL: CHEMBL1201156
- MeSH: Nortriptyline
- CAS: 1001637-77-9
- CAS: 894-71-3
- medchemexpress: HY-B1417
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao. Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation.
Cell communication and signaling : CCS.
2023 May; 21(1):123. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2022 10; 350(?):256-270. doi:
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BMC pharmacology & toxicology.
2022 08; 23(1):59. doi:
10.1186/s40360-022-00601-6. [PMID: 35932053] - Nicklas Hasselblad Lundstrøm, Nikolaj K Holgersen, Maija Bruun Haastrup. The effect of smoking on the plasma concentration of tricyclic antidepressants: a systematic review.
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Psychopharmacology.
2010 Jun; 210(3):331-6. doi:
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Journal of psychopharmacology (Oxford, England).
2010 Apr; 24(4):531-5. doi:
10.1177/0269881109105101. [PMID: 19395425] - Patricia Almudever, José-Esteban Peris, Teresa Garrigues, Octavio Diez, Ana Melero, Manuel Alós. Quantification of nortriptyline in plasma by HPLC and fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Mar; 878(9-10):841-4. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2010 Mar; 6(1):72-3. doi:
10.1007/s13181-010-0043-4. [PMID: 20306168] - Tiina Sikanen, Stig Pedersen-Bjergaard, Henrik Jensen, Risto Kostiainen, Knut Einar Rasmussen, Tapio Kotiaho. Implementation of droplet-membrane-droplet liquid-phase microextraction under stagnant conditions for lab-on-a-chip applications.
Analytica chimica acta.
2010 Jan; 658(2):133-40. doi:
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Addiction (Abingdon, England).
2009 Dec; 104(12):2110-7. doi:
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The pharmacogenomics journal.
2009 Aug; 9(4):225-33. doi:
10.1038/tpj.2009.12. [PMID: 19365399] - Patricia Huezo-Diaz, Rudolf Uher, Rebecca Smith, Marcella Rietschel, Neven Henigsberg, Andrej Marusic, Ole Mors, Wolfgang Maier, Joanna Hauser, Daniel Souery, Anna Placentino, Astrid Zobel, Erik Roj Larsen, Piotr M Czerski, Bhanu Gupta, Farzana Hoda, Nader Perroud, Anne Farmer, Ian Craig, Katherine J Aitchison, Peter McGuffin. Moderation of antidepressant response by the serotonin transporter gene.
The British journal of psychiatry : the journal of mental science.
2009 Jul; 195(1):30-8. doi:
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Journal of pharmaceutical sciences.
2009 Apr; 98(4):1587-601. doi:
10.1002/jps.21511. [PMID: 18780336] - Sarah J Billups, Thomas Delate, Daniel Dugan. Evaluation of risk factors for elevated tricyclic antidepressant plasma concentrations.
Pharmacoepidemiology and drug safety.
2009 Mar; 18(3):253-7. doi:
10.1002/pds.1697. [PMID: 19148878] - Aleksandra Rajewska-Rager, Monika Dmitrzak-Weglarz, Paweł Kapelski, Maria Skibińska, Magdalena Kaczmarkiewicz-Fass, Joanna Hauser. [Association between polymorphisms of ins/del in the 5-HTT gene and T102C in the 5HTR2A gene and the drug response for escitalopram and nortriptyline in depressed patients].
Psychiatria polska.
2008 Nov; 42(6):903-14. doi:
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Journal of separation science.
2008 Jul; 31(12):2288-94. doi:
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Talanta.
2008 Jun; 75(5):1293-9. doi:
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Clinical pharmacology and therapeutics.
2008 Mar; 83(3):436-42. doi:
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Journal of colloid and interface science.
2008 Mar; 319(1):81-93. doi:
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British journal of clinical pharmacology.
2008 Jan; 65(1):134-8. doi:
10.1111/j.1365-2125.2007.02969.x. [PMID: 17764479] - Matthew P Juhascik, Adam Negrusz, Diana Faugno, Linda Ledray, Pam Greene, Alice Lindner, Barbara Haner, R E Gaensslen. An estimate of the proportion of drug-facilitation of sexual assault in four U.S. localities.
Journal of forensic sciences.
2007 Nov; 52(6):1396-400. doi:
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Clinical pharmacology and therapeutics.
2007 Nov; 82(5):606-9. doi:
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Journal of mass spectrometry : JMS.
2007 Oct; 42(10):1342-7. doi:
10.1002/jms.1288. [PMID: 17902106] - Eduardo Luiz Pedrazza, Mario Roberto Senger, Eduardo Pacheco Rico, Fernanda Francine Zimmermann, Leonardo Pedrazza, João José de Freitas Sarkis, Carla Denise Bonan. Fluoxetine and nortriptyline affect NTPDase and 5'-nucleotidase activities in rat blood serum.
Life sciences.
2007 Sep; 81(15):1205-10. doi:
10.1016/j.lfs.2007.08.020. [PMID: 17889906] - Bohdan Pomahac, Bara Zuhaili, Yusef Kudsi, Oliver Bleiziffer, Patrik Velander, Elof Eriksson, Peter Gerner. Safety evaluation of topically applied amitriptyline in porcine full-thickness wounds.
Regional anesthesia and pain medicine.
2007 Sep; 32(5):377-81. doi:
10.1016/j.rapm.2007.06.003. [PMID: 17961834] - Che Zhang, Zi-Liang Tu, Qi-Bin Wang, Xiao-Li Cheng, Peng-Hua Zhang. [Influence of ORM1 polymorphism on serum concentration of free nortriptyline].
Yao xue xue bao = Acta pharmaceutica Sinica.
2007 Aug; 42(8):843-8. doi:
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The Chinese journal of physiology.
2006 Dec; 49(6):283-9. doi:
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JAMA.
2006 Oct; 296(13):1609-18. doi:
10.1001/jama.296.13.1609. [PMID: 17018806] - Marcelo Delmar Cantú, Daniel Rodrigo Toso, Cristina Alves Lacerda, Fernando Mauro Lanças, Emanuel Carrilho, Maria Eugênia Costa Queiroz. Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Analytical and bioanalytical chemistry.
2006 Sep; 386(2):256-63. doi:
10.1007/s00216-006-0629-5. [PMID: 16896629] - Soo-Youn Lee, Kwang Min Sohn, Ji Young Ryu, Young Ran Yoon, Jae Gook Shin, Jong-Won Kim. Sequence-based CYP2D6 genotyping in the Korean population.
Therapeutic drug monitoring.
2006 Jun; 28(3):382-7. doi:
10.1097/01.ftd.0000211823.80854.db. [PMID: 16778723] - Molly P Kurpius, Bruce Alexander. Rates of in vivo methylation of desipramine and nortriptyline.
Pharmacotherapy.
2006 Apr; 26(4):505-10. doi:
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Biological psychiatry.
2006 Feb; 59(3):287-90. doi:
10.1016/j.biopsych.2005.06.040. [PMID: 16271264] - Ewa Obuchowicz, Jan Kowalski, Krzysztof Labuzek, Robert Krysiak, Joanna Pendzich, Zbigniew S Herman. Amitriptyline and nortriptyline inhibit interleukin-1 release by rat mixed glial and microglial cell cultures.
The international journal of neuropsychopharmacology.
2006 Feb; 9(1):27-35. doi:
10.1017/s146114570500547x. [PMID: 15963243] - Stephanie Wenzel, Rolf Aderjan, Rainer Mattern, Ingo Pedal, Gisela Skopp. Tissue distribution of mirtazapine and desmethylmirtazapine in a case of mirtazapine poisoning.
Forensic science international.
2006 Jan; 156(2-3):229-36. doi:
10.1016/j.forsciint.2005.06.007. [PMID: 16051454] - Georgios Theodoridis. Application of solid-phase microextraction in the investigation of protein binding of pharmaceuticals.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jan; 830(2):238-44. doi:
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Drug metabolism and drug interactions.
2006; 21(3-4):139-62. doi:
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Brazilian journal of otorhinolaryngology.
2005 Nov; 71(6):820-7. doi:
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Journal of pharmacological and toxicological methods.
2005 Nov; 52(3):323-9. doi:
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Human psychopharmacology.
2005 Oct; 20(7):493-500. doi:
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Journal of analytical toxicology.
2005 Jul; 29(5):401-6. doi:
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Psychological medicine.
2005 Apr; 35(4):511-7. doi:
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Human psychopharmacology.
2005 Mar; 20(2):149-53. doi:
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