Heptaminol hydrochloride (BioDeep_00000661010)
代谢物信息卡片
6-amino-2-methylheptan-2-ol,hydrochloride
化学式: C8H20ClNO (181.123334)
中文名称: 6-氨基-2-甲基-2-庚醇盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCCC(C)(C)O)N.Cl
InChI: 1H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Z Nonikashvili, R Jūratė Gerbutavičienė. Ginkgo biloba, troxerutin and heptaminol chlorhydrate combined treatment for the management of venous insufficiency and hemorrhoidal crises.
European review for medical and pharmacological sciences.
2022 07; 26(14):5200-5209. doi:
10.26355/eurrev_202207_29309. [PMID: 35916818] - Sayed M Derayea, Pakinaz Y Khashaba, Mahmoud Abdelgaleel, Dalia M Nagy. Orthophthaldehyde as a fluorescent probe for the feasible and sensitive assay of heptaminol: application to dosage forms and real human plasma.
Luminescence : the journal of biological and chemical luminescence.
2022 Feb; 37(2):230-237. doi:
10.1002/bio.4164. [PMID: 34791769] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Monica E Halim, Mahmoud A Omar, Dalia M Nagy. Condensation of heptaminol hydrochloride for its spectrofluorimetric determination in pure form and tablets: application in human plasma.
Luminescence : the journal of biological and chemical luminescence.
2020 Sep; 35(6):821-826. doi:
10.1002/bio.3787. [PMID: 31994292] - Mahmoud A Omar, Dalia M Nagy, Monica E Halim. Fluorescamine-based fluorophore for spectrofluorimetric determination of heptaminol in human plasma; application to spiked human plasma.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Feb; 227(?):117711. doi:
10.1016/j.saa.2019.117711. [PMID: 31690484] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Josef Dib, Christina Bosse, Maria Tsivou, Anna-M Glatt, Thomas Geisendorfer, Hans Geyer, Günter Gmeiner, Gerd Sigmund, Mario Thevis. Is heptaminol a (major) metabolite of octodrine?.
Drug testing and analysis.
2019 Nov; 11(11-12):1761-1763. doi:
10.1002/dta.2737. [PMID: 31763761] - Mahmoud A Omar, Dalia M Nagy, Monica E Halim. Utility of ninhydrin reagent for spectrofluorimetric determination of heptaminol in human plasma.
Luminescence : the journal of biological and chemical luminescence.
2018 Sep; 33(6):1107-1112. doi:
10.1002/bio.3516. [PMID: 29968975] - Leila Gharibi, Kawtar Zouhair, Benyouness Ramdani, Hakima Benchikhi. Hair lightening in an hemodialysis patient treated by heptaminol (heptamyl).
Dermatology online journal.
2009 Apr; 15(4):16. doi:
NULL. [PMID: 19450409] - Ying Lung Tseng, Chin-Hung Liu, Fan-Hsin Kuo, Min-Hua Shieh. Solid-phase column chromatographic and gas chromatographic-mass spectrometric determination of heptaminol in human urine and related pharmacokinetic profiles.
Journal of analytical toxicology.
2006 Jul; 30(6):365-9. doi:
10.1093/jat/30.6.365. [PMID: 16872566] - Emmanouil Lyris, George Tsiakatouras, Yiannis Angelis, Michael Koupparis, Maria-Helen Spyridaki, Costas Georgakopoulos. Metabolism of isometheptene in human urine and analysis by gas chromatography-mass spectrometry in doping control.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Dec; 827(2):199-204. doi:
10.1016/j.jchromb.2005.09.037. [PMID: 16242387] - L Edno-Mcheik, J M Gaulier, I Combourieu, E Lacassie, A Hadzic. Heptaminol interferes in the AxSYM FPIA amphetamine/methamphetamine II assay.
Clinical chemistry.
2001 Aug; 47(8):1499-500. doi:
10.1093/clinchem/47.8.1499. [PMID: 11468252] - J Remacle, A Houbion, C Michiels. [A comparison of various phlebotonic agents on human endothelial cells of veins subjected to hypoxia].
Phlebologie.
1991 Nov; 44(4):881-9. doi:
". [PMID: 1805259] - B Pourrias. [Heptaminol chlorhydrate: new data].
Annales pharmaceutiques francaises.
1991; 49(3):127-38. doi:
NULL. [PMID: 1929117] - D Milon, H Allain, J M Reymann, G Morel, O Sabouraud, J Van den Driessche. Randomized double-blind trial of injectable heptaminol for controlling spontaneous or bromocriptine-induced orthostatic hypotension in parkinsonians.
Fundamental & clinical pharmacology.
1990; 4(6):695-705. doi:
10.1111/j.1472-8206.1990.tb00049.x. [PMID: 2096108] - F Kees, P Dominiak, H Grobecker. [Bioavailability of heptaminol in healthy subjects].
Arzneimittel-Forschung.
1987 Oct; 37(10):1182-5. doi:
NULL. [PMID: 3435592] - M Cociglio, D Sauvaire, R Alric. Liquid chromatographic assay of heptaminol in serum and its oral pharmacokinetics in the dog.
Journal of chromatography.
1984 May; 307(2):351-9. doi:
10.1016/s0378-4347(00)84106-7. [PMID: 6736182] - R R Brodie, L F Chasseaud, L Rooney, A Darragh, R F Lambe. Determination of heptaminol in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1983 May; 274(?):179-86. doi:
10.1016/s0378-4347(00)84421-7. [PMID: 6874820] - F Chanoine, M S Benedetti, J F Ancher, P Dostert. Absorption, distribution, elimination and metabolism of 14C-heptaminol hydrochloride in rat.
Arzneimittel-Forschung.
1981; 31(9):1430-5. doi:
NULL. [PMID: 7197949] - V R Zurawski, W J Kohr, J F Foster. Conformational properties of bovine plasma albumin with a cleaved internal peptide bond.
Biochemistry.
1975 Dec; 14(26):5579-86. doi:
10.1021/bi00697a007. [PMID: 1086] - M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1975 Sep; 71(6):609-29. doi:
NULL. [PMID: 281] - J LA BARRE, J DUMONT. [Digitalin poisoning and heptaminol hydrochloride in the guinea pig].
Comptes rendus des seances de la Societe de biologie et de ses filiales.
1955 May; 149(9-10):1073-5. doi:
". [PMID: 13270529] - J LA BARRE. [Rate of defixation of digitoxin in the presence of heptaminol hydrochloride].
Comptes rendus des seances de la Societe de biologie et de ses filiales.
1955 Mar; 149(5-6):608-9. doi:
". [PMID: 13261428]