piperaquine (BioDeep_00000660955)
代谢物信息卡片
piperaquine phosphate
化学式: C29H32Cl2N6 (534.2065372)
中文名称: 磷酸哌喹
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCCN2CCN(CC2)C3=C4C=CC(=CC4=NC=C3)Cl)C5=C6C=CC(=CC6=NC=C5)Cl
InChI: InChI=1S/C29H32Cl2N6/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29/h2-9,20-21H,1,10-19H2
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91231
- PubChem: 122262
- DrugBank: DB13941
- ChEMBL: CHEMBL303933
- CAS: 4085-31-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dancan M Wakoli, Bartholomew N Ondigo, Douglas O Ochora, Joseph G Amwoma, Winnie Okore, Edwin W Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H Opot, Agnes C Cheruiyot, Dennis Juma, Amanda Roth, Benhards R Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M Akala. Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs.
BMC medicine.
2022 11; 20(1):448. doi:
10.1186/s12916-022-02652-2. [PMID: 36397090] - Umi Cahyaningsih, Siti Sa'diah, Wasrin Syafii, Rita Kartika Sari, Abdul Jafar Maring, Arifin Budiman Nugraha. Antimalarial Efficacy of Aqueous Extract of Strychnos ligustrina and Its Combination with Dihydroartemisinin and Piperaquine Phosphate (DHP) against Plasmodium berghei Infection.
The Korean journal of parasitology.
2022 Oct; 60(5):339-344. doi:
10.3347/kjp.2022.60.5.339. [PMID: 36320110] - Clifford G Banda, Dumisile Nkosi, Elizabeth Allen, Lesley Workman, Mwayiwawo Madanitsa, Marumbo Chirwa, Mayamiko Kapulula, Sharon Muyaya, Steven Munharo, Lubbe Wiesner, Kamija S Phiri, Victor Mwapasa, Feiko O Ter Kuile, Gary Maartens, Karen I Barnes. Effect of dihydroartemisinin/piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV.
The Journal of antimicrobial chemotherapy.
2022 05; 77(6):1733-1737. doi:
10.1093/jac/dkac081. [PMID: 35288747] - Huixiang Liu, Yuewu Xie, Tianyu Cai, Jie Xing. No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects.
Current drug metabolism.
2022; 23(2):164-170. doi:
10.2174/1389200223666220215151945. [PMID: 35168517] - Chime Salome Amarachi, Anthony Amaechi Attama, Godswill Chukwunweike Onunkwo. Assessment of the Anti-Malarial Properties of Dihydroartemisinin- Piperaquine Phosphate Solid Lipid-Based Tablets.
Recent advances in anti-infective drug discovery.
2022; 17(2):103-117. doi:
10.2174/2772434417666220606105822. [PMID: 35670344] - Thanaporn Wattanakul, Mark Baker, Joerg Mohrle, Brett McWhinney, Richard M Hoglund, James S McCarthy, Joel Tarning. Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria.
Antimicrobial agents and chemotherapy.
2021 03; 65(4):. doi:
10.1128/aac.01583-20. [PMID: 33468477] - Liyuan Zhang, Zhaohua Liu, Yunrui Zhang, Yuewu Xie, Jie Xing. Metabolism is not a Major Contributor to the Toxicity of Piperaquine, a Long-acting Antimalarial Agent in Artemisinin-based Combination Therapy.
Current drug metabolism.
2021; 22(10):824-834. doi:
10.2174/1389200222666210928124943. [PMID: 34602032] - Guoming Li, Mei Yuan, Haihong Li, Changsheng Deng, Qi Wang, Yexiao Tang, Hongying Zhang, Weisheng Yu, Qin Xu, Yuanyuan Zou, Yueming Yuan, Jiawen Guo, Chunming Jin, Xiangdong Guan, Fengjie Xie, Jianping Song. Safety and efficacy of artemisinin-piperaquine for treatment of COVID-19: an open-label, non-randomised and controlled trial.
International journal of antimicrobial agents.
2021 Jan; 57(1):106216. doi:
10.1016/j.ijantimicag.2020.106216. [PMID: 33152450] - Rajabu Hussein Mnkugwe, Omary Minzi, Safari Kinung'hi, Appolinary Kamuhabwa, Eleni Aklillu. Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial.
PLoS neglected tropical diseases.
2020 09; 14(9):e0008619. doi:
10.1371/journal.pntd.0008619. [PMID: 32966290] - Norah Mwebaza, Vincent Cheah, Camilla Forsman, Richard Kajubi, Florence Marzan, Erika Wallender, Grant Dorsey, Philip J Rosenthal, Francesca Aweeka, Liusheng Huang. Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations.
PloS one.
2020; 15(5):e0233893. doi:
10.1371/journal.pone.0233893. [PMID: 32470030] - Rui Ma, Dong-Xiao Guo, Hui-Fen Li, Hui-Xiang Liu, Yun-Rui Zhang, Jian-Bo Ji, Jie Xing, Shu-Qi Wang. Spectroscopic methodologies and molecular docking studies on the interaction of antimalarial drug piperaquine and its metabolites with human serum albumin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Nov; 222(?):117158. doi:
10.1016/j.saa.2019.117158. [PMID: 31181505] - Helmi Pett, John Bradley, Joseph Okebe, Alassane Dicko, Alfred B Tiono, Bronner P Gonçalves, Will Stone, Ingrid Chen, Kjerstin Lanke, Mikko Neuvonen, Anna-Liina Mustaniemi, Alice C Eziefula, Roly Gosling, Umberto D'Alessandro, Chris Drakeley, Mikko Niemi, Teun Bousema. CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum.
Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00538-19. [PMID: 31383656] - Andrew Teo, Louise M Randall, Mwayiwawo Madanitsa, Victor Mwapasa, Linda Kalilani Phiri, Carole Khairallah, Christelle Buffet, Amalia Karahalios, David L Narum, Feiko O Ter Kuile, Stephen J Rogerson. Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women.
Scientific reports.
2019 05; 9(1):7878. doi:
10.1038/s41598-019-44340-x. [PMID: 31133672] - Menno R Smit, Eric O Ochomo, David Waterhouse, Titus K Kwambai, Bernard O Abong'o, Teun Bousema, Nabie M Bayoh, John E Gimnig, Aaron M Samuels, Meghna R Desai, Penelope A Phillips-Howard, Simon K Kariuki, Duolao Wang, Feiko O Ter Kuile, Stephen A Ward, Ghaith Aljayyoussi. Pharmacokinetics-Pharmacodynamics of High-Dose Ivermectin with Dihydroartemisinin-Piperaquine on Mosquitocidal Activity and QT-Prolongation (IVERMAL).
Clinical pharmacology and therapeutics.
2019 02; 105(2):388-401. doi:
10.1002/cpt.1219. [PMID: 30125353] - Erika Wallender, Nan Zhang, Melissa Conrad, Abel Kakuru, Mary Muhindo, Patrick Tumwebaze, Richard Kajubi, Daniel Mota, Jennifer Legac, Prasanna Jagannathan, Diane Havlir, Moses Kamya, Grant Dorsey, Francesca Aweeka, Philip J Rosenthal, Rada M Savic. Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01393-18. [PMID: 30530597] - Anurak Choemang, Kesara Na-Bangchang. An Alternative HPLC with Ultraviolet Detection for Determination of Piperaquine in Plasma.
Journal of chromatographic science.
2019 Jan; 57(1):27-32. doi:
10.1093/chromsci/bmy077. [PMID: 30169629] - Changsheng Deng, Bo Huang, Qi Wang, Wanting Wu, Shaoqin Zheng, Hongying Zhang, Di Li, Danghong Feng, Guoming Li, Linlu Xue, Tao Yang, Fei Tuo, Fouad Mohadji, Xin-Zhuan Su, Qin Xu, Zhibing Wu, Li Lin, Jiuyao Zhou, Hong Yan, Affane Bacar, Kamal Said Abdallah, Rachadi A Kéké, Ahamada Msa Mliva, Moussa Mohamed, Xinhua Wang, Shiguang Huang, Fatihou Oithik, Xiao-Bo Li, Fangli Lu, Michael P Fay, Xiao-Hong Liu, Thomas E Wellems, Jianping Song. Large-scale Artemisinin-Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2018 11; 67(11):1670-1676. doi:
10.1093/cid/ciy364. [PMID: 29846536] - Rada M Savic, Prasanna Jagannathan, Richard Kajubi, Liusheng Huang, Nan Zhang, Moses Were, Abel Kakuru, Mary K Muhindo, Norah Mwebaza, Erika Wallender, Tamara D Clark, Bishop Opira, Moses Kamya, Diane V Havlir, Philip J Rosenthal, Grant Dorsey, Francesca T Aweeka. Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2018 09; 67(7):1079-1088. doi:
10.1093/cid/ciy218. [PMID: 29547881] - Nguyen Ngoc Quang, Marina Chavchich, Chu Xuan Anh, Geoffrey W Birrell, Karin van Breda, Thomas Travers, Kerryn Rowcliffe, Michael D Edstein. Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.
The American journal of tropical medicine and hygiene.
2018 07; 99(1):65-72. doi:
10.4269/ajtmh.17-0434. [PMID: 29741150] - Alassane Dicko, Michelle E Roh, Halimatou Diawara, Almahamoudou Mahamar, Harouna M Soumare, Kjerstin Lanke, John Bradley, Koualy Sanogo, Daouda T Kone, Kalifa Diarra, Sekouba Keita, Djibrilla Issiaka, Sekou F Traore, Charles McCulloch, Will J R Stone, Jimee Hwang, Olaf Müller, Joelle M Brown, Vinay Srinivasan, Chris Drakeley, Roly Gosling, Ingrid Chen, Teun Bousema. Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial.
The Lancet. Infectious diseases.
2018 06; 18(6):627-639. doi:
10.1016/s1473-3099(18)30044-6. [PMID: 29422384] - Palang Chotsiri, Thanaporn Wattanakul, Richard M Hoglund, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Daniel Blessborn, Podjanee Jittamala, Nicholas J White, Nicholas P J Day, Joel Tarning. Population pharmacokinetics and electrocardiographic effects of dihydroartemisinin-piperaquine in healthy volunteers.
British journal of clinical pharmacology.
2017 12; 83(12):2752-2766. doi:
10.1111/bcp.13372. [PMID: 28695570] - Melissa D Conrad, Daniel Mota, Marissa Foster, Stephen Tukwasibwe, Jennifer Legac, Patrick Tumwebaze, Meghan Whalen, Abel Kakuru, Patience Nayebare, Erika Wallender, Diane V Havlir, Prasanna Jagannathan, Liusheng Huang, Francesca Aweeka, Moses R Kamya, Grant Dorsey, Philip J Rosenthal. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda.
The Journal of infectious diseases.
2017 11; 216(8):1008-1017. doi:
10.1093/infdis/jix421. [PMID: 28968782] - Olusola Olafuyi, Michael Coleman, Raj K S Badhan. The application of physiologically based pharmacokinetic modelling to assess the impact of antiretroviral-mediated drug-drug interactions on piperaquine antimalarial therapy during pregnancy.
Biopharmaceutics & drug disposition.
2017 Nov; 38(8):464-478. doi:
10.1002/bdd.2087. [PMID: 28710808] - Huixiang Liu, Meitong Zang, Aijuan Yang, Jianbo Ji, Jie Xing. Simultaneous determination of piperaquine and its N-oxidated metabolite in rat plasma using LC-MS/MS.
Biomedical chromatography : BMC.
2017 Oct; 31(10):. doi:
10.1002/bmc.3974. [PMID: 28299804] - Mohd Yusmaidie Aziz, Kurt-Jürgen Hoffmann, Michael Ashton. LC-MS/MS quantitation of antimalarial drug piperaquine and metabolites in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Sep; 1063(?):253-258. doi:
10.1016/j.jchromb.2017.06.035. [PMID: 28863865] - Pattaraporn Vanachayangkul, Chanthap Lon, Michele Spring, Sommethy Sok, Winita Ta-Aksorn, Chanikarn Kodchakorn, Sut-Thang Pann, Soklyda Chann, Mali Ittiverakul, Sabaithip Sriwichai, Nillawan Buathong, Worachet Kuntawunginn, Mary So, Theng Youdaline, Erin Milner, Mariusz Wojnarski, Charlotte Lanteri, Jessica Manning, Satharath Prom, Mark Haigney, Louis Cantilena, David Saunders. Piperaquine Population Pharmacokinetics and Cardiac Safety in Cambodia.
Antimicrobial agents and chemotherapy.
2017 05; 61(5):. doi:
10.1128/aac.02000-16. [PMID: 28193647] - Jesmin Permala, Joel Tarning, François Nosten, Nicholas J White, Mats O Karlsson, Martin Bergstrand. Prediction of Improved Antimalarial Chemoprevention with Weekly Dosing of Dihydroartemisinin-Piperaquine.
Antimicrobial agents and chemotherapy.
2017 05; 61(5):. doi:
10.1128/aac.02491-16. [PMID: 28242661] - Richard M Hoglund, Lesley Workman, Michael D Edstein, Nguyen Xuan Thanh, Nguyen Ngoc Quang, Issaka Zongo, Jean Bosco Ouedraogo, Steffen Borrmann, Leah Mwai, Christian Nsanzabana, Ric N Price, Prabin Dahal, Nancy C Sambol, Sunil Parikh, Francois Nosten, Elizabeth A Ashley, Aung Pyae Phyo, Khin Maung Lwin, Rose McGready, Nicholas P J Day, Philippe J Guerin, Nicholas J White, Karen I Barnes, Joel Tarning. Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.
PLoS medicine.
2017 01; 14(1):e1002212. doi:
10.1371/journal.pmed.1002212. [PMID: 28072872] - Justin A Green, Khadeeja Mohamed, Navin Goyal, Samia Bouhired, Azra Hussaini, Siôn W Jones, Gavin C K W Koh, Ivan Kostov, Maxine Taylor, Allen Wolstenholm, Stephan Duparc. Pharmacokinetic Interactions between Tafenoquine and Dihydroartemisinin-Piperaquine or Artemether-Lumefantrine in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2016 12; 60(12):7321-7332. doi:
10.1128/aac.01588-16. [PMID: 27697758] - Aijuan Yang, Meitong Zang, Huixiang Liu, Peihong Fan, Jie Xing. Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography-high-resolution mass spectrometry in combination with multiple data-mining tools in tandem.
Biomedical chromatography : BMC.
2016 Aug; 30(8):1324-30. doi:
10.1002/bmc.3689. [PMID: 26821381] - Brioni R Moore, John M Benjamin, Siu On Auyeung, Sam Salman, Gumul Yadi, Suzanne Griffin, Madhu Page-Sharp, Kevin T Batty, Peter M Siba, Ivo Mueller, Stephen J Rogerson, Timothy Me Davis. Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women.
British journal of clinical pharmacology.
2016 07; 82(1):199-212. doi:
10.1111/bcp.12910. [PMID: 26889763] - Chanaki Amaratunga, Pharath Lim, Seila Suon, Sokunthea Sreng, Sivanna Mao, Chantha Sopha, Baramey Sam, Dalin Dek, Vorleak Try, Roberto Amato, Daniel Blessborn, Lijiang Song, Gregory S Tullo, Michael P Fay, Jennifer M Anderson, Joel Tarning, Rick M Fairhurst. Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study.
The Lancet. Infectious diseases.
2016 Mar; 16(3):357-65. doi:
10.1016/s1473-3099(15)00487-9. [PMID: 26774243] - Muhammad Wahajuddin, Sheelendra Pratap Singh, Isha Taneja, Kanumuri Siva Rama Raju, Jiaur Rahman Gayen, Hefazat Hussain Siddiqui, Shio Kumar Singh. Development and validation of an LC-MS/MS method for simultaneous determination of piperaquine and 97-63, the active metabolite of CDRI 97-78, in rat plasma and its application in interaction study.
Drug testing and analysis.
2016 Feb; 8(2):221-7. doi:
10.1002/dta.1807. [PMID: 25975936] - Nancy C Sambol, Jordan W Tappero, Emmanuel Arinaitwe, Sunil Parikh. Rethinking Dosing Regimen Selection of Piperaquine for Malaria Chemoprevention: A Simulation Study.
PloS one.
2016; 11(5):e0154623. doi:
10.1371/journal.pone.0154623. [PMID: 27182702] - David C Warhurst, John C Craig, K Saki Raheem. Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance.
PloS one.
2016; 11(8):e0160091. doi:
10.1371/journal.pone.0160091. [PMID: 27483471] - Isha Taneja, Kanumuri Siva Rama Raju, Sheelendra Pratap Singh, Muhammad Wahajuddin. Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.
Scientific reports.
2015 Nov; 5(?):17264. doi:
10.1038/srep17264. [PMID: 26602250] - Borje Darpo, Georg Ferber, Peter Siegl, Bart Laurijssens, Fiona Macintyre, Stephen Toovey, Stephan Duparc. Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria.
British journal of clinical pharmacology.
2015 Oct; 80(4):706-15. doi:
10.1111/bcp.12680. [PMID: 25966781] - Stephanie E Reuter, Allan M Evans, Sepehr Shakib, Yvonne Lungershausen, Barbara Francis, Giovanni Valentini, Antonella Bacchieri, David Ubben, Silvia Pace. Effect of food on the pharmacokinetics of piperaquine and dihydroartemisinin.
Clinical drug investigation.
2015 Sep; 35(9):559-67. doi:
10.1007/s40261-015-0312-8. [PMID: 26293519] - Suwanna Chaorattanakawee, David L Saunders, Darapiseth Sea, Nitima Chanarat, Kritsanai Yingyuen, Siratchana Sundrakes, Piyaporn Saingam, Nillawan Buathong, Sabaithip Sriwichai, Soklyda Chann, Youry Se, You Yom, Thay Kheng Heng, Nareth Kong, Worachet Kuntawunginn, Kuntida Tangthongchaiwiriya, Christopher Jacob, Shannon Takala-Harrison, Christopher Plowe, Jessica T Lin, Char Meng Chuor, Satharath Prom, Stuart D Tyner, Panita Gosi, Paktiya Teja-Isavadharm, Chanthap Lon, Charlotte A Lanteri. Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest Emerging Piperaquine Resistance.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4631-43. doi:
10.1128/aac.00366-15. [PMID: 26014942] - Rithea Leang, Walter R J Taylor, Denis Mey Bouth, Lijiang Song, Joel Tarning, Meng Chuor Char, Saorin Kim, Benoit Witkowski, Valentine Duru, Anais Domergue, Nimol Khim, Pascal Ringwald, Didier Menard. Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4719-26. doi:
10.1128/aac.00835-15. [PMID: 26014949] - Brioni R Moore, Sam Salman, John Benjamin, Madhu Page-Sharp, Gumal Yadi, Kevin T Batty, Peter M Siba, Ivo Mueller, Timothy M E Davis. Pharmacokinetics of piperaquine transfer into the breast milk of Melanesian mothers.
Antimicrobial agents and chemotherapy.
2015 Jul; 59(7):4272-8. doi:
10.1128/aac.00327-15. [PMID: 25963980] - John M Benjamin, Brioni R Moore, Sam Salman, Madhu Page-Sharp, Somoyang Tawat, Gumal Yadi, Lina Lorry, Peter M Siba, Kevin T Batty, Leanne J Robinson, Ivo Mueller, Timothy M E Davis. Population pharmacokinetics, tolerability, and safety of dihydroartemisinin-piperaquine and sulfadoxine-pyrimethamine-piperaquine in pregnant and nonpregnant Papua New Guinean women.
Antimicrobial agents and chemotherapy.
2015 Jul; 59(7):4260-71. doi:
10.1128/aac.00326-15. [PMID: 25963981] - N C Sambol, L Yan, D J Creek, S A McCormack, E Arinaitwe, V Bigira, H Wanzira, A Kakuru, J W Tappero, N Lindegardh, J Tarning, F Nosten, F T Aweeka, S Parikh. Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria.
Clinical pharmacology and therapeutics.
2015 Jul; 98(1):87-95. doi:
10.1002/cpt.104. [PMID: 25732044] - Meitong Zang, Fanping Zhu, Lixia Zhao, Aijuan Yang, Xinxiu Li, Huixiang Liu, Jie Xing. The effect of UGTs polymorphism on the auto-induction phase II metabolism-mediated pharmacokinetics of dihydroartemisinin in healthy Chinese subjects after oral administration of a fixed combination of dihydroartemisinin-piperaquine.
Malaria journal.
2014 Dec; 13(?):478. doi:
10.1186/1475-2875-13-478. [PMID: 25476790] - Borimas Hanboonkunupakarn, Elizabeth A Ashley, Podjanee Jittamala, Joel Tarning, Sasithon Pukrittayakamee, Warunee Hanpithakpong, Palang Chotsiri, Thanaporn Wattanakul, Salwaluk Panapipat, Sue J Lee, Nicholas P J Day, Nicholas J White. Open-label crossover study of primaquine and dihydroartemisinin-piperaquine pharmacokinetics in healthy adult thai subjects.
Antimicrobial agents and chemotherapy.
2014 Dec; 58(12):7340-6. doi:
10.1128/aac.03704-14. [PMID: 25267661] - Martin Bergstrand, François Nosten, Khin Maung Lwin, Mats O Karlsson, Nicholas J White, Joel Tarning. Characterization of an in vivo concentration-effect relationship for piperaquine in malaria chemoprevention.
Science translational medicine.
2014 Oct; 6(260):260ra147. doi:
10.1126/scitranslmed.3005311. [PMID: 25355697] - B R Moore, J M Benjamin, S Salman, S Griffin, E Ginny, M Page-Sharp, L J Robinson, P Siba, K T Batty, I Mueller, T M E Davis. Effect of coadministered fat on the tolerability, safety, and pharmacokinetic properties of dihydroartemisinin-piperaquine in Papua New Guinean children with uncomplicated malaria.
Antimicrobial agents and chemotherapy.
2014 Oct; 58(10):5784-94. doi:
10.1128/aac.03314-14. [PMID: 25049242] - M A Onyamboko, C I Fanello, K Wongsaen, J Tarning, P Y Cheah, K A Tshefu, A M Dondorp, F Nosten, N J White, N P J Day. Randomized comparison of the efficacies and tolerabilities of three artemisinin-based combination treatments for children with acute Plasmodium falciparum malaria in the Democratic Republic of the Congo.
Antimicrobial agents and chemotherapy.
2014 Sep; 58(9):5528-36. doi:
10.1128/aac.02682-14. [PMID: 25001306] - Meitong Zang, Fanping Zhu, Xinxiu Li, Aijuan Yang, Jie Xing. Auto-induction of phase I and phase II metabolism of artemisinin in healthy Chinese subjects after oral administration of a new artemisinin-piperaquine fixed combination.
Malaria journal.
2014 Jun; 13(?):214. doi:
10.1186/1475-2875-13-214. [PMID: 24889062] - Jérome Dormoi, Hélène Savini, Rémy Amalvict, Eric Baret, Bruno Pradines. In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum.
Malaria journal.
2014 May; 13(?):189. doi:
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PloS one.
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The Journal of infectious diseases.
2013 Jun; 207(11):1646-54. doi:
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The American journal of tropical medicine and hygiene.
2012 Jul; 87(1):35-40. doi:
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Antimicrobial agents and chemotherapy.
2012 Jun; 56(6):3288-97. doi:
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Antimicrobial agents and chemotherapy.
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