Cimetidine hydrochloride (BioDeep_00000660402)
代谢物信息卡片
Cimetidine hydrochloride
化学式: C10H17ClN6S (288.0923872)
中文名称: 盐酸西咪替丁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(N=CN1)CSCCNC(=NC)NC#N.Cl
InChI: 1H
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:50362
- KEGGdrug: D03503
- PubChem: 50963
- ChEMBL: CHEMBL1201051
- MeSH: Cimetidine
- CAS: 70059-30-2
- CAS: 71989-90-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sunday Aderemi Adelakun, Babatunde Ogunlade, Olalekan Wasiu Akintunde, Victoria Ojima Omilachi. Long-term exposure to cimetidine induced gonado-toxicity in male rats: Modulating role of Ocimum gratissimum.
Revista internacional de andrologia.
2022 10; 20 Suppl 1(?):S2-S16. doi:
10.1016/j.androl.2020.10.012. [PMID: 35101366] - Ahmed A Ishola, Tanuja Joshi, Suliat I Abdulai, Habibu Tijjani, Hemlata Pundir, Subhash Chandra. Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19.
Journal of biomolecular structure & dynamics.
2022 08; 40(13):5785-5802. doi:
10.1080/07391102.2021.1873191. [PMID: 33491579] - Sherihan Salaheldin Abdelhamid Ibrahim, Sarah A Abd El-Aal, Ahmed M Reda, Samar El Achy, Yasmine Shahine. Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer.
Scientific reports.
2022 07; 12(1):11514. doi:
10.1038/s41598-022-15551-6. [PMID: 35798765] - Omolbanin Oladpour, Fereshteh Taghipour, Zuhair Mohammad Hassan, Mohammad Taghi Rezayati, Maryam Nemati, Zahra Taghipour, Abdollah Jafarzadeh. Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer.
Asian Pacific journal of cancer prevention : APJCP.
2022 Jun; 23(6):1847-1858. doi:
10.31557/apjcp.2022.23.6.1847. [PMID: 35763623] - Nasrin Abbasi Gharibkandi, Sajjad Molavipordanjani, Alireza Mardanshahi, Seyed Jalal Hosseinimehr. The Influence of Kidneys Ion Transport Inhibitors on the Pharmacokinetic and Tumor Uptake Behaviors of a HER2-targeted Small Size Radiolabeled Peptide.
Current drug metabolism.
2022; 23(1):82-87. doi:
10.2174/1389200223666220113101004. [PMID: 35049428] - Atsushi Kawase, Akira Kazaoka, Hiroaki Shimada, Masahiro Iwaki. Increased brain penetration of diphenhydramine and memantine in rats with adjuvant-induced arthritis.
Brain research.
2021 10; 1768(?):147581. doi:
10.1016/j.brainres.2021.147581. [PMID: 34280372] - Fereshteh Taghipour, Omolbanin Oladpour, Mohammad Taghi Rezayati, Hossain Khorramdelazad, Maryam Nemati, Zahra Taghipour, Javad Masoumi, Zuhair Mohammad Hassan, Abdollah Jafarzadeh. Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model.
Iranian journal of allergy, asthma, and immunology.
2021 Sep; 20(5):600-613. doi:
10.18502/ijaai.v20i5.7410. [PMID: 34664819] - Keita Morimoto, Go Kanzaki, Takahito Niikura, Kentaro Koike, Nanae Matsuo, Yukio Maruyama, Nobuo Tsuboi, Takashi Yokoo. Acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody following cimetidine treatment: a case report.
BMC nephrology.
2021 08; 22(1):294. doi:
10.1186/s12882-021-02502-y. [PMID: 34461843] - Hiroyuki Takita, Daniel Scotcher, Rajkumar Chinnadurai, Philip A Kalra, Aleksandra Galetin. Physiologically-Based Pharmacokinetic Modelling of Creatinine-Drug Interactions in the Chronic Kidney Disease Population.
CPT: pharmacometrics & systems pharmacology.
2020 12; 9(12):695-706. doi:
10.1002/psp4.12566. [PMID: 33049120] - Sabrina T Wiebe, Thomas Giessmann, Kathrin Hohl, Sven Schmidt-Gerets, Edith Hauel, Alen Jambrecina, Kerstin Bader, Naoki Ishiguro, Mitchell E Taub, Ashish Sharma, Thomas Ebner, Gerd Mikus, Martin F Fromm, Fabian Müller, Peter Stopfer. Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Clinical pharmacokinetics.
2020 12; 59(12):1627-1639. doi:
10.1007/s40262-020-00907-w. [PMID: 32504272] - Tom T G Nieskens, Mikael Persson, Edward J Kelly, Anna-Karin Sjögren. A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity.
Drug metabolism and disposition: the biological fate of chemicals.
2020 12; 48(12):1303-1311. doi:
10.1124/dmd.120.000098. [PMID: 33020068] - Clémence Chevalier, Sandrine Perrimond-Dauchy, Julie Dubourg, Pascale Fouqueray, Sébastien Bolze. Lack of Drug-Drug Interaction Between Cimetidine, a Renal Transporter Inhibitor, and Imeglimin, a Novel Oral Antidiabetic Drug, in Healthy Volunteers.
European journal of drug metabolism and pharmacokinetics.
2020 Dec; 45(6):725-733. doi:
10.1007/s13318-020-00642-4. [PMID: 32860624] - Nina Hanke, Denise Türk, Dominik Selzer, Naoki Ishiguro, Thomas Ebner, Sabrina Wiebe, Fabian Müller, Peter Stopfer, Valerie Nock, Thorsten Lehr. A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals.
Clinical pharmacokinetics.
2020 11; 59(11):1419-1431. doi:
10.1007/s40262-020-00896-w. [PMID: 32449077] - Marta Kantauskaitė, Anna Hucke, Moritz Reike, Sara Ahmed Eltayeb, Chuyan Xiao, Vivien Barz, Giuliano Ciarimboli. Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21145157. [PMID: 32708212] - Emily J Cicali, D Max Smith, Benjamin Q Duong, Lukas G Kovar, Larisa H Cavallari, Julie A Johnson. A Scoping Review of the Evidence Behind Cytochrome P450 2D6 Isoenzyme Inhibitor Classifications.
Clinical pharmacology and therapeutics.
2020 07; 108(1):116-125. doi:
10.1002/cpt.1768. [PMID: 31910286] - Mauricio A García, Danae Contreras, Pablo M González. Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability.
Pharmaceutical research.
2020 Jun; 37(7):121. doi:
10.1007/s11095-020-02824-w. [PMID: 32514792] - Marie-Laure Boof, Atef Halabi, Mike Ufer, Jasper Dingemanse. Impact of the organic cation transporter 2 inhibitor cimetidine on the single-dose pharmacokinetics of the glucosylceramide synthase inhibitor lucerastat in healthy subjects.
European journal of clinical pharmacology.
2020 Mar; 76(3):431-437. doi:
10.1007/s00228-019-02808-9. [PMID: 31836927] - Monireh Karami, Yadollah Yamini, Yousef Abdossalami Asl. On-chip ion pair-based dispersive liquid-liquid extraction for quantitative determination of histamine H2 receptor antagonist drugs in human urine.
Talanta.
2020 Jan; 206(?):120235. doi:
10.1016/j.talanta.2019.120235. [PMID: 31514880] - Hyun Mi Kang, Jung Hwa Lim, Kyung Hee Noh, Dongmin Park, Hyun-Soo Cho, Katalin Susztak, Cho-Rok Jung. Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.
Scientific reports.
2019 11; 9(1):17610. doi:
10.1038/s41598-019-53855-2. [PMID: 31772214] - Kevin Renfert, Wolfgang Rabsch, Angelika Fruth, Stephanie Speck, Michael Pees. The use of a salmonella bacteriophage in bearded dragons: application, passage time and reisolation.
Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere.
2019 Aug; 47(4):247-256. doi:
10.1055/a-0959-5528. [PMID: 31434125] - Kotaro Nishiyama, Kota Toshimoto, Wooin Lee, Naoki Ishiguro, Bojan Bister, Yuichi Sugiyama. Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine.
CPT: pharmacometrics & systems pharmacology.
2019 06; 8(6):396-406. doi:
10.1002/psp4.12398. [PMID: 30821133] - Ashraf Yousefzadeh, Jafar Abolhasani, Javad Hassanzadeh, Mohammad Hossein Somi. Ultrasensitive chemiluminescence assay for cimetidine detection based on the synergistic improving effect of Au nanoclusters and graphene quantum dots.
Luminescence : the journal of biological and chemical luminescence.
2019 Mar; 34(2):261-271. doi:
10.1002/bio.3604. [PMID: 30724006] - Mahboob Ahmad, Bilal Aslam, Faqir Muhammad, Mashkoor Mohsin, Ahmad Raza. Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits.
Pakistan journal of pharmaceutical sciences.
2019 Jan; 32(1):7-13. doi:
. [PMID: 30772784] - Fabian Müller, Dietmar Weitz, Katharina Mertsch, Jörg König, Martin F Fromm. Importance of OCT2 and MATE1 for the Cimetidine-Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition.
Molecular pharmaceutics.
2018 08; 15(8):3425-3433. doi:
10.1021/acs.molpharmaceut.8b00416. [PMID: 29975542] - Laura L Giusto, Patricia M Zahner, Daniel A Shoskes. An evaluation of the pharmacotherapy for interstitial cystitis.
Expert opinion on pharmacotherapy.
2018 07; 19(10):1097-1108. doi:
10.1080/14656566.2018.1491968. [PMID: 29972328] - Fan Hu, PinPing Wu, RuYa Wang, Wei Liu, Hua He. Colorimetric sensor for cimetidine detection in human urine based on d-xylose protected gold nanoparticles.
The Analyst.
2018 May; 143(10):2369-2376. doi:
10.1039/c8an00499d. [PMID: 29696278] - Jhohann Richard de Lima Benzi, Priscila Akemi Yamamoto, Jessica Hanna Stevens, Amanda Martins Baviera, Natália Valadares de Moraes. The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats.
Life sciences.
2018 May; 200(?):63-68. doi:
10.1016/j.lfs.2018.03.012. [PMID: 29551575] - Martina Ceckova, Josef Reznicek, Birgit Deutsch, Martin F Fromm, Frantisek Staud. Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate).
PloS one.
2018; 13(8):e0202706. doi:
10.1371/journal.pone.0202706. [PMID: 30114293] - Ming Zhang, Misha Vrolijk, Guido R M M Haenen. The Screening of Anticholinergic Accumulation by Traditional Chinese Medicine.
International journal of molecular sciences.
2017 Dec; 19(1):. doi:
10.3390/ijms19010018. [PMID: 29267212] - Liping Li, Yayun Weng, Wei Wang, Mengru Bai, Hongmei Lei, Hui Zhou, Huidi Jiang. Multiple organic cation transporters contribute to the renal transport of sulpiride.
Biopharmaceutics & drug disposition.
2017 Dec; 38(9):526-534. doi:
10.1002/bdd.2104. [PMID: 28926871] - B KuKanich, K KuKanich, J Black. The effects of ketoconazole and cimetidine on the pharmacokinetics of oral tramadol in greyhound dogs.
Journal of veterinary pharmacology and therapeutics.
2017 Dec; 40(6):e54-e61. doi:
10.1111/jvp.12424. [PMID: 28603935] - Naoyuki Fujimori, Michiharu Komatsu, Naoki Tanaka, Mai Iwaya, Hajime Nakano, Ayumi Sugiura, Tomoo Yamazaki, Soichiro Shibata, Yugo Iwaya, Takashi Muraki, Yuki Ichikawa, Takefumi Kimura, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Eiji Tanaka. Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury.
Clinical journal of gastroenterology.
2017 Oct; 10(5):452-458. doi:
10.1007/s12328-017-0760-1. [PMID: 28676994] - Robert Elsby, Stephen Chidlaw, Samuel Outteridge, Sarah Pickering, Amy Radcliffe, Rebecca Sullivan, Hayley Jones, Philip Butler. Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Pharmacology research & perspectives.
2017 10; 5(5):. doi:
10.1002/prp2.357. [PMID: 28971610] - Fabian Müller, Dietmar Weitz, Volker Derdau, Martin Sandvoss, Katharina Mertsch, Jörg König, Martin F Fromm. Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine.
Molecular pharmaceutics.
2017 09; 14(9):2991-2998. doi:
10.1021/acs.molpharmaceut.7b00179. [PMID: 28708400] - Harumasa Takano, Sumito Ito, Xuan Zhang, Hiroshi Ito, Ming-Rong Zhang, Hiroshi Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Tetsuya Suhara, Yuichi Sugiyama. Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist.
Journal of pharmaceutical sciences.
2017 09; 106(9):2558-2565. doi:
10.1016/j.xphs.2017.05.006. [PMID: 28499878] - T J Younkin, E G Davis, B Kukanich. Pharmacokinetics of oral terbinafine in adult horses.
Journal of veterinary pharmacology and therapeutics.
2017 Aug; 40(4):342-347. doi:
10.1111/jvp.12367. [PMID: 27885696] - Kyle E Rodenbach, Dana Y Fuhrman, Paula S Maier, George J Schwartz. Renal Response to a Protein Load in Healthy Young Adults as Determined by Iohexol Infusion Clearance, Cimetidine-Inhibited Creatinine Clearance, and Cystatin C Estimated Glomerular Filtration Rate.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2017 07; 27(4):275-281. doi:
10.1053/j.jrn.2017.01.021. [PMID: 28389059] - Johannes C van der Wouden, Renske van der Sande, Emma J Kruithof, Annet Sollie, Lisette Wa van Suijlekom-Smit, Sander Koning. Interventions for cutaneous molluscum contagiosum.
The Cochrane database of systematic reviews.
2017 05; 5(?):CD004767. doi:
10.1002/14651858.cd004767.pub4. [PMID: 28513067] - Fabrizia Mariotti, Giorgia Ciurlia, Luca Spaccapelo, Annamaria Muraro, Daniela Acerbi. A Two-Period Open-Label, Single-Dose Crossover Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Between Cimetidine and Inhaled Extrafine CHF 5993.
European journal of drug metabolism and pharmacokinetics.
2017 Apr; 42(2):269-279. doi:
10.1007/s13318-016-0345-2. [PMID: 27209586] - H K Knych, S D Stanley, R M Arthur, D S McKemie. Disposition of the anti-ulcer medications ranitidine, cimetidine, and omeprazole following administration of multiple doses to exercised Thoroughbred horses.
Journal of veterinary pharmacology and therapeutics.
2017 Jan; 40(1):92-96. doi:
10.1111/jvp.12328. [PMID: 27292271] - Mitsuhiro Goda, Kana Oda, Atsuko Oda, Naoki Kobayashi, Masato Otsuka. Involvement of the Multidrug and Toxic Compound Extrusion Transporter in Testosterone Release from Cultured Pig Leydig Cells.
Pharmacology.
2017; 100(1-2):31-39. doi:
10.1159/000460822. [PMID: 28441657] - Simone Hansmann, Adam Darwich, Alison Margolskee, Leon Aarons, Jennifer Dressman. Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models.
The Journal of pharmacy and pharmacology.
2016 Dec; 68(12):1501-1515. doi:
10.1111/jphp.12618. [PMID: 27781273] - Jia Yin, Haichuan Duan, Joanne Wang. Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation.
The Journal of pharmacology and experimental therapeutics.
2016 Dec; 359(3):401-410. doi:
10.1124/jpet.116.236158. [PMID: 27758931] - María García-García, Sergio Liarte, Nuria E Gómez-González, Alicia García-Alcázar, Jaume Pérez-Sánchez, José Meseguer, Victoriano Mulero, Alfonsa García-Ayala, Elena Chaves-Pozo. Cimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fish.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2016 Nov; 189(?):44-53. doi:
10.1016/j.cbpc.2016.07.004. [PMID: 27475025] - Joanna H Tu, Sarah L Sheu, Joyce M Teng. Novel Treatment Using Cimetidine for Erythropoietic Protoporphyria in Children.
JAMA dermatology.
2016 11; 152(11):1258-1261. doi:
10.1001/jamadermatol.2016.2303. [PMID: 27410690] - L P Li, F F Song, Y Y Weng, X Yang, K Wang, H M Lei, J Ma, H Zhou, H D Jiang. Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride.
British journal of pharmacology.
2016 08; 173(16):2543-54. doi:
10.1111/bph.13537. [PMID: 27324234] - H J Burt, S Neuhoff, L Almond, L Gaohua, M D Harwood, M Jamei, A Rostami-Hodjegan, G T Tucker, K Rowland-Yeo. Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2016 Jun; 88(?):70-82. doi:
10.1016/j.ejps.2016.03.020. [PMID: 27019345] - Mariusz J Świąder, Bartłomiej Barczyński, Michał Tomaszewski, Katarzyna Świąder, Stanisław J Czuczwar. The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
Pharmacological reports : PR.
2016 Apr; 68(2):283-8. doi:
10.1016/j.pharep.2015.09.009. [PMID: 26922528] - Yi-Fan Zhang, Xiao-Jian Dai, Yong Yang, Xiao-Yan Chen, Ting Wang, Yun-Biao Tang, Cheng-Yuan Tsai, Li-Wen Chang, Yu-Ting Chang, Da-Fang Zhong. Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers.
Drug design, development and therapy.
2016; 10(?):357-70. doi:
10.2147/dddt.s95934. [PMID: 26855561] - J Jansen, I E De Napoli, M Fedecostante, C M S Schophuizen, N V Chevtchik, M J Wilmer, A H van Asbeck, H J Croes, J C Pertijs, J F M Wetzels, L B Hilbrands, L P van den Heuvel, J G Hoenderop, D Stamatialis, R Masereeuw. Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations.
Scientific reports.
2015 Nov; 5(?):16702. doi:
10.1038/srep16702. [PMID: 26567716] - Jana Knop, Eva Hoier, Thomas Ebner, Martin F Fromm, Fabian Müller. Renal tubular secretion of pramipexole.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2015 Nov; 79(?):73-8. doi:
10.1016/j.ejps.2015.09.004. [PMID: 26360835] - Flávia L Beltrame, Paulo S Cerri, Estela Sasso-Cerri. Cimetidine-induced Leydig cell apoptosis and reduced EG-VEGF (PK-1) immunoexpression in rats: Evidence for the testicular vasculature atrophy.
Reproductive toxicology (Elmsford, N.Y.).
2015 Nov; 57(?):50-8. doi:
10.1016/j.reprotox.2015.05.009. [PMID: 26021711] - Butch KuKanich, Kate KuKanich. Chloramphenicol significantly affects the pharmacokinetics of oral methadone in Greyhound dogs.
Veterinary anaesthesia and analgesia.
2015 Nov; 42(6):597-607. doi:
10.1111/vaa.12257. [PMID: 25733012] - Henok Getachew, Yewondwossen Tadesse, Workineh Shibeshi. Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia.
BMC nephrology.
2015 Oct; 16(?):158. doi:
10.1186/s12882-015-0155-9. [PMID: 26446847] - Saeram Lee, Dawoon Jung, Younglim Kho, Kyunghee Ji, Pilje Kim, Byeongwoo Ahn, Kyungho Choi. Ecotoxicological assessment of cimetidine and determination of its potential for endocrine disruption using three test organisms: Daphnia magna, Moina macrocopa, and Danio rerio.
Chemosphere.
2015 Sep; 135(?):208-16. doi:
10.1016/j.chemosphere.2015.04.033. [PMID: 25957140] - Shabnam Delasoud, Dariush Minai-Tehrani, Hamidreza Mollasalehi. Enhancing effect of cimetidine on peroxidase activity of human erythrocyte hemoglobin.
Drug metabolism and personalized therapy.
2015 Sep; 30(3):189-93. doi:
10.1515/dmpt-2014-0032. [PMID: 26167985] - Suzanne Estaphan, Hassan Eissa, Samah Elattar, Laila Rashed, Mira Farouk. A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats.
Injury.
2015 Jul; 46(7):1223-30. doi:
10.1016/j.injury.2015.03.037. [PMID: 25930980] - Hong-mei Lei, Si-yuan Sun, Li-ping Li, Mei-juan Tu, Hui Zhou, Su Zeng, Hui-di Jiang. [Establishment of MDCK cell models expressing human MATE1 or co-expressing with human OCT1 or OCT2].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Jul; 50(7):842-7. doi:
NULL. [PMID: 26552145] - Siavash M Shanehsaz, Silva Ishkhanian. A comparative study between the efficacy of oral cimetidine and low-dose systemic meglumine antimoniate (MA) with a standard dose of systemic MA in the treatment of cutaneous leishmaniasis.
International journal of dermatology.
2015 Jul; 54(7):834-8. doi:
10.1111/ijd.12709. [PMID: 26108265] - Wenceslaus Luoga, Fadlul Mansur, Gillian Stepek, Ann Lowe, Ian R Duce, David J Buttle, Jerzy M Behnke. Host genetic influences on the anthelmintic efficacy of papaya-derived cysteine proteinases in mice.
Parasitology.
2015 Jun; 142(7):989-98. doi:
10.1017/s003118201500013x. [PMID: 25736575] - Irawati Kandela, Ioannis Zervantonakis. Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data.
eLife.
2015 May; 4(?):e06847. doi:
10.7554/elife.06847. [PMID: 25939392] - Subramaniyan Ramasundaram, Aseom Son, Mingizem Gashaw Seid, Sujin Shim, Sang Hyup Lee, Yun Chul Chung, Changha Lee, Jaesang Lee, Seok Won Hong. Photocatalytic applications of paper-like poly(vinylidene fluoride)-titanium dioxide hybrids fabricated using a combination of electrospinning and electrospraying.
Journal of hazardous materials.
2015 Mar; 285(?):267-76. doi:
10.1016/j.jhazmat.2014.12.004. [PMID: 25514651] - Simin Fazelipour, Seyyed B Kiaei, Zahra Tootian, Seyyed A Haeri, Omid Zehtabvar, Javad Sadeghinezhad. Cimetidine administration decreases radiogenic damage on the thyroid gland in mice.
International journal of radiation biology.
2015 Mar; 91(3):218-23. doi:
10.3109/09553002.2014.980464. [PMID: 25347146] - Ellen Mueller Fox, Christopher P Morris, Marc P Hübner, Edward Mitre. Histamine 1 Receptor Blockade Enhances Eosinophil-Mediated Clearance of Adult Filarial Worms.
PLoS neglected tropical diseases.
2015; 9(7):e0003932. doi:
10.1371/journal.pntd.0003932. [PMID: 26204515] - Xiaonan Li, Xiaolin Sun, Jiayin Chen, Yang Lu, Yongjie Zhang, Chunfeng Wang, Junxiu Li, Qing Zhang, Di Zhao, Xijing Chen. Investigation of the role of organic cation transporter 2 (OCT2) in the renal transport of guanfacine, a selective α2A-adrenoreceptor agonist.
Xenobiotica; the fate of foreign compounds in biological systems.
2015 Jan; 45(1):88-94. doi:
10.3109/00498254.2014.949904. [PMID: 25115365] - Kenji Ikemura. [Molecular Biological Analysis of Factors Influencing Pharmacokinetics to Achieve Personalized Pharmacotherapy].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2015; 135(9):1037-41. doi:
10.1248/yakushi.15-00169. [PMID: 26329549] - Ryan S Prosser, Stefan Trapp, Paul K Sibley. Modeling uptake of selected pharmaceuticals and personal care products into food crops from biosolids-amended soil.
Environmental science & technology.
2014 Oct; 48(19):11397-404. doi:
10.1021/es503067v. [PMID: 25207852] - Eve-Irene Lepist, Xuexiang Zhang, Jia Hao, Jane Huang, Alan Kosaka, Gabriel Birkus, Bernard P Murray, Roy Bannister, Tomas Cihlar, Yong Huang, Adrian S Ray. Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.
Kidney international.
2014 Aug; 86(2):350-7. doi:
10.1038/ki.2014.66. [PMID: 24646860] - Im-Sook Song, Tae Yeon Kong, Hyeon-Uk Jeong, Eun Nam Kim, Soon-Sang Kwon, Hee Eun Kang, Sang-Zin Choi, Miwon Son, Hye Suk Lee. Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo.
BMC complementary and alternative medicine.
2014 Jul; 14(?):251. doi:
10.1186/1472-6882-14-251. [PMID: 25034211] - Kan Zhong, Xiuli Li, Cen Xie, Yifan Zhang, Dafang Zhong, Xiaoyan Chen. Effects of renal impairment on the pharmacokinetics of morinidazole: uptake transporter-mediated renal clearance of the conjugated metabolites.
Antimicrobial agents and chemotherapy.
2014 Jul; 58(7):4153-61. doi:
10.1128/aac.02414-14. [PMID: 24820074] - Seyyed Mehdi Hosseinifard, Asieh Ahmadpour, Bagher Mojazi Amiri, Majid Razeghi Mansour, Arezo Ebrahimpour. Immunomodulatory effect of cimetidine in common carp (Cyprinus carpio L.).
Fish physiology and biochemistry.
2013 Dec; 39(6):1505-11. doi:
10.1007/s10695-013-9804-8. [PMID: 23703690] - Bo Feng, Susan Hurst, Yasong Lu, Manthena V Varma, Charles J Rotter, Ayman El-Kattan, Peter Lockwood, Brian Corrigan. Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.
Molecular pharmaceutics.
2013 Nov; 10(11):4207-15. doi:
10.1021/mp400295c. [PMID: 24066726] - Swati Dumitras, Romain Sechaud, Anton Drollmann, Parasar Pal, Sivakumar Vaidyanathan, Gian Camenisch, Guenther Kaiser. Effect of cimetidine, a model drug for inhibition of the organic cation transport (OCT2/MATE1) in the kidney, on the pharmacokinetics of glycopyrronium.
International journal of clinical pharmacology and therapeutics.
2013 Oct; 51(10):771-9. doi:
10.5414/cp201946. [PMID: 24040847] - Frank Thévenod, Giuliano Ciarimboli, Marcus Leistner, Natascha A Wolff, Wing-Kee Lee, Irina Schatz, Thorsten Keller, Rouvier Al-Monajjed, Valentin Gorboulev, Hermann Koepsell. Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+.
Molecular pharmaceutics.
2013 Aug; 10(8):3045-56. doi:
10.1021/mp400113d. [PMID: 23763587] - Maki Arakawa-Todo, Jun Ueyama, Hiroshi Nomura, Fumie Abe, Ikuto Tsukiyama, Katsuhiko Matsuura, Takaaki Hasegawa. Drug interaction between sunitinib and cimetidine and contribution of the efflux transporter ATP-binding cassette C2 to biliary excretion of sunitinib in rats.
Anticancer research.
2013 Aug; 33(8):3105-11. doi:
. [PMID: 23898066] - A Jafarzadeh, M Nemati, M T Rezayati, M Ebrahimi, Z M Hassan. Cimetidine enhances delayed-type hypersensitivity responses and serum interleukin (IL)-2, -10, -12, and IL-17 levels after burn injury in an animal model.
Journal of immunotoxicology.
2013 Apr; 10(2):201-9. doi:
10.3109/1547691x.2012.708365. [PMID: 22946962] - M Tolulope Olaleye, Afolabi C Akinmoladun, Olamide O Crown, Katty E Ahonsi, A O Adetuyi. Homopterocarpin contributes to the restoration of gastric homeostasis by Pterocarpus erinaceus following indomethacin intoxication in rats.
Asian Pacific journal of tropical medicine.
2013 Mar; 6(3):200-4. doi:
10.1016/s1995-7645(13)60023-1. [PMID: 23375033] - Tzu-Kai Lin, Mao-Qiang Man, Juan-Luis Santiago, Kyungho Park, Truus Roelandt, Yuko Oda, Melanie Hupe, Debra Crumrine, Hae-Jin Lee, Maria Gschwandtner, Jacob P Thyssen, Carles Trullas, Erwin Tschachler, Kenneth R Feingold, Peter M Elias. Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function.
The Journal of investigative dermatology.
2013 Feb; 133(2):469-78. doi:
10.1038/jid.2012.335. [PMID: 23014339] - Ji Ho Seo, Da Young Lee, Chang Woo Hong, In Hee Lee, Ki Sung Ahn, Gun Woo Kang. Severe lactic acidosis and acute pancreatitis associated with cimetidine in a patient with type 2 diabetes mellitus taking metformin.
Internal medicine (Tokyo, Japan).
2013; 52(19):2245-8. doi:
10.2169/internalmedicine.52.0697. [PMID: 24088760] - Kenji Ikemura, Erika Nakagawa, Tomohiko Kurata, Takuya Iwamoto, Masahiro Okuda. Altered pharmacokinetics of cimetidine caused by down-regulation of renal rat organic cation transporter 2 (rOCT2) after liver ischemia-reperfusion injury.
Drug metabolism and pharmacokinetics.
2013; 28(6):504-9. doi:
10.2133/dmpk.dmpk-13-rg-021. [PMID: 23774469] - Xiaofeng Bao, Shuiyu Lu, Jeih-San Liow, Cheryl L Morse, Kacey B Anderson, Sami S Zoghbi, Robert B Innis, Victor W Pike. [¹¹C]Rhodamine-123: synthesis and biodistribution in rodents.
Nuclear medicine and biology.
2012 Nov; 39(8):1128-36. doi:
10.1016/j.nucmedbio.2012.06.013. [PMID: 22898316] - Toru Arino, Seiji Karakawa, Yasuyoshi Ishiwata, Masashi Nagata, Masato Yasuhara. Effect of cimetidine on pentamidine induced hyperglycemia in rats.
European journal of pharmacology.
2012 Oct; 693(1-3):72-9. doi:
10.1016/j.ejphar.2012.07.043. [PMID: 22968103] - Margaret O Sofidiya, Lilian Agufobi, Abidemi J Akindele, Johnson A Olowe, Oluwole B Familoni. Effect of Flabellaria paniculata Cav. extracts on gastric ulcer in rats.
BMC complementary and alternative medicine.
2012 Oct; 12(?):168. doi:
10.1186/1472-6882-12-168. [PMID: 23031805] - Jing Zhang, Wen Zhou. Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Jul; 50(7):2289-93. doi:
10.1016/j.fct.2012.03.077. [PMID: 22525860] - Volker Vallon, Satish A Eraly, Satish Ramachandra Rao, Maria Gerasimova, Michael Rose, Megha Nagle, Naohiko Anzai, Travis Smith, Kumar Sharma, Sanjay K Nigam, Timo Rieg. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice.
American journal of physiology. Renal physiology.
2012 May; 302(10):F1293-9. doi:
10.1152/ajprenal.00013.2012. [PMID: 22338083] - Ana Paula de Vasconcellos Abdon, Greicy Coelho de Souza, Lílian Noronha Coelho de Souza, Renata Prado Vasconcelos, Carolina Araújo Castro, Marjorie Moreira Guedes, Roberto César Pereira Lima, Renato de Azevedo Moreira, Ana Cristina de Oliveira Monteiro-Moreira, Adriana Rolim Campos. Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions.
Fitoterapia.
2012 Apr; 83(3):604-8. doi:
10.1016/j.fitote.2012.01.005. [PMID: 22285860] - Ya-Hsueh Wu, Ming-Ling Wu, Chun-Chi Lin, Wei-Lan Chu, Chen-Chang Yang, Robert Tate Lin, Jou-Fang Deng. Determination of caprolactam and 6-aminocaproic acid in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Feb; 885-886(?):61-5. doi:
10.1016/j.jchromb.2011.12.014. [PMID: 22237132] - Clemence Tarirai, Alvaro M Viljoen, Josias H Hamman. Effects of dietary fruits, vegetables and a herbal tea on the in vitro transport of cimetidine: comparing the Caco-2 model with porcine jejunum tissue.
Pharmaceutical biology.
2012 Feb; 50(2):254-63. doi:
10.3109/13880209.2011.598169. [PMID: 22085278] - Nobuo Shinohara, Takashige Abe, Ataru Sazawa, Satoru Maruyama, Junri Shindo, Soshu Sato, Shin Suzuki, Katsuya Nonomura. Interferon-α-based immunotherapy in metastatic renal cell carcinoma patients with the primary tumor in situ.
Japanese journal of clinical oncology.
2012 Feb; 42(2):113-9. doi:
10.1093/jjco/hyr176. [PMID: 22131341] - Sumito Ito, Hiroyuki Kusuhara, Miyu Yokochi, Junko Toyoshima, Katsuhisa Inoue, Hiroaki Yuasa, Yuichi Sugiyama. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
The Journal of pharmacology and experimental therapeutics.
2012 Feb; 340(2):393-403. doi:
10.1124/jpet.111.184986. [PMID: 22072731] - Sarah Maud Fischer, Stephen Timothy Buckley, Wiebke Kirchmeyer, Gert Fricker, Martin Brandl. Application of simulated intestinal fluid on the phospholipid vesicle-based drug permeation assay.
International journal of pharmaceutics.
2012 Jan; 422(1-2):52-8. doi:
10.1016/j.ijpharm.2011.10.026. [PMID: 22027395] - Yinusa Raji, Ganiyat Kehinde Oloyede. Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2012; 9(1):112-9. doi:
10.4314/ajtcam.v9i1.16. [PMID: 23983328] - Denise Guckel, Giuliano Ciarimboli, Hermann Pavenstädt, Eberhard Schlatter. Regulation of organic cation transport in isolated mouse proximal tubules involves complex changes in protein trafficking and substrate affinity.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 30(1):269-81. doi:
10.1159/000339063. [PMID: 22759973] - J-C Tsai, C-C Lu, M-K Lin, J-W Guo, H-M Sheu. Effects of sebum on drug transport across the human stratum corneum in vivo.
Skin pharmacology and physiology.
2012; 25(3):124-32. doi:
10.1159/000336245. [PMID: 22343606] - C N Okwuosa, R Okoi-Ewa, P U Achukwu, A C Onuba, N C Azubuike. Gastro-protective effect of crude hexane leaf extract of Sesamum indicum in rabbits.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2011 Nov; 26(1):49-54. doi:
. [PMID: 22314987] - Y Raji, W A Oyeyemi, S T Shittu, A F Bolarinwa. Gastro-protective effect of methanol extract of Ficus asperifolia bark on indomethacin-induced gastric ulcer in rats.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2011 Nov; 26(1):43-8. doi:
". [PMID: 22314986] - Rajesh J Mandade, S A Sreenivas, D M Sakarkar, Avijit Choudhury. Pharmacological effects of aqueous-ethanolic extract of Hibiscus rosasinensis on volume and acidity of stimulated gastric secretion.
Asian Pacific journal of tropical medicine.
2011 Nov; 4(11):883-8. doi:
10.1016/s1995-7645(11)60213-7. [PMID: 22078951] - Takuya Shimizu, Tomoko Sugiura, Tomohiko Wakayama, Ai Kijima, Noritaka Nakamichi, Shoichi Iseki, David L Silver, Yukio Kato. PDZK1 regulates breast cancer resistance protein in small intestine.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Nov; 39(11):2148-54. doi:
10.1124/dmd.111.040295. [PMID: 21816982] - Pramod Kumar Singh, Indu Pal Kaur. Development and evaluation of a gastro-retentive delivery system for improved antiulcer activity of ginger extract (Zingiber officinale).
Journal of drug targeting.
2011 Nov; 19(9):741-51. doi:
10.3109/1061186x.2011.561855. [PMID: 21401390]