Pyrilamine maleate (BioDeep_00000660211)
代谢物信息卡片
Pyrilamine Maleate Salt
化学式: C21H27N3O5 (401.1951)
中文名称: 马来酸吡拉明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
InChI: 2-1-
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Mepyramine maleate, a first generation antihistamine, is an antagonist of histamine H1 receptor, with Kds of 0.8 nM, 5200 nM and >3000 nM for H1, H2, and H3 receptor, respectively, and a pKd of 9.4 for H1 receptor.
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D05660
- PubChem: 5284451
- ChEMBL: CHEMBL1201006
- MeSH: Pyrilamine
- CAS: 59-33-6
- medchemexpress: HY-B1281
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Shigeru Hishinuma, Hiroshi Komazaki, Hayato Tsukamoto, Hirokazu Hatahara, Hiroyuki Fukui, Masaru Shoji. Ca2+ -dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells.
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2018 01; 144(1):68-80. doi:
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Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia.
1996; 46(1):33-40. doi:
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1996 Jan; 40(1):112-8. doi:
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American journal of respiratory and critical care medicine.
1995 Dec; 152(6 Pt 1):1796-804. doi:
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British journal of pharmacology.
1995 Nov; 116(6):2715-23. doi:
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1995 Sep; 46(3):313-22. doi:
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The American journal of physiology.
1995 Jun; 268(6 Pt 1):L879-84. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
1995 Jun; 52(6):403-11. doi:
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The Journal of allergy and clinical immunology.
1995 May; 95(5 Pt 1):979-86. doi:
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European journal of pharmacology.
1995 Feb; 274(1-3):101-7. doi:
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Japanese journal of pharmacology.
1994 Oct; 66(2):173-80. doi:
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Acta anaesthesiologica Scandinavica.
1994 Aug; 38(6):569-74. doi:
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Endocrinology.
1994 Aug; 135(2):675-81. doi:
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The Biochemical journal.
1994 Jun; 300 ( Pt 3)(?):665-72. doi:
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Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1994 Jun; 24(6):582-9. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1994 May; 24(5):451-9. doi:
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Pulmonary pharmacology.
1994 Apr; 7(2):73-9. doi:
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Arzneimittel-Forschung.
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The Journal of pharmacology and experimental therapeutics.
1994 Feb; 268(2):959-64. doi:
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British journal of pharmacology.
1994 Jan; 111(1):29-34. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1994; 9(7):758-63. doi:
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Acta neurochirurgica. Supplementum.
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Circulatory shock.
1993 Nov; 41(3):185-96. doi:
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Journal of lipid mediators.
1993 Oct; 8(2):105-10. doi:
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Archives of oral biology.
1993 Oct; 38(10):893-901. doi:
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Biochemical and biophysical research communications.
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Gastroenterology.
1993 Sep; 105(3):764-72. doi:
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Pharmacology.
1993 Aug; 47(2):73-83. doi:
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Parasite immunology.
1993 Aug; 15(8):449-53. doi:
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1993 Jun; 43(6):668-71. doi:
. [PMID: 8102529]
