Thymic Factor trifluoroacetate salt (BioDeep_00000660189)
代谢物信息卡片
H-DL-Pyr-DL-Ala-DL-Lys-DL-Ser-DL-Gln-Gly-Gly-DL-Ser-DL-Asn-OH
化学式: C33H54N12O15 (858.3831)
中文名称: 血清胸腺因子
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C1CCC(=O)N1
InChI: InChI=1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)
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0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Paula C Reggiani, Eliana V Martines, Gisela A Camihort, Brenda Poch, Rodolfo G Goya, Gloria M Cónsole. Role of thymulin on the somatotropic axis in vivo.
Life sciences.
2012 Sep; 91(5-6):166-71. doi:
10.1016/j.lfs.2012.06.037. [PMID: 22781709] - Paula C Reggiani, Claudio G Barbeito, Gustavo O Zuccolilli, Gloria M Cónsole, Alicia M Flamini, Mireille Dardenne, Rodolfo G Goya. Neonatal thymulin gene therapy prevents ovarian dysgenesis and attenuates reproductive derangements in nude female mice.
Endocrinology.
2012 Aug; 153(8):3922-8. doi:
10.1210/en.2012-1183. [PMID: 22700775] - Agnieszka Piechal, Kamilla Blecharz-Klin, Justyna Pyrzanowska, Ewa Widy-Tyszkiewicz. Maternal zinc supplementation improves spatial memory in rat pups.
Biological trace element research.
2012 Jun; 147(1-3):299-308. doi:
10.1007/s12011-012-9323-y. [PMID: 22249889] - Artur Mierzecki, Dorota Strecker, Krystyna Radomska. A pilot study on zinc levels in patients with rheumatoid arthritis.
Biological trace element research.
2011 Nov; 143(2):854-62. doi:
10.1007/s12011-010-8952-2. [PMID: 21279466] - Yen-Kung Chen, Chia-Lu Yeh, Yen-Ling Chen, Su-Chen Wang, Ru-Hwa Cheng, Pan-Fu Kao. The frequency and spectrum of thymus 2-[fluorine-18] fluoro-2-deoxy-D-glucose uptake patterns in hyperthyroidism patients.
Academic radiology.
2011 Oct; 18(10):1292-7. doi:
10.1016/j.acra.2011.05.011. [PMID: 21893295] - Carlin Rafie, Adriana Campa, Sylvia Smith, Fatma Huffman, Fred Newman, Marianna K Baum. Cocaine reduces thymic endocrine function: another mechanism for accelerated HIV disease progression.
AIDS research and human retroviruses.
2011 Aug; 27(8):815-22. doi:
10.1089/aid.2010.0086. [PMID: 21142650] - Eliana Martines, Paula C Reggiani, José I Schwerdt, Rodolfo G Goya, Gloria Cónsole. Neonatal thymulin gene therapy in nude mice: Effects on the morphology of the pituitary corticotrope population.
Histology and histopathology.
2011 04; 26(4):471-9. doi:
10.14670/hh-26.471. [PMID: 21360440] - Eliana V Martines, Paula C Reggiani, José I Schwerdt, Rodolfo G Goya, Gloria M Cónsole. Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice.
Cells, tissues, organs.
2011; 194(1):67-75. doi:
10.1159/000322583. [PMID: 21212643] - Hugo Folch, Juana V Villegas, Víctor Leyan, Miguel Barría, Gisela Eller, Patricio Esquivel. Immunohistochemical evidences showing the presence of thymulin containing cells located in involuted thymus and in peripheral lymphoid organs.
Biological research.
2010; 43(3):291-8. doi:
/s0716-97602010000300005. [PMID: 21249300] - Sophie E Moore, A M Prentice, Y Wagatsuma, A J C Fulford, A C Collinson, R Raqib, M Vahter, L A Persson, S E Arifeen. Early-life nutritional and environmental determinants of thymic size in infants born in rural Bangladesh.
Acta paediatrica (Oslo, Norway : 1992).
2009 Jul; 98(7):1168-75. doi:
10.1111/j.1651-2227.2009.01292.x. [PMID: 19432828] - P Reggiani, E Martines, C Ferese, R Goya, G Cónsole. Morphological restoration of gonadotrope population by thymulin gene therapy in nude mice.
Histology and histopathology.
2009 06; 24(6):729-35. doi:
10.14670/hh-24.729. [PMID: 19337971] - Marcello Tonelli, Natasha Wiebe, Brenda Hemmelgarn, Scott Klarenbach, Catherine Field, Braden Manns, Ravi Thadhani, John Gill. Trace elements in hemodialysis patients: a systematic review and meta-analysis.
BMC medicine.
2009 May; 7(?):25. doi:
10.1186/1741-7015-7-25. [PMID: 19454005] - S A Farahat, L A Rashed, N H Zawilla, S M Farouk. Effect of occupational exposure to elemental mercury in the amalgam on thymulin hormone production among dental staff.
Toxicology and industrial health.
2009 Apr; 25(3):159-67. doi:
10.1177/0748233709105270. [PMID: 19482909] - Massimo Bracci, Marco Tomasetti, Marco Malavolta, Viviana Bonacucina, Eugenio Mocchegiani, Lory Santarelli. L-arginine reduces mercury accumulation in thymus of mercury-exposed mice: role of nitric oxide synthase activity and metallothioneins.
Industrial health.
2008 Dec; 46(6):567-74. doi:
10.2486/indhealth.46.567. [PMID: 19088408] - Angélica Flores, Alma I Gallegos, Jacqueline Velasco, Fernando D Mendoza, Cristina Montiel, Pamela M Everardo, María-Esther Cruz, Roberto Domínguez. The acute effects of bilateral ovariectomy or adrenalectomy on progesterone, testosterone and estradiol serum levels depend on the surgical approach and the day of the estrous cycle when they are performed.
Reproductive biology and endocrinology : RB&E.
2008 Oct; 6(?):48. doi:
10.1186/1477-7827-6-48. [PMID: 18954455] - Ananda S Prasad. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc.
Experimental gerontology.
2008 May; 43(5):370-7. doi:
10.1016/j.exger.2007.10.013. [PMID: 18054190] - Gustavo R Morel, Paula C Reggiani, Gloria M Console, Omar J Rimoldi, Silvan M Vesenbeckh, Margarita M Garcia-Bravo, Silvia S Rodriguez, Oscar A Brown, Rodolfo G Goya. Potential of gene therapy for restoration of endocrine thymic function in thymus-deficient animal models.
Current gene therapy.
2008 Feb; 8(1):49-53. doi:
10.2174/156652308783688518. [PMID: 18336249] - S M Lunin, M O Khrenov, T V Novoselova, S B Parfenyuk, E G Novoselova. Thymulin, a thymic peptide, prevents the overproduction of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice.
Immunological investigations.
2008; 37(8):858-70. doi:
10.1080/08820130802447629. [PMID: 18991101] - Rodolfo G Goya, Paula C Reggiani, Silvan M Vesenbeckh, Jean M Pléau, Yolanda E Sosa, Gloria M Cónsole, Rüdiger Schade, Peter Henklein, Mireille Dardenne. Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice.
American journal of physiology. Endocrinology and metabolism.
2007 Jul; 293(1):E182-7. doi:
10.1152/ajpendo.00085.2007. [PMID: 17389714] - Cristina Meazza, Eugenio Mocchegiani, Sara Pagani, Paola Travaglino, Mauro Bozzola. Relationship between thymulin and growth hormone secretion in healthy human neonates.
American journal of perinatology.
2007 Apr; 24(4):227-33. doi:
10.1055/s-2007-972924. [PMID: 17447187] - I F Labunets. [Thymic factors influence on melatonin-producing pineal function in mice of different age: the possible mechanisms].
Advances in gerontology = Uspekhi gerontologii.
2007; 20(1):86-91. doi:
NULL. [PMID: 17969591] - P C Reggiani, C B Hereñú, O J Rimoldi, O A Brown, J-M Pléau, M Dardenne, R G Goya. Gene therapy for long-term restoration of circulating thymulin in thymectomized mice and rats.
Gene therapy.
2006 Aug; 13(16):1214-21. doi:
10.1038/sj.gt.3302775. [PMID: 16617301] - Margarita M García de Bravo, Mónica P Polo, Paula C Reggiani, Omar J Rimoldi, Mireille Dardenne, Rodolfo G Goya. Partial prevention of hepatic lipid alterations in nude mice by neonatal thymulin gene therapy.
Lipids.
2006 Aug; 41(8):753-7. doi:
10.1007/s11745-006-5027-4. [PMID: 17120928] - Baha' N Noureddin, Christiane E Al-Haddad, Ziad Bashshur, Bared Safieh-Garabedian. Plasma thymulin and nerve growth factor levels in patients with primary open angle glaucoma and elevated intraocular pressure.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2006 Jun; 244(6):750-2. doi:
10.1007/s00417-005-0143-z. [PMID: 16217660] - Gustavo R Morel, Oscar A Brown, Paula C Reggiani, Claudia B Hereñú, Enrique L Portiansky, Gustavo O Zuccolilli, Jean M Pléau, Mireille Dardenne, Rodolfo G Goya. Peripheral and mesencephalic transfer of a synthetic gene for the thymic peptide thymulin.
Brain research bulletin.
2006 May; 69(6):647-51. doi:
10.1016/j.brainresbull.2006.03.015. [PMID: 16716832] - Lory Santarelli, Massimo Bracci, Eugenio Mocchegiani. In vitro and in vivo effects of mercuric chloride on thymic endocrine activity, NK and NKT cell cytotoxicity, cytokine profiles (IL-2, IFN-gamma, IL-6): role of the nitric oxide-L-arginine pathway.
International immunopharmacology.
2006 Mar; 6(3):376-89. doi:
10.1016/j.intimp.2005.08.028. [PMID: 16428073] - Gisela Camihort, Georgina Luna, Silvan Vesenbeckh, Celia Ferese, Mireille Dardenne, Rodolfo Goya, Gloria Cónsole. Morphometric assessment of the impact of serum thymulin immunoneutralization on pituitary cell populations in peripubertal mice.
Cells, tissues, organs.
2006; 184(1):23-30. doi:
10.1159/000096948. [PMID: 17190977] - Jing Chen, Ning Qu, Yi-Ming Xia. [Effect of zinc on thymulin level in mice].
Wei sheng yan jiu = Journal of hygiene research.
2005 Jul; 34(4):430-2. doi:
NULL. [PMID: 16229267] - L Santarelli, L Di Lorenzo, M Valentino, M Bracci, V Rapisarda, F Cassano, G Elia, M G Martino, G Neri, P Apostoli, L Soleo. [Reduced thymulin production during occupational exposure to lead].
Giornale italiano di medicina del lavoro ed ergonomia.
2005 Jan; 27 Suppl 1(?):68-72. doi:
NULL. [PMID: 15915658] - Lorena García, Lorena Hinojosa, Roberto Domínguez, Roberto Chavira, Patricia Rosas. Effects of injecting thymulin into the anterior or medial hypothalamus or the pituitary on induced ovulation in prepubertal mice.
Neuroimmunomodulation.
2005; 12(5):314-20. doi:
10.1159/000087111. [PMID: 16166812] - Wan-Pin Chang, Gerald F Combs, Colin G Scanes, James A Marsh. The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken.
Developmental and comparative immunology.
2005; 29(3):265-73. doi:
10.1016/j.dci.2004.07.004. [PMID: 15572074] - Wilson Savino, Vinícius Cotta-de-Almeida, Sylvia C van Buul-Offers, Johanna G Koster, Mireille Dardenne. Abnormal thymic microenvironment in insulin-like growth factor-II transgenic mice.
Neuroimmunomodulation.
2005; 12(2):100-12. doi:
10.1159/000083582. [PMID: 15785112] - Lorena Hinojosa, Lorena García, Roberto Domínguez, Marta C Romano, Pablo G Damián-Matsumura, Lourdes Castillo, Patricia Rosas. Effects of thymulin and GnRH on the release of gonadotropins by in vitro pituitary cells obtained from rats in each day of estrous cycle.
Life sciences.
2004 Dec; 76(7):795-804. doi:
10.1016/j.lfs.2004.07.017. [PMID: 15581911] - L Santarelli, M Valentino, M Bracci, V Rapisarda, L Soleo, E Mocchegiani. Reversibility of thymulin production impairment by L-arginine supplementation in mice exposed to inorganic mercury.
International journal of immunopathology and pharmacology.
2004 May; 17(2 Suppl):123-8. doi:
10.1177/03946320040170s220. [PMID: 15345203] - E S Schernhammer, K Schulmeister. Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels?.
British journal of cancer.
2004 Mar; 90(5):941-3. doi:
10.1038/sj.bjc.6601626. [PMID: 14997186] - Robertina Giacconi, Catia Cipriano, Mario Muzzioli, Nazzarena Gasparini, Florenza Orlando, Eugenio Mocchegiani. Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.
Mechanisms of ageing and development.
2003 Apr; 124(4):371-8. doi:
10.1016/s0047-6374(03)00011-3. [PMID: 12714242] - Iu Ia Hrinevych, H D Bendiuh, O M Ostapenko. [Effect of thymostimulin on endocrine thymus function in thyroidectomized rats during suppressive hormone therapy].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994).
2003; 49(6):43-6. doi:
NULL. [PMID: 14965037] - E K Barbour, M T Farran, S K Hamadeh, M Bouljihad, O Faroon, S Kreydiyyeh. Comparative impact of live chicken infectious anaemia virus vaccine versus natural exposure in meat chicken breeders on immunity to infectivity by CIA and inclusion body hepatitis viruses in their offspring.
Veterinary research communications.
2002 Jul; 26(5):397-405. doi:
10.1023/a:1016251013681. [PMID: 12212729] - Jing Chen, Ning Qu, Yi-ming Xia. [Capillary zone electrophoresis for determination of thymulin in human plasma].
Yao xue xue bao = Acta pharmaceutica Sinica.
2002 Mar; 37(3):214-6. doi:
NULL. [PMID: 12579766] - Daniel A Orringer, Peter Staeheli, James A Marsh. The effects of thymulin on macrophage responsiveness to interferon-gamma.
Developmental and comparative immunology.
2002 Jan; 26(1):95-102. doi:
10.1016/s0145-305x(01)00052-0. [PMID: 11687267] - Iu Ia Hrynevych, H D Bendiuh, L H Iuhrinova, T N Selezn'ova. [Endocrine function of the thymus in experimental hypothyroidism].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994).
2002; 48(5):34-8. doi:
NULL. [PMID: 12449612] - R Consolini, A Calleri, A Legitimo, F Massei. Immunological evaluation of patients with beta-thalassemia major.
Acta haematologica.
2001; 105(1):7-12. doi:
10.1159/000046526. [PMID: 11340247]
