Quinazoline (BioDeep_00000659696)
代谢物信息卡片
Quinazoline
化学式: C8H6N2 (130.0531)
中文名称: 喹唑啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=NC=N2
InChI: InChI=1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Gregorio Peron, Ganga Prasad Phuyal, Jan Hošek, Rameshwar Adhikari, Stefano Dall'Acqua. Identification of hydroxyquinazoline alkaloids from Justicia adhatoda L. leaves, a traditional natural remedy with NF-κB and AP-1-mediated anti-inflammatory properties and antioxidant activity.
Journal of ethnopharmacology.
2024 Sep; 331(?):118345. doi:
10.1016/j.jep.2024.118345. [PMID: 38754645] - Liliane Majed, Salem Hayar, Sylvie Dousset, Britt Marianna Maestroni, Khaled El Omari. Effect of vine leaves processing on Azoxystrobin, Fenazaquin and Indoxacarb residues dissipation: processing factors and consumer safety assessment.
Food chemistry.
2024 Jul; 447(?):139065. doi:
10.1016/j.foodchem.2024.139065. [PMID: 38513485] - Su-Li Zhu, Ming Qi, Mei-Ting Chen, Jia-Peng Lin, Hai-Fu Huang, Li-Juan Deng, Xing-Wang Zhou. A novel DDIT3 activator dehydroevodiamine effectively inhibits tumor growth and tumor cell stemness in pancreatic cancer.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155377. doi:
10.1016/j.phymed.2024.155377. [PMID: 38503154] - Chih-Shiang Chang, Li-Yuan Bai, Chang-Fang Chiu, Jing-Lan Hu, Jing-Ru Weng. Discovery of the tryptanthrin-derived indoloquinazoline as an anti-breast cancer agent via ERK/JNK activation.
Environmental toxicology.
2024 Jun; 39(6):3710-3720. doi:
10.1002/tox.24226. [PMID: 38511855] - Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, Yang-Chang Wu, Fang-Rong Chang, István Szatmári, Ferenc Fülöp. Synthesis of bioactive evodiamine and rutaecarpine analogues under ball milling conditions.
Organic & biomolecular chemistry.
2024 03; 22(13):2620-2629. doi:
10.1039/d4ob00056k. [PMID: 38451121] - Zilin Wu, Chun Zhang, Yuanqin Huang, Na Tao, Tao Wang, Xiaobo Cai, Zhenchao Wang, Xiangyang Li. Tryptanthrin Derivative B1 Binds Viral Genome-Linked Protein (VPg) of Potato Virus Y.
Journal of agricultural and food chemistry.
2024 Mar; 72(11):5699-5709. doi:
10.1021/acs.jafc.4c01306. [PMID: 38462724] - Jingyuan Chen, Shuhao Fan, Jianhua Guo, Jian Yang, Le Pan, Yong Xia. Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells.
Toxicology and applied pharmacology.
2024 Mar; 484(?):116878. doi:
10.1016/j.taap.2024.116878. [PMID: 38431229] - Xingxian Guo, Shiying Huang, Yonghong Zhang, Hong Wang, Lisha Li, Jianhua Ran, Dilong Chen, Xiaopeng Li, Jing Li. Evodiamine inhibits growth of vemurafenib drug-resistant melanoma via suppressing IRS4/PI3K/AKT signaling pathway.
Journal of natural medicines.
2024 Mar; 78(2):342-354. doi:
10.1007/s11418-023-01769-9. [PMID: 38324123] - Xuhong Yong, Bi Wang, Mengdi Wang, Hui Lyu, Min Yin, Tong Jin, Xu Feng, Yu Shan, Yan Liang, Qizhi Wang. Comprehensive Analysis of 11 Species of Euodia (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods.
Molecules (Basel, Switzerland).
2024 Feb; 29(5):. doi:
10.3390/molecules29051059. [PMID: 38474571] - Yandong Yi, Yuejin Zhang, Yuanlong Song, Yisheng Lu. Treadmill Running Regulates Adult Neurogenesis, Spatial and Non-spatial Learning, Parvalbumin Neuron Activity by ErbB4 Signaling.
Cellular and molecular neurobiology.
2024 Jan; 44(1):17. doi:
10.1007/s10571-023-01439-0. [PMID: 38285192] - Jingbo Liu, Bingyan Guo, Siying Zhong, Yabing Shi, Zhengping Li, Zhenwu Yu, Zesheng Hao, Li Zhang, Fengyun Li, Yuanhong Wang, Yuxin Li. Novel Evodiamine-Based Sulfonamide Derivatives as Potent Insecticide Candidates Targeting Insect Ryanodine Receptors.
Journal of agricultural and food chemistry.
2024 Jan; 72(2):1292-1301. doi:
10.1021/acs.jafc.3c05680. [PMID: 38178001] - Changju Ma, Xin Zhang, Xiaomin Mo, Yaya Yu, Zhenzhen Xiao, Jingjing Wu, Lina Ding, Chenjing Lei, Yanjuan Zhu, Haibo Zhang. Xie-Bai-San increases NSCLC cells sensitivity to gefitinib by inhibiting Beclin-1 mediated autophagosome formation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 125(?):155351. doi:
10.1016/j.phymed.2024.155351. [PMID: 38232540] - Pengxing He, Linna Du, Qingqing Dai, Guobo Li, Bin Yu, Linlin Chang. Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors.
Bioorganic chemistry.
2024 01; 142(?):106970. doi:
10.1016/j.bioorg.2023.106970. [PMID: 37984101] - Yalei Wang, Shuo Cheng, Huawei Zhang, Yali Zhang, Chengcheng Ding, Tiantian Peng, Weihang Chen, Ke Yang, Jiani Zhang, Yan Tan, Xu Wang, Zhaoheng Liu, Peng Wei, Miao Jiang, Qian Hua. Adverse Effects of Gefitinib on Skin and Colon in a Lung Cancer Mouse Model.
Recent patents on anti-cancer drug discovery.
2024; 19(3):308-315. doi:
10.2174/1574892818666230727143750. [PMID: 37723963] - Min Xu, Li-Hui Qian, Jun-Xiang Wang, Zi-Yang He, Xiao-Yang Ling, Wen-Hua Wang, Jin-Wen Wang, Yue Hu, Ming-Jie Gong. Rutaecarpine Alleviates Early Brain Injury-Induced Inflammatory Response Following Subarachnoid Hemorrhage via SIRT6/NF-[Formula: see text]B Pathway.
The American journal of Chinese medicine.
2024; 52(3):799-819. doi:
10.1142/s0192415x24500320. [PMID: 38752843] - Xin-Yi Ai, Xue-Feng Hou, Nian-Ping Feng. [Combination of shikonin and gefitinib reverses drug resistance in human non-small cell lung cancer and its mechanism].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Jan; 49(1):175-184. doi:
10.19540/j.cnki.cjcmm.20230810.401. [PMID: 38403350] - Yunlong Tang, Weiying Gu, Lingling Cheng. Evodiamine attenuates oxidative stress and ferroptosis by inhibiting the MAPK signaling to improve bortezomib-induced peripheral neurotoxicity.
Environmental toxicology.
2023 Nov; ?(?):. doi:
10.1002/tox.24035. [PMID: 38010754] - Heping Yang, Min Mo, Langlang Yang, Jia Yu, Jiao Li, Sha Cheng, Baofei Sun, Bixue Xu, Aihua Zhang, Heng Luo. A Novel Quinazoline Derivative Prevents and Treats Arsenic-Induced Liver Injury by Regulating the Expression of RecQ Family Helicase.
International journal of molecular sciences.
2023 Oct; 24(21):. doi:
10.3390/ijms242115521. [PMID: 37958505] - Guang-Long Zhang, Zhen-Chao Wang, Cheng-Peng Li, Dan-Ping Chen, Zhu-Rui Li, Yan Li, Gui-Ping Ouyang. Discovery of tryptanthrin analogues bearing F and piperazine moieties as novel phytopathogenic antibacterial and antiviral agents.
Pest management science.
2023 Oct; ?(?):. doi:
10.1002/ps.7834. [PMID: 37842924] - Shuai Yang, Benjie Li, Jiahong Tang, Hongxiang Peng, Chunmei Pu, Chen Zhao, Hanhong Xu. Structural optimization based on 4,5-dihydropyrazolo[1,5-a]quinazoline scaffold for improved insecticidal activities.
Pesticide biochemistry and physiology.
2023 Sep; 195(?):105533. doi:
10.1016/j.pestbp.2023.105533. [PMID: 37666607] - Yong He, Hong-Hong Liu, Xue-Lin Zhou, Ting-Ting He, Ao-Zhe Zhang, Xin Wang, Shi-Zhang Wei, Hao-Tian Li, Li-Sheng Chen, Lei Chang, Yan-Ling Zhao, Man-Yi Jing. Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway.
Molecules (Basel, Switzerland).
2023 Aug; 28(17):. doi:
10.3390/molecules28176294. [PMID: 37687125] - Yuan Cheng, XiaoPeng Huang, Yi Tang, Juan Li, Yimin Tan, Qianghua Yuan. Effects of evodiamine on ROS/TXNIP/NLRP3 pathway against gouty arthritis.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Aug; ?(?):. doi:
10.1007/s00210-023-02654-8. [PMID: 37555854] - Yaya Yu, Zhenzhen Xiao, Chenjing Lei, Changju Ma, Lina Ding, Qing Tang, Yihan He, Yadong Chen, Xuesong Chang, Yanjuan Zhu, Haibo Zhang. BYL719 reverses gefitinib-resistance induced by PI3K/AKT activation in non-small cell lung cancer cells.
BMC cancer.
2023 Aug; 23(1):732. doi:
10.1186/s12885-023-11243-0. [PMID: 37553597] - Gayathri Shama Bhat, Fayaz Shaik Mohammad. Computational Fragment-Based Design of Phytochemical Derivatives as EGFR Inhibitors.
Chemistry & biodiversity.
2023 Aug; 20(8):e202300681. doi:
10.1002/cbdv.202300681. [PMID: 37399183] - Pei-Jia Li, Ya Yan, Nan Wu, Ye-Hui Yang, Lian An, Guang-Min Tian, Xiao-Ping Bao. Design, synthesis, crystal structure, and antimicrobial activities of new quinazoline derivatives containing both the sulfonate ester and piperidinylamide moieties.
Pest management science.
2023 Aug; 79(8):2811-2822. doi:
10.1002/ps.7459. [PMID: 36924250] - Zhilan Zhou, Ya Wang, Zhengtao Shao, Guixi Zhang, Hang Jiang, Yiyuan Tang, Zening Huang, Yingdi Zhu, Juan Li. A multiparametric fluorescent visualization approach for detecting drug resistance in living cancer cells.
Talanta.
2023 Jul; 259(?):124564. doi:
10.1016/j.talanta.2023.124564. [PMID: 37080074] - Toshitaka Nakamura, Clara Hipp, André Santos Dias Mourão, Jan Borggräfe, Maceler Aldrovandi, Bernhard Henkelmann, Jonas Wanninger, Eikan Mishima, Elena Lytton, David Emler, Bettina Proneth, Michael Sattler, Marcus Conrad. Phase separation of FSP1 promotes ferroptosis.
Nature.
2023 Jul; 619(7969):371-377. doi:
10.1038/s41586-023-06255-6. [PMID: 37380771] - Guangkai Yao, Mengfan Wang, Benjie Li, Hongxiang Peng, Shuai Yang, Chen Zhao, Hanhong Xu. Design, synthesis, and biological activity of novel spiro-pyrazolo[1,5-a]quinazolines derivatives as potential insecticides.
Pest management science.
2023 Mar; 79(3):1164-1174. doi:
10.1002/ps.7287. [PMID: 36371599] - Yong Cai, Zhaoying Sheng, Zhiyi Dong, Jiying Wang. EGFR Inhibitor CL-387785 Suppresses the Progression of Lung Adenocarcinoma.
Current molecular pharmacology.
2023; 16(2):211-216. doi:
10.2174/1874467215666220329212300. [PMID: 35352671] - Huihui Guo, Xilin Zhang, Shangzhi Xie, Tianwei Chen, Dong Xie, Ying Cai, Dawei Cui, Liang Wang, Wei Chen, Xiang Wang. Gefitinib enhances the anti‑tumor immune response against EGFR‑mutated NSCLC by upregulating B7H5 expression and activating T cells via CD28H.
International journal of oncology.
2022 Dec; 61(6):. doi:
10.3892/ijo.2022.5436. [PMID: 36205136] - Ying Zhang, Ya-Nan Liu, Saili Xie, Xuegu Xu, Ren-Ai Xu. Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC-MS/MS assay.
Pharmaceutical biology.
2022 Dec; 60(1):621-626. doi:
10.1080/13880209.2022.2048862. [PMID: 35289238] - Ruifeng Liang, Wenjing Ge, Bingjie Li, Weifeng Cui, Xiaofan Ma, Yuying Pan, Gengsheng Li. Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs.
Pharmaceutical biology.
2022 Dec; 60(1):359-373. doi:
10.1080/13880209.2022.2036767. [PMID: 35171063] - Yan Liang, Honghua Zhang, Xi Zhang, Ying Peng, Jiedan Deng, Yuqing Wang, Ranhui Li, Linyi Liu, Zhen Wang. Discovery of evodiamine derivatives as potential lead antifungal agents for the treatment of superficial fungal infections.
Bioorganic chemistry.
2022 10; 127(?):105981. doi:
10.1016/j.bioorg.2022.105981. [PMID: 35785554] - Jingli Liu, Hui Guo, Jing Zhou, Yuwei Wang, Hao Yan, Ruyi Jin, Yuping Tang. Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911513. [PMID: 36232809] - Min Xu, Wenhua Wang, Wei Lu, Xiaoyang Ling, Qin Rui, Haibo Ni. Evodiamine prevents traumatic brain injury through inhibiting oxidative stress via PGK1/NRF2 pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Sep; 153(?):113435. doi:
10.1016/j.biopha.2022.113435. [PMID: 36076551] - Muhan Ding, Nan Wu, Qiao Lin, Ya Yan, Yehui Yang, Guangmin Tian, Lian An, Xiaoping Bao. Discovery of Novel Quinazoline-2-Aminothiazole Hybrids Containing a 4-Piperidinylamide Linker as Potential Fungicides against the Phytopathogenic Fungus Rhizoctonia solani.
Journal of agricultural and food chemistry.
2022 Aug; 70(33):10100-10110. doi:
10.1021/acs.jafc.1c07706. [PMID: 35960511] - Yanshu Liang, Shuang Zhi, Zhixia Qiao, Fancui Meng. Molecular dynamics simulations of a central nervous system-penetrant drug AZD3759 with lipid bilayer.
Journal of molecular modeling.
2022 Aug; 28(9):261. doi:
10.1007/s00894-022-05266-w. [PMID: 35986192] - Harsha K Tripathy, S V Nair Manju, Rama Murthy Bestha, Vinay Kiran, Sreekanth Dittakavi, Ramesh Mullangi. Validated liquid chromatography-tandem mass spectrometry method for simultaneous quantitation of bendamustine and copanlisib in mouse plasma: Application to a pharmacokinetic study in mice.
Biomedical chromatography : BMC.
2022 Aug; 36(8):e5387. doi:
10.1002/bmc.5387. [PMID: 35470912] - Weina Ma, Man Zhu, Bo Wang, Zhengyan Gong, Xia Du, Tianfeng Yang, Xianpeng Shi, Bingling Dai, Yingzhuan Zhan, Dongdong Zhang, Yanhong Ji, Yang Wang, Song Li, Yanmin Zhang. Vandetanib drives growth arrest and promotes sensitivity to imatinib in chronic myeloid leukemia by targeting ephrin type-B receptor 4.
Molecular oncology.
2022 07; 16(14):2747-2765. doi:
10.1002/1878-0261.13270. [PMID: 35689424] - Wei Feng, Xi Chen, Shao-Xing Guan, Hong-Lian Ruan, Yan Huang, Hui-Zhen Zhang, Yun-Peng Yang, Wen-Feng Fang, Hong-Yun Zhao, Wei Zhuang, Shuang Xin, You-Hao Chen, Fei Wang, Yue Gao, Min Huang, Xue-Ding Wang, Li Zhang. Rational application of gefitinib in NSCLC patients with sensitive EGFR mutations based on pharmacokinetics and metabolomics.
Acta pharmacologica Sinica.
2022 Jul; 43(7):1857-1864. doi:
10.1038/s41401-021-00791-5. [PMID: 34737420] - Yuejie Yu, Qinyan Lu, Feng Chen, Shangli Wang, Chunxiang Niu, Jiabao Liao, Hongwu Wang, Fengjuan Chen. Serum untargeted metabolomics analysis of the mechanisms of evodiamine on type 2 diabetes mellitus model rats.
Food & function.
2022 Jun; 13(12):6623-6635. doi:
10.1039/d1fo04396j. [PMID: 35635367] - Weiping Liu, Lingyan Ping, Yan Xie, Yingli Sun, Tingting Du, Yi Niu, Galia Cisternas, Funan Huang, Jose Garcia-Vargas, Barrett H Childs, Aruna Mehra, Susanne Reschke, Xiaopei Wang, Yuqin Song, Jun Zhu. A phase I pharmacokinetic study of copanlisib in Chinese patients with relapsed indolent non-Hodgkin lymphoma.
Cancer chemotherapy and pharmacology.
2022 Jun; 89(6):825-831. doi:
10.1007/s00280-022-04417-3. [PMID: 35322287] - Haizhen Hui, Mengxin Wang, Hongxing Guo, Yingjun Wang, Bingjun Shi. Poziotinib-induced cutaneous adverse reactions in the treatment of non-small cell lung cancer: A case report.
International journal of dermatology.
2022 06; 61(6):769-770. doi:
10.1111/ijd.16205. [PMID: 35394067] - Hao Sun, Kristen A Cardinal, Larry Wienkers, Alice Chin, Vineet Kumar, Calvin Neace, Clark Henderson, Christopher J Endres, Ariel Topletz-Erickson, Kelly Regal, Alex Vo, Stephen C Alley, Anthony J Lee. Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
Cancer chemotherapy and pharmacology.
2022 06; 89(6):737-750. doi:
10.1007/s00280-022-04429-z. [PMID: 35435471] - Jingbo Liu, Yabing Shi, Shuting Chen, Fengyun Li, Wen Wen, Yuanhong Wang. Discovery of evodiamine derivatives as potent insecticide candidates.
Bioorganic & medicinal chemistry.
2022 05; 62(?):116727. doi:
10.1016/j.bmc.2022.116727. [PMID: 35366437] - Shuai Liu, Lu Lu, Feng Pan, Chunsheng Yang, Jing Liang, Jinfeng Liu, Jian Wang, Rong Shen, Fu-Ze Xin, Nan Zhang. Real-World Data: Fruquintinib in Treating Metastatic Colorectal Cancer.
Oncology research.
2022 May; 29(1):25-31. doi:
10.3727/096504022x16427607626672. [PMID: 35063062] - Yongfeng Zhang, Yaqin Zhang, Yang Zhao, Wanyue Wu, Weiqi Meng, Yulin Zhou, Ye Qiu, Chenliang Li. Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects.
Molecular medicine reports.
2022 05; 25(5):. doi:
10.3892/mmr.2022.12704. [PMID: 35362542] - Karoline Waitman, Roberto Parise-Filho. New kinase and HDAC hybrid inhibitors: recent advances and perspectives.
Future medicinal chemistry.
2022 05; 14(10):745-766. doi:
10.4155/fmc-2021-0276. [PMID: 35543381] - Jingbo Liu, Yabing Shi, Zhicheng Tian, Fengyun Li, Zesheng Hao, Wen Wen, Li Zhang, Yuanhong Wang, Yuxin Li, Zhijin Fan. Bioactivity-Guided Synthesis Accelerates the Discovery of Evodiamine Derivatives as Potent Insecticide Candidates.
Journal of agricultural and food chemistry.
2022 Apr; 70(16):5197-5206. doi:
10.1021/acs.jafc.1c08297. [PMID: 35435667] - Jacqueline B McCrea, Karsten Menzel, Adedayo Adedoyin, Carolyn R Cho, Sabrina Fox-Bosetti, Sreeraj Macha, Tian Zhao, Fang Liu, Deborah Panebianco, S Aubrey Stoch, Marian Iwamoto. Drug-Drug Interaction of Letermovir and Atorvastatin in Healthy Participants.
Clinical pharmacology in drug development.
2022 04; 11(4):420-428. doi:
10.1002/cpdd.1071. [PMID: 35157785] - Ying Fan, Jing Qin, Na Han, Hongyang Lu. HER2 exon 20 insertion mutations in lung adenocarcinoma with leptomeningeal metastasis: a case report and response to poziotinib.
Annals of palliative medicine.
2022 Apr; 11(4):1582-1588. doi:
10.21037/apm-21-213. [PMID: 34118831] - Weihang Guo, Xianheng Wang, Jidong Zhang, Tingting Zhang, Hongfeng Lv, Changkuo Zhao. Synthesis of ring opening of evodiamine derivatives and evaluation on their biological activity.
Chemical biology & drug design.
2022 04; 99(4):535-546. doi:
10.1111/cbdd.13996. [PMID: 34923753] - Mina Wadie, Hoda M Marzouk, Mamdouh R Rezk, Ezzat M Abdel-Moety, Mahmoud A Tantawy. A sensing platform of molecular imprinted polymer-based polyaniline/carbon paste electrodes for simultaneous potentiometric determination of alfuzosin and solifenacin in binary co-formulation and spiked plasma.
Analytica chimica acta.
2022 Apr; 1200(?):339599. doi:
10.1016/j.aca.2022.339599. [PMID: 35256148] - Rassol Bahreini, Medhat Nasr, Cassandra Docherty, Samantha Muirhead, Olivia de Herdt, David Feindel. Miticidal activity of fenazaquin and fenpyroximate against Varroa destructor, an ectoparasite of Apis mellifera.
Pest management science.
2022 Apr; 78(4):1686-1697. doi:
10.1002/ps.6788. [PMID: 34994089] - Li-Yu Wang, Shu-Lan Yeh, Shih-Tien Hsu, Chao-Hsiang Chen, Chien-Chih Chen, Cheng-Hung Chuang. The Anti-Proliferative and Apoptotic Effects of Rutaecarpine on Human Esophageal Squamous Cell Carcinoma Cell Line CE81T/VGH In Vitro and In Vivo.
International journal of molecular sciences.
2022 Mar; 23(5):. doi:
10.3390/ijms23052843. [PMID: 35269987] - Ya-Nan Hao, Mo Yu, Kai-Hua Wang, Bin-Bing Zhu, Zi-Wen Wang, Yu-Xiu Liu, De-Jun Ma, Qing-Min Wang. Discovery of glyantrypine-family alkaloids as novel antiviral and antiphytopathogenic-fungus agents.
Pest management science.
2022 Mar; 78(3):982-990. doi:
10.1002/ps.6709. [PMID: 34761501] - Helen K Boffey, Timothy P C Rooney, Henriette M G Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E Scott, David Winpenny, James Duce, John Skidmore, Jonathan H Clarke, Stephen P Andrews. Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Journal of medicinal chemistry.
2022 02; 65(4):3359-3370. doi:
10.1021/acs.jmedchem.1c01819. [PMID: 35148092] - Xin Xiong, Yuanyuan Zhang, Ziyu Wang, Congya Zhou, Ping Yang, Xin Du, Li Yang, Wei Liu. Simultaneous quantitative detection of afatinib, erlotinib, gefitinib, icotinib, osimertinib and their metabolites in plasma samples of patients with non-small cell lung cancer using liquid chromatography-tandem mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry.
2022 Feb; 527(?):1-10. doi:
10.1016/j.cca.2021.12.028. [PMID: 34999058] - Giacomo G Rossetti, Marianna A Ossorio, Stephan Rempel, Annika Kratzel, Vasilis S Dionellis, Samia Barriot, Laurence Tropia, Christoph Gorgulla, Haribabu Arthanari, Volker Thiel, Peter Mohr, Remo Gamboni, Thanos D Halazonetis. Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits.
Scientific reports.
2022 02; 12(1):2505. doi:
10.1038/s41598-022-06306-4. [PMID: 35169179] - Cédric Guy Tchatchouang Noulala, Judith Laure Nantchouang Ouete, Albert Fouda Atangana, Gabin Thierry Bitchagno Mbahbou, Ghislain Wabo Fotso, Hans-Georg Stammler, Bruno Ndjakou Lenta, Emmanuel Ngeufa Happi, Norbert Sewald, Bonaventure Tchaleu Ngadjui. Soyauxinine, a New Indolopyridoquinazoline Alkaloid from the Stem Bark of Araliopsis soyauxii Engl. (Rutaceae).
Molecules (Basel, Switzerland).
2022 Feb; 27(3):. doi:
10.3390/molecules27031104. [PMID: 35164367] - Heba Samir Elama, Shereen M Shalan, Yasser El-Shabrawy, Manal I Eid, Abdallah M Zeid. Utilization of a micellar matrix for simultaneous spectrofluorimetric estimation of alfuzosin hydrochloride and vardenafil hydrochloride.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Feb; 266(?):120420. doi:
10.1016/j.saa.2021.120420. [PMID: 34619505] - Fernanda Ortiz, Marko Lempinen, Sari Aaltonen, Niina Koivuviita, Ilkka Helanterä. Letermovir treatment for CMV infection in kidney and pancreas transplantation: A valuable option for complicated cases.
Clinical transplantation.
2022 02; 36(2):e14537. doi:
10.1111/ctr.14537. [PMID: 34797574] - Margaret R Jorgenson, Hanna Kleiboeker, Neetika Garg, Sandesh Parajuli, Didier A Mandelbrot, Jon S Odorico, Christopher M Saddler, Jeannina A Smith. Letermovir conversion after valganciclovir treatment in cytomegalovirus high-risk abdominal solid organ transplant recipients may promote development of cytomegalovirus-specific cell mediated immunity.
Transplant infectious disease : an official journal of the Transplantation Society.
2022 Feb; 24(1):e13766. doi:
10.1111/tid.13766. [PMID: 34799964] - Shuxuan Wang, Yao Chen, Houshun Fang, Yan Xu, Ming Ding, Chunshuang Ma, Yanyan Lin, Zhiyan Cui, Huiying Sun, Qun Niu, Shuzhang Sun, Bin-Bing S Zhou, Ning Xiao, Hui Li. A γ-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells.
FEBS letters.
2022 02; 596(4):437-448. doi:
10.1002/1873-3468.14285. [PMID: 35040120] - Marita Prohn, Carolyn R Cho, Anders Viberg, Kevin Dykstra, Casey Davis, Philip Sabato, Julie Stone, Cyrus Badshah, Yoshihiko Murata, Randi Leavitt, Craig Fancourt, Sreeraj Macha. Exposure-Response Analyses of Letermovir Following Oral and Intravenous Administration in Allogeneic Hematopoietic Cell Transplantation Recipients.
Clinical pharmacology and therapeutics.
2022 02; 111(2):485-495. doi:
10.1002/cpt.2456. [PMID: 34674258] - Ziyi Liang, Fang Lei, Jiedan Deng, Honghua Zhang, Yuqing Wang, Junfang Li, Tao Shi, Xiaoyan Yang, Zhen Wang. Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer.
European journal of medicinal chemistry.
2022 Jan; 228(?):113960. doi:
10.1016/j.ejmech.2021.113960. [PMID: 34774339] - Shin Morioka, Hiroki Nakanishi, Toshiyoshi Yamamoto, Junya Hasegawa, Emi Tokuda, Tomoya Hikita, Tomoko Sakihara, Yuuki Kugii, Chitose Oneyama, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki. A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation.
Nature communications.
2022 01; 13(1):83. doi:
10.1038/s41467-021-27648-z. [PMID: 35013169] - Cheng-Jie Yang, Hai-Xin Li, Jing-Ru Wang, Zhi-Jun Zhang, Tian-Lin Wu, Ying-Qian Liu, Chen Tang, Qing-Ru Chu, Sha-Sha Du, Ying-Hui He. Design, synthesis and biological evaluation of novel evodiamine and rutaecarpine derivatives against phytopathogenic fungi.
European journal of medicinal chemistry.
2022 Jan; 227(?):113937. doi:
10.1016/j.ejmech.2021.113937. [PMID: 34710744] - Ali S Abdelhameed, Mohamed W Attwa, Mohamed I Attia, Amer M Alanazi, Obaid S Alruqi, Haitham AlRabiah. Development of novel univariate and multivariate validated chemometric methods for the analysis of dasatinib, sorafenib, and vandetanib in pure form, dosage forms and biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Jan; 264(?):120336. doi:
10.1016/j.saa.2021.120336. [PMID: 34481256] - Yuhe Lei, Meiching Chan, Haiyan Liu, Wenyu Lyu, Lei Chen, Yinqin Zhong, Hua Gan, Mei Wang, Ming Qi, Yu Guo, Junshan Liu, Enxin Zhang. Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Disease markers.
2022; 2022(?):4399334. doi:
10.1155/2022/4399334. [PMID: 35899176] - Jürgen Scheuenpflug, Dirk Kropeit, Katharina Erb-Zohar, Jochen G W Theis, Hans-Peter Stobernack, David McCormick, Holger Zimmermann, Helga Rübsamen-Schaeff. The Effect of Oral Letermovir Administration on the Pharmacokinetics of a Single Oral Dose of P-Glycoprotein Substrate Digoxin in Healthy Volunteers.
Clinical pharmacology in drug development.
2022 01; 11(1):6-15. doi:
10.1002/cpdd.1043. [PMID: 34812580] - Meixia Fan, Lei Yao. The Synthesis, Structural Modification and Mode of Anticancer Action of Evodiamine: A Review.
Recent patents on anti-cancer drug discovery.
2022; 17(3):284-296. doi:
10.2174/1574892817666211221165739. [PMID: 34939550] - Yufan Dai, Wenyu Zhu, Jiaxuan Zhou, Tao Shen. The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2022; 55(?):e12096. doi:
10.1590/1414-431x2022e12096. [PMID: 35584453] - Dirk Kropeit, David McCormick, Katharina Erb-Zohar, Hans-Peter Stobernack, Holger Zimmermann, Helga Rübsamen-Schaeff. Pharmacokinetics and Safety of Letermovir and Midazolam Coadministration in Healthy Subjects.
Clinical pharmacology in drug development.
2022 01; 11(1):16-24. doi:
10.1002/cpdd.1027. [PMID: 34714967] - Yuting Li, Yuming Wang, Xiaoqun Wang, Lulu Jin, Lu Yang, Jinli Zhu, Hongwu Wang, Fang Zheng, Huantian Cui, Xiaojiang Li, Yingjie Jia. Evodiamine suppresses the progression of non-small cell lung carcinoma via endoplasmic reticulum stress-mediated apoptosis pathway in vivo and in vitro.
International journal of immunopathology and pharmacology.
2022 Jan; 36(?):3946320221086079. doi:
10.1177/03946320221086079. [PMID: 35388733] - Xingming Hou, Clemens Malainer, Atanas G Atanasov, Elke H Heiß, Verena M Dirsch, Limei Wang, KeWei Wang. Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice.
Journal of natural products.
2021 12; 84(12):3110-3116. doi:
10.1021/acs.jnatprod.1c00881. [PMID: 34902249] - Y D Gao, A Zhu, L D Li, T Zhang, S Wang, D P Shan, Y Z Li, Q Wang. [Cytotoxicity and underlying mechanism of evodiamine in HepG2 cells].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2021 Dec; 53(6):1107-1114. doi:
. [PMID: 34916690] - Livio Racané, Maja Cindrić, Ivo Zlatar, Tatjana Kezele, Astrid Milić, Karmen Brajša, Marijana Hranjec. Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles.
Journal of enzyme inhibition and medicinal chemistry.
2021 Dec; 36(1):163-174. doi:
10.1080/14756366.2020.1850711. [PMID: 33404264] - Weiping Ji, Jiquan Shen, Bo Wang, Feifei Chen, Deru Meng, Shuanghu Wang, Dapeng Dai, Yunfang Zhou, Changxiong Wang, Quan Zhou. Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro.
Pharmaceutical biology.
2021 Dec; 59(1):457-464. doi:
10.1080/13880209.2021.1914114. [PMID: 33899675] - Qiong Wang, Yubao Cui, Xufeng Wu, Junfang Wang. Evodiamine protects against airway remodelling and inflammation in asthmatic rats by modulating the HMGB1/NF-κB/TLR-4 signalling pathway.
Pharmaceutical biology.
2021 Dec; 59(1):192-199. doi:
10.1080/13880209.2020.1871374. [PMID: 33577738] - Mohammed M H Al-Gayyar, Abdullah Alattar, Reem Alshaman, Ahmed M Hamdan. QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model.
Cytokine.
2021 12; 148(?):155710. doi:
10.1016/j.cyto.2021.155710. [PMID: 34564023] - Kimitaka Suetsugu, Shota Muraki, Junshiro Fukumoto, Ryosuke Matsukane, Yasuo Mori, Takeshi Hirota, Toshihiro Miyamoto, Nobuaki Egashira, Koichi Akashi, Ichiro Ieiri. Effects of Letermovir and/or Methylprednisolone Coadministration on Voriconazole Pharmacokinetics in Hematopoietic Stem Cell Transplantation: A Population Pharmacokinetic Study.
Drugs in R&D.
2021 Dec; 21(4):419-429. doi:
10.1007/s40268-021-00365-0. [PMID: 34655050] - Stephan Ursprung, Helen Mossop, Ferdia A Gallagher, Evis Sala, Richard Skells, Jamal A N Sipple, Thomas J Mitchell, Anita Chhabra, Kate Fife, Athena Matakidou, Gemma Young, Amanda Walker, Martin G Thomas, Mireia Crispin Ortuzar, Mark Sullivan, Andrew Protheroe, Grenville Oades, Balaji Venugopal, Anne Y Warren, John Stone, Tim Eisen, James Wason, Sarah J Welsh, Grant D Stewart. The WIRE study a phase II, multi-arm, multi-centre, non-randomised window-of-opportunity clinical trial platform using a Bayesian adaptive design for proof-of-mechanism of novel treatment strategies in operable renal cell cancer - a study protocol.
BMC cancer.
2021 Nov; 21(1):1238. doi:
10.1186/s12885-021-08965-4. [PMID: 34794412] - Syeda Tehreem, Saeedur Rahman, Muhammad Salman Bhatti, Reaz Uddin, Muhammad Noman Khan, Saba Tauseef, Hesham R El-Seedi, Abdullatif Bin Muhsinah, Jalal Uddin, Syed Ghulam Musharraf. A UPLC-DAD-Based Bio-Screening Assay for the Evaluation of the Angiotensin Converting Enzyme Inhibitory Potential of Plant Extracts and Compounds: Pyrroquinazoline Alkaloids from Adhatoda vasica as a Case Study.
Molecules (Basel, Switzerland).
2021 Nov; 26(22):. doi:
10.3390/molecules26226971. [PMID: 34834066] - Monica Mazzarino, Cristian Camuto, Fabio Comunità, Xavier de la Torre, Carlotta Stacchini, Francesco Botrè. Application of liquid chromatography coupled to data-independent acquisition mass spectrometry for the metabolic profiling of N-ethyl heptedrone.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Nov; 1185(?):122989. doi:
10.1016/j.jchromb.2021.122989. [PMID: 34678705] - Nora Isberner, Ruth Van Daele, Hartwig Klinker, Sabrina Kraus, Fatemeh Aghai, Greet De Vlieger, Dirk Kuypers, Yves Debaveye, Isabel Spriet. Letermovir exposure in transplant patients with end-stage renal disease on renal replacement therapy.
The Journal of antimicrobial chemotherapy.
2021 11; 76(12):3322-3325. doi:
10.1093/jac/dkab316. [PMID: 34473284] - Ali S Abdelhameed, Eman S Hassan, Mohamed W Attwa, Nasser S Al-Shakliah, Amer M Alanazi, Haitham AlRabiah. Simple and efficient spectroscopic-based univariate sequential methods for simultaneous quantitative analysis of vandetanib, dasatinib, and sorafenib in pharmaceutical preparations and biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Nov; 260(?):119987. doi:
10.1016/j.saa.2021.119987. [PMID: 34082354] - Elena Rho, Bettina Näf, Thomas F Müller, Rudolf P Wüthrich, Thomas Schachter, Seraina von Moos. Use of letermovir-valganciclovir combination as a step-down treatment after foscarnet for ganciclovir-resistant CMV infection in kidney transplant recipients.
Clinical transplantation.
2021 11; 35(11):e14401. doi:
10.1111/ctr.14401. [PMID: 34181768] - Thuy Doan Minh, Tuan Nguyen Thanh Ha, Thuan Nguyen Duy, Ngan Nguyen Hoang, Dung PhamTien, Hung Pham Thai, Hoa Nguyen Thi, Phuong Dang Thi Lan, Binh Pham Quoc, D Y Ivkin, M N Povydysh, Bang Nguyen Cong, M V Krasnova. Linh Phu Khang Tue Tinh inhibited prostate proliferation in rats induced benign prostatic hyperplasia by testosterone propionate.
Journal of ethnopharmacology.
2021 Oct; 279(?):114388. doi:
10.1016/j.jep.2021.114388. [PMID: 34224813] - Chun-Jen Huang, Wei-Chieh Huang, Wei-Ting Lin, Lan-Hsin Shu, Joen-Rong Sheu, Oanh-Thi Tran, Chih-Wei Hsia, Thanasekaran Jayakumar, Periyakali Saravana Bhavan, Cheng-Ying Hsieh, Chao-Chien Chang. Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3β Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism.
International journal of molecular sciences.
2021 Oct; 22(20):. doi:
10.3390/ijms222011109. [PMID: 34681769] - Shuo Yuan, Bo Wang, Qing-Qing Dai, Xiao-Nan Zhang, Jing-Ya Zhang, Jia-Hui Zuo, Hui Liu, Zhe-Sheng Chen, Guo-Bo Li, Shaomeng Wang, Hong-Min Liu, Bin Yu. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors.
Journal of medicinal chemistry.
2021 10; 64(19):14895-14911. doi:
10.1021/acs.jmedchem.1c01452. [PMID: 34546748] - Zhijun Zhao, Yurun Xue, Gaohua Zhang, Jie Jia, Ruilian Xiu, Yugai Jia, Yuanyuan Wang, Xiangchong Wang, Honglin Li, Pingping Chen, Xuan Zhang. Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum.
European journal of pharmacology.
2021 Oct; 908(?):174340. doi:
10.1016/j.ejphar.2021.174340. [PMID: 34265294] - Chun-Qi Yang, Wen-Yu Lian, Yu-Guang Wang, Yue Gao. [Research progress in pharmacology and toxicology of evodiamine].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Oct; 46(20):5218-5225. doi:
10.19540/j.cnki.cjcmm.20210518.602. [PMID: 34738422] - Ping Ping Li, Lei Zhang, Jian Ping Wang. Research Note: Study on the residue depletion of febrifugine and isofebrifugine in broiler chicken.
Poultry science.
2021 Oct; 100(10):101390. doi:
10.1016/j.psj.2021.101390. [PMID: 34391965] - Alessandro Poli, Shidqiyyah Abdul-Hamid, Antonio Enrico Zaurito, Francesca Campagnoli, Valeria Bevilacqua, Bhavwanti Sheth, Roberta Fiume, Massimiliano Pagani, Sergio Abrignani, Nullin Divecha. PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity.
Proceedings of the National Academy of Sciences of the United States of America.
2021 08; 118(31):. doi:
10.1073/pnas.2010053118. [PMID: 34312224] - Shaunik Sharma, Steven Carlson, Adriana Gregory-Flores, Andy Hinojo-Perez, Ashley Olson, Thimmasettappa Thippeswamy. Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy.
Neurobiology of disease.
2021 08; 156(?):105410. doi:
10.1016/j.nbd.2021.105410. [PMID: 34087381] - Margaret R Jorgenson, Jillian L Descourouez, Neetika Garg, Sandesh Parajuli, Didier A Mandelbrot, Jon S Odorico, Christopher M Saddler, Jeannina A Smith. The addition of adjunctive letermovir to valganciclovir for refractory cytomegalovirus viremia in kidney transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2021 Aug; 23(4):e13693. doi:
10.1111/tid.13693. [PMID: 34309158] - Saad Tayyab, Milisha Koh A Magesvaran, Md Zahirul Kabir, Nor Farrah Wahidah Ridzwan, Saharuddin B Mohamad. Biophysical and computational view on the in vitro combination between an anticancer drug, saracatinib and human serum albumin.
Journal of biomolecular structure & dynamics.
2021 Jul; 39(10):3565-3575. doi:
10.1080/07391102.2020.1766571. [PMID: 32397949] - Jin-Yuarn Lin, Tzu-He Yeh. Rutaecarpine administration inhibits cancer cell growth in allogenic TRAMP-C1 prostate cancer mice correlating with immune balance in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111648. doi:
10.1016/j.biopha.2021.111648. [PMID: 33945915]
