Phenoxazine (BioDeep_00000659685)
代谢物信息卡片
Phenoxazine
化学式: C12H9NO (183.0684)
中文名称: 吩噁嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)NC3=CC=CC=C3O2
InChI: InChI=1S/C12H9NO/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jia-Fei Poon, Omkar Zilka, Derek A Pratt. Potent Ferroptosis Inhibitors Can Catalyze the Cross-Dismutation of Phospholipid-Derived Peroxyl Radicals and Hydroperoxyl Radicals.
Journal of the American Chemical Society.
2020 08; 142(33):14331-14342. doi:
10.1021/jacs.0c06379. [PMID: 32698570] - Stane Pajk, Hana Majaron, Matej Novak, Boštjan Kokot, Janez Štrancar. New coumarin- and phenoxazine-based fluorescent probes for live-cell STED nanoscopy.
European biophysics journal : EBJ.
2019 Jul; 48(5):485-490. doi:
10.1007/s00249-019-01354-7. [PMID: 30879103] - Qian Chen, Xiaodong Liu, Jiawen Chen, Jianfeng Zeng, Zhenping Cheng, Zhuang Liu. A Self-Assembled Albumin-Based Nanoprobe for In Vivo Ratiometric Photoacoustic pH Imaging.
Advanced materials (Deerfield Beach, Fla.).
2015 Nov; 27(43):6820-7. doi:
10.1002/adma.201503194. [PMID: 26418312] - Trinh Thi Thuy, Nguyen Thi Thanh Huong, Le Thi Hong Nhung, Pham Thi Ninh, Domenico V Delfino, Tran Van Sung. Isolation, characterisation and biological evaluation of a phenoxazine, a natural dyestuff isolated from leaves of Peristrophe bivalvis.
Natural product research.
2013 Apr; 27(8):771-4. doi:
10.1080/14786419.2012.698409. [PMID: 22712581] - Byung Hee Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach, Gregory J Zipfel. Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy.
Molecular neurodegeneration.
2011 Dec; 6(?):86. doi:
10.1186/1750-1326-6-86. [PMID: 22192811] - Undurti N Das, N Madhavi. Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro.
Lipids in health and disease.
2011 Sep; 10(?):159. doi:
10.1186/1476-511x-10-159. [PMID: 21917129] - Parvana Hajieva, Justyna B Mocko, Bernd Moosmann, Christian Behl. Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity.
Journal of neurochemistry.
2009 Jul; 110(1):118-32. doi:
10.1111/j.1471-4159.2009.06114.x. [PMID: 19486265] - Xichun Zhang, Fahe Chen, Zhiyong Huang. Apoptosis induced by acrylamide is suppressed in a 21.5\% fat diet through caspase-3-independent pathway in mice testis.
Toxicology mechanisms and methods.
2009 Mar; 19(3):219-24. doi:
10.1080/15376510802499048. [PMID: 19750022] - Yasemin Yücel Yücel, Ozden Tacal, Inci Ozer. Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase.
Archives of biochemistry and biophysics.
2008 Oct; 478(2):201-5. doi:
10.1016/j.abb.2008.07.006. [PMID: 18656440] - Tuba Küçükkilinç, Inci Ozer. Multi-site inhibition of human plasma cholinesterase by cationic phenoxazine and phenothiazine dyes.
Archives of biochemistry and biophysics.
2007 May; 461(2):294-8. doi:
10.1016/j.abb.2007.02.029. [PMID: 17428437] - Naoko Miyano-Kurosaki, Kunihiko Kurosaki, Michiko Hayashi, Hiroshi Takaku, Masaaki Hayafune, Ken Shirato, Teruhiko Kasuga, Takahiko Endo, Akio Tomoda. 2-aminophenoxazine-3-one suppresses the growth of mouse malignant melanoma B16 cells transplanted into C57BL/6Cr Slc mice.
Biological & pharmaceutical bulletin.
2006 Nov; 29(11):2197-201. doi:
10.1248/bpb.29.2197. [PMID: 17077514] - Andrzej B Hendrich, Kamila Stańczak, Małgorzata Komorowska, Noboru Motohashi, Masami Kawase, Krystyna Michalak. A study on the perturbation of model lipid membranes by phenoxazines.
Bioorganic & medicinal chemistry.
2006 Sep; 14(17):5948-54. doi:
10.1016/j.bmc.2006.05.021. [PMID: 16735123] - Kuntebommanahalli N Thimmaiah, John B Easton, Glen S Germain, Christopher L Morton, Shantaram Kamath, John K Buolamwini, Peter J Houghton. Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.
The Journal of biological chemistry.
2005 Sep; 280(36):31924-35. doi:
10.1074/jbc.m507057200. [PMID: 16009706] - Keiichi Hara, Mayumi Okamoto, Toshihiko Aki, Hideo Yagita, Hirotoshi Tanaka, Yoichi Mizukami, Hiroshi Nakamura, Akio Tomoda, Naotaka Hamasaki, Dongchon Kang. Synergistic enhancement of TRAIL- and tumor necrosis factor alpha-induced cell death by a phenoxazine derivative.
Molecular cancer therapeutics.
2005 Jul; 4(7):1121-7. doi:
10.1158/1535-7163.mct-05-0067. [PMID: 16020670] - Kota Jagannath, Madhusudana Rao Chaluvadi, Ramesh Mullangi, N V S Rao Mamidi, Nuggehally R Srinivas. Intravenous pharmacokinetics, oral bioavailability and dose proportionality of ragaglitazar, a novel PPAR-dual activator in rats.
Biopharmaceutics & drug disposition.
2004 Oct; 25(7):323-8. doi:
10.1002/bdd.413. [PMID: 15386480] - Peter Sazani, Anna Astriab-Fischer, Ryszard Kole. Effects of base modifications on antisense properties of 2'-O-methoxyethyl and PNA oligonucleotides.
Antisense & nucleic acid drug development.
2003; 13(3):119-28. doi:
10.1089/108729003768247583. [PMID: 12954112] - B Moosmann, T Skutella, K Beyer, C Behl. Protective activity of aromatic amines and imines against oxidative nerve cell death.
Biological chemistry.
2001 Nov; 382(11):1601-12. doi:
10.1515/bc.2001.195. [PMID: 11767950] - B B Lohray, V B Lohray, A C Bajji, S Kalchar, R R Poondra, S Padakanti, R Chakrabarti, R K Vikramadithyan, P Misra, S Juluri, N V Mamidi, R Rajagopalan. (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.
Journal of medicinal chemistry.
2001 Aug; 44(16):2675-8. doi:
10.1021/jm010143b. [PMID: 11472221] - W M Flanagan, J J Wolf, P Olson, D Grant, K Y Lin, R W Wagner, M D Matteucci. A cytosine analog that confers enhanced potency to antisense oligonucleotides.
Proceedings of the National Academy of Sciences of the United States of America.
1999 Mar; 96(7):3513-8. doi:
10.1073/pnas.96.7.3513. [PMID: 10097067] - W M Flanagan, R W Wagner, D Grant, K Y Lin, M D Matteucci. Cellular penetration and antisense activity by a phenoxazine-substituted heptanucleotide.
Nature biotechnology.
1999 Jan; 17(1):48-52. doi:
10.1038/5220. [PMID: 9920268] - M Cini, R G Fariello, A Bianchetti, A Moretti. Studies on lipid peroxidation in the rat brain.
Neurochemical research.
1994 Mar; 19(3):283-8. doi:
10.1007/bf00971576. [PMID: 8177367]
