7-amino-AMD (BioDeep_00000659531)

   


代谢物信息卡片


7-Aminoactinomycin D

化学式: C62H87N13O16 (1269.6393422)
中文名称: 7-氨基放线菌素D(7-AAD)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=CC(=C(C4=C3N=C5C(=C(C(=O)C(=C5O4)C)N)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)C)N
InChI: InChI=1S/C62H87N13O16/c1-26(2)42-59(85)74-21-17-19-36(74)57(83)70(13)24-38(76)72(15)48(28(5)6)61(87)89-32(11)44(55(81)66-42)68-53(79)34-23-35(63)30(9)51-46(34)65-47-40(41(64)50(78)31(10)52(47)91-51)54(80)69-45-33(12)90-62(88)49(29(7)8)73(16)39(77)25-71(14)58(84)37-20-18-22-75(37)60(86)43(27(3)4)67-56(45)82/h23,26-29,32-33,36-37,42-45,48-49H,17-22,24-25,63-64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes

同义名列表

2 个代谢物同义名

7-Aminoactinomycin D; 7-amino-AMD



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nicolas Guillaume. Improved flow cytometry crossmatching in kidney transplantation. HLA. 2018 12; 92(6):375-383. doi: 10.1111/tan.13403. [PMID: 30270577]
  • Daishi Chen, Ilker Y Eyupoglu, Nicolai Savaskan. Ferroptosis and Cell Death Analysis by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). 2017; 1601(?):71-77. doi: 10.1007/978-1-4939-6960-9_6. [PMID: 28470518]
  • Alexander Zipperer, Dorothee Kretschmer. Cytotoxicity Assays as Predictors of the Safety and Efficacy of Antimicrobial Agents. Methods in molecular biology (Clifton, N.J.). 2017; 1520(?):107-118. doi: 10.1007/978-1-4939-6634-9_6. [PMID: 27873248]
  • Nikolett Sali, Sándor Nagy, Miklós Poór, Tamás Kőszegi. Multiparametric luminescent cell viability assay in toxicology models: A critical evaluation. Journal of pharmacological and toxicological methods. 2016 May; 79(?):45-54. doi: 10.1016/j.vascn.2016.01.004. [PMID: 26777595]
  • Ioannis Karagiannidis, Agapi Kataki, Georgia Glustianou, Nikolaos Memos, Apostolos Papalois, Nikolaos Alexakis, George C Zografos, Manoussos M Konstadoulakis. EXTENDED CYTOPROTECTIVE EFFECT OF AUTOPHAGY IN THE LATE STAGES OF SEPSIS AND FLUCTUATIONS IN SIGNAL TRANSDUCTION PATHWAYS IN A RAT EXPERIMENTAL MODEL OF KIDNEY INJURY. Shock (Augusta, Ga.). 2016 Feb; 45(2):139-47. doi: 10.1097/shk.0000000000000505. [PMID: 26513702]
  • Mehmet Yabas, Weidong Jing, Sarah Shafik, Stefan Bröer, Anselm Enders. ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. PloS one. 2016; 11(1):e0146774. doi: 10.1371/journal.pone.0146774. [PMID: 26799398]
  • Chia-Te Kung, Chih-Min Su, Hsueh-Wen Chang, Hsien-Hung Cheng, Sheng-Yuan Hsiao, Tsung-Cheng Tsai, Nai-Wen Tsai, Hung-Chen Wang, Yu-Jih Su, Wei-Che Lin, Ben-Chung Cheng, Ya-Ting Chang, Yi-Fang Chiang, Cheng-Hsien Lu. The prognostic value of leukocyte apoptosis in patients with severe sepsis at the emergency department. Clinica chimica acta; international journal of clinical chemistry. 2015 Jan; 438(?):364-9. doi: 10.1016/j.cca.2014.09.017. [PMID: 25261855]
  • Ning Su, Samuel X Shi, Xiaodong Zhu, Aimee Borazanci, Fu-Dong Shi, Yan Gan. Interleukin-7 expression and its effect on natural killer cells in patients with multiple sclerosis. Journal of neuroimmunology. 2014 Nov; 276(1-2):180-6. doi: 10.1016/j.jneuroim.2014.08.618. [PMID: 25218211]
  • Margaret M Tropea, Bonnie J A Harper, Grace M Graninger, Terry M Phillips, Gabriela Ferreyra, Howard S Mostowski, Robert L Danner, Anthony F Suffredini, Michael A Solomon. Isolation of a circulating CD45-, CD34dim cell population and validation of their endothelial phenotype. Thrombosis and haemostasis. 2014 Oct; 112(4):770-80. doi: 10.1160/th14-01-0043. [PMID: 25057108]
  • Hung-Chen Wang, Tzu-Ming Yang, Yu-Jun Lin, Wu-Fu Chen, Jih-Tsun Ho, Yu-Tsai Lin, Aij-Lie Kwan, Cheng-Hsien Lu. Serial serum leukocyte apoptosis levels as predictors of outcome in acute traumatic brain injury. BioMed research international. 2014; 2014(?):720870. doi: 10.1155/2014/720870. [PMID: 24864256]
  • Ke-Wang Sun, Ying-Yu Ma, Tian-Pei Guan, Ying-Jie Xia, Chang-Ming Shao, Le-Gao Chen, Ya-Jun Ren, Hai-Bo Yao, Qiong Yang, Xu-Jun He. Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway. World journal of gastroenterology. 2012 Dec; 18(48):7166-74. doi: 10.3748/wjg.v18.i48.7166. [PMID: 23326121]
  • Sussan K Ardestani, Fatemeh Poorrajab, Sepideh Razmi, Alireza Foroumadi, Soheila Ajdary, Behnaz Gharegozlou, Mina Behrouzi-Fardmoghadam, Abbas Shafiee. Cell death features induced in Leishmania major by 1,3,4-thiadiazole derivatives. Experimental parasitology. 2012 Oct; 132(2):116-22. doi: 10.1016/j.exppara.2012.06.002. [PMID: 22959410]
  • Donald Wlodkowic, Joanna Skommer, Zbigniew Darzynkiewicz. Rapid quantification of cell viability and apoptosis in B-cell lymphoma cultures using cyanine SYTO probes. Methods in molecular biology (Clifton, N.J.). 2011; 740(?):81-9. doi: 10.1007/978-1-61779-108-6_10. [PMID: 21468970]
  • Maya Zimmermann, Norbert Meyer. Annexin V/7-AAD staining in keratinocytes. Methods in molecular biology (Clifton, N.J.). 2011; 740(?):57-63. doi: 10.1007/978-1-61779-108-6_8. [PMID: 21468968]
  • Harsha Wechalekar, Brian P Setchell, Eleanor J Peirce, Mario Ricci, Chris Leigh, William G Breed. Whole-body heat exposure induces membrane changes in spermatozoa from the cauda epididymidis of laboratory mice. Asian journal of andrology. 2010 Jul; 12(4):591-8. doi: 10.1038/aja.2010.41. [PMID: 20531278]
  • Donald Wlodkowic, Joanna Skommer, Dagmara McGuinness, Shannon Faley, Walter Kolch, Zbigniew Darzynkiewicz, Jonathan M Cooper. Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells. Analytical chemistry. 2009 Aug; 81(16):6952-9. doi: 10.1021/ac9010217. [PMID: 19572560]
  • Cornelia Bortolotti, Thomas Kunit, Angelika Moder, Clemens Hufnagl, Sabine Schmidt, Arnulf Hartl, Christian Langelueddecke, Johannes Fürst, John P Geibel, Markus Ritter, Martin Jakab. The phytostilbene resveratrol induces apoptosis in INS-1E rat insulinoma cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2009; 23(4-6):245-54. doi: 10.1159/000218171. [PMID: 19471092]
  • Alessandra Cucina, Andrea Fuso, Pierpaolo Coluccia, Antonino Cavallaro. Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor. The Journal of surgical research. 2008 Dec; 150(2):227-35. doi: 10.1016/j.jss.2007.10.019. [PMID: 18295799]
  • J-P Allam, F Fronhoffs, A Fathy, N Novak, I Oltermann, T Bieber, H-C Schuppe, G Haidl. High percentage of apoptotic spermatozoa in ejaculates from men with chronic genital tract inflammation. Andrologia. 2008 Oct; 40(5):329-34. doi: 10.1111/j.1439-0272.2008.00864.x. [PMID: 18811924]
  • Mark S McClain, Timothy L Cover. Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin. Infection and immunity. 2007 Apr; 75(4):1785-93. doi: 10.1128/iai.01643-06. [PMID: 17261609]
  • Lin Zheng, Yida Yang, Lu Guocai, C David Pauza, Maria S Salvato. HIV Tat protein increases Bcl-2 expression in monocytes which inhibits monocyte apoptosis induced by tumor necrosis factor-alpha-related apoptosis-induced ligand. Intervirology. 2007; 50(3):224-8. doi: 10.1159/000100565. [PMID: 17356300]
  • Johanna Atamaniuk, Katharina Ruzicka, Karl M Stuhlmeier, Alireza Karimi, Manfred Eigner, Mathias M Mueller. Cell-free plasma DNA: a marker for apoptosis during hemodialysis. Clinical chemistry. 2006 Mar; 52(3):523-6. doi: 10.1373/clinchem.2005.058883. [PMID: 16510434]
  • Dong Il Won, Hee Du Jeong, Yong Lim Kim, Jang Soo Suh. Simultaneous detection of antibody binding and cytotoxicity in flow cytometry crossmatch for renal transplantation. Cytometry. Part B, Clinical cytometry. 2006 Mar; 70(2):82-90. doi: 10.1002/cyto.b.20089. [PMID: 16470535]
  • Alfredo Prieto, David Díaz, Hugo Barcenilla, Julio García-Suárez, Eduardo Reyes, Jorge Monserrat, Esther San Antonio, David Melero, Antonio de la Hera, Alberto Orfao, Melchor Alvarez-Mon. Apoptotic rate: a new indicator for the quantification of the incidence of apoptosis in cell cultures. Cytometry. 2002 Aug; 48(4):185-93. doi: 10.1002/cyto.10132. [PMID: 12210142]
  • E Ortega, I Algarra, M J Serrano, G Alvarez de Cienfuegos, J J Gaforio. The use of 7-amino-actinomycin D in the analysis of Candida albicans phagocytosis and opsonization. Journal of immunological methods. 2001 Jul; 253(1-2):189-93. doi: 10.1016/s0022-1759(01)00358-1. [PMID: 11384680]
  • H J Hasper, R M Weghorst, D J Richel, J H Meerwaldt, F M Olthuis, C E Schenkeveld. A new four-color flow cytometric assay to detect apoptosis in lymphocyte subsets of cultured peripheral blood cells. Cytometry. 2000 Jun; 40(2):167-71. doi: 10.1002/(sici)1097-0320(20000601)40:2<167::aid-cyto11>3.0.co;2-1. [PMID: 10805937]
  • M Pallis, N Russell. P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway. Blood. 2000 May; 95(9):2897-904. doi: . [PMID: 10779437]
  • M A King, M A Radicchi-Mastroianni, J V Wells. There is substantial nuclear and cellular disintegration before detectable phosphatidylserine exposure during the camptothecin-induced apoptosis of HL-60 cells. Cytometry. 2000 May; 40(1):10-8. doi: 10.1002/(sici)1097-0320(20000501)40:1<10::aid-cyto2>3.0.co;2-f. [PMID: 10754512]
  • T N Dieye, J P Van Vooren, M L Delforge, C Liesnard, M Devleeschouwer, C M Farber. Spontaneous apoptosis and highly active antiretroviral therapy (HAART). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2000 Feb; 54(1):16-20. doi: 10.1016/s0753-3322(00)88636-9. [PMID: 10721458]
  • H Chun, K Cipolone, J Procter, D F Stroncek. Granulocyte storage and antigen stability. Transfusion. 1999 Sep; 39(9):983-90. doi: 10.1046/j.1537-2995.1999.39090983.x. [PMID: 10533825]
  • J Rzymowska, A Gawron, B Pawlikowska-Pawlega, J Jakubowicz-Gil, J Wojcierowski. The effect of quercetin on induction of apoptosis. Folia histochemica et cytobiologica. 1999; 37(2):125-6. doi: NULL. [PMID: 10352990]
  • B J Shenker, T L Guo, I M Shapiro. Low-level methylmercury exposure causes human T-cells to undergo apoptosis: evidence of mitochondrial dysfunction. Environmental research. 1998 May; 77(2):149-59. doi: 10.1006/enrs.1997.3816. [PMID: 9600808]
  • H Lecoeur, E Ledru, M C Prévost, M L Gougeon. Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods. Journal of immunological methods. 1997 Dec; 209(2):111-23. doi: 10.1016/s0022-1759(97)00138-5. [PMID: 9461328]
  • V Camp, P Martin. The role of macrophages in clearing programmed cell death in the developing kidney. Anatomy and embryology. 1996 Oct; 194(4):341-8. doi: 10.1007/bf00198535. [PMID: 8896697]
  • A Lichtenstein, Y Tu, C Fady, R Vescio, J Berenson. Interleukin-6 inhibits apoptosis of malignant plasma cells. Cellular immunology. 1995 May; 162(2):248-55. doi: 10.1006/cimm.1995.1076. [PMID: 7743552]