4-Chlorodiazepam (BioDeep_00000659524)
代谢物信息卡片
4-Chlorodiazepam
化学式: C16H12Cl2N2O (318.0327)
中文名称: 4-氯地西泮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
描述信息
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ana Ilic, Dusan Todorovic, Slavica Mutavdzin, Novica Boricic, Biljana Bozic Nedeljkovic, Sanja Stankovic, Tatjana Simic, Predrag Stevanovic, Vera Celic, Dragan Djuric. Translocator Protein Modulation by 4'-Chlorodiazepam and NO Synthase Inhibition Affect Cardiac Oxidative Stress, Cardiometabolic and Inflammatory Markers in Isoprenaline-Induced Rat Myocardial Infarction.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062867. [PMID: 33799869] - Dyfrig A Hughes. Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam.
British journal of pharmacology.
2020 11; 177(21):4975-4989. doi:
10.1111/bph.15101. [PMID: 32415690] - Barbara Costa, Chiara Cavallini, Eleonora Da Pozzo, Sabrina Taliani, Federico Da Settimo, Claudia Martini. The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.
ACS chemical neuroscience.
2017 07; 8(7):1448-1454. doi:
10.1021/acschemneuro.7b00027. [PMID: 28362078] - Xiaoming Liu, Hongjun Liu, Shuangshuang Xu, Zongxiang Tang, Weiliang Xia, Zhuqiang Cheng, Weiyan Li, Yi Jin. Spinal translocator protein alleviates chronic neuropathic pain behavior and modulates spinal astrocyte-neuronal function in rats with L5 spinal nerve ligation model.
Pain.
2016 Jan; 157(1):103-116. doi:
10.1097/j.pain.0000000000000339. [PMID: 26307860] - Sabrina Castellano, Sabrina Taliani, Monica Viviano, Ciro Milite, Eleonora Da Pozzo, Barbara Costa, Elisabetta Barresi, Agostino Bruno, Sandro Cosconati, Luciana Marinelli, Giovanni Greco, Ettore Novellino, Gianluca Sbardella, Federico Da Settimo, Claudia Martini. Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Journal of medicinal chemistry.
2014 Mar; 57(6):2413-28. doi:
10.1021/jm401721h. [PMID: 24580635] - Beatriz Caballero, Leo Veenman, Julia Bode, Svetlana Leschiner, Moshe Gavish. Concentration-dependent bimodal effect of specific 18 kDa translocator protein (TSPO) ligands on cell death processes induced by ammonium chloride: potential implications for neuropathological effects due to hyperammonemia.
CNS & neurological disorders drug targets.
2014; 13(4):574-92. doi:
10.2174/18715273113126660194. [PMID: 24168369] - J Y Chung, H Chen, A Midzak, A L Burnett, V Papadopoulos, B R Zirkin. Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells.
Endocrinology.
2013 Jun; 154(6):2156-65. doi:
10.1210/en.2012-2226. [PMID: 23525219] - Stéphanie Paradis, Valerio Leoni, Claudio Caccia, Alain Berdeaux, Didier Morin. Cardioprotection by the TSPO ligand 4'-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion.
Cardiovascular research.
2013 Jun; 98(3):420-7. doi:
10.1093/cvr/cvt079. [PMID: 23554458] - Britta Haenisch, Michael Huber, Thomas Wilhelm, Michael Steffens, Gerhard J Molderings. Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling.
Life sciences.
2013 Mar; 92(6-7):345-51. doi:
10.1016/j.lfs.2013.01.010. [PMID: 23352970] - Nico Mitro, Gaia Cermenati, Silvia Giatti, Federico Abbiati, Marzia Pesaresi, Donato Calabrese, Luis Miguel Garcia-Segura, Donatella Caruso, Roberto C Melcangi. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals.
Neurochemistry international.
2012 May; 60(6):616-21. doi:
10.1016/j.neuint.2012.02.025. [PMID: 22406419] - L Veenman, M Gavish. The role of 18 kDa mitochondrial translocator protein (TSPO) in programmed cell death, and effects of steroids on TSPO expression.
Current molecular medicine.
2012 May; 12(4):398-412. doi:
10.2174/1566524011207040398. [PMID: 22348610] - S Mukherjee, S K Das. Translocator protein (TSPO) in breast cancer.
Current molecular medicine.
2012 May; 12(4):443-57. doi:
NULL. [PMID: 22348612] - Victor W Pike, Sabrina Taliani, Talakad G Lohith, David R J Owen, Isabella Pugliesi, Eleonora Da Pozzo, Jinsoo Hong, Sami S Zoghbi, Roger N Gunn, Christine A Parker, Eugenii A Rabiner, Masahiro Fujita, Robert B Innis, Claudia Martini, Federico Da Settimo. Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.
Journal of medicinal chemistry.
2011 Jan; 54(1):366-73. doi:
10.1021/jm101230g. [PMID: 21133364] - Amardeep Jaiswal, Santosh Kumar, Rajesh Enjamoori, Sandeep Seth, Amit Kumar Dinda, Subir Kumar Maulik. Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats.
European journal of pharmacology.
2010 Oct; 644(1-3):146-53. doi:
10.1016/j.ejphar.2010.06.058. [PMID: 20621082] - Kazuhiko Yanamoto, Katsushi Kumata, Masayuki Fujinaga, Nobuki Nengaki, Makoto Takei, Hidekatsu Wakizaka, Rie Hosoi, Sotaro Momosaki, Tomoteru Yamasaki, Joji Yui, Kazunori Kawamura, Akiko Hatori, Osamu Inoue, Ming-Rong Zhang. In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC.
Nuclear medicine and biology.
2010 Oct; 37(7):853-60. doi:
10.1016/j.nucmedbio.2010.04.183. [PMID: 20870161] - Mariano A Ostuni, Leeyah Issop, Gabriel Péranzi, Francine Walker, Magali Fasseu, Carole Elbim, Vassilios Papadopoulos, Jean-Jacques Lacapere. Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value.
Inflammatory bowel diseases.
2010 Sep; 16(9):1476-87. doi:
10.1002/ibd.21250. [PMID: 20222126] - Sabrina Taliani, Eleonora Da Pozzo, Marusca Bellandi, Sara Bendinelli, Isabella Pugliesi, Francesca Simorini, Concettina La Motta, Silvia Salerno, Anna Maria Marini, Federico Da Settimo, Barbara Cosimelli, Giovanni Greco, Ettore Novellino, Claudia Martini. Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.
Journal of medicinal chemistry.
2010 May; 53(10):4085-93. doi:
10.1021/jm100100q. [PMID: 20438080] - M Sakai, V Ferraz-de-Paula, M L Pinheiro, A Ribeiro, W M Quinteiro-Filho, M B Rone, D B Martinez-Arguelles, M L Z Dagli, V Papadopoulos, J Palermo-Neto. Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo.
European journal of pharmacology.
2010 Jan; 626(2-3):131-8. doi:
10.1016/j.ejphar.2009.09.036. [PMID: 19782064] - Federico Da Settimo, Francesca Simorini, Sabrina Taliani, Concettina La Motta, Anna Maria Marini, Silvia Salerno, Marusca Bellandi, Ettore Novellino, Giovanni Greco, Barbara Cosimelli, Eleonora Da Pozzo, Barbara Costa, Nicola Simola, Micaela Morelli, Claudia Martini. Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Journal of medicinal chemistry.
2008 Sep; 51(18):5798-806. doi:
10.1021/jm8003224. [PMID: 18729350] - Weiping Yu, Eric Wang, Ronald J Voll, Andrew H Miller, Mark M Goodman. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.
Bioorganic & medicinal chemistry.
2008 Jun; 16(11):6145-55. doi:
10.1016/j.bmc.2008.04.046. [PMID: 18472268] - Angela Maria Falchi, Barbara Battetta, Francesca Sanna, Marco Piludu, Valeria Sogos, Mariangela Serra, Marta Melis, Martina Putzolu, Giacomo Diaz. Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands.
Neuropharmacology.
2007 Aug; 53(2):318-29. doi:
10.1016/j.neuropharm.2007.05.016. [PMID: 17631921] - Lorenzo Corsi, Rossella Avallone, Elisa Geminiani, Francesca Cosenza, Ivo Venturini, Mario Baraldi. Peripheral benzodiazepine receptors in potatoes (Solanum tuberosum).
Biochemical and biophysical research communications.
2004 Jan; 313(1):62-6. doi:
10.1016/j.bbrc.2003.11.089. [PMID: 14672698] - Fábio Ribeiro da Silva, Ricardo Lazzarini, Luiz Carlos de Sá-Rocha, Maria Silvia F A Morgulis, Cristina de Oliveira Massoco, João Palermo-Neto. Effects of acute and long-term diazepam administrations on neutrophil activity: a flow cytometric study.
European journal of pharmacology.
2003 Oct; 478(2-3):97-104. doi:
10.1016/j.ejphar.2003.08.046. [PMID: 14575793] - S Miachon, S Augier, M Jouvenet, P Boucher, J J Vallon. Nutritional parameters modify muricidal behavior of male Wistar rats: preventive effects of amino acids and 4' Cl diazepam.
Life sciences.
2001 Oct; 69(23):2745-57. doi:
10.1016/s0024-3205(01)01344-3. [PMID: 11720079] - S Selleri, F Bruni, C Costagli, A Costanzo, G Guerrini, G Ciciani, B Costa, C Martini. 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
Bioorganic & medicinal chemistry.
2001 Oct; 9(10):2661-71. doi:
10.1016/s0968-0896(01)00192-4. [PMID: 11557354] - J J Lacapère, F Delavoie, H Li, G Péranzi, J Maccario, V Papadopoulos, B Vidic. Structural and functional study of reconstituted peripheral benzodiazepine receptor.
Biochemical and biophysical research communications.
2001 Jun; 284(2):536-41. doi:
10.1006/bbrc.2001.4975. [PMID: 11394915] - R Lazzarini, B E Malucelli, J Palermo-Neto. Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone.
Immunopharmacology and immunotoxicology.
2001 May; 23(2):253-65. doi:
10.1081/iph-100103864. [PMID: 11417852] - T Nayyar, S Mukherjee, S K Das. Alterations in binding characteristics of peripheral benzodiazepine receptors in testes by vitamin A deficiency in guinea pigs.
Molecular and cellular biochemistry.
2000 Aug; 211(1-2):47-50. doi:
10.1023/a:1007198330496. [PMID: 11055546] - M Landau, A Weizman, E Zoref-Shani, E Beery, L Wasseman, O Landau, M Gavish, S Brenner, J Nordenberg. Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells.
Biochemical pharmacology.
1998 Oct; 56(8):1029-34. doi:
10.1016/s0006-2952(98)00149-x. [PMID: 9776314] - J L Do-Rego, A G Mensah-Nyagan, M Feuilloley, P Ferrara, G Pelletier, H Vaudry. The endozepine triakontatetraneuropeptide diazepam-binding inhibitor [17-50] stimulates neurosteroid biosynthesis in the frog hypothalamus.
Neuroscience.
1998 Mar; 83(2):555-70. doi:
10.1016/s0306-4522(97)00362-x. [PMID: 9460762] - R Weizman, S Leschiner, W Schlegel, M Gavish. Peripheral-type benzodiazepine receptor ligands and serum steroid hormones.
Brain research.
1997 Oct; 772(1-2):203-8. doi:
10.1016/s0006-8993(97)00815-9. [PMID: 9406973] - G Trapani, M Franco, L Ricciardi, A Latrofa, G Genchi, E Sanna, F Tuveri, E Cagetti, G Biggio, G Liso. Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type.
Journal of medicinal chemistry.
1997 Sep; 40(19):3109-18. doi:
10.1021/jm970112+. [PMID: 9301675] - E Caldiroli, F De Ponti, M Cosentino, F Marino, A M Fietta, M Taddei, A Tartara, A Zibetti, A Mazzone, S Lecchini, G M Frigo. Carbamazepine affects neutrophil function through an action on peripheral benzodiazepine receptors.
Immunopharmacology and immunotoxicology.
1997 Aug; 19(3):367-82. doi:
10.3109/08923979709046982. [PMID: 9248864] - C H Park, L G Lukacs, J Mastropaolo, S I Deutsch. Selective effects of MAO inhibition on peripheral benzodiazepine receptor binding in the mouse.
The Israel journal of psychiatry and related sciences.
1997; 34(4):300-7. doi:
. [PMID: 9409087] - M J Woods, D M Zisterer, D C Williams. Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver.
Biochemical pharmacology.
1996 May; 51(10):1283-92. doi:
10.1016/0006-2952(96)00034-2. [PMID: 8787543] - A Courtiere, F Molard, J Reybaud. Differential effects of in vitro peroxidation on peripheral- and central-type benzodiazepine receptors. Protection by diverse antioxidants.
Biochemical pharmacology.
1995 Nov; 50(11):1815-22. doi:
10.1016/0006-2952(95)02058-6. [PMID: 8615860] - B Cuparencu, J Horák. Effects of 4'-chlordiazepam on glycemia and serum lipids in hyperlipidemic rats: interactions with PK 11195 and flumazenil.
Research communications in molecular pathology and pharmacology.
1995 Jul; 89(1):57-66. doi:
NULL. [PMID: 7582862] - L A Monasterolo, J E Ochoa, L Trumper, M M Elías. Vascular and tubular actions of diazepam in isolated and perfused rat kidney.
European journal of pharmacology.
1995 Apr; 276(3):201-5. doi:
10.1016/0014-2999(95)00019-h. [PMID: 7601205] - P V Holmes, R C Drugan. Stress-induced regulation of the renal peripheral benzodiazepine receptor: possible role of the renin-angiotensin system.
Psychoneuroendocrinology.
1994; 19(1):43-54. doi:
10.1016/0306-4530(94)90058-2. [PMID: 9210211] - E Romeo, S Cavallaro, A Korneyev, A P Kozikowski, D Ma, A Polo, E Costa, A Guidotti. Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex.
The Journal of pharmacology and experimental therapeutics.
1993 Oct; 267(1):462-71. doi:
. [PMID: 8229777] - V Taupin, S Toulmond, A Serrano, J Benavides, F Zavala. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand.
Journal of neuroimmunology.
1993 Feb; 42(2):177-85. doi:
10.1016/0165-5728(93)90008-m. [PMID: 8429103] - A Berkovich, C Ferrarese, G Cavaletti, H Alho, C Marzorati, G Bianchi, A Guidotti, E Costa. Topology of two DBI receptors in human lymphocytes.
Life sciences.
1993; 52(15):1265-77. doi:
10.1016/s0024-3205(05)80016-5. [PMID: 8385252] - D J Calvo, J H Medina. Calcium induced modulation of peripheral-type benzodiazepine receptors in rat kidney membranes.
Journal of receptor research.
1993; 13(6):975-87. doi:
10.3109/10799899309073704. [PMID: 8389870] - D J Calvo, O Tumilasci, J H Medina. Ethanol and the peripheral benzodiazepine receptor: in vivo and in vitro experiments.
General pharmacology.
1992 Nov; 23(6):1217-9. doi:
10.1016/0306-3623(92)90314-a. [PMID: 1336753] - P V Holmes, R C Drugan. Angiotensin II rapidly modulates the renal peripheral benzodiazepine receptor.
European journal of pharmacology.
1992 Jun; 226(2):189-90. doi:
10.1016/0922-4106(92)90184-w. [PMID: 1322309] - P Guarneri, V Papadopoulos, B Pan, E Costa. Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam.
Proceedings of the National Academy of Sciences of the United States of America.
1992 Jun; 89(11):5118-22. doi:
10.1073/pnas.89.11.5118. [PMID: 1317582] - D J Calvo, J H Medina. Regulation of peripheral-type benzodiazepine receptors following repeated benzodiazepine administration.
Functional neurology.
1992 May; 7(3):227-30. doi:
NULL. [PMID: 1323506] - D M Zisterer, A M Gorman, D C Williams, M P Murphy. The effects of the peripheral-type benzodiazepine acceptor ligands, Ro 5-4864 and PK 11195, on mitochondrial respiration.
Methods and findings in experimental and clinical pharmacology.
1992 Mar; 14(2):85-90. doi:
NULL. [PMID: 1317932] - T Shiraishi, K L Black, K Ikezaki, D P Becker. Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells.
Journal of neuroscience research.
1991 Nov; 30(3):463-74. doi:
10.1002/jnr.490300303. [PMID: 1666128] - K Tuominen, E R Korpi. Diminished stress responses in the alcohol-sensitive ANT rat line.
Pharmacology, biochemistry, and behavior.
1991 Oct; 40(2):409-15. doi:
10.1016/0091-3057(91)90572-j. [PMID: 1666675] - R Moreno-Sánchez, B A Hogue, C Bravo, A H Newman, A S Basile, P K Chiang. Inhibition of substrate oxidation in mitochondria by the peripheral-type benzodiazepine receptor ligand AHN 086.
Biochemical pharmacology.
1991 May; 41(10):1479-84. doi:
10.1016/0006-2952(91)90564-l. [PMID: 1850277] - R C Drugan, P V Holmes, A P Stringer. Sexual dimorphism of stress-induced changes in renal peripheral benzodiazepine receptors in rat.
Neuropharmacology.
1991 Apr; 30(4):413-6. doi:
10.1016/0028-3908(91)90069-n. [PMID: 1649421] - L Rägo, A Adojaan, J Harro, R A Kiivet. Correlation between exploratory activity in an elevated plus-maze and number of central and peripheral benzodiazepine binding sites.
Naunyn-Schmiedeberg's archives of pharmacology.
1991 Mar; 343(3):301-6. doi:
10.1007/bf00251130. [PMID: 1650920] - D J Calvo, M B Campos, R S Calandra, J H Medina, M N Ritta. Effect of long term diazepam administration on testicular benzodiazepine receptors and steroidogenesis.
Life sciences.
1991; 49(7):519-25. doi:
10.1016/0024-3205(91)90069-n. [PMID: 1650416] - M Awad, M Gavish. Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon.
Life sciences.
1991; 49(16):1155-61. doi:
10.1016/0024-3205(91)90562-p. [PMID: 1654492] - R Moreno-Sánchez, C Bravo, J Gutiérrez, A H Newman, P K Chiang. Release of Ca2+ from heart and kidney mitochondria by peripheral-type benzodiazepine receptor ligands.
The International journal of biochemistry.
1991; 23(2):207-13. doi:
10.1016/0020-711x(91)90191-o. [PMID: 1847885] - A Courtiere, J Reybaud, C Camilla, P Lobert, J Drouet, G Jadot. Oxygen-induced modifications of benzodiazepine receptors and D2 dopamine receptors in the rat under hyperoxia.
Free radical research communications.
1991; 15(1):29-34. doi:
10.3109/10715769109049122. [PMID: 1663066] - R C Drugan, P V Holmes, A P Stringer. Pentobarbital blocks the stress-induced decrease in [3H]Ro 5-4864 binding in rat kidney.
Brain research.
1990 Dec; 535(1):151-4. doi:
10.1016/0006-8993(90)91834-4. [PMID: 1963342] - B A Weissman, H F Elson, D Kaplan, A H Newman. Presence of peripheral benzodiazepine binding sites on primary rat skeletal fibroblasts.
European journal of pharmacology.
1990 Oct; 187(3):369-75. doi:
10.1016/0014-2999(90)90364-c. [PMID: 1963592] - S F Chesley, A D Schatzki, J DeUrrutia, D J Greenblatt, R I Shader, L G Miller. Cocaine augments peripheral benzodiazepine binding in humans.
The Journal of clinical psychiatry.
1990 Oct; 51(10):404-6. doi:
NULL. [PMID: 2170346] - W C Broaddus, J P Bennett. Peripheral-type benzodiazepine receptors in human glioblastomas: pharmacologic characterization and photoaffinity labeling of ligand recognition site.
Brain research.
1990 Jun; 518(1-2):199-208. doi:
10.1016/0006-8993(90)90973-f. [PMID: 2167748] - A E Calogero, T C Kamilaris, R Bernardini, E O Johnson, G P Chrousos, P W Gold. Effects of peripheral benzodiazepine receptor ligands on hypothalamic-pituitary-adrenal axis function in the rat.
The Journal of pharmacology and experimental therapeutics.
1990 May; 253(2):729-37. doi:
NULL. [PMID: 2160009] - G B O'Beirne, M J Woods, D C Williams. Two subcellular locations for peripheral-type benzodiazepine acceptors in rat liver.
European journal of biochemistry.
1990 Feb; 188(1):131-8. doi:
10.1111/j.1432-1033.1990.tb15380.x. [PMID: 2156692] - K Ikezaki, K L Black. Stimulation of cell growth and DNA synthesis by peripheral benzodiazepine.
Cancer letters.
1990 Feb; 49(2):115-20. doi:
10.1016/0304-3835(90)90146-o. [PMID: 2155058] - S H Snyder, M W McEnery, A Verma. Molecular mechanisms of peripheral benzodiazepine receptors.
Neurochemical research.
1990 Feb; 15(2):119-23. doi:
10.1007/bf00972201. [PMID: 2159119] - B A Weissman, G T Bolger, P K Chiang. Interactions between nitrogen oxide-containing compounds and peripheral benzodiazepine receptors.
FEBS letters.
1990 Jan; 260(2):169-72. doi:
10.1016/0014-5793(90)80095-z. [PMID: 1688811] - E R Korpi, K Tuominen, M Uusi-Oukari, P Saransaari, S S Oja, P D Suzdak. Mechanisms of alcohol intoxication in a rodent model: blunted alcohol-opposing reaction in 'alcohol-sensitive' rats.
Annals of medicine.
1990; 22(4):253-8. doi:
10.3109/07853899009148936. [PMID: 2248761] - R Sprengel, P Werner, P H Seeburg, A G Mukhin, M R Santi, D R Grayson, A Guidotti, K E Krueger. Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor.
The Journal of biological chemistry.
1989 Dec; 264(34):20415-21. doi:
10.1016/s0021-9258(19)47078-6. [PMID: 2555358] - M Awad, M Gavish. Species differences and heterogeneity of solubilized peripheral-type benzodiazepine binding sites.
Biochemical pharmacology.
1989 Nov; 38(21):3843-9. doi:
10.1016/0006-2952(89)90594-7. [PMID: 2557031] - G Puia, M R Santi, S Vicini, D B Pritchett, P H Seeburg, E Costa. Differences in the negative allosteric modulation of gamma-aminobutyric acid receptors elicited by 4'-chlorodiazepam and by a beta-carboline-3-carboxylate ester: a study with natural and reconstituted receptors.
Proceedings of the National Academy of Sciences of the United States of America.
1989 Sep; 86(18):7275-9. doi:
10.1073/pnas.86.18.7275. [PMID: 2476816] - L Rägo, R A Kiivet, J Harro, M Pŏld. Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists.
Pharmacology, biochemistry, and behavior.
1989 Apr; 32(4):879-83. doi:
10.1016/0091-3057(89)90052-x. [PMID: 2552477] - Y Katz, M Gavish. Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors.
Anesthesiology.
1989 Jan; 70(1):109-11. doi:
10.1097/00000542-198901000-00020. [PMID: 2536252] - L Garau, M Memo, M Pizzi, C Missale, M A Carai, W Boi, M G Ennas, P E Manconi, P F Spano. Properties of benzodiazepine binding sites in peripheral blood lymphocytes.
Journal of clinical laboratory analysis.
1989; 3(6):332-6. doi:
10.1002/jcla.1860030603. [PMID: 2559177] - S Mihara, M Fujimoto. High-affinity binding sites for PK 11195, but not for RO5-4864, in porcine aortic smooth muscle.
Life sciences.
1989; 44(22):1713-20. doi:
10.1016/0024-3205(89)90488-8. [PMID: 2733549] - J D Hirsch, C F Beyer, L Malkowitz, B Beer, A J Blume. Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control.
Molecular pharmacology.
1989 Jan; 35(1):157-63. doi:
NULL. [PMID: 2464128] - J D Hirsch, C F Beyer, L Malkowitz, C C Loullis, A J Blume. Characterization of ligand binding to mitochondrial benzodiazepine receptors.
Molecular pharmacology.
1989 Jan; 35(1):164-72. doi:
NULL. [PMID: 2536464] - A S Basile, G T Bolger, H W Lueddens, P Skolnick. Electrophysiological actions of Ro5-4864 on cerebellar Purkinje neurons: evidence for 'peripheral' benzodiazepine receptor-mediated depression.
The Journal of pharmacology and experimental therapeutics.
1989 Jan; 248(1):463-9. doi:
NULL. [PMID: 2536432] - A H Newman, P Arora, B McRae, R T McCabe, P Skolnick. Fluorescent probes for peripheral-type benzodiazepine receptor visualization and localization.
NIDA research monograph.
1989; 95(?):520-1. doi:
NULL. [PMID: 2561846] - A Verma, S H Snyder. Characterization of porphyrin interactions with peripheral type benzodiazepine receptors.
Molecular pharmacology.
1988 Dec; 34(6):800-5. doi:
NULL. [PMID: 2849047] - M E Van Dort, B J Ciliax, D L Gildersleeve, P S Sherman, K C Rosenspire, A B Young, L Junck, D M Wieland. Radioiodinated benzodiazepines: agents for mapping glial tumors.
Journal of medicinal chemistry.
1988 Nov; 31(11):2081-6. doi:
10.1021/jm00119a005. [PMID: 2846836] - F N Ziyadeh, Z S Agus. Benzodiazepines inhibit transport-related oxygen consumption in thick ascending limb.
The American journal of physiology.
1988 Sep; 255(3 Pt 1):C385-92. doi:
10.1152/ajpcell.1988.255.3.c385. [PMID: 3421319] - G B O'Beirne, D C Williams. The subcellular location in rat kidney of the peripheral benzodiazepine acceptor.
European journal of biochemistry.
1988 Aug; 175(2):413-21. doi:
10.1111/j.1432-1033.1988.tb14211.x. [PMID: 2841135] - R C Drugan, A S Basile, J N Crawley, S M Paul, P Skolnick. Characterization of stress-induced alterations in [3H] Ro5-4864 binding to peripheral benzodiazepine receptors in rat heart and kidney.
Pharmacology, biochemistry, and behavior.
1988 Aug; 30(4):1015-20. doi:
10.1016/0091-3057(88)90134-7. [PMID: 2852369] - J M Olson, B J Ciliax, W R Mancini, A B Young. Presence of peripheral-type benzodiazepine binding sites on human erythrocyte membranes.
European journal of pharmacology.
1988 Jul; 152(1-2):47-53. doi:
10.1016/0014-2999(88)90834-5. [PMID: 2850202] - F N Ziyadeh, E Kelepouris, Z S Agus. Benzodiazepines stimulate sodium ion transport in frog skin epithelium.
Biochimica et biophysica acta.
1988 May; 940(1):93-8. doi:
10.1016/0005-2736(88)90012-0. [PMID: 3259147] - P E Keane, A Bachy, M Morre, K Biziere. Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. II. In vitro and in vivo interactions with benzodiazepine binding sites.
The Journal of pharmacology and experimental therapeutics.
1988 May; 245(2):699-705. doi:
NULL. [PMID: 2896795] - K Beaumont, R Skowronski, D A Vaughn, D D Fanestil. Interactions of lipids with peripheral-type benzodiazepine receptors.
Biochemical pharmacology.
1988 Mar; 37(6):1009-14. doi:
10.1016/0006-2952(88)90502-3. [PMID: 2833268] - P J Syapin, R L Alkana. Chronic ethanol exposure increases peripheral-type benzodiazepine receptors in brain.
European journal of pharmacology.
1988 Feb; 147(1):101-9. doi:
10.1016/0014-2999(88)90638-3. [PMID: 2836214] - D S Lukeman, D A Vaughn, D D Fanestil. Selective pharmacological modulation of renal peripheral-type benzodiazepine binding by treatment with diuretic drugs.
Life sciences.
1988; 42(4):367-73. doi:
10.1016/0024-3205(88)90074-4. [PMID: 2828789] - I Armando, G Levin, M Barontini. Stress increases endogenous benzodiazepine receptor ligand-monoamine oxidase inhibitory activity (tribulin) in rat tissues.
Journal of neural transmission.
1988; 71(1):29-37. doi:
10.1007/bf01259407. [PMID: 2830363] - M Awad, M Gavish. Differential effect of detergents on [3H]Ro 5-4864 and [3H]PK 11195 binding to peripheral-type benzodiazepine-binding sites.
Life sciences.
1988; 43(2):167-75. doi:
10.1016/0024-3205(88)90294-9. [PMID: 2839748] - A S Basile, P Skolnick. Tissue specific regulation of 'peripheral-type' benzodiazepine receptor density after chemical sympathectomy.
Life sciences.
1988; 42(3):273-83. doi:
10.1016/0024-3205(88)90636-4. [PMID: 2826958] - S Z Langer, S Arbilla. Limitations of the benzodiazepine receptor nomenclature: a proposal for a pharmacological classification as omega receptor subtypes.
Fundamental & clinical pharmacology.
1988; 2(3):159-70. doi:
10.1111/j.1472-8206.1988.tb00629.x. [PMID: 2841212] - R Skowroński, K Beaumont, D D Fanestil. Modification of the peripheral-type benzodiazepine receptor by arachidonate, diethylpyrocarbonate and thiol reagents.
European journal of pharmacology.
1987 Nov; 143(3):305-14. doi:
10.1016/0014-2999(87)90454-7. [PMID: 2826190] - M Awad, M Gavish. Binding of [3H]Ro 5-4864 and [3H]PK 11195 to cerebral cortex and peripheral tissues of various species: species differences and heterogeneity in peripheral benzodiazepine binding sites.
Journal of neurochemistry.
1987 Nov; 49(5):1407-14. doi:
10.1111/j.1471-4159.1987.tb01007.x. [PMID: 2822854] - A H Newman, H W Lueddens, P Skolnick, K C Rice. Novel irreversible ligands specific for 'peripheral' type benzodiazepine receptors: (+/-)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N- (2-isothiocyanatoethyl)-3-isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl )-2H-1,4-benzodiazepin-2-one.
Journal of medicinal chemistry.
1987 Oct; 30(10):1901-5. doi:
10.1021/jm00393a036. [PMID: 2821259] - A S Basile, B A Weissman, P Skolnick. Maximal electroshock increases the density of [3H]Ro 5-4864 binding to mouse cerebral cortex.
Brain research bulletin.
1987 Jul; 19(1):1-7. doi:
10.1016/0361-9230(87)90158-4. [PMID: 2820550] - D S Lukeman, D D Fanestil. Interactions of diuretics with the peripheral-type benzodiazepine receptor in rat kidney.
The Journal of pharmacology and experimental therapeutics.
1987 Jun; 241(3):950-5. doi:
. [PMID: 3037074] - A S Basile, P Skolnick. Preservation of 'peripheral' benzodiazepine receptors: differential effects of freezing on [3H]Ro 5-4864 and [3H]PK 11195 binding.
Journal of pharmacological methods.
1987 Apr; 17(2):149-56. doi:
10.1016/0160-5402(87)90025-8. [PMID: 3035290]
