NAN-190 hydrobromide (BioDeep_00000659517)
代谢物信息卡片
化学式: C23H28BrN3O3 (473.1313918000001)
中文名称: NAN-190氢溴酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A[1][3].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:64123
- PubChem: 107966
- ChEMBL: CHEMBL1256701
- CAS: 115388-32-4
- CAS: 115338-32-4
- medchemexpress: HY-19818A
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- James Oluwagbamigbe Fajemiroye, Pablinny Moreira Galdino, Suzana Fereirra Alves, Joelma Abadia Marciano de Paula, José Realino de Paula, Paulo Cesár Ghedini, Elson Alves Costa. Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus.
Journal of ethnopharmacology.
2012 Jun; 141(3):872-7. doi:
10.1016/j.jep.2012.03.043. [PMID: 22472106] - Pei-Lu Yi, Chun-Pang Lin, Chon-Haw Tsai, Jaung-Geng Lin, Fang-Chia Chang. The involvement of serotonin receptors in suanzaorentang-induced sleep alteration.
Journal of biomedical science.
2007 Nov; 14(6):829-40. doi:
10.1007/s11373-007-9197-8. [PMID: 17657585] - Stefan Uckert, Mark H Fuhlenriede, Armin J Becker, Christian G Stief, Friedemann Scheller, Wolfram H Knapp, Wolf G Forssmann, Udo Jonas. Is serotonin significant for the control of penile flaccidity and detumescence in the human male?.
Urological research.
2003 Jun; 31(2):55-60. doi:
10.1007/s00240-002-0292-z. [PMID: 12768258] - J Passchier, A van Waarde, P Doze, P H Elsinga, W Vaalburg. Influence of P-glycoprotein on brain uptake of [18F]MPPF in rats.
European journal of pharmacology.
2000 Nov; 407(3):273-80. doi:
10.1016/s0014-2999(00)00752-4. [PMID: 11068023] - Y Masuda, T Sugiyama. The effect of globopentaosylceramide on a depression model, mouse forced swimming.
The Tohoku journal of experimental medicine.
2000 May; 191(1):47-54. doi:
10.1620/tjem.191.47. [PMID: 10896039] - H W Lambert, J M Lauder. Serotonin receptor agonists that increase cyclic AMP positively regulate IGF-I in mouse mandibular mesenchymal cells.
Developmental neuroscience.
1999; 21(2):105-12. doi:
10.1159/000017372. [PMID: 10449982] - M Kakoki, Y Hirata, H Hayakawa, H Nishimatsu, Y Suzuki, D Nagata, E Suzuki, K Kikuchi, T Nagano, M Omata. Effects of vasodilatory beta-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidney.
Hypertension (Dallas, Tex. : 1979).
1999 Jan; 33(1 Pt 2):467-71. doi:
10.1161/01.hyp.33.1.467. [PMID: 9931149] - C C Wilson, K M Faber, J H Haring. Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism.
Brain research.
1998 Jan; 782(1-2):235-9. doi:
10.1016/s0006-8993(97)01284-5. [PMID: 9519268] - J R Moiseiwitsch, J M Lauder. Regulation of gene expression in cultured embryonic mouse mandibular mesenchyme by serotonin antagonists.
Anatomy and embryology.
1997 Jan; 195(1):71-8. doi:
10.1007/s004290050026. [PMID: 9006717] - S E Mulroney, C Skudlarek, A Shemer, M D Lumpkin, K J Kellar. Tandospirone stimulates prolactin secretion in the rat by an action at serotonin-1A receptors.
The Journal of pharmacology and experimental therapeutics.
1994 Feb; 268(2):862-7. doi:
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Brain research.
1993 May; 611(2):330-2. doi:
10.1016/0006-8993(93)90521-n. [PMID: 8334526] - J E Welch, G E Farrar, A J Dunn, D Saphier. Central 5-HT1A receptors inhibit adrenocortical secretion.
Neuroendocrinology.
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Pain.
1992 Sep; 50(3):365-372. doi:
10.1016/0304-3959(92)90042-a. [PMID: 1454390] - E Przegaliński, A M Ismaiel, E Chojnacka-Wójcik, B Budziszewska, E Tatarczyńska, E Błaszczyńska. The behavioural, but not the hypothermic or corticosterone, response to 8-hydroxy-2-(DI-n-propylamino)-tetralin, is antagonized by NAN-190 in the rat.
Neuropharmacology.
1990 Jun; 29(6):521-6. doi:
10.1016/0028-3908(90)90063-w. [PMID: 2143565]