Fosinopril sodium (BioDeep_00000659411)
代谢物信息卡片
Fosinopril sodium (Monopril)
化学式: C30H45NNaO7P (585.2831189999999)
中文名称: 福辛普利钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)[O-])C3CCCCC3.[Na+]
InChI: /q
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:5164
- KEGGdrug: D00622
- PubChem: 23681451
- PubChem: 23667962
- ChEMBL: CHEMBL3188382
- MeSH: Fosinopril
- CAS: 1217528-56-7
- CAS: 88889-14-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jun Wu, Yingtao Xu, Zikai Geng, Jianqing Zhou, Qingping Xiong, Zhimeng Xu, Hailun Li, Yun Han. Chitosan oligosaccharide alleviates renal fibrosis through reducing oxidative stress damage and regulating TGF-β1/Smads pathway.
Scientific reports.
2022 11; 12(1):19160. doi:
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Journal of hypertension.
2022 10; 40(10):1909-1917. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 100(?):154078. doi:
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Journal of the American Heart Association.
2022 04; 11(7):e023182. doi:
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International journal of clinical and experimental pathology.
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Blood purification.
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Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2013 Jul; 24(4):737-42. doi:
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Journal of applied toxicology : JAT.
2013 Jun; 33(6):458-65. doi:
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Cell biochemistry and biophysics.
2012 Dec; 64(3):205-11. doi:
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Hypertension (Dallas, Tex. : 1979).
2012 Aug; 60(2):339-46. doi:
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2011; 34(5):350-7. doi:
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Kidney & blood pressure research.
2010; 33(3):186-92. doi:
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2009 May; 34(5):448-52. doi:
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The Annals of pharmacotherapy.
2008 Dec; 42(12):1887-92. doi:
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Diabetes care.
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Srpski arhiv za celokupno lekarstvo.
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Kardiologiia.
2005; 45(1):45-50. doi:
NULL. [PMID: 16502517] - Alberto Zanchetti, Gaetano Crepaldi, M Gene Bond, Giuseppe Gallus, Fabrizio Veglia, Giuseppe Mancia, Alessandro Ventura, Giovannella Baggio, Lorena Sampieri, Paolo Rubba, Giovanni Sperti, Alberto Magni. Different effects of antihypertensive regimens based on fosinopril or hydrochlorothiazide with or without lipid lowering by pravastatin on progression of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a randomized double-blind trial.
Stroke.
2004 Dec; 35(12):2807-12. doi:
10.1161/01.str.0000147041.00840.59. [PMID: 15514192] - Seham A el-Batran, Siham M el-Shenawy, Salwa M Nofal, Omar M E Abdel-Salam, Mahmoud S Arbid. Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats.
Pharmacological research.
2004 Aug; 50(2):131-6. doi:
10.1016/j.phrs.2003.12.019. [PMID: 15177300] - Nicolás Roberto Robles, E Angulo, J Grois, A Barquero. Comparative effects of fosinopril and irbesartan on hematopoiesis in essential hypertensives.
Renal failure.
2004 Jul; 26(4):399-404. doi:
10.1081/jdi-120039824. [PMID: 15462108] - Cheuk-Man Yu, Kevin Wing-Hon Lai, Pik-Shan Li, Kar-Yee Lam, Joseph C K Leung, Kar-Neng Lai. Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action.
Journal of molecular and cellular cardiology.
2004 Mar; 36(3):445-53. doi:
10.1016/j.yjmcc.2004.01.002. [PMID: 15010283] - A E Berezin. [Effect of fosinopril on the rate of neurohumoral and proinflammatory activation in patients with heart failure].
Klinicheskaia meditsina.
2004; 82(9):29-32. doi:
. [PMID: 15540418] - Sally A Mifsud, Louise M Burrell, Eiji Kubota, Kassie Jaworski, Mark E Cooper, Jennifer L Wilkinson-Berka. Cardiorenal protective effects of vasopeptidase inhibition with omapatrilat in hypertensive transgenic (mREN-2)27 rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2004 Jan; 26(1):69-80. doi:
10.1081/ceh-120027332. [PMID: 15000298] - Nadège Lods, Paolo Ferrari, Felix J Frey, Andreas Kappeler, Celine Berthier, Bruno Vogt, Hans-Peter Marti. Angiotensin-converting enzyme inhibition but not angiotensin II receptor blockade regulates matrix metalloproteinase activity in patients with glomerulonephritis.
Journal of the American Society of Nephrology : JASN.
2003 Nov; 14(11):2861-72. doi:
10.1097/01.asn.0000092789.67966.5c. [PMID: 14569096] - Michel Azizi, Alvine Bissery, Alessandra Bura-Rivière, Joël Ménard. Dual renin-angiotensin system blockade restores blood pressure-renin dependency in individuals with low renin concentrations.
Journal of hypertension.
2003 Oct; 21(10):1887-95. doi:
10.1097/00004872-200310000-00016. [PMID: 14508195] - Alice Wei, Godfrey C Burns, Brent A Williams, Nazim B Mohammed, Paul Visintainer, Steven L Sivak. Long-term renal survival in HIV-associated nephropathy with angiotensin-converting enzyme inhibition.
Kidney international.
2003 Oct; 64(4):1462-71. doi:
10.1046/j.1523-1755.2003.00230.x. [PMID: 12969167] - Xia Tao, Gao-lin Liu. Protection of organic trauma in sinoaortic-denervated rats treated with fosinopril.
Yao xue xue bao = Acta pharmaceutica Sinica.
2003 Oct; 38(10):743-7. doi:
NULL. [PMID: 14730896] - Yuan-hang Huang, Hai-tao Wang, Qi-zhi Zhu, Hong Zhang, Wen Shen, Yin Wang. [Combination therapy with losartan and fosinopril for early diabetic nephropathy].
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA.
2003 Sep; 23(9):963-5. doi:
. [PMID: 13129736] - H Krum, M Skiba, R E Gilbert. Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy.
Diabetic medicine : a journal of the British Diabetic Association.
2003 Sep; 20(9):708-12. doi:
10.1046/j.1464-5491.2003.01023.x. [PMID: 12925048] - M Bayerle-Eder, M Zangeneh, G Kreiner, W Raffesberg, P Nowotny, H Vierhapper, W Waldhäusl, M Wolzt, H Pleiner, S Gasic. ANP but not BNP reflects early left diastolic dysfunction in type 1 diabetics with myocardial dysinnervation.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2003 May; 35(5):301-7. doi:
10.1055/s-2003-41306. [PMID: 12916000] - Chollada Buranakarl, Anusak Kitjtawonrat, Somchai Pondeenana, Boonmee Sunyasujaree, Sumolaya Kanchanapangka, Narongsak Chaiyabutr, Kenneth C Bovee. Comparison of dipyridamole and fosinopril on renal progression in nephrectomized rats.
Nephrology (Carlton, Vic.).
2003 Apr; 8(2):80-91. doi:
10.1046/j.1440-1797.2003.00141.x. [PMID: 15012738] - Hariprasad Trivedi, Sunder M Lal. A prospective, randomized, open labeled crossover trial of fosinopril and theophylline in post renal transplant erythrocytosis.
Renal failure.
2003 Jan; 25(1):77-86. doi:
10.1081/jdi-120017470. [PMID: 12617335] - Paolo Mulatero, Franco Rabbia, Alberto Milan, Cristina Paglieri, Fulvio Morello, Livio Chiandussi, Franco Veglio. Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism.
Hypertension (Dallas, Tex. : 1979).
2002 Dec; 40(6):897-902. doi:
10.1161/01.hyp.0000038478.59760.41. [PMID: 12468576] - Walter Raasch, Torsten Bartels, Christopher Schwartz, Walter Häuser, Hartmut Rütten, Peter Dominiak. Regression of ventricular and vascular hypertrophy: are there differences between structurally different angiotensin-converting enzyme inhibitors?.
Journal of hypertension.
2002 Dec; 20(12):2495-504. doi:
10.1097/01.hjh.0000042885.24999.e9. [PMID: 12473875] - Calin V Maniu, Donna M Meyer, Margaret M Redfield. Hemodynamic and humoral effects of vasopeptidase inhibition in canine hypertension.
Hypertension (Dallas, Tex. : 1979).
2002 Oct; 40(4):528-34. doi:
10.1161/01.hyp.0000033223.17484.b1. [PMID: 12364358] - Michel Azizi, Maxime Lamarre-Cliche, Agnès Labatide-Alanore, Alvine Bissery, Than Tam Guyene, Joël Ménard. Physiologic consequences of vasopeptidase inhibition in humans: effect of sodium intake.
Journal of the American Society of Nephrology : JASN.
2002 Oct; 13(10):2454-63. doi:
10.1097/01.asn.0000030142.80452.11. [PMID: 12239234] - Faiez Zannad, Michèle Kessler, Jean Pierre Grünfeld, Christian Thuilliez. FOSIDIAL: a randomised placebo controlled trial of the effects of fosinopril on cardiovascular morbidity and mortality in haemodialysis patients. Study design and patients' baseline characteristics.
Fundamental & clinical pharmacology.
2002 Oct; 16(5):353-60. doi:
10.1046/j.1472-8206.2002.00127.x. [PMID: 12602460] - Guolong Yu, Xiaoqiu Liang, Xiumei Xie, Tianlun Yang, Ming Sun, Shuiping Zhao. Apoptosis, myocardial fibrosis and angiotensin II in the left ventricle of hypertensive rats treated with fosinopril or losartan.
Chinese medical journal.
2002 Sep; 115(9):1287-91. doi:
. [PMID: 12411096] - Marco Pahor, Lonneke V Franse, Steven R Deitcher, William C Cushman, Karen C Johnson, Ronald I Shorr, Kandice Kottke-Marchant, Russell P Tracy, Grant W Somes, William B Applegate. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1.
Circulation.
2002 Jan; 105(4):457-61. doi:
10.1161/hc0402.102929. [PMID: 11815428] - H Rosolová, J Cech, F Sefrna. [Effectiveness and tolerance of fosinopril in the treatment of arterial hypertension of mild and medium severity].
Vnitrni lekarstvi.
2001 Dec; 47(12):834-9. doi:
NULL. [PMID: 11826546] - G Yu, X Liang, X Xie, M Su, S Zhao. Diverse effects of chronic treatment with losartan, fosinopril, and amlodipine on apoptosis, angiotensin II in the left ventricle of hypertensive rats.
International journal of cardiology.
2001 Dec; 81(2-3):123-9; discussion 129. doi:
10.1016/s0167-5273(01)00539-3. [PMID: 11744126] - G L Yu, X Q Liang, J Q Zheng. [Contrast of losartan, fosinopril and amlodipine on cardiomyocyte apoptosis and left ventricular remolding in hypertensive rats].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2001 Oct; 26(5):405-8. doi:
. [PMID: 12536482] - C Shu, H Shen, U Hopfer, D E Smith. Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures.
Drug metabolism and disposition: the biological fate of chemicals.
2001 Oct; 29(10):1307-15. doi:
. [PMID: 11560874] - R Marin, L M Ruilope, P Aljama, P Aranda, J Segura, J Diez. A random comparison of fosinopril and nifedipine GITS in patients with primary renal disease.
Journal of hypertension.
2001 Oct; 19(10):1871-6. doi:
10.1097/00004872-200110000-00023. [PMID: 11593109] - Daniel Glicklich, Larry Burris, Agnes Urban, Vivian Tellis, Stuart Greenstein, Richard Schechner, Prasad Devarajan, Helena Croizat. Angiotensin-converting enzyme inhibition induces apoptosis in erythroid precursors and affects insulin-like growth factor-1 in posttransplantation erythrocytosis.
Journal of the American Society of Nephrology : JASN.
2001 Sep; 12(9):1958-1964. doi:
10.1681/asn.v1291958. [PMID: 11518790] - Z Cao, L M Burrell, I Tikkanen, F Bonnet, M E Cooper, R E Gilbert. Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats.
Kidney international.
2001 Aug; 60(2):715-21. doi:
10.1046/j.1523-1755.2001.060002715.x. [PMID: 11473654] - H H Chen, J G Lainchbury, Y Matsuda, G J Harty, J C Burnett . Endogenous natriuretic peptides participate in renal and humoral actions of acute vasopeptidase inhibition in experimental mild heart failure.
Hypertension (Dallas, Tex. : 1979).
2001 Aug; 38(2):187-91. doi:
10.1161/01.hyp.38.2.187. [PMID: 11509474] - C Buranakarl, A Kijtawornrat, P Nampimoon. Effects of fosinopril on renal function, baroreflex response and noradrenaline pressor response in conscious normotensive dogs.
Veterinary research communications.
2001 Jul; 25(5):355-66. doi:
10.1023/a:1010638609216. [PMID: 11469507] - B X He, G L Yu, X Q Liang. [Effects of lorsartan, fosinopril on myocardial fibrosis, angiotensin II and cardiac remolding in hypertensive rats].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2001 Apr; 26(2):118-20. doi:
. [PMID: 12536639] - B Eryonucu, L Koldas, F Ayan, N Keser, A Sirmaci. Comparison of the first dose response of fosinopril and captopril in congestive heart failure: a randomized, double-blind, placebo controlled study.
Japanese heart journal.
2001 Mar; 42(2):185-91. doi:
10.1536/jhj.42.185. [PMID: 11384079] - A Zanchetti, G Crepaldi, M G Bond, G V Gallus, F Veglia, A Ventura, G Mancia, G Baggio, L Sampieri, P Rubba, S Collatina, E Serrotti. Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima-media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study. PHYLLIS study group.
Journal of hypertension.
2001 Jan; 19(1):79-88. doi:
10.1097/00004872-200101000-00011. [PMID: 11204308] - C A Aguilar-Salinas, S A Arellano, O Villanueva-Sanchez, G A Magos, L E Guillén-Pineda, R Rodriguez, F J Gómez-Pérez. Effects of omapatrilat on blood pressure and insulin sensitivity in an animal model of insulin resistance.
Blood pressure.
2001; 10(3):164-9. doi:
10.1080/080370501753182389. [PMID: 11688764]